Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3451 - 3500 OF 15658 RESULTS

An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development
Nature Immunology, ISSN: 15292916 15292908
Prachi Bagadia; Xiao Huang; Tian-Tian Liu; Vivek Durai; Gary E. Grajales-Reyes; Maximilian Nitschke; Zora Modrusan; Jeffrey M. Granja; Ansuman T. Satpathy; Carlos G. Briseño; Marco Gargaro; Arifumi Iwata; Sunkyung Kim; Howard Y. Chang; Andrey S. Shaw; Theresa L. Murphy; Kenneth M. Murphy
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Neoadjuvant trastuzumab emtansine and pertuzumab in human epidermal growth factor receptor 2–positive breast cancer: Three-year outcomes from the phase III KristinE study
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Sara A. Hurvitz; Miguel Martín; Kyung Hae Jung; Chiun-Sheng Huang; Nadia Harbeck; Vicente Valero; Daniil Stroyakovskiy; Hans Wildiers; Mario Campone; Jean-François Boileau; Peter A. Fasching; Karen Afenjar; Gonzalo Spera; Vanesa Lopez-Valverde; Chunyan Song; Peter C. Trask; Thomas Boulet; Joseph Sparano; W Fraser Symmans; Alastair M. Thompson; Dennis J. Slamon
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Reply to S. Sorscher
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Federico Innocenti; Fang-Shu Ou; Xueping Qu; Tyler J. Zemla; Donna Niedzwiecki; Rachel Tam; Shilpi Mahajan; Richard M. Goldberg; Monica M. Bertagnolli; Charles D. Blanke; Hanna Sanoff; James Atkins; Blase Polite; Alan P. Venook; Heinz-Josef Lenz; Omar Kabbarah
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Characterization of the Ontogeny of Hepatic UDP-Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Justine Badée; Nahong Qiu; Abby C. Collier; Ryan Takahashi; William F. Forrest; Neil Parrott; Stephan Schmidt; Stephen Fowler
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Vapor-Phase Hydrogen Peroxide Uptake by Silicone Tubing and Primary Packaging Components during Protein Drug Product Aseptic Filling: Impact of Pretreatment and Sterilization Process
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124
Devon Roshan Eisner; Aaron Hubbard; Kirk Eppler; Vassia Tegoulia; Maa
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Retrospective Evaluation of Cycled Resin in Viral Clearance Studies-A Multiple Company Collaboration
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124
John Mattila; Sherrie Curtis; Yenny Webb-Vargas; Eileen Wilson; Olga Galperina; David Roush; Scott A. Tobler; Bradford Stanley; Mike Clark; Justin Weaver; Jeremy Pike; Deqiang Yu; Xinfang Li; Andreas Flicker; Johanna Kindermann; Norbert Schuelke; Richard Whitcombe; Louise Bennett
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Inclusion of telemetry cardiovascular parameters in small molecule repeat-dose toxicity studies, a potential refinement in animal use
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X
Dale Stevens; Lisa P. Wong; Leah Schutt; Thomas R. Gelzleichter
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Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes
Cell Reports, ISSN: 22111247
Myles J. Lewis; Michael R. Barnes; Blighe; Katriona Goldmann; Sharmila Rana; Jason A. Hackney; Nandhini Ramamoorthi; Christopher R. John; David S. Watson; Sarah K. Kummerfeld; Rebecca Hands; Sudeh Riahi; Vidalba Rocher-Ros; Felice Rivellese; Frances Humby; Stephen Kelly; Michele Bombardieri; Nora Ng; Maria Dicicco; Desirée Van Der Heijde; Robert Landewé; Annette H. M. Van Der Helm-van Mil; Alberto Cauli; McInnes; Christopher D. Buckley; Ernest Choy; Taylor; Michael J. Townsend; Costantino Pitzalis
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RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity
Cell Reports, ISSN: 22111247
