Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 501 - 550 OF 15801 RESULTS

The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression
Journal of Cell Science, ISSN: 00219533
Katherine A. Young; Katarzyna Wojdyla; Tiffany Lai; Katie E. Mulholland; Silvia Aldaz Casanova; Robin Antrobus; Simon Andrews; Laura Biggins; Betania Mahler-Araujo; Philippa R. Barton; Keith R. Anderson; Gareth W. Fearnley; Hayley J. Sharpe
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Investigation of the state of hydration of a non-stoichiometric hydrate in a low dose formulation using 19F solid-state NMR
Journal of Pharmaceutical Sciences, ISSN: 00223549
Jonathan Hau; Antonio G. DiPasquale; Joseph W. Lubach; Paroma Chakravarty
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Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses
Analytical Chemistry, ISSN: 00032700
Julien Camperi; Brian Roper; Emily C. Freund; Rebecca Leylek; Ariane Nissenbaum; Carolina Galan; Roger Caothien; Zhilan Hu; Peggy Ko; Allison Lee; Kamalakar Chatla; Luladey Ayalew; Feng Yang; Steffen Lippold; Axel Guilbaud
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RIP1 inhibition protects retinal ganglion cells in glaucoma models of ocular injury
Cell Death and Differentiation, ISSN: 13509047
Bo Kyoung Kim; Tatiana Goncharov; Sébastien A. Archaimbault; Filip Roudnicky; Webster; Peter D. Westenskow; Domagoj Vucic
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Immunogenicity risk assessment and mitigation for engineered antibody and protein therapeutics
Nature Reviews Drug Discovery, ISSN: 14741776
Paul J. Carter; Quarmby
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Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification
Nature Genetics, ISSN: 10614036
Simone M. Haag; Shiqi Xie; Celine Eidenschenk; Jean-Philippe Fortin; Marinella G. Callow; Michael Costa; Aaron T. L. Lun; Christian Cox; Sunny Z. Wu; Rachana Pradhan; Jaclyn Y. Lock; Julia A. Kuhn; Loryn Holokai; Minh Thai; Emily C. Freund; Ariane Nissenbaum; Mary E. Keir; Christopher J. Bohlen; Scott E. Martin; Kathryn R. Geiger-Schuller; Hussein A. Hejase; Brian L. Yaspan; Sandra Melo Carlos; Shannon J. Turley; Aditya Murthy
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Development of a Robust Pd-Catalyzed C-S Coupling for the Synthesis of Janus Kinase Inhibitor GDC-9918
Organic Process Research and Development, ISSN: 10836160
Derek M. Dalton; Juno Castillo Siu; Marcelino Varona-Ortiz; C. Gregory Sowell; Francis Gosselin
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A comparison of data visualization tools: A case study in health-related research
Information Visualization, ISSN: 14738716
Hongtai Huang; Sreedevi Ravi; Timothy Warrington; Howe Cui; Carlson Wang; Mark McCreary; Benjamin E. Lauffer; Christina Lu
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Considerations for Industry—Preparing for the FDA Model-Informed Drug Development (MIDD) Paired Meeting Program
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Gerald R. Galluppi; Malidi Ahamadi; Souvik Bhattacharya; Nageshwar Budha; Ferdous Gheyas; Chi-Chung Li; Yuan Chen; Anne-Gaëlle Dosne; Niels Rode Kristensen; Mindy Magee; Mahesh N. Samtani; Vikram Sinha; Kunal S. Taskar; Vijay V. Upreti; Jianning Yang; Jack Cook
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Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Xenobiotica, ISSN: 00498254
Michael Z. Liao; Douglas Leipold; Shang-Chiung Chen; Zao Li; Amrita Kamath; Chunze Li
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Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species
Xenobiotica, ISSN: 00498254
