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Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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Nature Communications, ISSN: 20411723
Akhilesh Pandey; Eric Stawiski; Steffen Durinck; Harsha Gowda; Leonard Goldstein; Mustafa A. Barbhuiya; Markus S. Schröder; Sreelakshmi K. Sreenivasamurthy; Sun-Whe Kim; Sameer Phalke; Kushal Suryamohan; Kayla Lee; Papia Chakraborty; Vasumathi Kode; Xiaoshan Shi; Aditi Chatterjee; Keshava Datta; Aafaque A. Khan; Tejaswini Subbannayya; Jing Wang; Subhra Chaudhuri; Sanjiv Gupta; Braj Raj Shrivastav; Bijay Jaiswal; Satish S. Poojary; Shushruta Bhunia; Patricia Garcia; Carolina Bizama; Lorena Rosa; Wooil Kwon; Hongbeom Kim; Youngmin Han; Thakur Deen Yadav; Vedam Laxmi Ramprasad; Amitabha Chaudhuri; Zora Modrusan; Juan Carlos Roa; Pramod Kumar Tiwari; Jin-Young Jang; Somasekar Seshagiri
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
Nature Communications,
Henry Maun; Rajesh Vij; Ben Walters; Ashley Morando; Janet Jackman; Ping Wu; Alberto Estevez; Xiaocheng Chen; Yvonne Franke; Terry Lipari; Mark Dennis; Daniel Kirchhofer; Claudio Ciferri; Kelly Loyet; Tangsheng Yi; Charles Eigenbrot; Bob Lazarus; JT Koerber
Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling
npj Systems Biology and Applications,
Iraj Hosseini; Kapil Gadkar; Eric Stefanich; Chi-Chung Li; Laura Sun; Yu-Waye Chu; Saroja Ramanujan
Journal of Patient-Reported Outcomes, ISSN: 25098020
Rachael Lawrance; Evgeny Degtyarev; Philip Griffiths; Peter Trask; Helen Lau; Denise D’Alessio; Ingolf Griebsch; Gudrun Wallenstein; Kim Cocks; Kaspar Rufibach
Journal of Urology, ISSN: 15273792
Guru Sonpavde; Juliane Manitz; Chen Gao; Darren Tayama; Constanze Kaiser; Daniel Hennessy; Doris Makari; Ashok Gupta; Shaad Essa Abdullah; Günter Niegisch; Jonathan E. Rosenberg; Dean Bajorin; Petros Grivas; Andrea B. Apolo; Robert Dreicer; Noah M. Hahn; Matthew D. Galsky; Andrea Necchi; Sandy Srinivas; Thomas Powles; Toni K. Choueiri; Gregory Russell Pond
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Amanda R. Moore; Scott C. Rosenberg; Frank McCormick; Shiva Malek
Communications Biology, ISSN: 23993642
Andrew Ah Young; Sterling C. Eckard; Alvin Gogineni; Hongkang Xi; S. Jack Lin; Gerhardy; Christian Cox; Qui T. Phung; Jason Hackney; Anand Kumar Katakam; Mike Reichelt; Patrick Caplazi; Paolo Manzanillo; Juan Zhang; Meron Roose-Girma; Lucinda W. Tam; Robert J (Research) Newman; Aditya Murthy; Robby Weimer; Jennie Lill; Wyne P. Lee; Michele Grimbaldeston; Daniel Kirchhofer; Menno van Lookeren Campagne
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials
npj Breast Cancer,
