Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3751 - 3800 OF 15805 RESULTS

Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines
Journal of Organic Chemistry, ISSN: 15206904 00223263
Haiming Zhang; Beryl X. Li; Brian Wong; Andreas Stumpf; C. Gregory Sowell; Francis Gosselin
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Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: Final update of the pivotal ERIVANCE BCC study (BMC Cancer. (2017) 17 (332) DOI: 10.1186/s12885-017-3286-5)
BMC Cancer, ISSN: 14712407
Aleksandar Sekulic; Michael R. Migden; Nicole Basset-Seguin; Claus Garbe; Anja Gesierich; Christopher D. Lao; Chris Miller; Laurent Mortier; Dedee F. Murrell; Omid Hamid; Jorge F. Quevedo; Jeannie Hou; Edward McKenna; Natalie Dimier; Sarah Williams; Dirk Schadendorf; Axel Hauschild
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BcGST-an interactive bias-correction method to identify over-represented gene-sets in boutique arrays
Bioinformatics, ISSN: 14602059 13674803
Kevin Y.X. Wang; Alexander M. Menzies; Ines Pires da Silva; James S. Wilmott; Yibing Yan; Matthew Wongchenko; Richard F. Kefford; Richard A. Scolyer; Georgina V. Long; Garth Tarr; Samuel Mueller; Yang
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Central nervous system metastasis in patients with HER2-positive metastatic breast cancer: Patient characteristics, treatment, and survival from systhers
Clinical Cancer Research, ISSN: 15573265 10780432
Sara A. Hurvitz; O'Shaughnessy; Ginny Mason; Denise A. Yardley; Mohammad Jahanzeb; Adam Brufsky; Hope S. Rugo; Sandra M. Swain; Peter A. Kaufman; Debasish Tripathy; Laura Chu; Haocheng Li; Vincent Antao; Melody A. Cobleigh
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Human growth hormone
Pharmaceutical Biotechnology: Fundamentals and Applications,
Dao; Barbara M. Lippe; Mike Laird; Ingrid Beierle
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Recombinant human deoxyribonuclease I
Pharmaceutical Biotechnology: Fundamentals and Applications,
Lazarus; Wagener
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Monoclonal antibodies: From structure to therapeutic application
Pharmaceutical Biotechnology: Fundamentals and Applications,
Rong Deng; C. Andrew Boswell; Wendy Putnam; Meina Tao Tang; Amit Garg; Chunze Li; Shan Chung; Sandhya Girish
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General Purpose Water Model Can Improve Atomistic Simulations of Intrinsically Disordered Proteins
Journal of Chemical Theory and Computation, ISSN: 15499626 15499618
Parviz Seifpanahi Shabane; Saeed Izadi; Alexey V. Onufriev
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Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity
Cell Reports, ISSN: 22111247
Devorkin; Nils Pavey; Gillian Carleton; Alexandra Comber; Cally Ho; Junghyun Lim; Erin McNamara; Haochu Huang; Kim; Lauren G. Zacharias; Noboru Mizushima; Tatsuya Saitoh; Shizuo Akira; Wayne Beckham; Alireza Lorzadeh; Michelle Moksa; Qi Cao; Aditya Murthy; Martin Hirst; DeBerardinis; Julian J. Lum
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RALying Regeneration through Wnt Internalization in Stem Cells
Cell Stem Cell, ISSN: 18759777 19345909
Helen Tauc; Heinrich Jasper
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Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation
Cell Reports, ISSN: 22111247
Denise De Almeida Nagata; Eugene Y. Chiang; Suchit Jhunjhunwala; Patrick Caplazi; Vidhyalakshmi Arumugam; Zora Modrusan; Emily Chan; Mark Merchant; Lingyan Jin; David Arnott; F. Anthony Romero; Steven Magnuson; Karen Gascoigne; Jane L. Grogan
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Single-institution retrospective review of patients with recurrent glioblastoma treated with bevacizumab in clinical practice
