Scientists / Publications

Publications

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DISPLAYING 4101 - 4150 OF 15805 RESULTS

Conventional wastewater treatment and reuse site practices modify bacterial community structure but do not eliminate some opportunistic pathogens in reclaimed water
Science of the Total Environment, ISSN: 18791026 00489697
Prachi Kulkarni; Nathan D. Olson; Joseph N. Paulson; Mihai Pop; Cynthia Maddox; Emma Claye; Rachel E. Rosenberg Goldstein; Manan Sharma; Shawn G. Gibbs; Emmanuel F. Mongodin; Amy R. Sapkota
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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
Cancer Cell, ISSN: 18783686 15356108
Ivana Yen; Frances Shanahan; Mark Merchant; Christine Orr; Thomas Hunsaker; Matthew Durk; Hank La; Xiaolin Zhang; Scott E. Martin; Eva Lin; John Chan; Yihong Yu; Dhara Amin; Richard M. Neve; Amy Gustafson; Avinashnarayan Venkatanarayan; Scott A. Foster; Joachim Rudolph; Christiaan N. Klijn; Shiva Malek
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Quality assessment and interference detection in targeted mass spectrometry data using machine learning 03 Chemical Sciences 0301 Analytical Chemistry
Clinical Proteomics, ISSN: 15590275 15426416
Shadi Toghi Eshghi; Paul Auger; W Rodney Mathews
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Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin
Journal of Organic Chemistry, ISSN: 15206904 00223263
Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin
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High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants
mAbs, ISSN: 19420870 19420862
Danielle DiCara; Nisana Andersen; Ruby Chan; James A. Ernst; Gai Ayalon; Greg A. Lazar; Nick Agard; Amy Hilderbrand; Isidro Hötzel
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Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid
mAbs, ISSN: 19420870 19420862
Rina Fong; Kimberly K. Kajihara; Matthew Chen; Isidro Hötzel; Sanjeev Mariathasan; Wouter L. W. Hazenbos; Patrick J. Lupardus
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Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model
mAbs, ISSN: 19420870 19420862
Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola M. Saad; Montserrat Carrasco-Triguero; S. Cyrus Khojasteh; Rong Deng
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Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry
mAbs, ISSN: 19420870 19420862
Jintang He; Shang-Fan Yu; Sharon Fong Yee; Surinder Kaur; Keyang Xu
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Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US
Journal of Medical Economics, ISSN: 1941837X 13696998
Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen A. Bernaards; Tania Krivasi; David L. Veenstra
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Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole
Xenobiotica, ISSN: 13665928 00498254
Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah J. Robinson; Aleksandr Kolesnikov; Susan C. Wong; Xiaojing Wang; Jae H. Chang
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The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function
Cell Reports, ISSN: 22111247
Sairy Hernandez; Jing Qing; Rebecca Hong Thibodeau; Xiangnan Du; Summer Park; Hyang-Mi Lee; Min Xu; Soyoung Oh; Armando Navarro; Merone Roose-Girma; Robert J. Newman; Søren Warming; Michelle Nannini; Deepak Sampath; Kim; Jane L. Grogan; Ira Mellman
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Long-term safety of pirfenidone: Results of the prospective, observational PASSPORT study
ERJ Open Research, ISSN: 23120541
Vincent Cottin; Dirk Koschel; Andreas Günther; Carlo Albera; Arata Azuma; C Magnus Sköld; Sara Tomassetti; Philip Hormel; John L. Stauffer; Indiana Strombom; Klaus-Uwe Kirchgaessler; Toby M. Maher