Jan Hudeček; Leonie Voorwerk; Maartje Van Seijen; Iris Nederlof; Michiel de Maaker; Jose van den Berg; Koen Van De Vijver; Karolina Sikorska; Sylvia Adams; Sandra Demaria; Viale; Torsten Nielsen; Sunil Badve; Stefan Michiels; W Fraser Symmans; Christos Sotiriou; David Rimm; Stephen M. Hewitt; Carsten Denkert; Sibylle Loibl; Sherene Loi; John M. S. Bartlett; Giancarlo Pruneri; Deborah A. Dillon; Maggie Chon U. Cheang; Andrew Tutt; Jacqueline A. Hall; Zuzana Kos; Roberto Salgado; Kok; Hugo M. Horlings; Aini Hyytiäinen; Akira I. Hida; Alastair Thompson; Alex Lefevre; Alexander J. Lazar; Allen Gown; Amy Lo; Anna Sapino; Anant Madabhushi; Andre Moreira; Andrea Richardson; Andrea Vingiani; Andrew H. Beck; Andrew M. Bellizzi; A. Steven Guerrero; Anita Grigoriadis; Anna Ehinger; Ana C. Garrido-Castro; Anne Vincent-Salomon; Anne-Vibeke Laenkholm; Ashish Sharma; Ashley Cimino-Mathews; Ashok Srinivasan; Balazs Acs; Baljit Singh; Benjamin Calhoun; Benjamin Haibe-Kans; Benjamin Solomon; Bibhusal Thapa; Brad H. Nelson;
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
npj Breast Cancer,
Zuzana Kos; Elvire Roblin; Rim S. Kim; Stefan Michiels; Brandon D. Gallas; Weijie Chen; Koen Van De Vijver; Shom Goel; Sylvia Adams; Sandra Demaria; Viale; Torsten Nielsen; Sunil Badve; W Fraser Symmans; Christos Sotiriou; David Rimm; Stephen M. Hewitt; Carsten Denkert; Sibylle Loibl; Stephen J Luen; John M. S. Bartlett; Peter Savas; Giancarlo Pruneri; Deborah A. Dillon; Maggie Chon U. Cheang; Andrew Tutt; Jacqueline A. Hall; Kok; Hugo M. Horlings; Anant Madabhushi; Jeroen van der Laak; Francesco Ciompi; Anne-Vibeke Laenkholm; Enrique Bellolio; Tina Gruosso; Stephen B. Fox; Juan Carlos Araya; Giuseppe Floris; Jan Hudeček; Leonie Voorwerk; Andrew H. Beck; Jen Kerner; Denis Larsimont; Sabine Declercq; Gert G.G.M. Van Den Eynden; Pusztai; Anna Ehinger; Wentao Yang; Khalid AbdulJabbar; Yinyin Yuan; Rajendra Singh; Crispin Hiley; Maise al Bakir; Alexander J. Lazar; Stephen Naber; Stephan Wienert; Miluska Castillo; Giuseppe Curigliano; Maria V. Dieci; Fabrice Andre; Charles Swanton; Jorge S. Reis-Filho; Joseph
Scientific Reports, ISSN: 20452322
Rebecca M. Reese; Michelle Dourado; Keith Anderson; Soren Warming; Kimberly L. Stark; Alessia Balestrini; Eric Suto; Wyne Lee; Lorena Riol Blanco; Shannon Shields; David Hackos
Nature Communications, ISSN: 20411723
Keren Bahar Halpern; Hassan Massalha; Rachel K. Zwick; Andreas E. Moor; David Castillo-Azofeifa; Milena Rozenberg; Lydia Farack; Adi Egozi; Dan R. Miller; Inna Averbukh; Yotam Harnik; Noa Weinberg-Corem; Frederic De Sauvage; Ido Amit; Ophir D. Klein; Michal Shoshkes-Carmel; Shalev Itzkovitz
Nature Communications, ISSN: 20411723
Kelvin F. Cho; Taylur Ma; Christopher M. Rose; Donald S. Kirkpatrick; Kebing Yu; Robert Blake
Calibrating the in vitro–in vivo correlation for OATP-mediated drug-drug interactions with rosuvastatin using static and PBPK models
Drug Metabolism and Disposition, ISSN: 00909556
Rucha Sane; Kit Wun Kathy Cheung; Péter Kovács; Taleah Farasyn; Ruina Li; Annamaria Bui; Luna Musib; Emese Kis; Emile Plise; Zsuzsanna Gáborik
Advances in Therapy, ISSN: 18658652 0741238X
Jennie Best; Shalini V. Mohan; Amanda M. Kong; Krish Patel; John M. Pagel; Boris Ivanov; Otis W. Brawley; Krutika Jariwala-Parikh; James Zazzali; John Pauk
Cell Reports, ISSN: 22111247
Otto Morris; Hansong Deng; Christine Tam; Heinrich Jasper