Susana Orozco; Brian P. Daniels; Nader Yatim; Michelle N. Messmer; Giovanni Quarato; Haiyin Chen-Harris; Sean P. Cullen; Annelise G. Snyder; Ralli-Jain; Sharon Frase; Stephen W.G. Tait; Douglas R. Green; Matthew L. Albert; Andrew Oberst
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MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure
Molecular Cell, ISSN: 10974164 10972765
Zhihao Wu; Ishaq Tantray; Junghyun Lim; Songjie Chen; Yu Li; Zoe Davis; Cole Sitron; Jason Dong; Suzana Gispert; Georg Auburger; Onn Brandman; Xiaolin Bi; Michael Snyder; Bingwei Lu
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Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy
Cell Reports, ISSN: 22111247
Tiffany Wu; Borislav Dejanovic; Vineela D. Gandham; Alvin Gogineni; Rose Edmonds; Stephen P. Schauer; Karpagam Srinivasan; Melanie A. Huntley; Yuanyuan Wang; Tzu-Ming Wang; Maj Hedehus; Kai H. Barck; Maya Stark; Hai Ngu; Oded Foreman; William J. Meilandt; Justin Elstrott; Michael C. Chang; David V. Hansen; Richard A. D. Carano; Morgan Sheng; Jesse E. Hanson
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Validation of diagnosis codes to identify side of colon in an electronic health record registry
BMC Medical Research Methodology, ISSN: 14712288
Patricia Luhn; Deborah Kuk; Gillis Carrigan; Nathan Nussbaum; Rachael Sorg; Rebecca Rohrer; Melisa Tucker; Brandon Arnieri; Michael D. Taylor; Neal J. Meropol
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Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice
mAbs, ISSN: 19420870 19420862
T. Noelle Lombana; Sharmila Rajan; Julie A. Zorn; Danielle Mandikian; Eugene C. Chen; Alberto Estevez; Victor Yip; Daniel D. Bravo; Wilson Phung; Farzam Farahi; Sharon Viajar; Sophia Lee; Avinash Gill; Wendy N. Sandoval; Jianyong Wang; Claudio Ciferri; C. Andrew Boswell; Marissa L. Matsumoto; Christoph Spiess
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Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus
mAbs, ISSN: 19420870 19420862
Rong Deng; Chenguang Zhou; Dongwei Li; Hao Cai; Siddharth Sukumaran; Montserrat Carrasco-Triguero; Ola M. Saad; Denise Nazzal; Christopher Lowe; Ramanujan; Amrita Kamath
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Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members
mAbs, ISSN: 19420870 19420862
Yanli Yang; Sherry Yeh; Shravan Madireddi; Wadim L. Matochko; Chen Gu; Patricia Pacheco-Sanchez; Ultsch; Gladys De Leon Boenig; Seth F. Harris; Brandon Leonard; Suzie J. Scales; Jing W. Zhu; Erin Christensen; Julie Qi Hang; Randall J. Brezski; Scot A. Marsters; Avi Ashkenazi; Siddharth Sukumaran; Chiu; Rafael Cubas; Kim; Greg A. Lazar
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Evaluating the quality of the 1000 genomes project data
BMC Genomics, ISSN: 14712164
Saurabh Belsare; Michal Levy-Sakin; Yulia Mostovoy; Durinck; Subhra Chaudhuri; Ming Xiao; Andrew S. Peterson; Pui-Yan Kwok; Somasekar Seshagiri; Jeffrey D. Wall
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BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale
Organic Process Research and Development, ISSN: 1520586X 10836160
Chong Han; Lady Mae Alabanza; Sean M. Kelly; Douglas L. Orsi; Francis Gosselin; Ryan A. Altman
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Linking aggregation and interfacial properties in monoclonal antibody-surfactant formulations
Journal of Colloid and Interface Science, ISSN: 10957103 00219797
Aadithya Kannan; Ian C. Shieh; Gerald G. Fuller
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Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Sarah M. Bronner; Karl A. Merrick; Jeremy Murray; Laurent Salphati; John Moffat; Jodie Pang; Chris J. Sneeringer; Nicholas A. Dompe; Patrick Cyr; Hans E. Purkey; Gladys de Leon Boenig; Jun Li; Aleksandr Kolesnikov; Larouche-Gauthier; Kwong Wah Lai; Xiaoli Shen; Samuel Aubert-Nicol; Yi-Chen Chen; Jonathan Cheong; James J. Crawford; Marc Hafner; Pouyan Haghshenas; Araz Jakalian; Jean-Philippe Leclerc; Ngiap-Kie Lim; Thomas O'Brien; Emile G. Plise; Shalan; Claudio Sturino; John Wai; Yang Xiao; Jianping Yin; Zhao; Stephen Gould; Alan G. Olivero; Timothy P. Heffron
