Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 201 - 250 OF 11804 RESULTS

Safety analysis of rFVIIa with emicizumab dosing in congenital hemophilia A with inhibitors: Experience from the HAVEN clinical program
Journal of Thrombosis and Haemostasis, ISSN: 15387933
Gallia Levy; Elina Asikanius; Peter Kuebler; Soraya Benchikh El Fegoun; Sille Esbjerg; Stephanie Seremetis
Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153
Jake Luoma; Graham Magill; Lokesh Kumar; Zakaria Yusoff
Enantioselective synthesis of GNE-6688, a potent and selective inhibitor of interleukin-2 inducible T-cell kinase (ITK)
Tetrahedron Letters, ISSN: 00404039
Jared Moore; Kevin Lau; Xiaofeng Xu; Yamin Zhang; Jason Burch
Bioinformatics, ISSN: 14602059 13674803
Kevin Y.X. Wang; Alexander M. Menzies; Ines P. Silva; James S. Wilmott; Yibing Yan; Matthew Wongchenko; Richard F. Kefford; Richard A. Scolyer; Georgina V. Long; Garth Tarr; Samuel Mueller; Jean Y.H. Yang
A flexible and scalable high-throughput platform for recombinant membrane protein production
Methods in Molecular Biology, ISSN: 10643745
Hui Xu; Thomas Clairfeuille; Christine C. Jao; Hoangdung Ho; Zach Sweeney; Jian Payandeh; Chris Koth
Autophagy of Sensory Neurons in the Trigeminal and Dorsal Root Ganglia of Cynomolgus Monkeys (Macaca fascicularis)
Toxicologic Pathology, ISSN: 01926233
Mark T. Butt; Reina Fuji; Mike Reichelt; Alok K. Sharma; Sarah Cramer
Bromodomains: a new target class for drug development
Nature Reviews Drug Discovery, ISSN: 14741776
Andrea Cochran; Andrew R. Conery; Robert J. Sims
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Sarah M. Bronner; Karl A. Merrick; Jeremy Murray; Laurent Salphati; John Moffat; Jodie Pang; Christopher Sneeringer; Nick Dompe; Patrick Cyr; Hans Purkey; Gladys de Leon Boenig; Jun Li; Aleksandr Kolesnikov; Larouche-Gauthier; Kwong Wah Lai; Xiaoli Shen; Samuel Aubert-Nicol; Yi-Chen Chen; Jonathan Cheong; James Crawford; Marc Hafner; Pouyan Haghshenas; Araz Jakalian; Jean-Philippe Leclerc; Ngiap-Kie Lim; Thomas O'Brien; Emile Plise; Shalan; Claudio Sturino; John Wai; Yang Xiao; Peter Yin; Zhao; Stephen Gould; Alan Olivero; Tim Heffron
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Sharada Labadie; Jun Li; Robert Blake; Jae H. Chang; Simon Goodacre; Steven J. Hartman; Weiling Liang; James Kiefer; Tracy Kleinheinz; Tommy Lai; Jiangpeng Liao; Dan Ortwine; Vidhi Mody; Nicholas C. Ray; Fabien Roussel; Maia Vinogradova; Siew Kuen Yeap; Birong Zhang; Xiaoping Zheng; Jason Zbieg; Jun Liang; Gina Wang
High-throughput protein analysis using negative stain electron microscopy and 2D classification
Methods in Molecular Biology, ISSN: 10643745
Chris Arthur; Claudio Ciferri
Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye
PLoS ONE,
Whitney Shatz; Phil Hass; Nikhil Peer; Maciej Paluch; Craig Blanchette; Guanghui Han; Wendy Sandoval; Ashley Morando; Kelly Loyet; Vladimir Bantseev; Helen Booler; Susan Crowell; Amrita Kamath; Justin Scheer; Robert Kelley
Impact of Surfactant and Surfactant-Polymer Interaction on Desupersaturation of Clotrimazole
Journal of Pharmaceutical Sciences, ISSN: 00223549
Wei Zhang; Siddhi S. Hate; David J. Russell; Hao Helen Hou; Karthik Nagapudi
Semiautomated small-scale purification method for high-throughput expression analysis of recombinant proteins
Methods in Molecular Biology, ISSN: 10643745