Targeting Autophagy to Treat Cancer: Challenges and Opportunities
Frontiers in Pharmacology,
Junghyun Lim; Aditya Murthy
Practical Early Development Synthesis of Nav17 Inhibitor GDC-0310
Synthesis (Germany), ISSN: 00397881
Andy Stumpf; Frederic St-Jean; David Lao; Zhiyong (Jay) Cheng; Remy Angelaud; Francis Gosselin
Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis
Cell Reports Medicine,
Xia Gao; Jim Jia; Anna Guttman; Daryle DePianto; Katrina B. Morshead; Kai-Hui Sun; Nandhini Ramamoorthi; Jason A. Vander Heiden; Zora Modrusan; Paul J. Wolters; Angelika Jahreis; Joe Arron; Dinesh Khanna; Thiru Ramalingam
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Amos Baruch; Chin Wong; Leslie W. Chinn; Vaze; Jun Sonoda; Tom Gelzleichter; Shan Chen; Nicholas Lewin-Koh; Linda Morrow; Suresh Dheerendra; Richard Boismenu; Johnny Gutierrez; Eric Wakshull; Maria E. Wilson; Puneet S. Arora
Generalized additive mixed modeling of longitudinal tumor growth reduces bias and improves decision making in translational oncology
Cancer Research, ISSN: 00085472
Bill Forrest; Bruno Alicke; Oleg Mayba; Magdalena Osinska; Michal Jakubczak; Pawel Piatkowski; Lech Choniawko; Alice Starr; Stephen Gould
Using differential scanning calorimetry for the development of non-reduced capillary electrophoresis sodium dodecyl sulfate methods for monoclonal antibodies
Analytical Biochemistry, ISSN: 00032697
Patricia Molina; Arthur J. Schick; Leslie Welch; Thomas Niedringhaus; Gabriella del Hierro; Galahad Deperalta; Aaron Hieb
Frontiers in Immunology, ISSN: 16643224
Steve Hack; Zhu; Yulei Wang
Improving Prediction of Free Fatty Acid Particle Formation in Biopharmaceutical Drug Products: Incorporating Ester Distribution during Polysorbate 20 Degradation
Molecular Pharmaceutics,
Nidhi Doshi; Joelle Martin; Anthony Tomlinson
Impact of Silicone Oil on Free Fatty Acid Particle Formation due to Polysorbate 20 Degradation
Pharmaceutical Research, ISSN: 07248741
Raphael Fish; Jasper Lin; Nidhi Doshi
Urology, ISSN: 15279995 00904295
Kyle A. Richards; Wenny Lin; Ching-Yi Chuo; Christina L. Derleth; Jingbo Yi; Marko Zivkovic; Sarika Ogale; Sandip Prasad; G. Joel Decastro; Gary D. Steinberg
Water related impact of energy: Cost and carbon footprint analysis of water for biopharmaceuticals from tap to waste
Chemical Engineering Science: X,
Alessandro Luigi Cataldo; Bernhard Sissolak; Karl Metzger; Kristi Budzinski; Osamu Shirokizawa; Markus Luchner; Alois Jungbauer; Peter Satzer
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Frances Humby; Myles J. Lewis; Michael Townsend; Costantino Pitzalis
Comparison of techniques to control ice nucleation during lyophilization
Processes,
Jake Luoma; Erika Ingham; Carmen Lema Martinez; Andrea Allmendinger
Eye, ISSN: 14765454 0950222X
Anthony Adamis; Christopher Brittain; Atul Dandekar; Jill Hopkins
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats
Drug Metabolism and Disposition,