Health Science Reports, ISSN: 23988835
Annick Desjardins; James E. Herndon; Frances McSherry; Arliene Ravelo; Eric S. Lipp; Patrick Healy; Katherine B. Peters; John H. Sampson; Dina Randazzo; Nicolas Sommer; Allan H. Friedman; Henry S. Friedman
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IMpower030: Phase III study evaluating neoadjuvant treatment of resectable stage II-IIIB non-small cell lung cancer (NSCLC) with atezolizumab (atezo) + chemotherapy
Annals of Oncology, ISSN: 15698041
Solange Peters; Kim; Benjamin Solomon; David R. Gandara; Rafal Dziadziuszko; Brunelli; Marina C. Garassino; Martin Reck; Wang; To; Sun; Barbara Gitlitz; Alan Sandler; Naiyer A. Rizvi
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Prognostic power of pathogen cell-free DNA in staphylococcus aureus bacteremia
Open Forum Infectious Diseases, ISSN: 23288957
Alessander O. Guimaraes; Johnny Gutierrez; Stacey A. Maskarinec; Yi Cao; Kyu Hong; Felicia Ruffin; Montserrat Carrasco-Triguero; Melicent Peck; Vance G. Fowler; Amos Baruch; Carrie M. Rosenberger
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Sustained circulating bacterial deoxyribonucleic acid is associated with complicated staphylococcus aureus bacteremia
Open Forum Infectious Diseases, ISSN: 23288957
Johnny Gutierrez; Alessander O. Guimaraes; Nicholas Lewin-Koh; Aklile Berhanu; Min Xu; Yi Cao; Janice Kim; Donghong Yan; Joanna K. Chang; Jason Dinoso; Catherine A. Koss; Angelo Clemenzi-Allen; Chambers; Melicent Peck; Amos Baruch; Carrie M. Rosenberger
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A rapid derivatization based LC-MS/MS method for quantitation of short chain fatty acids in human plasma and urine
Bioanalysis, ISSN: 17576199 17576180
Allan Jaochico; Dewakar Sangaraju; Sheerin Shahidi-Latham
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Incidence and risk of glucocorticoid-associated adverse effects in patients with rheumatoid arthritis
Arthritis Care and Research, ISSN: 21514658 2151464X
Jessica C. Wilson; Khaled Sarsour; Sara Gale; Attila Pethö-Schramm; Susan S. Jick; Christoph R. Meier
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Anti-PD-L1 treatment results in functional remodeling of the macrophage compartment
Cancer Research, ISSN: 15387445 00085472
Huizhong Xiong; Stephanie Mittman; Ryan Rodriguez; Marina Moskalenko; Patricia Pacheco-Sanchez; Yagai Yang; Dorothee Nickles; Rafael Cubas
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The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification
PLoS ONE, ISSN: 19326203
Mona Abed; Erik Verschueren; Hanna G. Budayeva; Peter S. Liu; Donald S. Kirkpatrick; Rohit Reja; Sarah K. Kummerfeld; Webster; Sarah Gierke; Mike Reichelt; Keith R. Anderson; Robert J. Newman; Merone Roose-Girma; Zora Modrusan; Hazal Pektas; Emin Maltepe; Kim Newton; Vishva M. Dixit
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Low-pass whole-genome sequencing of circulating cell-free DNA demonstrates dynamic changes in genomic copy number in a squamous lung cancer clinical cohort
Clinical Cancer Research, ISSN: 15573265 10780432
Xiaoji Chen; Ching-Wei Chang; Jill M. Spoerke; Kathryn E. Yoh; Vidushi Kapoor; Charles Baudo; Junko Aimi; Mamie Yu; May M. Y. Liang-Chu; Rebecca Suttmann; Huw; Steven Gendreau; Cummings; Lackner
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Activation of naïve CD4 + T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 + T cells
Nature Immunology, ISSN: 15292916 15292908
Jason P. Twohig; Ana Cardus Figueras; Robert Andrews; Florian Wiede; Benjamin C. Cossins; Alicia Derrac Soria; Myles J. Lewis; Michael J. Townsend; David Millrine; Jasmine Li; David G. Hill; Javier Uceda Fernandez; Xiao Liu; Barbara Szomolay; Christopher J. Pepper; Philip R. Taylor; Costantino Pitzalis; Tony Tiganis; Nigel Williams; Gareth W. Jones; Simon A. Jones