Edward Kraft; Yvonne Franke; Katharine Heeringa; Stephanie Shriver; Inna Zilberleyb; Christine Kugel; Trisha Dela Vega; Athena Wong; Bobby Brillantes; Claudio Ciferri; George Dutina; Grace Lee; Isabelle Lehoux; Zhong Rong Li; Lee Lior-Hoffmann; Jiyoung Hwang; Chris Lonergan; Lynn Martin; Kyle Mortara; Lananh Nguyen; Jian Payandeh; Andrew Perez; Jun Sampang; Lovejit Singh; Kurt Schroeder; Christine Tam; Shu Ti; Ye Naing Win; Krista Bowman
Time-to-Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine-Citrulline-Monomethylauristatin E Antibody–Drug Conjugates
CPT: Pharmacometrics and Systems Pharmacology,
Kagedal; Divya Samineni; Gillespie; Dan Lu; Bernard Fine; Sandhya Girish; Chunze Li; Jin Y. Jin
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Federico Innocenti; Fang-Shu Ou; Xueping Qu; Tyler J. Zemla; Donna Niedzwiecki; Rachel Tam; Shilpi Mahajan; Richard M. Goldberg; Monica M. Bertagnolli; Charles D. Blanke; Hanna Sanoff; James Atkins; Blase Polite; Alan P. Venook; Heinz-Josef Lenz; Omar Kabbarah
Science, ISSN: 10959203 00368075
Meng He; Mira S. Chaurushiya; Webster; Sarah Kummerfeld; Rohit Reja; Subhra Chaudhuri; Jasmine Chen; Zora Modrusan; Benjamin Haley; Debbie Dugger; Jeff Eastham; Shari Lau; Anwesha Dey; Roger Caothien; Meron Roose-Girma; Kim Newton; Vishva Dixit
A Rapid High-Sensitivity Reversed -Phase Ultra High Performance Liquid Chromatography Mass Spectrometry Method for Assessing Polysorbate 20 Degradation in Protein Therapeutics
Journal of Pharmaceutical Sciences, ISSN: 00223549
Ying Cheng; Mark Hu; Camellia Zamiri; Toshiro Carcelen; Barthelemy Demeule; Anthony Tomlinson; Jie Gu; Yinges Yigzaw; Matt Kalo; X. Christopher Yu
mAbs, ISSN: 19420870 19420862
Shan Chung; Van Nguyen; Linda Lin; Julien Lafrance-Vanasse; Suzie Scales; Kevin Lin; Rong Deng; Kathi Williams; Gizette Sperinde; Juan Jenny Li; Kai Zheng; Sid Sukumaran; Devin Tesar; James A. Ernst; Sally Fischer; Greg Lazar; Saileta Prabhu; An Song
Cellular mechanisms of etrolizumab treatment in inflammatory bowel disease
Frontiers in Pharmacology,
Charlotte Lichnog; Sha Klabunde; Emily Becker; Franklin Fuh; Philipp Tripal; Raja Atreya; Entcho Klenske; Rich Erickson; Henry Chiu; Chae Reed; Shan Chung; Clemens Neufert; Imke Atreya; Jacqueline McBride; Markus F. Neurath; Sebastian Zundler
Haemophilia, ISSN: 13652516 13518216
Johnny N. Mahlangu; Johannes Oldenburg; Michael U. Callaghan; Midori Shima; Mancuso; Peter Trask; Michael Recht; Claudia Garcia; Renchi Yang; Michaela Lehle; Harrison Macharia; Elina Asikanius; Gallia Levy; Kruse-Jarres; Sylvia von Mackensen
Current Medical Research and Opinion, ISSN: 14734877 03007995
Jason P. Swindle; Yaping Xu; Yunming Mu; Paul Solari
Trends in Cancer, ISSN: 24058033
Philamer C. Calses; James Crawford; Jennie Lill; Anwesha Dey
Clinical Rheumatology, ISSN: 14349949 07703198
Vivian P. Bykerk; Ostor; José Alvaro-Gracia; Karel Pavelka; José Andrés Román Ivorra; Michael T. Nurmohamed; Yves Luder; Paris N. M. Sidiropoulos; Jenny Devenport; Jean Sibilia
Clinical Cancer Research, ISSN: 15573265 10780432
Aparna R. Parikh; Fa-Chyi Lee; Linda Yau; Han Koh; James Knost; Edith P. Mitchell; Ivan Bosanac; Nicholas Choong; Frank Scappaticci; Christoph Mancao; Heinz-Josef Lenz
Pharmacokinetics of trastuzumab emtansine (T-DM1) as a single agent or in combination with pertuzumab in HER2-positive breast cancer patients with recurrent or locally advanced metastatic breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Dan Lu; Chunze Li; Matthew Riggs; Daniel Polhamus; Jonathan French; Priya Agarwal; Shang-Chiung Chen; Shweta Vadhavkar; Patre; Alexander Strasak; Angelica Quartino; Jin Yan Jin; Sandhya Girish
Angewandte Chemie - International Edition, ISSN: 15213773 14337851