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Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (bTMB) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)
Annals of Oncology, ISSN: 15698041
Edward S. Kim; Velcheti; Tarek Mekhail; Leal; Dowell; Tsai; Dakhil; Stella; Shen; Hu; Sarah M. Paul; David S. Shames; Erica Schleifman; David Fabrizio; Yun; Phan; Mark A. Socinski
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Biological features and clinical outcomes in atezolizumab (atezo)-treated patients (pts) with metastatic urothelial cancer (mUC) of the upper vs lower urinary tract (UTUC vs LTUC)
Annals of Oncology, ISSN: 15698041
Matthew D. Galsky; Romain Banchereau; Edward E. Kadel III; Teresa Ramirez-Montagut; Sanjeev Mariathasan; AnnChristine Thåström; Jonathan E. Rosenberg; Thomas Powles; Michiel S Van Der Heijden; Andrea Necchi
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MORPHEUS: A phase Ib/II umbrella study platform evaluating the safety and efficacy of multiple cancer immunotherapy (CIT)-based combinations in different tumour types
Annals of Oncology, ISSN: 15698041
Chau; Haag; Rahma; Teresa Macarulla; Steven McCune; Denise A. Yardley; Benjamin Solomon; Melissa L. Johnson; Vidal; Schmid; Guillem Argiles; Dimick; Sami Mahrus; Abdullah; He; Sayyed; Barak; Bleul; Edward Cha; Alexandra Drakaki
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IMpower130: Progression-free survival (PFS) and safety analysis from a randomised phase III study of carboplatin + nab-paclitaxel (CnP) with or without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC
Annals of Oncology, ISSN: 15698041
Federico Cappuzzo; Michael McCleod; Maen Hussein; Alessandro Morabito; Achim Rittmeyer; Henry J Conter; Hans-Georg Kopp; Davey B Daniel; Steven McCune; Tarek Mekhail; Alona Zer; Niels Reinmuth; Ahad Sadiq; Venice Archer; Tania Ochi Lohmann; Lijia Wang; Marcin Kowanetz; Wei Lin; Alan Sandler; Howard West
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IMpassion130: Results from a global, randomised, double-blind, phase III study of atezolizumab (atezo) + nab-paclitaxel (nab-P) vs placebo + nab-P in treatment-naive, locally advanced or metastatic triple-negative breast cancer (mTNBC)
Annals of Oncology, ISSN: 15698041
Schmid; Sylvia Adams; Hope S. Rugo; Andreas Schneeweiss; Carlos H. Barrios; Iwata; Diéras; Roberto Hegg; Seock-Ah Im; Wright; Henschel; Luciana L. Molinero; Chui; Roel Funke; Amreen Husain; Eric P. Winer; Loi; Leisha A. Emens
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Safety and tolerability of atezolizumab (atezo) plus bevacizumab (bev) vs sunitinib (sun) in untreated metastatic renal cell carcinoma (mRCC): Pooled analysis of IMmotion150 and IMmotion151
Annals of Oncology, ISSN: 15698041
Cristina Suárez; Toni K. Choueiri; David McDermott; Bernard Escudier; Michael B. Atkins; Thomas Powles; Brian I Rini; Robert J. Motzer; Sumanta Kumar Pal; Lawrence Fong; De Giorgi; Wang; Tarik Khaznadar; Di Nucci; Constanze Kaiser; Darren Tayama; Frede Donskov
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Dissecting gastric cancer biology and how and when to use immunotherapy
Annals of Oncology, ISSN: 15698041
Meghna Das Thakur; Kwame Okrah; David S. Shames; Priti Hegde; Carlos Bais
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Clinical and analytical validation of an FDA approved comprehensive genomic profiling (CGP) assay incorporating multiple companion diagnostics for targeted and immunotherapies
Annals of Oncology, ISSN: 15698041
Li; James X. Sun; Skoletsky; Milbury; Burns; W-K Yip; Dewal; He; Tuesdell; Peters; Erica Schleifman; Johannes Noé; Jenkins; Elvin; Geoff A. Otto; Doron Lipson; Jeffrey S. Ross; Vincent A. Miller; Doherty; Vietz
