Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3001 - 3050 OF 15805 RESULTS

Quantitative mapping of transcriptome and proteome dynamics during polarization of human ipsc-derived neurons
eLife, ISSN: 2050084X
Feline W Lindhout; Robbelien Kooistra; Sybren Portegies; Lotte J. Herstel; Riccardo Stucchi; Basten L. Snoek; Maarten Altelaar; Harold MacGillavry; Corette J. Wierenga; Casper C Hoogenraad
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Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Yoshiro Itatani; Takamasa Yamamoto; Cuiling Zhong; Alfredo A. Molinolo; Jane Ruppel; Priti Hegde; M. Mark Taketo; Napoleone Ferrara
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Unstable mechanisms of resistance to inhibitors of escherichia coli lipoprotein signal peptidase
mBio, ISSN: 21507511 21612129
Homer Pantua; Elizabeth Skippington; Marie-Gabrielle Braun; Cameron Noland; Jingyu Diao; Yutian Peng; Susan L. Gloor; Donghong Yan; Jing Kang; Anand K. Katakam; Janina Reeder; Georgette M. Castanedo; Keira Garland; László Kömüves; Meredith Sagolla; Cary D. Austin; Jeremy Murray; Yiming Xu; Zora Modrusan; Min Xu; Emily J. Hanan; Sharookh B. Kapadia
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Prognostic impact of somatic mutations in diffuse large B-cell lymphoma and relationship to cell-of-origin: data from the phase III GOYA study
Haematologica, ISSN: 15928721 03906078
Christopher R. Bolen; Magdalena Klanova; Marek Trneny; Laurie H. Sehn; Jie He; Jing Tong; Joseph N. Paulson; Eugene Kim; Umberto Vitolo; Alice Di Rocco; Guenter Fingerle-Rowson; Tina Nielsen; Lenz; Mikkel Z. Oestergaard
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Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Suzie J. Scales; Nidhi Gupta; Ann De Mazière; George Posthuma; Cecilia Chiu; Andrew A Pierce; Kathy Hötzel; Jianhua Tao; Oded Foreman; Georgios Koukos; Francesca Oltrabella; Judith Klumperman; Wei Yu Lin; Andrew S. Peterson
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Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Nidhi Gupta; Xinhua Wang; Xiaohui Wen; Paul Moran; Maciej Paluch; Hass; Amy Heidersbach; Benjamin Haley; Daniel Kirchhofer; Randall J. Brezski; Andrew S. Peterson; Suzie J. Scales
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A Physiologically Based Pharmacokinetic Model of Vismodegib: Deconvoluting the Impact of Saturable Plasma Protein Binding, pH-Dependent Solubility and Nonsink Permeation
AAPS Journal, ISSN: 15507416
Michael J. Dolton; Po-Chang Chiang; Fang Ma; Jin Yan Jin; Yuan Chen
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Fenebrutinib Versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double-Blind, Phase II Trial
Arthritis and Rheumatology, ISSN: 23265205 23265191
Stanley B. Cohen; Katie Tuckwell; Tamiko R. Katsumoto; Rui Zhao; Joshua Galanter; Chin H. Lee; Julie Rae; Balazs Toth; Nandhini Ramamoorthi; Jason A. Hackney; Alberto Berman; Nemanja Damjanov; Dmytro Fedkov; Slawomir Jeka; Leslie Chinn; Michael J. Townsend; Alyssa M. Morimoto; Mark C. Genovese
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Bioactivation of a,b-unsaturated carboxylic acids through acyl glucuronidation
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Teresa Mulder; Sudheer Bobba; Kevin Johnson; Jessica M. Grandner; Wei Wang; Chenghong Zhang; Jingwei Cai; Edna F. Choo; Cyrus Khojasteh; Donglu Zhang
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Efficacy of Every Four Monthly and Quarterly Dosing of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration: The STAIRWAY Phase 2 Randomized Clinical Trial
JAMA Ophthalmology, ISSN: 21686173 21686165
Arshad M. Khanani; Sunil Patel; Philip J. Ferrone; Aaron Osborne; Jayashree Sahni; Susanna M. Grzeschik; Karen Basu; Jason S. Ehrlich; Zdenka Haskova; Pravin U. Dugel
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Asian race and origin have no clinically meaningful effects on polatuzumab vedotin pharmacokinetics in patients with relapsed/refractory B-cell non-Hodgkin lymphoma
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Rong Shi; Tong Lu; Grace Ku; Hao Ding; Tomohisa Saito; Leonid Gibiansky; Priya Agarwal; Xiaobin Li; Jin Yan Jin; Sandhya Girish; Dale Miles; Chunze Li; Dan Lu