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Structurally-defined deubiquitinase inhibitors provide opportunities to investigate disease mechanisms
Drug Discovery Today: Technologies, ISSN: 17406749
Ingrid E. Wertz; Jeremy Murray
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A comparison of total and plasma membrane abundance of transporters in suspended, plated, sandwich-cultured human hepatocytes versus human liver tissue using quantitative targeted proteomics and cell surface biotinylation S
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Vineet Kumar; Laurent Salphati; Cornelis E. Hop; Guangqing Xiao; Yurong Lai; Anita Mathias; Xiaoyan Chu; W. Griffith Humphreys; Mingxiang Liao; Scott Heyward; Jashvant D. Unadkat
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Exposure–Response-Based Product Profile–Driven Clinical Utility Index for Ipatasertib Dose Selection in Prostate Cancer
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Rui Zhu; Bill Poland; Russell D. Wada; Qi Liu; Luna Musib; Daniel Maslyar; Eunpi Cho; Wei Yu; Han Ma; Jin Yan Jin; Nageshwar Budha
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Cost-Effectiveness Analysis of Pertuzumab With Trastuzumab and Chemotherapy Compared to Trastuzumab and Chemotherapy in the Adjuvant Treatment of HER2-Positive Breast Cancer in the United States
Value in Health, ISSN: 15244733 10983015
Louis P. Garrison Jr.; Joseph B. Babigumira; Clément Tournier; Hans-Peter Goertz; Solomon J. Lubinga; Edith A. Perez
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Efficacy of Pirfenidone in the Context of Multiple Disease Progression Events in Patients With Idiopathic Pulmonary Fibrosis
Chest, ISSN: 19313543 00123692
Steven D Nathan; Ulrich Costabel; Ian Glaspole; Marilyn K Glassberg; Lisa H Lancaster; David J. Lederer; Carlos A Pereira; Benjamin L. Trzaskoma; Elizabeth A. Morgenthien; Susan L. Limb; Athol Wells
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New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue
Journal of Pathology, ISSN: 10969896 00223417
Jérémie Decalf; Matthew L. Albert; James Ziai
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c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis
Nature Immunology, ISSN: 15292916 15292908
Christian Neumann; Jonas Blume; Urmi Roy; Peggy P. Teh; Ajithkumar Vasanthakumar; Alexander Beller; Yang Liao; Frederik Heinrich; Teresita L. Arenzana; Jason A. Hackney; Celine Eidenschenk; Eric J. C. Gálvez; Christina Stehle; Gitta A. Heinz; Patrick Maschmeyer; Tom Sidwell; Yifang Hu; Derk Amsen; Chiara Romagnani; Hyun-Dong Chang; Andrey Kruglov; Mir-Farzin Mashreghi; Wei Shi; Till Strowig; Sascha Rutz; Axel Kallies; Alexander Scheffold
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Determination of a novel antifibrotic small molecule GDC-3280 in human plasma and urine by liquid chromatography tandem mass spectrometry to support its first-in-human clinical trial
Biomedical chromatography : BMC, ISSN: 10990801 02693879
Jianshuang Wang; Michael Van Parys; Lin Pan; Yuan Chen; Dorothy S. Cheung; McKnight; Dennis Milanowski; Xiao Ding; Brian J. Dean
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Interaction of cell culture process parameters for modulating mAb afucosylation
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Anh Nguyen Dang; Melissa Mun; Christopher M. Rose; Patrick Ahyow; Angela Meier; Wendy N. Sandoval; Inn H. Yuk