Seung Wook Kim; Tabitha T. Schempp; Jason Zbieg; Craig Stivala; Michael J. Krische
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
Cell Death and Differentiation, ISSN: 13509047
Snahel Patel; Webster; Eugene Varfolomeev; Youngsu Kwon; Jason Cheng; Juan Zhang; Debbie Dugger; Kate Wickliffe; Maltzman; Swathi Sujatha-Bhaskar; Pawan Bir Kohli; Sreema Ramaswamy; Gauri Deshmukh; Bianca Liederer; Rina Fong; Gregory L. Hamilton; Patrick Lupardus; Patrick Caplazi; Wyne P. Lee; Menno van Lookeren Campagne; Adam Johnson; Brent McKenzie; Melissa Junttila; Kim Newton; Domagoj Vucic
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Steven J. McKerrall; Teresa Nguyen; Kwong Wah Lai; Philippe Bergeron; Lunbin Deng; Antonio DiPasquale; Jae Chang; Jun Chen; Tania Chernov-Rogan; David Hackos; Jonathan M. Maher; Dan Ortwine; Jodie Pang; Jian Payandeh; Will Proctor; Shannon Shields; Jennifer Vogt; Pengfei Ji; Wenfeng Liu; Elisa Ballini; Lilia Schumann; Glauco Tarozzo; Girish Bankar; Sultan Chowdhury; Abid Hasan; Johnson; Kuldip Khakh; Sophia Lin; Charles J. Cohen; Christoph Dehnhardt; Brian Safina; Dan Sutherlin
Tetrahedron, ISSN: 14645416 00404020
Chong Han; Sean Kelly; Theresa Cravillion; Scott Savage; Tina Nguyen; Francis Gosselin
Ophthalmology, ISSN: 15494713 01616420
Peter A. Campochiaro; Dennis Marcus; Carl C. Awh; Carl D. Regillo; Anthony Adamis; Vladimir Bantseev; Yawen Chiang; Jason Ehrlich; Signe Erickson; William D. Hanley; Joshua Horvath; Katie F. Maass; Natasha Singh; Fan Tang; Giulio Barteselli
trackr: A Framework for Enhancing Discoverability and Reproducibility of Data Visualizations and Other Artifacts in R
Journal of Computational and Graphical Statistics, ISSN: 10618600
Gabriel Becker; Sara E. Moore; Michael Lawrence
Methods in Molecular Biology, ISSN: 10643745
Amelia Au-Yeung; Chikara Takahashi; Rod Mathews; William E. O'Gorman
Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients
Nature Medicine, ISSN: 10788956
Ryan J. Sullivan; Omid Hamid; Rene Gonzalez; Jeffery R. Infante; Manish R. Patel; F. Stephen Hodi; Karl Lewis; Hussein Tawbi; Genevive Hernandez; Matthew Wongchenko; YiMeng Chang; Louise Roberts; Marcus Ballinger; Yibing Yan; Edward Cha; Patrick Hwu
Correction: First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL (Oncotarget(2018) 9 (13023 -13035) DOI: 10.18632/oncotarget.24310)
Oncotarget,
John C. Byrd; Stephen Smith; Nina D. Wagner-Johnston; Jeff P. Sharman; Andy I. Chen; Ranjana H. Advani; Bradley Augustson; Paula Marlton; Renee Commerford; Kwame Okrah; Lichuan Liu; Elaine Murray; Elicia Penuel; Ashley F. Ward; Ian Flinn
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623
Callie Bryan; Joy Drobnick; Alberto Gobbi; Aleksandr Kolesnikov; Yongsheng Chen; Naomi S. Rajapaksa; Chudi Ndubaku; Jianwen Feng; Willy Chang; Ross Francis; Christine Yu; Edna Choo; Kevin DeMent; Yingqing Ran; Le An; Claire Emson; Zhiyu Huang; Swathi Sujatha-Bhaskar; Hans Brightbill; Antonio DiPasquale; Jonathan M. Maher; John Wai; Brent McKenzie; Patrick Lupardus; Ali Zarrin; James Kiefer
Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site
Journal of Biological Chemistry, ISSN: 00219258
Shu Xu; Jashim Uddin; Surajit Banerjee; Kelsey Duggan; Joel Musee; James Kiefer; Kebreab Ghebreselasie; Carol A. Rouzer; Lawrence J. Marnett
Palladium-catalyzed enantioselective decarboxylative allylic alkylation of fully substituted: N -acyl indole-derived enol carbonates
Chemical Science, ISSN: 20416520
Eric J. Alexy; Tyler J. Fulton; Haiming Zhang; Brian M. Stoltz