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Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Sharada Labadie; Jun Li; Robert A. Blake; Jae H. Chang; Simon Goodacre; Steven J. Hartman; Weiling Liang; James R. Kiefer; Tracy L. Kleinheinz; Tommy Lai; Jiangpeng Liao; Daniel F. Ortwine; Vidhi Mody; Nicholas C. Ray; Fabien Roussel; Maia Vinogradova; Siew Kuen Yeap; Birong Zhang; Xiaoping Zheng; Jason R. Zbieg; Jun Liang; Xiaojing Wang
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Safety Considerations in the Development of Hippo Pathway Inhibitors in Cancers
Frontiers in Cell and Developmental Biology, ISSN: 2296634X
Satoko Kakiuchi-Kiyota; Melissa Schutten; Yu Zhong; James J. Crawford; Anwesha Dey
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Disruption of IRE1α through its kinase domain attenuates multiple myeloma
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Jonathan M. Harnoss; Adrien Le Thomas; Anna Shemorry; Scot A. Marsters; David Lawrence; Min Lu; Yung-Chia Ariel Chen; Jing Qing; Klara Totpal; David Kan; Ehud Segal; Mark Merchant; Mike Reichelt; Heidi J. A. Wallweber; Weiru Wang; Clark; Susan Kaufman; Beresini; Steven T. Laing; Wendy N. Sandoval; Maria N. Lorenzo; Jiansheng Wu; Justin Ly; Tom De Bruyn; Amy Heidersbach; Benjamin Haley; Alvin Gogineni; Robby M. Weimer; Dong Lee; Marie-Gabrielle Braun; Joachim Rudolph; Michael J. VanWyngarden; Daniel W. Sherbenou; Patricia Gomez-Bougie; Amiot; Diego Acosta-Alvear; Peter Walter; Avi Ashkenazi
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Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids
Tetrahedron, ISSN: 14645416 00404020
Chong Han; Sean M. Kelly; Theresa Cravillion; Scott Savage; Nguyen; Francis Gosselin
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Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids
Tetrahedron, ISSN: 14645416 00404020
Chong Han; Sean M. Kelly; Theresa Cravillion; Scott Savage; Tina Nguyen; Francis Gosselin
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Design and evaluation of highly selective human immunoproteasome inhibitors reveal a compensatory process that preserves immune cell viability
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Ena Ladi; Christine Everett; Craig E. Stivala; Blake E. Daniels; Matthew Durk; Seth F. Harris; Malcolm P. Huestis; Hans E. Purkey; Steven T. Staben; Martin Augustin; Michael Blaesse; Stefan Steinbacher; Celine Eidenschenk; Rajita Pappu; Michael Siu
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Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility
Cell, ISSN: 10974172 00928674
Jane Guan; Wei Zhou; Marc Hafner; Robert A. Blake; Cecile Chalouni; Irene P. Chen; Tom De Bruyn; Jennifer M. Giltnane; Steven J. Hartman; Amy Heidersbach; Rene Houtman; Ellen Ingalla; Kategaya; Tracy L. Kleinheinz; Jun Li; Scott E. Martin; Zora Modrusan; Michelle Nannini; Jason Oeh; Savita Ubhayakar; Xiaojing Wang; Ingrid E. Wertz; Amy Young; Mamie Yu; Deepak Sampath; Jeffrey H. Hager; Lori S. Friedman; Anneleen Daemen; Ciara Metcalfe
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MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Du; Jack Bevers; Ryan Cook; T. Noelle Lombana; Kamalakannan Rajasekaran; Marissa L. Matsumoto; Christoph Spiess; Kim; Zhengmao Ye
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Healthcare costs among patients with hemophilia A treated with factor replacement or bypassing agents
Current Medical Research and Opinion, ISSN: 14734877 03007995
