Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5051 - 5100 OF 15805 RESULTS

January 1, 2017

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade S. Blair; Christine Chang; Donnie Delarosa; Jason Devoss; James Driscoll; Eigenbrot; Simon Goodacre; Nico Ghilardi; Calum Macleod; Adam R. Johnson; Pawan Bir Kohli; Yingjie Lai; Zhonghua Lin; Priscilla Mantik; Kapil Menghrajani; Hieu Nguyen; Ivan Peng; Amy Sambrone; Steven Shia; Jan Smith; Sue J. Sohn; Vickie Tsui; Ultsch; Karen Williams; Lawren C. Wu; Wenqian Yang; Birong Zhang; Steven Magnuson

January 1, 2017

Preferences for multiple sclerosis treatments: Using a discrete-choice experiment to examine differences across subgroups of US patients

International Journal of MS Care, ISSN: 15372073

Carol Mansfield; Nina Parikh Thomas; David Gebben; Maria Lucas; Brett Hauber

January 1, 2017

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation

Journal of Experimental Medicine, ISSN: 15409538 00221007

Michael C. Chang; Karpagam Srinivasan; Brad A. Friedman; Eric Suto; Zora Modrusan; Wyne P. Lee; Joshua S. Kaminker; David V. Hansen; Morgan Sheng

January 1, 2017

CYP1A1-mediated intramolecular rearrangement of aminoazepane in GDC-0339

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Ryan Takahashi; Xiaojing Wang; Nathaniel Segraves; Jing Wang; Jae H. Chang; S. Cyrus Khojasteh; Shuguang Ma

January 1, 2017

Considerations from the IQ induction working group in response to drug-drug interaction guidance from regulatory agencies: Focus on downregulation, CYP2C induction, and CYP2B6 positive control

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Niresh Hariparsad; Diane Ramsden; Jairam Palamanda; Joshua G. DeKeyser; Odette A. Fahmi; Jane R. Kenny; Heidi J. Einolf; Michael A. Mohutsky; Magalie Pardon; Y. Amy Siu; Liangfu Chen; Michael Sinz; Barry C Jones; Robert L. Walsky; Shannon Dallas; Suresh K. Balani; George Zhang; David Buckley; Donald J. Tweedie

January 1, 2017

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

Advances in Anatomic Pathology, ISSN: 15334031 10724109

Shona Hendry; Roberto Salgado; Thomas Gevaert; Prudence A. Russell; Tom John; Bibhusal Thapa; Michael Christie; Koen Van De Vijver; Mónica V. Estrada; Paula I. Gonzalez-Ericsson; Melinda E. Sanders; Benjamin Solomon; Cinzia Solinas; Gert G.G.M. Van Den Eynden; Yves Allory; Matthias Preusser; Johannes Hainfellner; Giancarlo Pruneri; Andrea Vingiani; Sandra Demaria; W Fraser Symmans; Nuciforo; Laura Comerma; Thompson; Sunil Lakhani; Seong-Rim Kim; Stuart J. Schnitt; Cecile Colpaert; Christos Sotiriou; Stefan J. Scherer; Michail Ignatiadis; Sunil Badve; Robert H. Pierce; Giuseppe Viale; Nicolas Sirtaine; Frederique Penault-Llorca; Tomohagu Sugie; Susan Fineberg; Soonmyung Paik; Ashok Srinivasan; Andrea Richardson; Yihong Wang; Ewa Chmielik; Jane Brock; Douglas B. Johnson; Justin M. Balko; Stephan Wienert; Veerle Bossuyt; Stefan Michiels; Nils Ternes; Nicole Burchardi; Stephen J Luen; Peter Savas; Frederick Klauschen; Peter H. Watson; Brad H. Nelson; Carmen Criscitiello; Sandra O'Toole; Denis Larsimont; Roland De Wind; Giuseppe Curigliano; Fabrice Andre; Magali Lacroix-Triki; Mark Van De Vijver; Federico Rojo; Giuseppe Floris; Shahinaz Bedri; Joseph Sparano; David Rimm; Torsten Nielsen; Zuzana Kos; Stephen M. Hewitt; Baljit Singh; Gelareh Farshid; Sibylle Loibl; Kimberly H. Allison; Nadine Tung; Sylvia Adams; Karen Willard-Gallo; Hugo M. Horlings; Leena Gandhi; Andre Moreira; Fred R. Hirsch; Maria V. Dieci; Maria Urbanowicz; Iva Brcic; Konstanty Korski; Fabien Gaire; Koeppen; Amy Lo; Jennifer M. Giltnane; Marlon C. Rebelatto; Keith E. Steele; Jiping Zha; Kenneth Emancipator; Jonathan W. Juco; Carsten Denkert; Jorge S. Reis-Filho; Sherene Loi; Stephen B. Fox

