Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3501 - 3550 OF 15805 RESULTS

Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association
Journal of Pathology, ISSN: 10969896 00223417
Esther Abels; Liron Pantanowitz; Famke Aeffner; Mark D Zarella; Jeroen van der Laak; Marilyn M Bui; Venkata NP Vemuri; Anil V Parwani; Jeff Gibbs; Emmanuel Agosto-Arroyo; Andrew H Beck; Cleopatra Kozlowski
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Data-Driven Development of Predictive Models for Sustained Drug Release
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Stijn H.S. Koshari; Debby P. Chang; Nathan B. Wang; Isidro E. Zarraga; Karthikan Rajagopal; Abraham M. Lenhoff; Norman J. Wagner
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Comparative Efficacy of Second- and Subsequent-line Treatments for Metastatic NSCLC: A Fractional Polynomials Network Meta-analysis of Cancer Immunotherapies
Clinical Lung Cancer, ISSN: 19380690 15257304
Christian Schulz; David R. Gandara; Carmen Galani Berardo; Rachel Rosenthal; Jason Foo; Chaienna Morel; Ballinger; Claire Watkins; Paula Chu
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Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Sarah Billington; Steven Shoner; Scott Lee; Kindra Clark-Snustad; Matthew Pennington; David Lewis; Mark Muzi; Shirley Rene; Jean Lee; Tot Bui Nguyen; Vineet Kumar; Kazuya Ishida; Laigao Chen; Xiaoyan Chu; Yurong Lai; Laurent Salphati; Cornelis E. Hop; Guangqing Xiao; Mingxiang Liao; Jashvant D. Unadkat
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Safety, pharmacokinetics, and pharmacodynamic activity of obinutuzumab, a type 2 anti-CD20 monoclonal antibody for the desensitization of candidates for renal transplant
American Journal of Transplantation, ISSN: 16006143 16006135
Robert R. Redfield; Stanley C. Jordan; Stephan Busque; Vincenti; E. Steve Woodle; Niraj Desai; Elaine Reed; Simon Tremblay; Andrea A. Zachary; Ashley A. Vo; Richard Formica; Thomas Schindler; Ha Tran; Looney; Candice Jamois; Cherie Green; Alyssa M. Morimoto; Richa Rajwanshi; Aaron Schroeder; Matthew Cascino; Paul Brunetta; Dominic Borie
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An ancient mechanism of arginine-specific substrate cleavage: What's ‘up’ with NSP4?
Biochimie, ISSN: 61831638 03009084
Andrew P. AhYoung; S. Jack Lin; Gerhardy; Menno Van Lookeren Campagne; Daniel Kirchhofer
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Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation
Cell Death and Differentiation, ISSN: 14765403 13509047
Jason E. Long; Matthew Wongchenko; Dorothee Nickles; Wei-Jen Chung; Bu-Er Wang; Johannes Riegler; Ji Li; Qingling Li; Wendy N. Sandoval; Jeffrey Eastham-Anderson; Zora Modrusan; Teemu T. Junttila; Richard A. D. Carano; Oded Foreman; Yibing Yan; Melissa Junttila
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Response to: 'Effectiveness and safety of tocilizumab for the treatment of refractory systemic sclerosis associated interstitial lung disease: a case series' by Narváez
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Dinesh Khanna; Angelika Jahreis; Celia J.F. Lin
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sumrep: A Summary Statistic Framework for Immune Receptor Repertoire Comparison and Model Validation
Frontiers in Immunology, ISSN: 16643224
Branden J. Olson; Pejvak Moghimi; Chaim A. Schramm; Anna Obraztsova; Duncan Ralph; Jason A. Vander Heiden; Mikhail Shugay; Adrian J. Shepherd; William Lees; Frederick A. Matsen
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Seasonal variability of lung function and Asthma Quality of Life Questionnaire Scores in adults with uncontrolled asthma
BMJ Open Respiratory Research, ISSN: 20524439
Rebecca N. Bauer; Xiaoying Yang; Tracy Staton; Julie Olsson; Cecile Holweg; Joseph R. Arron; John Matthews; David F. Choy