Hao Cai; Victor Yip; Violet Lee; Sylvia Wong; Ola Saad; Shuguang Ma; Nina Ljumanovic; S Cyrus Khojasteh; Amrita Kamath; Ben-Quan Shen
AAPS Journal, ISSN: 15507416
Arian Emami Riedmaier; Kevin DeMent; James Huckle; Phil Bransford; Cordula Stillhart; Richard Lloyd; Ravindra Alluri; Sumit Basu; Yuan Chen; Varsha Dhamankar; Stephanie Dodd; Priyanka Kulkarni; Andrés Olivares-Morales; Chi-Chi Peng; Xavier Pepin; Xiaojun Ren; Thuy Tran; Christophe Tistaert; Tycho Heimbach; Filippos Kesisoglou; Christian Wagner; Neil Parrott
Frontiers in Immunology, ISSN: 16643224
Sébastien Wieckowski; Cécile Avenal; Arturo Orjalo; Daniel Gygax; Florian Cymer
Nature, ISSN: 14764687 00280836
Erik L. Bao; Satish K. Nandakumar; Xiaotian Liao; Alexander G. Bick; Juha Karjalainen; Marcin Tabaka; Olga I. Gan; Aki S. Havulinna; Tuomo T. J. Kiiskinen; Caleb A. Lareau; Aitzkoa L. de Lapuente Portilla; Bo Li; Connor Emdin; Veryan Codd; Christopher P. Nelson; Christopher J. Walker; Claire Churchhouse; Albert de la Chapelle; Daryl E. Klein; Björn Nilsson; Peter W. F. Wilson; Kelly Cho; Saiju Pyarajan; J. Michael Gaziano; Nilesh J. Samani; Aarno Palotie; Mark Daly; Howard Jacob; Heiko Runz; Sally John; Robert M. Plenge; Mark McCarthy; Dawn Waterworth; Caroline Fox; Anders Malarstig; Kathy Klinger; Kathy Call; Tomi P. Mäkelä; Jaakko Kaprio; Petri Virolainen; Kari Pulkki; Terhi Kilpi; Markus Perola; Jukka Partanen; Anne Pitkäranta; Riitta Kaarteenaho; Seppo Vainio; Veli-Matti Kosma; Urho Kujala; Jeff Waring; Heiko Runz; Jimmy Liu; Shameek Biswas; Dawn Waterworth; Meg Ehm; Caroline S. Fox; Anders Mälarstig; Catherine Marshall; Xinli Hu; Kathy Call; Kathy Klinger; Matthias Gossel; Samuli Ripatti; Johanna Sc
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Emily Hanan; Jun Liang; Xiaojing Wang; Robert Blake; Nicole Blaquiere; Steven Staben
Biochemistry, ISSN: 15204995 00062960
Nicholas P. D. Liau; Avinashnarayan Venkatanarayan; John Quinn; Wilson Phung; Shiva Malek; Sarah Hymowitz; Jawahar Sudhamsu
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Keira Garland; Homer Pantua; Marie-Gabrielle Braun; Dan Burdick; Georgette Castanedo; Yi-Chen Chen; Yun-Xing Cheng; Jonathan Cheong; Blake Daniels; Gauri Deshmukh; Yuhong Fu; Paul Gibbons; Susan Gloor; Rongbao Hua; Sharada Labadie; Xiongcai Liu; Rich Pastor; Craig Stivala; Min Xu; Yiming Xu; Hao Zheng; Sharookh Kapadia; Emily Hanan
ACS Medicinal Chemistry Letters, ISSN: 19485875
Le Wang; George A. Doherty; Andrew S. Judd; Zhi-Fu Tao; T. Matthew Hansen; Robin R. Frey; Xiaohong Song; Bruncko; Aaron R. Kunzer; Xilu Wang; Michael D. Wendt; John Flygare; Nathaniel D. Catron; Russell A. Judge; Chang H. Park; Shashank Shekhar; Darren C. Phillips; Paul M. Nimmer; Morey L. Smith; Stephen K. Tahir; Yu Xiao; John Xue; Haichao Zhang; Phuong N. Le; Michael J. Mitten; Erwin R. Boghaert; Wenqing Gao; Peter J. Kovar; Edna Choo; Dolores Diaz; Wayne Fairbrother; Steven W. Elmore; Deepak Sampath; Joel D. Leverson; Andrew J. Souers
Single-cell transcriptome profiling of the kidney glomerulus identifies key cell types and reactions to injury