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Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Birong Zhang; James R. Kiefer; Robert A. Blake; Jae H. Chang; Steven J. Hartman; Ellen Ingalla; Tracy L. Kleinheinz; Vidhi Mody; Michelle Nannini; Daniel F. Ortwine; Yingqing Ran; Amy Sambrone; Deepak Sampath; Maia Vinogradova; Yu Zhong; Jerome C. Nwachukwu; Kendall W. Nettles; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Hai Chen; Xiaojing Wang; Jun Liang
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Risk of serious infections in tocilizumab versus other biologic drugs in patients with rheumatoid arthritis: A multidatabase cohort study
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Ajinkya Pawar; Rishi J. Desai; Daniel H. Solomon; Adrian J. Santiago Ortiz; Sara Gale; Bao; Khaled Sarsour; Sebastian Schneeweiss; Seoyoung C. Kim
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Characterizing and enhancing virus removal by protein A chromatography
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Chinwei Pan; Alejandro Becerra-Arteaga; Benjamin Tran; Michael Chinn; Hua Wang; Qi Chen; Herbert Lutz; Min Zhang
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Omalizumab effectiveness in asthma-COPD overlap: Post hoc analysis of PROSPERO
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Nicola A. Hanania; Bradley E. Chipps; Noelle M. Griffin; Bongin Yoo; Ahmar Iqbal; Thomas B. Casale
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Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS
Neurobiology of Disease, ISSN: 1095953X 09699961
Arundhati Sengupta Ghosh; Sara L. Dominguez; Luke Xie; Kai H. Barck; Zhiyu Jiang; Timothy K. Earr; Jose Imperio; Lilian Phu; Hanna G. Budayeva; Donald S. Kirkpatrick; Hao Cai; Jeffrey Eastham-Anderson; Hai Ngu; Oded Foreman; Maj Hedehus; Mike Reichelt; Isidro Hötzel; Yonglei Shang; Richard A. D. Carano; Gai Ayalon; Amy Easton
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Pyruvate Kinase Muscle-1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study
Biotechnology Journal, ISSN: 18607314 18606768
Danming Tang; Jayashree Subramanian; Benjamin Haley; Jordan Baker; Lucas Luo; Wendy Hsu; Peter S. Liu; Wendy N. Sandoval; Mike Laird; Snedecor; Masaru Shiratori; Shahram Misaghi
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CLINICOPATHOLOGIC CORRELATION OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION
Retina, ISSN: 15392864 0275004X
Miaoling Li; Rosa Dolz-Marco; Carrie Huisingh; Jeffrey D. Messinger; Richard M. Feist; Daniela Ferrara; K. Bailey Freund; Christine A. Curcio; David J. Wilson
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Bevacizumab at first recurrence after standard radio-chemotherapy is associated with improved overall survival in glioblastoma patients with large tumor burden
Neuro-Oncology Practice, ISSN: 20542585 20542577
Huy Tram Nguyen; Nhung Nguyen; Liang Yen Liu; Laura Dovek; Daniel Lenchner; Robert J. Harris; Byram Ozer; Arliene Ravelo; Nicolas Sommer; Myung Shin Sim; Robert Elashoff; Richard Green; Phioanh L. Nghiemphu; Timothy Cloughesy; Benjamin M. Ellingson; Albert Lai
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Introduction of a process mass intensity metric for biologics
New Biotechnology, ISSN: 18764347 18716784
Kristi L. Budzinski; Megan Blewis; Philip Dahlin; Daniel D'Aquila; Julia Esparza; Jack Gavin; Sa V. Ho; Clarice Hutchens; David Kahn; Stefan G. Koenig; Robert E. Kottmeier; Jeff Millard; Matt Snyder; Stanard; Lixin Sun
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Structural basis of a-scorpion toxin action on Na v channels
Science, ISSN: 10959203 00368075
Thomas Clairfeuille; Alexander Cloake; Daniel T. Infield; José P. Llongueras; Christopher P. Arthur; Zhong Rong Li; Yuwen Jian; Marie-France Martin-Eauclaire; Pierre E. Bougis; Claudio Ciferri; Christopher A. Ahern; Frank Bosmans; David Hackos; Alexis Rohou; Jian Payandeh