Victor Yip; Ola M. Saad; Douglas Leipold; Chunze Li; Amrita Kamath; Shen
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A Novel Step-Up Dosage Regimen for Enhancing the Benefit-to-Risk Ratio of Mosunetuzumab in Relapsed or Refractory Follicular Lymphoma
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Chi-Chung Li; Brendan C. Bender; Justin Wilkins; Feifei Li; Turner; Wang; Rong Deng; Shweta Vadhavkar; Zao Li; Antonia Kwan; Huang Huang; Kun Peng; Elicia M. Penuel; Huw; Pascal Chanu; Chunze Li; Shen Yin; Michael C. Wei
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Interim Results of the Phase III Portal Extension Trial of the Port Delivery System with Ranibizumab in Neovascular Age-Related Macular Degeneration
Ophthalmology Retina,
Peter A. Campochiaro; David Eichenbaum; Margaret A. Chang; W. Lloyd Clark; Jordan M. Graff; Sophie Le Pogam; Melina Cavichini-Cordeiro; Shamika Gune; Melvin D. Rabena; Natasha Singh; Stephanie L. Lin; Natalia F. Callaway
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A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution
Pharmaceutical Research, ISSN: 07248741
Karthik Salish; Chi So; Seong Hoon Jeong; Hao Helen Hou; Chen Mao
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Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy
Journal of Pathology, ISSN: 00223417
Xiao Li; Jeffrey Eastham; Jennifer M. Giltnane; Wei Zou; Andries Zijlstra; Evgeniy Tabatsky; Romain Banchereau; Ching-Wei Chang; Barzin Y. Nabet; Namrata S. Patil; Luciana L. Molinero; Steve Chui; Maureen Harryman; Shari Lau; Linda Rangell; Yannick Waumans; Mark Kockx; Darya Y. Orlova; Koeppen
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Analysis of kallikrein-related peptidase 7 (KLK7) autolysis reveals novel protease and cytokine substrates
Biological Chemistry, ISSN: 14374315 14316730
Swapnil V. Ghodge; Lazarus
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Caregiver Global Impression Observations from EMBARK: A Phase 3 Study Evaluating Delandistrogene Moxeparvovec in Ambulatory Patients with Duchenne Muscular Dystrophy
Neurology and Therapy, ISSN: 21936536 21938253
Craig M. McDonald; Jacob S. Elkins; Sai Dharmarajan; Katherine Gooch; Teofil Ciobanu; Lansdall; Alexander P. Murphy; Fiona McDougall; Eugenio Mercuri; Ivana Audhya
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Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation
Toxicologic Pathology, ISSN: 15331601 01926233
Adedeji; Adi Wasserkrug Naor
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The dynamics of hematopoiesis over the human lifespan
Nature Methods, ISSN: 15487105 15487091
Hojun Li; Parker Côté; Michael Kuoch; Jideofor Ezike; Katie Frenis; Anton Afanassiev; Laura Greenstreet; Mayuri Tanaka-Yano; Giuseppe Tarantino; Stephen Zhang; Jennifer Whangbo; Vincent L. Butty; Enrico Moiso; Marcelo Falchetti; Kate Lu; Guinevere G. Connelly; Vivian Morris; Dahai Wang; Antonia F. Chen; Giada Bianchi; George Q. Daley; Salil Garg; David R. Liu; Stella T. Chou; Aviv Regev; Edroaldo Lummertz da Rocha; Geoffrey Schiebinger; R. Grant Rowe
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Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human
Xenobiotica, ISSN: 13665928 00498254
Laurent Salphati; Jodie Pang; Emile G. Plise; Jonathan Cheong; Marie-Gabrielle Braun; Lori S. Friedman; Rebecca Hong Thibodeau; Allan Jaochico; Ryan Johnson; Ning Liu; Michelle Nannini; Deepak Sampath; Kyung Song; Emily J. Hannan; Steven T. Staben
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A workflow for accurate and consistent quantitation of host cell proteins by SWATH LC–MS/MS analysis to support process development