Jason P. Swindle; Yaping Xu; Yunming Mu; Paul G. Solari
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Palladium-catalyzed α,β-dehydrogenation of acyclic ester equivalents promoted by a novel electron deficient phosphinooxazoline ligand
Tetrahedron, ISSN: 14645416 00404020
Tyler J. Fulton; Brenda Wu; Eric J. Alexy; Haiming Zhang; Brian M. Stoltz
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Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: An interventional open-label study
Thorax, ISSN: 14683296 00406376
John Busby; Cecile Holweg; Akiko Chai; Peter Bradding; Fang Cai; Rekha Chaudhuri; Adel Mansur; James Lordan; Matthews; Andrew Menzies-Gow; Robert Niven; Tracy Staton; Liam G. Heaney
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The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration: Results from the Randomized Phase 2 Ladder Clinical Trial
Ophthalmology, ISSN: 15494713 01616420
Peter A. Campochiaro; Dennis Marcus; Carl C. Awh; Carl D. Regillo; Anthony P. Adamis; Vlad Bantseev; Yawen Chiang; Jason S. Ehrlich; Signe Erickson; William D. Hanley; Joshua Horvath; Katie F. Maass; Natasha Singh; Fan Tang; Giulio Barteselli
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Safety, clinical activity and biomarker assessments of atezolizumab from a Phase I study in advanced/recurrent ovarian and uterine cancers
Gynecologic Oncology, ISSN: 10956859 00908258
Joyce F. Liu; Michael S. Gordon; Jennifer Veneris; Fadi S. Braiteh; Ani Balmanoukian; Joseph Paul Eder; Ana Oaknin; Hamilton; Wang; Indrani Sarkar; Luciana L. Molinero; Marcella Fassò; Carol E. O'Hear; Yvonne G. Lin; Leisha A. Emens
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The safety evaluation of long-acting ocular delivery systems
Drug Discovery Today, ISSN: 18785832 13596446
Evan A Thackaberry; Florence Lorget; Cindy A. Farman; Vlad Bantseev
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Hydrogels for sustained delivery of biologics to the back of the eye
Drug Discovery Today, ISSN: 18785832 13596446
Debby P. Chang; Kinam Park; Amin Famili
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Protein conjugates and fusion proteins as ocular therapeutics
Drug Discovery Today, ISSN: 18785832 13596446
Shrenik C. Mehta; Robert F. Kelley; Devin B. Tesar
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Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Shuguang Ma; Julia Suchomel; Evelyn Yanez; Edward Yost; Xiaorong Liang; Rui Zhu; Hoa Le; Nicholas Siebers; Lori Joas; Roland Morley; Stephanie Royer-Joo; Andrea Pirzkall; Laurent Salphati; Joseph A. Ware; Kari M. Morrissey
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Efficacious dose of metformin for breast cancer therapy is determined by cation transporter expression in tumours
British Journal of Pharmacology, ISSN: 14765381 00071188
Hao Cai; Ruth S. Everett; Dhiren R. Thakker
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Long-Term Safety of Rituximab in Patients With Rheumatoid Arthritis: Results of a Five-Year Observational Study
Arthritis Care and Research, ISSN: 21514658 2151464X
Kevin L. Winthrop; Saag; Matthew Cascino; Jinglan Pei; Ani John; Angelika Jahreis; Tmirah Haselkorn; Daniel E. Furst
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Bromodomains: a new target class for drug development
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Andrea G Cochran; Andrew R. Conery; Robert J. Sims
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CBP/p300 drives the differentiation of regulatory T cells through transcriptional and non-transcriptional mechanisms
Cancer Research, ISSN: 15387445 00085472