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Obinutuzumab plus CHOP is effective and has a tolerable safety profile in previously untreated, advanced diffuse large B-cell lymphoma: the phase II GATHER study
Leukemia and Lymphoma, ISSN: 10292403 10428194
Jeff P. Sharman; Andres Forero; Luciano J. Costa; Ian W. Flinn; Lowell Inhorn; Kevin Kelly; Alberto Bessudo; Luis E. Fayad; Kaminski; Andrew M. Evens; Christopher R. Flowers; Deniz Sahin; Kirsten E. Mundt; Thomas Sandmann; Guenter Fingerle-Rowson; Charlotte Vignal; Mehrdad Mobasher; Zelenetz
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Application and practice of digital pathology
Pathological Specimens And Genomic Medicine: Emerging Issues,
Webster; Jeffrey Eastham-Anderson
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Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies
Cancer Cell, ISSN: 18783686 15356108
Yi-Zhou Jiang; Ding Ma; Chen Suo; Jinxiu Shi; Mengzhu Xue; Xin Hu; Yi Xiao; Ke-Da Yu; Yi-Rong Liu; Ying Yu; Yuanting Zheng; Xiangnan Li; Chenhui Zhang; Pengchen Hu; Jing Zhang; Qi Hua; Jiyang Zhang; Wanwan Hou; Luyao Ren; Ding Bao; Bingying Li; Jingcheng Yang; Ling Yao; Wen-Jia Zuo; Shen Zhao; Yue Gong; Yi-Xing Ren; Ya-Xin Zhao; Yun-Song Yang; Zhenmin Niu; Zhi-Gang Cao; Daniel G. Stover; Claire F. Verschraegen; Virginia Kaklamani; Anneleen Daemen; John R. Benson; Kazuaki Takabe; Fan Bai; Da-Qiang Li; Peng Wang; Leming Shi; Wei Huang; Zhimin Shao
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Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance
Cancer Cell, ISSN: 18783686 15356108
Jonathan Cooper; Filippo G Giancotti
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Water molecules in protein–ligand interfaces. Evaluation of software tools and SAR comparison
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Eva Nittinger; Paul Gibbons; Eigenbrot; Douglas R. Davies; Brigitte Maurer; Christine Yu; James R. Kiefer; Andreas Kuglstatter; Jeremy Murray; Daniel F. Ortwine; Yong Tang; Vickie Tsui
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Treatment Patterns and Outcomes in Patients with KRAS Wild-Type Metastatic Colorectal Cancer Treated in First Line with Bevacizumab- or Cetuximab-Containing Regimens
Journal of Gastrointestinal Cancer, ISSN: 19416636 19416628
Arthur C. Houts; Sarika Ogale; Nicolas Sommer; Sacha Satram-Hoang; Mark S. Walker
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Progression-Free Survival in Patients Receiving Chemotherapy Alone (C) or Chemotherapy with Bevacizumab (CB) for First-Line Treatment of KRAS Mutant Metastatic Colorectal Cancer in Community Oncology Settings
Journal of Gastrointestinal Cancer, ISSN: 19416636 19416628
Arthur C. Houts; Sarika Ogale; Yousuf Zafar; Joleen M. Hubbard; Sacha Satram-Hoang; Nicolas Sommer; Mark S. Walker
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Enantioselective synthesis of GNE-6688, a potent and selective inhibitor of interleukin-2 inducible T-cell kinase (ITK)
Tetrahedron Letters, ISSN: 18733581 00404039
Jared Moore; Kevin Lau; Xiaofeng Xu; Yamin Zhang; Jason D. Burch
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Strategies to optimize drug half-life in lead candidate identification
Expert Opinion on Drug Discovery, ISSN: 1746045X 17460441
Broccatelli; Cornelis E. Hop; Matthew Wright
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Adverse Events in Giant Cell Arteritis and Rheumatoid Arthritis Patient Populations: Analyses of Tocilizumab Clinical Trials and Claims Data
Rheumatology and Therapy, ISSN: 21986584 21986576
Sara Gale; Huong Trinh; Katie Tuckwell; Neil Collinson; John H. Stone; Khaled Sarsour; Jinglan Pei; Jennie Best; Christine Birchwood; Shalini V. Mohan
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