Palladium-catalyzed α,β-dehydrogenation of acyclic ester equivalents promoted by a novel electron deficient phosphinooxazoline ligand
Tetrahedron, ISSN: 00404020
Tyler J. Fulton; Brenda Wu; Eric J. Alexy; Haiming Zhang; Brian M. Stoltz
Pharmacokinetic and exposure–response analysis of pertuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Whitney P. Kirschbrown; Wang; Ihsan Nijem; Atsushi Ohtsu; Paulo M. Hoff; Manish A. Shah; Lin Shen; Yoon-Koo Kang; Maria Alsina; Sandhya Girish; Amit Garg
Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data
Clinical and Translational Science, ISSN: 17528054
Chunze Li; Cindy Zhang; Rong Deng; Douglas Leipold; Dongwei Li; Brandon Latifi; Yuying Gao; Crystal Zhang; Zao Li; Dale Miles; Shang-Chiung Chen; Divya Samineni; Wang; Priya Agarwal; Dan Lu; Saileta Prabhu; Sandhya Girish; Amrita Kamath
Probing interaction of lipid-modified wnt protein and its receptors by ELISA
Methods in Molecular Biology, ISSN: 10643745
Aaron Nile; Rami Hannoush
Safety, clinical activity and biomarker assessments of atezolizumab from a Phase I study in advanced/recurrent ovarian and uterine cancers
Gynecologic Oncology, ISSN: 00908258
Joyce F. Liu; Michael S. Gordon; Jennifer Veneris; Fadi S. Braiteh; Ani Balmanoukian; Joseph Paul Eder; Ana Oaknin; Hamilton; Wang; Indrani Sarkar; Luciana Molinero; Marcella Fasso; Carol E. O'Hear; Yvonne G. Lin; Leisha A. Emens
Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers
Clinical Drug Investigation, ISSN: 11732563
Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Dan Sutherlin; Michael Ward; William Cho
The safety evaluation of long-acting ocular delivery systems
Drug Discovery Today, ISSN: 13596446
Evan Thackaberry; Florence Lorget; Cindy A. Farman; Vladimir Bantseev
Unequal absorption of radiolabeled and nonradiolabeled drug from the oral dose leads to incorrect estimates of drug absorption and circulating metabolites in a mass balance study
Drug Metabolism Letters, ISSN: 18723128
Ryan Takahashi; Jae H. Chang; Jodie Pang; Xiaorong Liang; Shuguang Ma
A potent and effective suicidal listeria vaccine platform
Infection and Immunity, ISSN: 00199567
William G. Hanson; Erin L. Benanti; Edward E. Lemmens; Weiqun Liu; Justin Skoble; Meredith L. Leong; Chris S. Rae; Marcella Fasso; Dirk Brockstedt; Chen Chen; Daniel A. Portnoy; Thomas W. Dubensky; Peter Lauer
An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development
Nature Immunology, ISSN: 15292908
Prachi Bagadia; Xiao Huang; Tian-Tian Liu; Vivek Durai; Gary E. Grajales-Reyes; Maximilian Nitschke; Zora Modrusan; Jeffrey M. Granja; Ansuman T. Satpathy; Carlos G. Briseño; Marco Gargaro; Arifumi Iwata; Sunkyung Kim; Howard Y. Chang; Andrey S. Shaw; Theresa L. Murphy; Kenneth M. Murphy
CHAPTER 11: Duocarmycin-PBD Dimers as Antibody-Drug Conjugate (ADC) Payloads
RSC Drug Discovery Series, ISSN: 20413203
Thomas Pillow; Moana Tercel
Cell Reports, ISSN: 22111247
Tiffany Wu; Borislav Dejanovic; Vineela Gandham; Alvin Gogineni; Rose Edmonds; Stephen Schauer; Karpagam Srinivasan; Melanie Huntley; Yuanyuan Wang; Tzu-Ming Wang; Maj Hedehus; Kai Barck; Maya Stark; Hai Ngu; Oded Foreman; Bill Meilandt; Justin Elstrott; Michael C. Chang; David Hansen; Rick Carano; Morgan Sheng; Jesse Hanson
Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability
Journal of Medicinal Chemistry, ISSN: 00222623
Ena Ladi; Christine Everett; Craig Stivala; Blake Daniels; Matthew Durk; Seth Harris; Malcolm Huestis; Hans Purkey; Steven Staben; Martin Augustin; Michael Blaesse; Stefan Steinbacher; Celine Eidenschenk; Rajita Pappu; Mike Siu