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Molecular correlates differentiate response to atezolizumab (atezo) + bevacizumab (bev) vs sunitinib (sun): Results from a phase III study (IMmotion151) in untreated metastatic renal cell carcinoma (mRCC)
Annals of Oncology, ISSN: 15698041
Brian I Rini; Mahrukh Huseni; Michael B. Atkins; David McDermott; Thomas Powles; Bernard Escudier; Romain Banchereau; L-F Liu; Ning Leng; Fan; Doss; Sam C. Nalle; Carroll; Li; Christina Schiff; Marjorie Green; Robert J. Motzer
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Identification of biological axes associated with stage II/III CRC recurrence risk and outcome after adjuvant therapy revealed a T-effector-independent prognostic role for granzyme B
Annals of Oncology, ISSN: 15698041
Meghna Das Thakur; Akshata R. Udyavar; Thomas Sandmann; Li; Bosch; William E. O'Gorman; Li; Amelia Au-Yeung; Chikara Takahashi; Richard Bourgon; Daemen; Priti Hegde; Carlos Bais
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Ranibizumab Induces Regression of Diabetic Retinopathy in Most Patients at High Risk of Progression to Proliferative Diabetic Retinopathy
Kidney International Reports, ISSN: 24686530
Charles C. Wykoff; David Eichenbaum; Daniel B. Roth; Lauren Hill; Anne E. Fung; Zdenka Haskova
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Humoral immunity goes hormonal: Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to eshcerichia coli
Nature Immunology, ISSN: 15292916 15292908
Joseph Chavarria-Smith; Wouter L. W. Hazenbos; Menno van Lookeren Campagne
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Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial
Annals of Neurology, ISSN: 15318249 03645134
Wolinsky; Montalban; Stephen L. Hauser; Giovannoni; Patrick Vermersch; Corrado Bernasconi; Gurpreet Deol-Bhullar; Hideki Garren; Peter Chin; Belachew; Ludwig Kappos
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Pertuzumab plus trastuzumab and chemotherapy for HER2-positive metastatic gastric or gastro-oesophageal junction cancer (JACOB): final analysis of a double-blind, randomised, placebo-controlled phase 3 study
The Lancet Oncology, ISSN: 14745488 14702045
Tabernero; Paulo M. Hoff; Lin Shen; Atsushi Ohtsu; Manish A. Shah; Karen Cheng; Chunyan Song; Haiyan Wu; Jennifer Eng-Wong; Katherine Kim; Yoon-Koo Kang
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Serum periostin as a biomarker in eosinophilic granulomatosis with polyangiitis
PLoS ONE, ISSN: 19326203
Rennie L. Rhee; Cecile Holweg; Kit Wong; David Cuthbertson; Simon Carette; Nader A. Khalidi; Curry L. Koening; Langford; Carol A. McAlear; Paul A. Monach; Larry W. Moreland; Christian Pagnoux; Seo; Specks; Antoine G. Sreih; Steven R. Ytterberg; Peter A. Merkel
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Anatomy and physiology of the digestive tract of drosophila melanogaster
Genetics, ISSN: 19432631 00166731
Irene Miguel-Aliaga; Heinrich Jasper; Bruno Lemaitre
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Humoral immunity goes hormonal: Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to eshcerichia coli
Nature Immunology, ISSN: 15292916 15292908
Joseph Chavarria-Smith; Wouter L. W. Hazenbos; Menno van Lookeren Campagne
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Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products
AAPS PharmSciTech, ISSN: 15309932
Jane Li; Konstantin Tsinman; Oksana Tsinman; Larry Wigman
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Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer
Nature Cell Biology, ISSN: 14764679 14657392