Journal of the American Society of Nephrology, ISSN: 10466673
Jun-Jae Chung; Leonard Goldstein; Jasmine Chen; Jiyeon Lee; Webster; Meron Roose-Girma; Sharad C. Paudyal; Zora Modrusan; Anwesha Dey; Andrey Shaw
Inter-individual and inter-regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors
Pharmacology Research and Perspectives,
Albert P. Li; Ming-Chih D Ho; Novera Alam; Walter Mitchell; Susan Wong; Zhengyin Yan; Jane Kenny; Cornelis E C A Hop
Atezolizumab for first-line treatment of PD-L1–selected patients with NSCLC
New England Journal of Medicine, ISSN: 00284793
Roy S. Herbst; Giuseppe Giaccone; Filippo De Marinis; Niels Reinmuth; Alain Vergnenegre; Carlos H. Barrios; Masahiro Morise; Enriqueta Felip; Zoran Andric; Sarayut Geater; Mustafa Özgüroğlu; Wei Zou; Alan Sandler; Ida Enquist; Kimberly Komatsubara; Deng; Hiroshi Kuriki; Wen; Mark McCleland; Simonetta Mocci; Jacek Jassem; David Spigel
Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy
Journal for ImmunoTherapy of Cancer,
Rafael Cubas; Zia Khan; Qian Gong; Marina Moskalenko; Huizhong Xiong; Qinglin Ou; Christine Pai; Ryan Rodriguez; Jeanne Cheung; Andrew A. Chan
Bioanalysis, ISSN: 17576199 17576180
Gizette Sperinde; Meire Bremer; Henry Maun; Amos Baruch; Bob Lazarus; JT Koerber; Rajesh Vij; Tangsheng Yi; Sally Fischer; Tracy Staton
Bioanalysis, ISSN: 17576199
Sally Fischer; Kathi Williams; Ian Harmon; Bryan Bothwell; Hua Xu; Emmanuel Capio; Mikhail Briman
Pulmonary Pharmacology and Therapeutics, ISSN: 15229629 10945539
John Busby; Cecile Holweg; Akiko Chai; Peter Bradding; Rekha Chaudhuri; Adel Mansur; John Matthews; Andrew Menzies-Gow; James Lordan; Robert Niven; Liam G. Heaney
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Divya Samineni; Hao Ding; Fang Ma; Rong Shi; Dan Lu; Dale Miles; Jialin Mao; Chunze Li; Jin Jin; Matthew Wright; Sandhya Girish; Yuan Chen
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Chunze Li; Shang-Chiung Chen; Yuan Chen; Sandhya Girish; Matts Kaagedal; Dan Lu; Tong Lu; Divya Samineni; Jin Y. Jin
Organic Process Research and Development, ISSN: 1520586X 10836160
Nicholas A. White; Kyle Clagg; Lauren Sirois; Ngiap-Kie Lim; William A. Nack; Paul D. O'Shea; Haiming Zhang; Francis Gosselin
JCI insight, ISSN: 23793708
Kasia Owczarczyk; Matthew Cascino; Cecile Holweg; Wei Tew; Ward Ortmann; Timothy Behrens; Thomas Schindler; Langford; E. William St. Clair; Merkel; Spiera; Seo; Cees Gm Kallenberg; Specks; Noha Lim; John H. Stone; Paul Brunetta; Marco Prunotto
Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates
Analytical Chemistry, ISSN: 00032700
Violet Lee; Surinder Kaur; Ola Saad
Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates
Journal of Medicinal Chemistry,
Leanna Staben; Jinhua Chen; Josefa Dela Cruz-Chuh; Geoff Del Rosario; Mary Ann Go; Jun Guo; S Cyrus Khojasteh; Kathy Kozak; Ginny Li; Carl Ng; Gail D. Lewis Phillips; Thomas Pillow; Rebecca K. Rowntree; John Wai; Binqing Wei; Keyang Xu; Zijin Xu; Shang-Fan Yu; Donglu Zhang; Peter Dragovich