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Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Philippe Gevaert; Theodore A. Omachi; Jonathan Corren; Joaquim Mullol; Joseph Han; Stella E. Lee; Derrick G. Kaufman; Monica Ligueros-Saylan; Monet Howard; Rui Zhu; Ryan Owen; Kit Wong; Lutaf Islam; Claus Bachert
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Survival outcomes in an older US population with advanced melanoma and central nervous system metastases: SEER-Medicare analysis
Cancer Medicine, ISSN: 20457634
Natalia Sadetsky; Alexandra Hernandez; Chris J. Wallick; Edward McKenna; Andy Surinach; Dawn Colburn
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A cross-industry forum on benchmarking critical quality attribute identification and linkage to process characterization studies
Biologicals, ISSN: 10958320 10451056
Sarah Demmon; Swapnil Bhargava; Doreen Ciolek; Jennifer Halley; Nomalie Jaya; Marisa K. Joubert; Edward Koepf; Phillip Smith; Melody Trexler-Schmidt; Philip Tsai
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In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk
Archives of Toxicology, ISSN: 14320738 03405761
Leah M. Norona; Aaron Fullerton; Chris Lawson; Leslie Leung; Jochen Brumm; Tomomi Kiyota; Jonathan M. Maher; Cyrus Khojasteh; William R. Proctor
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Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Diabetologia, ISSN: 14320428 0012186X
Wendy K. Chung; Karel Erion; Jose C. Florez; Andrew T. Hattersley; Marie-France Hivert; Christine G. Lee; Mark I. McCarthy; John J. Nolan; Jill M. Norris; Ewan Pearson; Louis Philipson; Allison T. McElvaine; William T. Cefalu; Stephen S. Rich; Paul W. Franks
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Clinical Activity and Safety of Atezolizumab in a Phase 1 Study of Patients With Relapsed/Refractory Small-Cell Lung Cancer
Clinical Lung Cancer, ISSN: 19380690 15257304
Chiang; Lecia Van Dam Sequist; Gilbert; Paul Conkling; Thompson; Marcoux; Scott Gettinger; Marcin Kowanetz; Luciana L. Molinero; Carol E. O'Hear; Marcella Fassò; Lam; Michael S. Gordon
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Phase 1b study of anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) in patients with platinum-sensitive recurrent ovarian cancer
Gynecologic Oncology, ISSN: 10956859 00908258
Kevin L. Moore; Michael J. Birrer; James C. Marsters Jr.; Wang; Younjeong Choi; Stephanie Royer-Joo; Lemahieu; Katy Armstrong; Julie Cordova; Divya Samineni; Schuth; Vaze; Daniel Maslyar; Eric W. Humke; Hamilton; Joyce F. Liu
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The Hippo Pathway as a Driver of Select Human Cancers
Trends in Cancer, ISSN: 24058033
Aishwarya Kulkarni; Matthew T. Chang; Joseph H.A. Vissers; Anwesha Dey; Kieran F. Harvey
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Budget Impact of 12-Month Fixed Treatment Duration Venetoclax in Combination with Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia Patients in the United States
PharmacoEconomics, ISSN: 11792027 11707690
Sang Kyu Cho; Beenish S. Manzoor; Kavita Sail; Hélène Parisé; Arliene Ravelo; Sheila Shapouri; Tatyana Kapustyan; Simon Sharmokh; Suchin Virabhak; Matthew S. Davids; Scott Johnson
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Contribution of monocarboxylate transporter 6 to the pharmacokinetics and pharmacodynamics of bumetanide in mice
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Robert S. Jones; Donna Ruszaj; Mark D. Parker; Marilyn E. Morris
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Hallmarks of aging Drosophila intestinal stem cells
Mechanisms of Ageing and Development, ISSN: 18726216 00476374
Imilce A. Rodriguez-Fernandez; Helen Tauc; Heinrich Jasper
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An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Vincent Debruycker; Andrew Hutchin; Matthieu Masureel; Emel Ficici; Chloé Martens; Pierre Legrand; Richard A. Stein; Hassane S. Mchaourab; José D. Faraldo-Gómez; Han Remaut; Cedric Govaerts
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The role of clinical pharmacology across novel treatment modalities
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Karen Thudium Mueller; Chi-Chung Li; Phipps
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Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation
Cell Reports Medicine, ISSN: 26663791
Derek K. Smith; Lance Kates; Durinck; Nisha Patel; Eric Stawiski; Noelyn Kljavin; Oded Foreman; Bence Sipos; Mark J. Solloway; Bernard B. Allan; Andrew S. Peterson