January 1, 2017

Vemurafenib treatment for patients with locally advanced, unresectable stage IIIC or metastatic melanoma and activating exon 15 BRAF mutations other than V600E

Melanoma Research, ISSN: 14735636 09608931

Sigrun Hallmeyer; Rene Gonzalez; David Lawson; Lee Cranmer; Gerald Linette; Igor Puzanov; Bret Taback; C. Lance Cowey; Antoni Ribas; Gregory Daniels; Timothy Moore; Geoffrey T. Gibney; Hussein Tawbi; Eric Whitman; Geraldine Lee; Yong Mun; Shiyao Liu; Omid Hamid

January 1, 2017

Enhancing the resolution of 1H and 13C solid-state NMR spectra by reduction of anisotropic bulk magnetic susceptibility broadening

Physical Chemistry Chemical Physics, ISSN: 14639076

Michael P. Hanrahan; Amrit Venkatesh; Scott L. Carnahan; Julie L. Calahan; Joseph W. Lubach; Eric Munson; Aaron J. Rossini

January 1, 2017

Enhancing reproducibility and collaboration via management of R package cohorts

Journal of Statistical Software, ISSN: 15487660

Gabriel Becker; Robert Gentleman; Cory Barr; Michael Lawrence

January 1, 2017

Cathepsin B is dispensable for cellular processing of cathepsin B-cleavable antibody–drug conjugates

Cancer Research, ISSN: 15387445 00085472

Niña G. Caculitan; Josefa Chuh; Yong Ma; Donglu Zhang; Katherine R. Kozak; Yichin Liu; Thomas H. Pillow; Jack D. Sadowsky; Tommy K. Cheung; Qui Phung; Benjamin Haley; Byoung-Chul Lee; Robert W. Akita; Mark X. Sliwkowski; Andrew G. Polson

January 1, 2017

2017 White paper on recent issues in bioanalysis: Rise of hybrid lba/lcms immunogenicity assays (part 2: Hybrid lba/lcms biotherapeutics, biomarkers & immunogenicity assays and regulatory agencies' inputs)

Bioanalysis, ISSN: 17576199 17576180

Hendrik Neubert; An Song; Anita Lee; Cong Wei; Jeff Duggan; Keyang Xu; Eric Woolf; Christopher Evans; Joe Palandra; Omar Laterza; Shashi Amur; Isabella Berger; Mark Bustard; Mark T. Cancilla; Shang-Chiung Chen; Seongeun Julia Cho; Eugene Ciccimaro; Isabelle Cludts; Cocea; Celia D'Arienzo; Lieza Danan-Leon; Lorella Di Donato; Fabio Garofolo; Sam Haidar; Akiko Ishii-Watabe; Hao Jiang; John Kadavil; Sean Kassim; Pekka Kurki; Olivier Le Blaye; Kai Liu; Rod Mathews; Gustavo Mendes Lima Santos; Makoto Niwa; Joao Pedras-Vasconcelos; Mark Qian; Brian Rago; Ola M. Saad; Yoshiro Saito; Natasha Savoie; Dian Su; Matthew Szapacs; Nilufer Tampal; Stephen Vinter; Jian Wang; Jan Welink; Emma Whale; Amanda Wilson; Xue

January 1, 2017

The comparative effectiveness and cost-effectiveness of ranibizumab for neovascular macular degeneration revisited