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Jia Guo; Regina Kufer; Midori Greenwood-Goodwin; Stefanie Wohlrab; Fem Woodruff; Delia Li; Katharina Reckermann; Jonghae Youn; Dilip Kumar Reddy Kandula; Lei Xiong; Feng Yang
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Deoxygenative alcohol–nucleophile coupling via carbocations
Chem Catalysis, ISSN: 26671093 26671107
Léa Thai-Savard; Jason R. Zbieg; Jack A. Terrett
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Retinal Fluid and Thickness Fluctuations in Archway Trial for Port Delivery System with Ranibizumab versus Monthly Ranibizumab Injections
Ophthalmology Retina, ISSN: 24686530
Veeral Sheth; Nancy M. Holekamp; Arshad M. Khanani; Aleksandra Rachitskaya; Steven Blotner; Shamika Gune; Dominic Heinrich; Katie F. Maass; Usha Chakravarthy
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Prognostic Significance of Recurrence and Timing of Recurrence on Survival Among Patients with Early-Stage Hepatocellular Carcinoma in U.S. Clinical Practice
Annals of Surgical Oncology, ISSN: 15344681 10689265
Shishir K. Maithel; Rongrong Wang; Joanna Harton; Adam Yopp; Shimul A. Shah; Flavio G. Rocha; Sairy Hernandez; Spencer Cheng; Sarika Ogale; Ruoding Tan
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Long-term 3-year follow-up of mosunetuzumab in relapsed or refractory follicular lymphoma after ≥2 prior therapies
Blood, ISSN: 15280020 00064971
Laurie H. Sehn; Nancy L. Bartlett; Matthew Matasar; Stephen J. Schuster; Sarit E. Assouline; Pratyush Giri; Kuruvilla; Mazyar Shadman; Chan Yoon Cheah; Sascha Dietrich; Keith Fay; Matthew Ku; Loretta J. Nastoupil; Michael C. Wei; Shen Yin; Iris To; Derrick Kaufman; Antonia Kwan; Elicia M. Penuel; Christopher R. Bolen; Lihua E. Budde
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Macular Sensitivity Endpoints in Geographic Atrophy: Exploratory Analysis of Chroma and Spectri Clinical Trials
Ophthalmology Science,
Dolly Chang; Natalia F. Callaway; Verena Steffen; Karl G. Csaky; Robyn H. Guymer; David G. Birch; Praveen J. Patel; Michael S. Ip; Simon S. Gao; Jayla Briggs; Lee Honigberg; Phillip Lai; Daniela Ferrara; Yasir J. Sepah
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Inhibitors targeting BamA in gram-negative bacteria
Biochimica et Biophysica Acta - Molecular Cell Research, ISSN: 01674889
Kelly M. Storek; Dawei Sun; Steven T. Rutherford
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Recombinant Human Deoxyribonuclease I
Pharmaceutical Biotechnology: Fundamentals and Applications, Sixth Edition,
Lazarus; Wagener
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Lymphoid System
Toxicologic Pathology: a Primer,
Steven T. Laing
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Dose Optimization in Oncology Drug Development: An International Consortium for Innovation and Quality in Pharmaceutical Development White Paper
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Divya Samineni; Karthik Venkatakrishnan; Ahmed A. Othman; Yazdi K. Pithavala; Srinivasu Poondru; Chirag Patel; Pavan Vaddady; Wendy Ankrom; Ramanujan; Nageshwar Budha; Michael Wu; Nahor Haddish-Berhane; Holger Fritsch; Azher Hussain; Jitendra Kanodia; Meng Li; Mengyao Li; Murad Melhem; Apurvasena Parikh; Vijay V. Upreti; Neeraj Gupta
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Patient preferences for chronic lymphocytic leukemia treatments: a discrete-choice experiment
Future Oncology, ISSN: 14796694
Arliene Ravelo; Kelley Myers; Robyn Brumble; Cooper Bussberg; Brian Koffman; Beenish S. Manzoor; Juliana M L Biondo; Carol Mansfield