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Teamwork by T cells boosts immunotherapy
Nature, ISSN: 14764687 00280836
Jonathan L. Linehan; Lélia Delamarre
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Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo
Acta Neuropathologica Communications, ISSN: 20515960
Lena Will; Sybren Portegies; Jasper van Schelt; Merel van Luyk; Dick Jaarsma; Casper C Hoogenraad
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Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Michael J. Holliday; Ryan Ferrao; Gladys De Leon Boenig; Alberto Estevez; Elizabeth Helgason; Alexis Rohou; Erin C. Dueber; Wayne J. Fairbrother
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MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Science, ISSN: 10959203 00368075
Michael G. Constantinides; Verena M. Link; Samira Tamoutounour; Andrea C. Wong; P. Juliana Perez-Chaparro; Seong-Ji Han; Y. Erin Chen; Kelin Li; Sepideh Farhat; Antonin Weckel; Siddharth R. Krishnamurthy; Ivan Vujkovic-Cvijin; Jonathan L. Linehan; Nicolas Bouladoux; E. Dean Merrill; Sobhan Roy; Daniel J. Cua; Erin J. Adams; Avinash Bhandoola; Tiffany C. Scharschmidt; Jeffrey Aubé; Michael A. Fischbach; Yasmine Belkaid
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Tumor immune microenvironment and genomic evolution in a patient with metastatic triple negative breast cancer and a complete response to atezolizumab
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Luciana L. Molinero; Yijin Li; Ching-Wei Chang; Sophia L. Maund; Maureen Berg; Jeanne Harrison; Marcella Fassò; Carol E. O'Hear; Priti Hegde; Leisha A. Emens
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Feedback-Driven Assembly of the Axon Initial Segment
Neuron, ISSN: 10974199 08966273
Amélie Fréal; Dipti Rai; Roderick P. Tas; Xingxiu Pan; Eugene A Katrukha; Dieudonnée van de Willige; Riccardo Stucchi; Amol Aher; Chao Yang; Maarten Altelaar; Karin Vocking; Jan Andries Post; Martin Harterink; Lukas C. Kapitein; Anna Akhmanova; Casper C Hoogenraad
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Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population
Journal of Infectious Diseases, ISSN: 15376613 00221899
Michele D. Spring; Jason C. Sousa; Qigui Li; Christian A. Darko; Meshell N. Morrison; Sean R. Marcsisin; Kristin T. Mills; Brittney M. Potter; Kristopher M. Paolino; Patrick S. Twomey; James E. Moon; Donna M. Tosh; Susan B. Cicatelli; Jeffrey W. Froude; Brandon S. Pybus; Thomas G. Oliver; William F. McCarthy; Norman C. Waters; Philip L. Smith; Gregory A. Reichard; Jason W. Bennett
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A Green Chemistry Continuum for a Robust and Sustainable Active Pharmaceutical Ingredient Supply Chain
ACS Sustainable Chemistry and Engineering, ISSN: 21680485
Stefan G. Koenig; Cisco Bee; Alina Borovika; Christiana Briddell; Juan Colberg; Guy R. Humphrey; Michael E. Kopach; Isamir Martinez; Sudhir Nambiar; Scott Plummer; Seth D. Ribe; Frank Roschangar; Jeremy P. Scott; Helen F. Sneddon
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Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
Nature, ISSN: 14764687 00280836
Kim Newton; Katherine E. Wickliffe; Dugger; Maltzman; Merone Roose-Girma; Monika Dohse; László Kömüves; Webster; Vishva M. Dixit
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Safety, clinical activity, and biological correlates of response in patients with metastatic melanoma: Results from a phase I trial of atezolizumab
Clinical Cancer Research, ISSN: 15573265 10780432
Omid Hamid; Luciana L. Molinero; Christopher R. Bolen; Jeffrey A. Sosman; Eva Muñoz-Couselo; Harriet M. Kluger; David McDermott; John D. Powderly; Indrani Sarkar; Ballinger; Marcella Fassò; Carol E. O'Hear; Daniel S. Chen; Priti Hegde; F. Stephen Hodi