Kristiaan J. Lenos; Daniël M. Miedema; Sophie C. Lodestijn; Lisanne E. Nijman; Tom van den Bosch; Xavier Romero Ros; Filipe C. Lourenço; Maria C. Lecca; Maartje van der Heijden; Sanne M. van Neerven; Anita van Oort; Nicolas Leveille; Ronja S. Adam; Felipe de Sousa e Melo; Joy Otten; Patrick Veerman; Guillaume Hypolite; Lianne Koens; Scott K. Lyons; Stassi; Douglas J. Winton; Jan Paul Medema; Edward Morrissey; Maarten F. Bijlsma; Louis Vermeulen
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Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process
Molecular Pharmaceutics, ISSN: 15438392 15438384
Ankai Xu; Hok Seon Kim; Samarkand Estee; Sharon Viajar; William J. Galush; Avinash Gill; Isidro Hötzel; Greg A. Lazar; Paul McDonald; Nisana Andersen; Christoph Spiess
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Modeled Prognostic Subgroups for Survival and Treatment Outcomes in BRAF V600-Mutated Metastatic Melanoma: Pooled Analysis of 4 Randomized Clinical Trials
JAMA Oncology, ISSN: 23742445 23742437
Axel Hauschild; James Larkin; Antoni Ribas; Brigitte Dréno; Keith Flaherty; Paolo A. Ascierto; Karl Lewis; Edward McKenna; Qian Zhu; Yong Mun; McArthur
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An automated mapping method for Nissl-stained mouse brain histologic sections
Journal of Neuroscience Methods, ISSN: 1872678X 01650270
Smadar Shiffman; Sayantani Basak; Cleopatra Kozlowski; Reina N. Fuji
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Investigation of Metal-Catalyzed Antibody Carbonylation With an Improved Protein Carbonylation Assay
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yi Yang; Anna Mah; Inn H. Yuk; Parbir Grewal; Abigail F.J. Pynn; Will Cole; Di Gao; Fan Zhang; Jia Chen; Lynn Gennaro; Christian Schöneich
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Development and validation of a novel semi-homogenous clinical assay for quantitation of Ranibizumab in human serum
Journal of Immunological Methods, ISSN: 18727905 00221759
John Lowe; Eric Wakshull; Theresa Shek; Anan Chuntharapai; Rebecca Elliott; Jeriza Rusit; Mauricio Maia
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Buffer exchange path influences the stability and viscosity upon storage of a high concentration protein
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Mary E. Krause; Ajit S. Narang; Gregory Barker; Sibylle Herzer; Smeet Deshmukh; Wenkui Lan; Daniel Fichana; John M. Wasylyk; Bahar Demirdirek; Limin Zhang; John Fiske; Matthew McGann; Monica L. Adams; Rajesh B. Gandhi
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Applying a weight of evidence approach to the evaluation of developmental toxicity of biopharmaceuticals
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Meredith Rocca; LaRonda L. Morford; Diann Blanset; Wendy Halpern; Joy A. Cavagnaro; Christopher J. Bowman
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High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells
Biotechnology Journal, ISSN: 18607314 18606768
Meg Tung; Danming Tang; Szu-Han Wang; Dejin Zhan; Karen Kiplinger; Shu Pan; Yifeng Jing; Amy Shen; Patrick Ahyow; Snedecor; Martin Gawlitzek; Shahram Misaghi
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Efficacy of Ranibizumab in Eyes with Diabetic Macular Edema and Macular Nonperfusion in RIDE and RISE
Ophthalmology, ISSN: 15494713 01616420
Rahul K. Reddy; Dante Joseph Pieramici; Shamika Gune; Avanti Ghanekar; Na Lu; Carlos Quezada-Ruiz; Caroline R. Baumal
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Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics
Seminars in Cancer Biology, ISSN: 10963650 1044579X
Priti Hegde; Jeffery J. Wallin; Christoph Mancao
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Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Michael Siu; Arundhati Sengupta Ghosh; Joe Lewcock
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A phase Ib study to assess the efficacy and safety of vismodegib in combination with ruxolitinib in patients with intermediate- or high-risk myelofibrosis 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology
Journal of Hematology and Oncology, ISSN: 17568722
Stephen Couban; Giulia Benevolo; William Donnellan; Jennifer Cultrera; Steffen Koschmieder; Srdan Verstovsek; Gregory Hooper; Christian Hertig; Tandon; Natalie Dimier; Vikram Malhi; Francesco Passamonti
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Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE)
Alzheimer's Research and Therapy, ISSN: 17589193
Stephen Salloway; Lee Honigberg; William Cho; Michael Ward; Michel Friesenhahn; Flavia Brunstein; Angelica Quartino; David Clayton; Deborah L. Mortensen; Tobias Bittner; Carole Ho; Christina Rabe; Stephen P. Schauer; Kristin R. Wildsmith; Reina N. Fuji; Shehnaaz Suliman; Eric M. Reiman; Kewei Chen; Robert Paul
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Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain
Cell Reports, ISSN: 22111247
Girish Bankar; Samuel J. Goodchild; Sarah Howard; Karen Nelkenbrecher; Matthew Waldbrook; Michelle Dourado; Noah Shuart; Sophia Lin; Clint Young; Zhiwei Xie; Kuldip Khakh; Elaine Chang; Luis E. Sojo; Andrea Lindgren; Sultan Chowdhury; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Christoph Dehnhardt; Jodie Pang; Jae H. Chang; Brian S. Safina; Daniel P. Sutherlin; Johnson; David Hackos; C. Lee Robinette; Charles J. Cohen
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Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities
Cell Reports, ISSN: 22111247
Stephanie Grabow; Andrew J. Kueh; Francine Ke; Hannah K. Vanyai; Bilal N. Sheikh; Michael A. Dengler; William Chiang; Samantha Eccles; Ian M. Smyth; Lynelle K. Jones; Frederic J. De Sauvage; Mark Scott; Lachlan Whitehead; Voss; Andreas Strasser
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Phase II study of Taselisib (GDC-0032) in combination with fulvestrant in patients with HER2-negative, hormone receptor–positive advanced breast cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Maura N. Dickler; Saura; Donald A. Richards; Ian E. Krop; Andrés Cervantes; Philippe L. Bedard; Manish R. Patel; Pusztai; Oliveira; Alison Cardenas; Na Cui; Wilson; Thomas J. Stout; Michael C. Wei; Jerry Y. Hsu; Baselga
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Tumor elastography and its association with collagen and the tumor microenvironment
Clinical Cancer Research, ISSN: 15573265 10780432
Johannes Riegler; Yassin Labyed; Stephen Rosenzweig; Vincent Javinal; Alessandra Castiglioni; Claudia X. Dominguez; Jason E. Long; Qingling Li; Wendy N. Sandoval; Melissa Junttila; Shannon J. Turley; Jill Schartner; Richard A. D. Carano
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Optimized arylomycins are a new class of Gram-negative antibiotics
Nature, ISSN: 14764687 00280836
Peter A. Smith; Michael F. T. Koehler; Hany S. Girgis; Donghong Yan; Yongsheng Chen; Yuan Chen; James J. Crawford; Matthew Durk; Robert I. Higuchi; Jing Kang; Jeremy Murray; Prasuna Paraselli; Summer Park; Wilson Phung; John Quinn; Tucker C. Roberts; Lionel Rouge; Jacob B. Schwarz; Elizabeth Skippington; John Wai; Min Xu; Zhiyong Yu; Hua Zhang; Man-Wah Tan; Christopher E. Heise
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The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors
Science Signaling, ISSN: 19379145 19450877
Thijs Hagenbeek; Webster; Noelyn Kljavin; Matthew T. Chang; Trang Pham; Ho-June Lee; Christiaan N. Klijn; Allen G. Cai; Klara Totpal; Buvana Ravishankar; Nai-Ying Yang; Da-Hye Lee; Kevin B. Walsh; Georgia Hatzivassiliou; Cecile C. de la Cruz; Stephen Gould; Xiumin Wu; Wyne P. Lee; Shuqun Yang; Zhixiang Zhang; Qingyang Gu; Qunsheng Ji; Erica L. Jackson; Dae-Sik Lim; Anwesha Dey
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