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Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model
Journal of Medicinal Chemistry, ISSN: 00222623
Marie-Gabrielle Braun; Avi Ashkenazi; Ramsay E. Beveridge; Georgette M. Castanedo; Heidi J. A. Wallweber; Beresini; Clark; Tom De Bruyn; Liqiang Fu; Paul Gibbons; Fan Jiang; Susan Kaufman; David Kan; James R. Kiefer; Jean-Philippe Leclerc; Alexandre Lemire; Cuong Q. Ly; Ehud Segal; Jessica Sims; Weiru Wang; Wentao Wei; Zhao; Jacob B. Schwarz; Joachim Rudolph
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A novel biomarker assay qualification strategy for rare human matrices–a case study of biomarkers in aqueous humor
Bioanalysis, ISSN: 17576180
Jennifer A. Getz; Trung Nguy; Randall Dere; Mauricio Maia
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Role of NaV1.7 in postganglionic sympathetic nerve function in human and guinea-pig arteries
Journal of Physiology, ISSN: 00223751
Joyce S. Kim; Sonya Meeker; Fei Ru; Minh Tran; Tanja S. Zabka; David Hackos; Bradley J. Undem
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Online Nucleotide Mapping of mRNAs
Analytical Chemistry, ISSN: 00032700
Alexandre Goyon; Brandon Scott; Peter M. Yehl; Kelly Zhang
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A New Approach for Preparing Stable High-Concentration Peptide Nanoparticle Formulations
Pharmaceuticals,
Chloe Hu; Nanzhi Zang; Yu Tong Tam; Desmond Dizon; Kaylee Lee; Jodie Pang; Elizabeth Torres; Yusi Cui; Chun-Wan Yen; Dennis H. Leung
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Model-based comparisons of post-treatment free IgE and FEV1 between omalizumab asthma dosing tables in the United States and European Union
British Journal of Clinical Pharmacology, ISSN: 03065251
Rui Zhu; Rik Schoemaker; Aurelie Gautier; Xianbin Tian; Cheryl HooiMing Sim; Theodore A. Omachi; Amita Joshi; Jin Jin; Ryan Owen
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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy
Frontiers in Pharmacology,
Rajbharan Yadav; Suzanne Schubbert; Patrick Holder; Eugene Y. Chiang; Nargess Kiabi; Liz Bogaert; Irene Leung; Rumana Rashid; Kendra N. Avery; Christine Bonzon; John Desjarlais; Shomyseh Sanjabi; Amy Sharma; Lepherd; Amy Shelton; Pamela Chan; Yanqiu Liu; Louis R. Joslyn; Iraj Hosseini; Stefanich; Amrita Kamath; Matthew Bernett; Vittal Shivva
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Bioproduction Platform to Generate Functionalized Disulfide-Constrained Peptide Analogues
ACS Bio and Med Chem Au,
Sunhee Hwang; Aaron T. Balana; Bryan Martin; Michael Clarkson; Paola Di Lello; Hao Wu; Yanjie Li; Jakob Fuhrmann; Yavuz S. Dagdas; Patrick Holder; Christina I. Schroeder; Stephen E. Miller; Xinxin Gao
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PROTEIN DISCOVERY WITH DISCRETE WALK-JUMP SAMPLING
12th International Conference on Learning Representations, ICLR 2024,
Nathan C. Frey; Daniel Berenberg; Karina Zadorozhny; Joseph Kleinhenz; Julien Lafrance-Vanasse; Isidro Hötzel; Yan Wu; Stephen Ra; Richard Bonneau; Kyunghyun Cho; Andreas Loukas; Vladimir Gligorijevic; Saeed Saremi
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Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation
Organic Process Research and Development, ISSN: 10836160
Carmela Molinaro; Nicholas Wong; Nicholas A. White; Lauren E. Sirois; Raphael Bigler; Quentin P. Bindschaedler; Steven Do; Sushant Malhotra; Francis Gosselin
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Efficacy of Faricimab versus Aflibercept in Diabetic Macular Edema in the 20/50 or Worse Vision Subgroup in Phase III YOSEMITE and RHINE Trials