International Journal of Retina and Vitreous, ISSN: 20569920

Gary C. Brown; Melissa M. Brown; Heidi B. Lieske; Adam Turpcu; Yamina Rajput

January 1, 2017

Bio-Repository

Analytical Characterization of Biotherapeutics,

Anne Baldwin; Kurt A. Schroeder; Lovejit Singh; Karen L Billeci

January 1, 2017

Analytical Tools for Biologics Molecular Assessment

Analytical Characterization of Biotherapeutics,

Wilson Phung; Wendy N. Sandoval; Robert F. Kelley; Jennie R. Lill

January 1, 2017

Introduction to Biotherapeutics

Analytical Characterization of Biotherapeutics,

Jennie R. Lill

January 1, 2017

Mass Spectrometric Characterization of Recombinant Proteins

Analytical Characterization of Biotherapeutics,

Corey Bakalarski; Wendy N. Sandoval; Jennie R. Lill

January 1, 2017

Characterization of Residual Host Cell Protein Impurities in Biotherapeutics

Analytical Characterization of Biotherapeutics,

Denise C. Krawitz; Jason C. Rouse; Justin B. Sperry; Wendy N. Sandoval; Vanderlaan

January 1, 2017

Practical considerations for assessing product ouality of biosynthetic proteins by HPLC

High-Performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis, and Conformation,

Chloupek; John E. Battersby; William S. Hancock

January 1, 2017

Analytical Characterization of Biotherapeutics

Analytical Characterization of Biotherapeutics,

Jennie R. Lill; Wendy N. Sandoval

January 1, 2017

Characterization of Bispecific or Other Hybrid Molecules

Analytical Characterization of Biotherapeutics,

T. Noelle Lombana; Christoph Spiess

January 1, 2017

Assessing Activity and Conformation of Recombinant Proteins

Analytical Characterization of Biotherapeutics,

Diego Ellerman; Till Maurer; Justin M. Scheer

January 1, 2017

Results from the Phase III Randomized Trial of Onartuzumab plus Erlotinib Versus Erlotinib in Previously Treated Stage IIIB or IV Non–Small-Cell Lung Cancer: METLung

Journal of Clinical Oncology, ISSN: 15277755 0732183X

David Spigel; Martin J. Edelman; Kenneth O'Byrne; Luis Paz-Ares; Mocci; See Phan; David S. Shames; Dustin Smith; Wei Yu; Virginia Paton; Tony Mok

January 1, 2017

Interleukin-13 in asthma and other eosinophilic disorders

Frontiers in Medicine, ISSN: 2296858X

Emma Doran; Fang Cai; Cecile Holweg; Kit Wong; Jochen Brumm; Joseph R. Arron

January 1, 2017

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs

Xenobiotica, ISSN: 13665928 00498254

Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Cornelis E. Hop; S. Cyrus Khojasteh; Edna F. Choo

January 1, 2017

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

Cell Death and Differentiation, ISSN: 14765403 13509047

Maria Cristina De Almagro; Tatiana Goncharov; Anita Izrael-Tomasevic; Stefanie Duttler; Matthias Kist; Eugene Varfolomeev; Xiumin Wu; Wyne P. Lee; Jeremy Murray; Webster; Kebing Yu; Donald S. Kirkpatrick; Kim Newton; Domagoj Vucic

January 1, 2017

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics

AAPS Journal, ISSN: 15507416

Siddharth Sukumaran; Crystal Zhang; Douglas Leipold; Ola M. Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Wang; Marija Milojic-Blair; Montserrat Carrasco-Triguero; Bonnee Rubinfeld; Fielder; Kedan Lin; Ramanujan

January 1, 2017

Degradation Mechanisms of Polysorbate 20 Differentiated by 18O-labeling and Mass Spectrometry

Pharmaceutical Research, ISSN: 1573904X 07248741

Lin Zhang; Sandeep Yadav; Barthélemy Demeule; Y. John Wang; Olivier Mozziconacci; Christian Schöneich

January 1, 2017

Specific Immune Response to Phospholipase B-Like 2 Protein, a Host Cell Impurity in Lebrikizumab Clinical Material

AAPS Journal, ISSN: 15507416

Saloumeh Kadkhodayan Fischer; Melissa Cheu; Kun Peng; John Lowe; James Araujo; Elaine R. Murray; Mcclintock; Matthews; Patricia Siguenza; An Song