Joseph Castillo; Esther Wu; Christopher Lowe; Shrividhya Srinivasan; Mccord; Marie-Claire Wagle; Sangeeta Jayakar; Melissa Gonzalez Edick; Jeffrey Eastham-Anderson; Bonnie Liu; Katherine E. Hutchinson; Wendell Jones; Matthew P. Stokes; Somayeh S. Tarighat; Thomas Holcomb; Andrew Glibicky; F. Anthony Romero; Steven Magnuson; Shih-Min A. Huang; Vicki Plaks; Jennifer M. Giltnane; Lackner; Zineb Mounir
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Prognostic impact of natural killer cell count in follicular lymphoma and diffuse large b-cell lymphoma patients treated with immunochemotherapy
Clinical Cancer Research, ISSN: 15573265 10780432
Magdalena Klanova; Mikkel Z. Oestergaard; Marek Trneny; Wolfgang Hiddemann; Robert Marcus; Laurie H. Sehn; Umberto Vitolo; Alexandra Bazeos; Valentin Goede; Harald Zeuner; Andrea Knapp; Deniz Sahin; Nathalie Spielewoy; Christopher R. Bolen; Andres Cardona; Christian Klein; Jeffrey M. Venstrom; Tina Nielsen; Guenter Fingerle-Rowson
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FAIRLANE, a double-blind placebo-controlled randomized phase II trial of neoadjuvant ipatasertib plus paclitaxel for early triple-negative breast cancer
Annals of Oncology, ISSN: 15698041 09237534
Oliveira; Saura; Nuciforo; Calvo; Andersen; Passos-Coelho; Gil Gil; Bermejo; Debra Patt; Eva Ciruelos; Lorena de la Peña; Xu; Matthew Wongchenko; Shi; Stina M. Singel; Isakoff
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Impact of consensus molecular subtype on survival in patients with metastatic colorectal cancer: Results from CALGB/SWOG 80405 (Alliance)
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Heinz-Josef Lenz; Fang-Shu Ou; Alan P. Venook; Hochster; Donna Niedzwiecki; Richard M. Goldberg; Robert J. Mayer; Monica M. Bertagnolli; Charles D. Blanke; Tyler J. Zemla; Xueping Qu; Pratyaksha Wirapati; Sabine Tejpar; Federico Innocenti; Omar Kabbarah
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Protein conjugates and fusion proteins as ocular therapeutics
Drug Discovery Today, ISSN: 18785832 13596446
Shrenik Mehta; Robert F. Kelley; Devin B. Tesar
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Pharmacokinetics of the BCL-2 Inhibitor Venetoclax in Subjects with Hepatic Impairment
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Ahmed Hamed Salem; Nimita Dave; Thomas Marbury; Beibei Hu; Dale Miles; Suresh K. Agarwal; Orlando F. Bueno; Rajeev M. Menon
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Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: An interventional open-label study
Thorax, ISSN: 14683296 00406376
John Busby; Cecile Holweg; Akiko Chai; Peter Bradding; Fang Cai; Rekha Chaudhuri; Adel Mansur; James Lordan; John Matthews; Andrew Menzies-Gow; Robert Niven; Tracy Staton; Liam G. Heaney
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Functions and regulation of T cell-derived interleukin-10
Seminars in Immunology, ISSN: 10963618 10445323
Christian Neumann; Alexander Scheffold; Sascha Rutz
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Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid
Annals of Neurology, ISSN: 15318249 03645134
Ting Yang; Yifan Dang; Beth Ostaszewski; David Mengel; Verena Steffen; Christina Rabe; Tobias Bittner; Dominic M. Walsh; Dennis J. Selkoe
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Classification and Diagnosis of Bioprocess Cell Growth Productions Using Early-Stage Data
Industrial and Engineering Chemistry Research, ISSN: 15205045 08885885
Yuan Jin; Joe Qin; Qiang Huang; Victor Saucedo; Zheng Li; Angela Meier; Siddhartha Kundu; Bri Lehr; Salim Charaniya
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Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Laurel M. Pegram; Jennifer C. Liddle; Yao Xiao; Maria Hoh; Johannes Rudolph; Dylan B. Iverson; Guy Vigers; Darin Smith; Hailong Zhang; Weiru Wang; John Moffat; Natalie G. Ahn
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