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VAP-SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function
EMBO Journal, ISSN: 14602075 02614189
Feline W Lindhout; Yujie Cao; Josta T Kevenaar; Anna Bodzęta; Riccardo Stucchi; Maria M Boumpoutsari; Eugene A Katrukha; Maarten Altelaar; Harold MacGillavry; Casper C Hoogenraad
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The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function
Nature, ISSN: 14764687 00280836
Nina Oberbeck; Victoria Pham; Webster; Rohit Reja; Christine S. Huang; Yue Zhang; Merone Roose-Girma; Søren Warming; Qingling Li; Andrew Birnberg; Weng Wong; Wendy N. Sandoval; László Kömüves; Kebing Yu; Dugger; Maltzman; Kim Newton; Vishva M. Dixit
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Elucidating Molecular-and Particle-Level Changes during the Annealing of a Micronized Crystalline Drug
Molecular Pharmaceutics, ISSN: 15438392 15438384
Vibha Puri; Jagdeep Shur; Ajit S. Narang
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Comprehensive Evaluation of Bile Acid Homeostasis in Human Hepatocyte Co-Culture in the Presence of Troglitazone, Pioglitazone, and Acetylsalicylic Acid
Molecular Pharmaceutics, ISSN: 15438392 15438384
Jae H. Chang; Dewakar Sangaraju; Ning Liu; Allan Jaochico; Emile G. Plise
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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
Cell, ISSN: 10974172 00928674
Henry R. Maun; Janet Jackman; David F. Choy; Kelly M. Loyet; Tracy Staton; Guiquan Jia; Amy Dressen; Jason A. Hackney; Meire C. Bremer; Benjamin T. Walters; Rajesh Vij; Xiaocheng Chen; Neil N. Trivedi; Ashley Morando; Michael T. Lipari; Yvonne Franke; Xiumin Wu; Juan Zhang; John Liu; Ping Wu; Diana Chang; Luz D. Orozco; Erin Christensen; Manda Wong; Corpuz; Julie Qi Hang; Jeff Lutman; Siddharth Sukumaran; Yan Wu; Savita Ubhayakar; Xiaorong Liang; Lawrence B. Schwartz; Magda Babina; Prescott G. Woodruff; John V. Fahy; Rahul Ahuja; George H. Caughey; Aija Kusi; Dennis; Eigenbrot; Daniel Kirchhofer; Cary D. Austin; Lawren C. Wu; James T. Koerber; Wyne P. Lee; Brian L. Yaspan; Kathila R. Alatsis; Joseph R. Arron; Lazarus; Tangsheng Yi
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Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells
mAbs, ISSN: 19420870 19420862
Kamal Kishore Joshi; Wilson Phung; Guanghui Han; Yiyuan Yin; Ingrid Kim; Wendy N. Sandoval; Paul J. Carter
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Characterization of a single reporter-gene potency assay for T-cell-dependent bispecific molecules
mAbs, ISSN: 19420870 19420862
Ho Young Lee; Ames C. Register; Jeongsup Shim; Edward Contreras; Qiang Wu; Guoying Jiang
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Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
Advances in Therapy, ISSN: 18658652 0741238X
Marilyn K Glassberg; Steven D Nathan; Chin-Yu Lin; Elizabeth A. Morgenthien; John L. Stauffer; Willis Chou; Paul W. Noble
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Development of an IL-6 point-of-care assay: Utility for real-time monitoring and management of cytokine release syndrome and sepsis
Bioanalysis, ISSN: 17576199 17576180
Saloumeh Kadkhodayan Fischer; Kathi Williams; Ling Wang; Emmanuel Capio; Mikhail Briman
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Clinically meaningful visual improvements and predictors of early vision gains with ranibizumab for diabetic macular oedema
BMJ Open Ophthalmology, ISSN: 23973269
Lawrence S. Morse; Linda Yau; Lisa Tuomi
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Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging
PLoS ONE, ISSN: 19326203
Chenguang Zhou; Hao Cai; Amos Baruch; Nicholas Lewin-Koh; Meng Yang; Fengxun Guo; Deming Xu; Rong Deng; Wouter L. W. Hazenbos; Amrita Kamath