January 1, 2017

Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products

Pharmaceutical Research, ISSN: 1573904X 07248741

Jessica Bane; Olivier Mozziconacci; Li Yi; Y. John Wang; Alavattam Sreedhara; Christian Schöneich

January 1, 2017

TIGIT: A Key Inhibitor of the Cancer Immunity Cycle

Trends in Immunology, ISSN: 14714981 14714906

Nicholas A. Manieri; Eugene Y. Chiang; Jane L. Grogan

January 1, 2017

Quantitative Systems Pharmacology: A Case for Disease Models

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Musante; Ramanujan; Brian J. Schmidt; Ghobrial; Lu; Heatherington

January 1, 2017

Bevacizumab plus paclitaxel versus placebo plus paclitaxel as first-line therapy for HER2-negative metastatic breast cancer (MERiDiAN): A double-blind placebo-controlled randomised phase III trial with prospective biomarker evaluation

European Journal of Cancer, ISSN: 18790852 09598049

David W. Miles; David Cameron; Igor Bondarenko; Lyudmila Manzyuk; Juan Carlos Alcedo; Roberto Ivan Lopez; Seock-Ah Im; Jean-Luc Canon; Yaroslav Shparyk; Denise A. Yardley; Norikazu Masuda; Jungsil Ro; Neelima Denduluri; Stanislas Hubeaux; Quah; Carlos Bais; O'Shaughnessy

January 1, 2017

Integrated lead optimization: Translational models as we advance toward the clinic

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Bianca M. Liederer; Xingrong Liu; Simon Wong; Daniel R Mudra

January 1, 2017

Ubiquitin in cell-cycle regulation and dysregulation in cancer

Annual Review of Cancer Biology, ISSN: 24723428

Natalie A. Borg; Vishva M. Dixit

January 1, 2017

Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD)

Journal of Alzheimer's Disease, ISSN: 18758908 13872877

Stephane Nave; Rachelle S. Doody; Mercè Boada; Timo Grimmer; Juha-Matti Savola; Paul Delmar; Meike Pauly-Evers; Tania Nikolcheva; Christian Czech; Edilio Borroni; Benedicte Ricci; Juergen Dukart; Marie Mannino; Tracie Carey; Emma Moran; Inma Gilaberte; Nicoletta Milani Muelhardt; Irene Gerlach; Luca Santarelli; Ostrowitzki; Fontoura; Krista Lanctôt

January 1, 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer

Oncotarget, ISSN: 19492553

Soma Samanta; Shuzo Tamura; Louis Dubeau; Paulette Mhawech-Fauceglia; Yohei Miyagi; Hisamori Kato; Rich Lieberman; Ronald J. Buckanovich; Yvonne G. Lin; Nouri Neamati

January 1, 2017

Glycan Characterization: Determining the Structure, Distribution, and Localization of Glycoprotein Glycans

Analytical Characterization of Biotherapeutics,

Briggs

December 28, 2016

Utilization of In Vitro Neurotoxicity Models in Pre-Clinical Toxicity Assessment

Stem Cells in Toxicology and Medicine,

Karin Staflin; Misner; Donna M. Dambach

December 22, 2016

IL-13 is a therapeutic target in radiation lung injury

Scientific Reports, ISSN: 20452322

Su I. Chung; Jason A. Horton; Thirumalai R. Ramalingam; Ayla O. White; Eun Joo Chung; Kathryn E. Hudak; Bradley T. Scroggins; Joseph R. Arron; Thomas A. Wynn; Deborah E. Citrin

December 20, 2016

Structure of crenezumab complex with aβ shows loss of β-hairpin

Scientific Reports, ISSN: 20452322

Ultsch; Bing Li; Till Maurer; Mary Mathieu; Oskar Adolfsson; Andreas Muhs; Andrea Pfeifer; Maria Pihlgren; Travis W. Bainbridge; Mike Reichelt; James A. Ernst; Eigenbrot; Fuh; Jasvinder K. Atwal; Ryan J. Watts; Weiru Wang

December 20, 2016

Characterization of chain pairing variants of bispecific IgG Expressed in a single host cell by high-resolution native and denaturing mass spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Luis Schachner; Guanghui Han; Michael Dillon; Jianhui Zhou; Luke McCarty; Diego Ellerman; Yiyuan Yin; Christoph Spiess; Jennie R. Lill; Paul J. Carter; Wendy N. Sandoval