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Structure of the essential inner membrane lipopolysaccharide–PbgA complex
Nature, ISSN: 14764687 00280836
Thomas Clairfeuille; Kerry R. Buchholz; Qingling Li; Erik Verschueren; Peter S. Liu; Dewakar Sangaraju; Summer Park; Cameron Noland; Kelly M. Storek; Nicholas N. Nickerson; Lynn Martin; Trisha Dela Vega; Anh Miu; Janina Reeder; Maria Ruiz-Gonzalez; Danielle L. Swem; Guanghui Han; Daniel P. DePonte; Mark S. Hunter; Cornelius Gati; Sheerin Shahidi-Latham; Min Xu; Nicholas J. Skelton; Benjamin D. Sellers; Elizabeth Skippington; Wendy N. Sandoval; Emily J. Hanan; Jian Payandeh; Steven T. Rutherford
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Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media
Journal of Biotechnology, ISSN: 18734863 01681656
Salina Louie; Jayanthi Lakkyreddy; Brian M. Castellano; Benjamin Haley; Anh Nguyen Dang; Cynthia Lam; Danming Tang; Steven E. Lang; Snedecor; Shahram Misaghi
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Nanolipoprotein Particles as a Delivery Platform for Fab Based Therapeutics
Bioconjugate Chemistry, ISSN: 15204812 10431802
Martine Darwish; Whitney Shatz; Brandon Leonard; Kelly M. Loyet; Kathy Barrett; Janice L. Wong; Hong Li; Ryan Abraham; May Lin; Yvonne Franke; Christine Tam; Kyle Mortara; Inna Zilberleyb; Craig D. Blanchette
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Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity
ACS Medicinal Chemistry Letters, ISSN: 19485875
James J. Crawford; Wendy Lee; Adam R. Johnson; Kelly Delatorre; Jacob Z. Chen; Eigenbrot; Julia Heidmann; Satoko Kakiuchi-Kiyota; Arna Katewa; James R. Kiefer; Lichuan Liu; Joseph W. Lubach; Misner; Hans E. Purkey; Karin Reif; Jennifer Vogt; Harvey Wong; Christine Yu; Wendy B. Young
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Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Elisia Villemure; Steven T. Staben
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STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells
EMBO Molecular Medicine, ISSN: 17574684 17574676
Sascha Kahlfuss; Ulrike Kaufmann; Axel R Concepcion; Lucile Noyer; Dimitrius Raphael; Martin Vaeth; Jun Yang; Priya Pancholi; Mate Maus; James Muller; Lina Kozhaya; Alireza Khodadadi-Jamayran; Zhengxi Sun; Patrick Shaw; Derya Unutmaz; Peter B Stathopulos; Cori Feist; Scott B Cameron; Stuart E Turvey; Stefan Feske
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Impact of initial treatment and prognostic factors on postprogression survival in BRAF-mutated metastatic melanoma treated with dacarbazine or vemurafenib ± cobimetinib: A pooled analysis of four clinical trials
Journal of Translational Medicine, ISSN: 14795876
Paolo A. Ascierto; Antoni Ribas; James Larkin; McArthur; Karl Lewis; Axel Hauschild; Keith Flaherty; Edward McKenna; Qian Zhu; Yong Mun; Brigitte Dréno
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Method screening strategies of stereoisomers of compounds with multiple chiral centers and a single chiral center
Journal of Chromatography A, ISSN: 18733778 00219673
Jessica Lin; Charlotte Tsang; Raymond Lieu; Kelly Zhang
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Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis
JCI insight, ISSN: 23793708
Kasia Owczarczyk; Matthew Cascino; Cecile Holweg; Tew; Ward Ortmann; Timothy W. Behrens; Thomas Schindler; Langford; William St.Clair; Peter A. Merkel; Spiera; Seo; Cees Kallenberg; Specks; Noha Lim; John H. Stone; Paul Brunetta; Marco Prunotto
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Immunoaffinity LC-MS/MS is more suitable than ELISA to quantify a PEGylated molecule in cynomolgus monkey serum
Bioanalysis, ISSN: 17576199 17576180
Yanqiu Liu; Luna Liu; Nancy Yu; Lu Dai; Cinzia Stella; Vincent Chang; Surinder Kaur; Keyang Xu; Eric Wakshull
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Point-of-care and utility in clinical trials: Making quicker decisions to transform patient care and drug development
Bioanalysis, ISSN: 17576199 17576180
Saloumeh Kadkhodayan Fischer
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Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering
Biochemical Society Transactions, ISSN: 14708752 03005127
Daniel Kirchhofer; Burdick; Nicholas J. Skelton; Yingnan Zhang; Ultsch