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Optimizing venetoclax dose in combination with low intensive therapies in elderly patients with newly diagnosed acute myeloid leukemia: An exposure-response analysis
Hematological Oncology, ISSN: 10991069 02780232
Suresh K. Agarwal; Sathej Gopalakrishnan; Sven Mensing; Jalaja Potluri; John Hayslip; Whitney P. Kirschbrown; Anna Friedel; Rajeev M. Menon; Ahmed Hamed Salem
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Scientific and Regulatory Policy Committee Points to Consider*: The Toxicologic Pathologist’s Role in the 3Rs
Toxicologic Pathology, ISSN: 15331601 01926233
Renee R. Hukkanen; Noel Dybdal; Niraj K. Tripathi; Patricia V. Turner; Sean P. Troth
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Correction to: Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (Advances in Therapy, (2019), 36, 10, (2910-2926), 10.1007/s12325-019-01052-y)
Advances in Therapy, ISSN: 18658652 0741238X
Marilyn K Glassberg; Steven D Nathan; Chin-Yu Lin; Elizabeth A. Morgenthien; John L. Stauffer; Willis Chou; Paul W. Noble
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Real-World Clinical and Economic Outcomes and the Role of Bevacizumab in Patients With Non-Small-Cell Lung Cancer With Liver Metastases
Journal of Oncology Practice, ISSN: 1935469X
Wong; Ning Wu; Erru Yang; Jessica Davies; Young Kwang Chae
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Rapid development of glaucoma via ITV nonselective ANGPT 1/2 antibody: A potential role for ANGPT/Tie2 signaling in primate aqueous humor outflow
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Evan A Thackaberry; Yi Zhou; Christina L. Zuch de Zafra; Fuh; Chingwei V. Lee; Sarah Sanowar; John B.B. Ridgway; Aija Kusi; Cindy A. Farman; Helen Booler; Daniel Sheinson; Carol A. Rasmussen; Paul Miller; Eric Wakshull; Minhong Yan; Vlad Bantseev
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ErbB3 and IGF1R signaling are required for Nrf2-dependent growth in Keap1-mutant lung cancer
Cancer Research, ISSN: 15387445 00085472
Steffan Vartanian; James Lee; Christiaan N. Klijn; Florian Gnad; Maria Bagniewska; Gabriele Schaefer; Donglu Zhang; Jenille Tan; Sara A. Watson; Liling Liu; Chen; Yuxin Liang; Colin K. Watanabe; Trinna L. Cuellar; David Kan; Ryan J. Hartmaier; Ted Lau; Michael Costa; Scott E. Martin; Mark Merchant; Benjamin Haley; David Stokoe
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MetagenomeFeatures: An R package for working with 16S rRNA reference databases and marker-gene survey feature data
Bioinformatics, ISSN: 14602059 13674803
Nathan D. Olson; Nidhi Shah; Jayaram Kancherla; Justin Wagner; Joseph N. Paulson; Hector Corrada Bravo
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Using the Healthy Days Measure to Assess Factors Associated with Poor Health-Related Quality of Life for Patients with Metastatic Breast, Lung, or Colorectal Cancer Enrolled in a Medicare Advantage Health Plan
Population Health Management, ISSN: 19427905 19427891
Adrianne Casebeer; Dana Drzayich Antol; Sari Hopson; Raya Khoury; Andrew Renda; Aparna R. Parikh; Alisha Stein; Todd Michael; Stephen Stemkowski; Mikele M. Bunce
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Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
Nature Immunology, ISSN: 15292916 15292908
Nathan W. Zammit; Owen M. Siggs; Paul Gray; Keisuke Horikawa; David B. Langley; Stacey N. Walters; Stephen R. Daley; Claudia Loetsch; Joanna Warren; Jin Yan Yap; Daniele Cultrone; Amanda Russell; Elisabeth K. Malle; Jeanette E. Villanueva; Mark J. Cowley; Velimir Gayevskiy; Marcel E. Dinger; Robert Brink; David Zahra; Geeta Chaudhri; Gunasegaran Karupiah; Belinda Whittle; Carla Roots; Edward M. Bertram; Michiko Yamada; Yogesh Jeelall; Anselm Enders; Benjamin E. Clifton; Peter D. Mabbitt; Colin J. Jackson; Susan R. Watson; Craig N. Jenne; Lewis L. Lanier; Tim Wiltshire; Matthew H Spitzer; Garry P. Nolan; Frank Schmitz; Alan Aderem; Benjamin T. Porebski; Ashley M. Buckle; Derek W. Abbott; John B. Ziegler; Maria E. Craig; Paul Benitez-Aguirre; Juliana Teo; Stuart G. Tangye; Cecile King; Melanie Wong; Murray P. Cox; Wilson Phung; Jia Tang; Wendy N. Sandoval; Ingrid E. Wertz; Daniel Christ; Christopher C. Goodnow; Shane T. Grey