December 16, 2016

Rhodium(III)-Catalyzed C-H Functionalization of 1-(2H)-Phthalazinones at C8

Journal of Organic Chemistry, ISSN: 15206904 00223263

Malcolm P. Huestis

December 16, 2016

Transition-Metal-Free Synthesis of Tertiary Aminocyclopropanes

Organic Letters, ISSN: 15237052 15237060

Patrick Cyr; Alexandre Côté-Raiche; Sarah M. Bronner

December 15, 2016

Impact of blood-brain barrier integrity on tumor growth and therapy response in brain metastases

Clinical Cancer Research, ISSN: 15573265 10780432

Matthias Osswald; Jonas Blaes; Yunxiang Liao; Gergely Solecki; Miriam Gömmel; Anna S. Berghoff; Laurent Salphati; Jeffery J. Wallin; Phillips; Wick; Frank Winkler

December 15, 2016

Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter

Oncogene, ISSN: 14765594 09509232

Xueping Qu; Thomas Sandmann; Frierson; Ling Fu; Eloisa Fuentes; Kimberly Walter; Kwame Okrah; Rumpel; Moskaluk; Shan Lu; Wang; Richard Bourgon; Elicia M. Penuel; Andrea Pirzkall; Lukas Amler; Lackner; Tabernero; Garret M. Hampton; Omar Kabbarah

December 15, 2016

Phase Ib study of duligotuzumab (MEHD7945A) plus cisplatin/5-fluorouracil or carboplatin/paclitaxel for first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck

Cancer, ISSN: 10970142 0008543X

Antonio Jimeno; Jean-Pascal Machiels; Lori Wirth; Pol Specenier; Tanguy Y. Seiwert; Feby Mardjuadi; Xiaodong Wang; Amy V. Kapp; Stephanie Royer-Joo; Elicia M. Penuel; Bruce Mccall; Andrea Pirzkall; Paul M. Clement

December 14, 2016

The molecular landscape of high-risk early breast cancer: Comprehensive biomarker analysis of a phase III adjuvant population

npj Breast Cancer, ISSN: 23744677

Wilson; Yu; Xuyang Lu; Jill M. Spoerke; Yuanyuan Xiao; Carol O’brien; Heidi Savage; Huw; Wei Zou; Koeppen; William F. Forrest; Jane Fridlyand; Ling Fu; Rachel Tam; Erica Schleifman; Teiko Sumiyoshi; Luciana L. Molinero; Garret M. Hampton; O'Shaughnessy; Lackner

December 13, 2016

Communicating laboratory test results for rheumatoid factor: What do patients and physicians want?

Patient Preference and Adherence, ISSN: 1177889X

Ariella Kelman; Caroline O. Robinson; Elisenda Cochin; Nina J. Ahluwalia; Julia Braverman; Emil Chiauzzi; Kristina Simacek

December 9, 2016

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models

Molecular Neurodegeneration, ISSN: 17501326

Mitchell S. Wold; Junghyun Lim; Véronik Lachance; Zhiqiang Deng; Zhenyu Yue

December 8, 2016

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Terry Crawford; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Alexander M. Taylor; Gladys De Leon Boenig; Cameron Noland; Jeremy Murray; Justin Ly; Edna F. Choo; Thomas Hunsaker; Emily Chan; Mark Merchant; Samir Kharbanda; Karen Gascoigne; Susan Kaufman; Beresini; Jiangpeng Liao; Wenfeng Liu; Kevin Chen; Zhongguo Chen; Andrew R. Conery; Alexandre Côté; Hariharan Jayaram; Ying Jiang; James R. Kiefer; Tracy L. Kleinheinz; Yingjie Li; Jonathan M. Maher; Eneida Pardo; Florence Poy; Kerry L. Spillane; Fei Wang; Jian Wang; Xiaocang Wei; Zhaowu Xu; Zhongya Xu; Ivana Yen; Laura E. Zawadzke; Xiaoyu Zhu; Steve Bellon; Richard T Cummings; Andrea G Cochran; Brian K Albrecht; Steven Magnuson

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