Ophthalmology, ISSN: 01616420
Marco A. Zarbin; David Tabano; Ayesha Ahmed; Manuel Amador; Allan Ding; Nancy M. Holekamp; Xiao-Yu Lu; Ivaylo Stoilov; Ming Yang
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Faricimab for neovascular age-related macular degeneration and diabetic macular edema: from preclinical studies to phase 3 outcomes
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN: 0721832X
Hansjurgen Agostini; Francis Abreu; Caroline R. Baumal; Dolly Chang; Karl G. Csaky; Anna M. Demetriades; Laurent Kodjikian; Jennifer I. Lim; Philippe Margaron; Jordi Monés; Tunde Peto; Federico Ricci; Matthias Rüth; Rishi Singh; Ivaylo Stoilov; Balakumar Swaminathan; Jeffrey R. Willis; Peter D. Westenskow
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Development of an advanced separation and characterization platform for mRNA and lipid nanoparticles using multi-detector asymmetrical flow field-flow fractionation
Analytical and Bioanalytical Chemistry, ISSN: 16182642
Ziting Gao; Jessica Lin; Wan-Chih Su; Kelly Zhang; Jason Gruenhagen; Wenwan Zhong; Yuchen Fan; Juan Bian
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Sequential Optimal Experimental Design of Perturbation Screens Guided by Multi-modal Priors
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), ISSN: 03029743
Kexin Huang; Romain Lopez; Jan-Christian Hütter; Takamasa Kudo; Antonio Rios; Aviv Regev
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α,β-Desaturation and Formal β-C(sp3)-H Fluorination of N-Substituted Amines: A Late-Stage Functionalization Strategy Enabled by Electrochemistry
Journal of the American Chemical Society, ISSN: 00027863
Luiz F. T. Novaes; Justin S. K. Ho; Kaining Mao; Elisia Villemure; Jack A. Terrett; Song Lin
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On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy
Journal of the American Chemical Society, ISSN: 00027863
Pragya Adhikari; Guangmin Li; MaryAnn Go; Danielle Mandikian; Hanine Rafidi; Carl Ng; Sagana Anifa; Kevin Johnson; Linda Bao; Hilda Hernandez-Barry; Rebecca K. Rowntree; Nick Agard; Cong Wu; Kang-Jye Chou; Donglu Zhang; Katherine R. Kozak; Thomas H. Pillow; Gail D. Lewis; Shang-Fan Yu; C. Andrew Boswell; Jack D. Sadowsky
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A non-comparative, randomized, phase II trial of atezolizumab or atezolizumab plus tiragolumab for programmed death-ligand 1-positive recurrent cervical cancer (SKYSCRAPER-04)
International Journal of Gynecological Cancer, ISSN: 1048891X
Ritu Salani; Mary McCormack; Yong-Man Kim; Sharad Ghamande; Shaundra L. Hall; Domenica Lorusso; Lisa Barraclough; Lucy Gilbert; Adrian Guzman Ramirez; Chien-Hsing Lu; Renaud Sabatier; Nicoletta Colombo; Youyou Hu; Venkatesh Krishnan; Luciana L. Molinero; Yuning Feng; Nicole Kim; Marcela Castro; Yvonne G. Lin; Bradley J. Monk
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PARP inhibition with rucaparib alone followed by combination with atezolizumab: Phase Ib COUPLET clinical study in advanced gynaecological and triple-negative breast cancers
British Journal of Cancer, ISSN: 00070920
Rebecca Kristeleit; Leary; Ana Oaknin; Redondo Sanchez; Angela George; Chui; Aicha Seiller; Liste Hermoso; Jenna C. Willis; Colby S. Shemesh; Jim J. Xiao; Kevin K. Lin; Luciana L. Molinero; Yinghui Guan; Ray-Coquard; Linda Mileshkin
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Modulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations
mAbs, ISSN: 19420862
Joel Heisler; Daniel Kovner; Saeed Izadi; Jonathan Zarzar; Paul J. Carter
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