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Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Filip Roudnicky; Jitao David Zhang; Bo Kyoung Kim; Nikhil J. Pandya; Yanjun Lan; Lisa Sach-Peltason; Heloise Ragelle; Pamela Strassburger; Sabine Gruener; Mirjana Lazendic; Sabine Uhles; Franco Revelant; Oliv Eidam; Gregor Sturm; Verena Kueppers; Klaus Christensen; Leonard D. Goldstein; Manuel Tzouros; Balazs Banfai; Zora Modrusan; Martin Graf; Christoph Patsch; Mark Burcin; Claas A. Meyer; Peter D. Westenskow; Chad A. Cowan
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Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis following First-Line Therapy in Patients with Metastatic Colorectal Cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Xiaoju Max Ma; Bendell; Herbert Hurwitz; Christine Ju; John J. Lee; Alex Lovejoy; Christoph Mancao; Alan Nicholas; Richard Price; Nicolas Sommer; Nalin Tikoo; Lijing Yao; Stephanie J. Yaung; John F. Palma
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EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL
Retina, ISSN: 15392864 0275004X
Vlad Bantseev; Chris Schuetz; Helen Booler; Joshua Horvath; Kristof Hovaten; Signe Erickson; Ellison Bentley; T. Michael Nork; William R. Freeman; Jay M. Stewart; Giulio Barteselli
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Regulation of cell death and immunity by xiap
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Philipp J. Jost; Domagoj Vucic
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NADPH-independent inactivation of CYP2B6 and NADPH-dependent inactivation of CYP3A4/5 by PBD: Potential implication for assessing covalent modulators for time-dependent inhibition
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Mika Kosaka; Donglu Zhang; Simon Wong; Zhengyin Yan
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Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Byung-Gil Lee; Fabian Merkel; Matteo Allegretti; Markus Hassler; Christopher Cawood; Léa Lecomte; Francis J. O’Reilly; Ludwig R. Sinn; Pilar Gutierrez-Escribano; Marc Kschonsak; Sol Bravo; Takanori Nakane; Juri Rappsilber; Luis Aragon; Martin Beck; Jan Löwe; Christian H. Haering
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In Situ-Forming Glucose-Responsive Hydrogel from Hyaluronic Acid Modified with a Boronic Acid Derivative
Macromolecular Chemistry and Physics, ISSN: 15213935 10221352
Emily Holz; Karthikan Rajagopal
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RAS-targeted therapies: is the undruggable drugged?
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Amanda R. Moore; Scott C. Rosenberg; Frank McCormick; Shiva Malek
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Evaluating the Pharmacokinetics and Systemic Effects of a Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl)amino] Caprylate in Rats
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Gauri Deshmukh; Jia Liu; Karthik Nagapudi; Jacob Z. Chen; Nicole R. Valle; Ruina Li; Emile G. Plise; Matthew Durk
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Tumor Segmentation and Feature Extraction from Whole-Body FDG-PET/CT Using Cascaded 2D and 3D Convolutional Neural Networks
Journal of Digital Imaging, ISSN: 1618727X 08971889
Skander Jemaa; Jill Fredrickson; Richard A. D. Carano; Tina Nielsen; De Crespigny; Thomas Bengtsson
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Timing of Peak Vision Gains in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab
Ophthalmology Retina, ISSN: 24686530
Rahul N. Khurana; Louis K. Chang; Bann-Mo Day; Avanti Ghanekar; Ivaylo Stoilov
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Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous NSCLC (IMpower131): Results From a Randomized Phase III Trial
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Jotte; Federico Cappuzzo; Ihor Vynnychenko; Daniil Stroyakovskiy; Rodriguez-Abreu; Maen Hussein; Ross A. Soo; Henry J Conter; Kozuki; Kuan-Chieh Huang; Graupner; Sun; Tien Hoang; Helen Jessop; Mark L. McCleland; Ballinger; Alan Sandler; Mark A. Socinski
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A Review on Mixing-Induced Protein Particle Formation: The Puzzle of Bottom-Mounted Mixers
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Benson Gikanga; Maa
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