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Genomic and Transcriptomic Characterization of Papillary Microcarcinomas with Lateral Neck Lymph Node Metastases
Journal of Clinical Endocrinology and Metabolism, ISSN: 19457197 0021972X
DIlmi Perera; Ronald Ghossein; Niedzica Camacho; Yasin Senbabaoglu; Venkatraman Seshan; Juan Li; Nancy Bouvier; Laura Boucai; Min Zeng; Nicholas D Socci; Brian R. Untch; Mithat Gonen; Jeffrey Knauf; James A. Fagin; Michael Berger; R Michael Tuttle
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VCAM-1 Density and Tumor Perfusion Predict T-cell Infiltration and Treatment Response in Preclinical Models
Neoplasia (United States), ISSN: 14765586 15228002
Johannes Riegler; Herman S. Gill; Annie Ogasawara; Maj Hedehus; Vincent Javinal; Jason Oeh; Gregory Z. Ferl; Jan Marik; Simon P. Williams; Deepak Sampath; Jill Schartner; Richard A. D. Carano
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Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin
British Journal of Pharmacology, ISSN: 14765381 00071188
Dongwei Li; Donna W. Lee; Randall Dere; Bing Zheng; Shang-Fan Yu; Franklin Fuh; Katherine R. Kozak; Shan Chung; Daniela Bumbaca Yadav; Denise Nazzal; Dimitry Danilenko; MaryAnn Go; Marna Williams; Andrew G. Polson; Kirsten Achilles Poon; Saileta Prabhu
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Impact of depth of response on survival in patients treated with cobimetinib ± vemurafenib: pooled analysis of BRIM-2, BRIM-3, BRIM-7 and coBRIM
British Journal of Cancer, ISSN: 15321827 00070920
Karl Lewis; James Larkin; Antoni Ribas; Keith Flaherty; McArthur; Paolo A. Ascierto; Brigitte Dréno; Yibing Yan; Matthew Wongchenko; Edward McKenna; Qian Zhu; Yong Mun; Axel Hauschild
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Stereoselective supercritical fluidic chromatography –mass spectrometry (SFC-MS) as a fast bioanalytical tool to assess chiral inversion in vivo and in vitro
International Journal of Mass Spectrometry, ISSN: 13873806
Liuxi Chen; Brian J. Dean; Hank La; Yuan Chen; Xiaorong Liang
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Impact of Surfactant and Surfactant-Polymer Interaction on Desupersaturation of Clotrimazole
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Wei Zhang; Siddhi S. Hate; David J. Russell; Hao Helen Hou; Karthik Nagapudi
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Risk of malignancy associated with use of tocilizumab versus other biologics in patients with rheumatoid arthritis: A multi-database cohort study
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Seoyoung C. Kim; Ajinkya Pawar; Rishi J. Desai; Daniel H. Solomon; Sara Gale; Bao; Khaled Sarsour; Sebastian Schneeweiss
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CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions
Frontiers in Immunology, ISSN: 16643224
Courtney Easley-Neal; Oded Foreman; Neeraj Sharma; Ali A. Zarrin; Robby M. Weimer
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Improved Synthesis of the Nav1.7 Inhibitor GDC-0276 via a Highly Regioselective SNAr Reaction
Organic Process Research and Development, ISSN: 1520586X 10836160
Andreas Stumpf; Zhigang Cheng; Danial Beaudry; Remy Angelaud; Francis Gosselin
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Dynamics of Bone Cell Interactions and Differential Responses to PTH and Antibody-Based Therapies
Bulletin of Mathematical Biology, ISSN: 15229602 00928240
Vincent Lemaire; David R. Cox
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