Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5851 - 5900 OF 15797 RESULTS

Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Benjamin P. Fauber; Alberto Gobbi; Pascal P. A. Savy; Brenda Burton; Yuzhong Deng; Christine Everett; Hank La; Adam R. Johnson; Peter Lockey; Maxine Norman; Harvey Wong
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Patients with slowly proliferative early breast cancer have low five-year recurrence rates in a phase III adjuvant trial of capecitabine
Clinical Cancer Research, ISSN: 15573265 10780432
O'Shaughnessy; Koeppen; Yuanyuan Xiao; Lackner; Devchand Paul; Christopher Stokoe; John Pippen; Lea Krekow; Frankie Ann Holmes; Svetislava Vukelja; Deborah Lindquist; Scot Sedlacek; Ragene Rivera; Robert Brooks; Kristi McIntyre; Carrie Brownstein; Silke Hoersch; Blum; Stephen Jones
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Therapeutic antibodies: Discovery, design and deployment
Molecular Immunology, ISSN: 18729142 01615890
Paul A. Ramsland; Andrew T. Hutchinson; Paul J. Carter
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Scientific and Regulatory Policy Committee Points-to-consider Paper∗: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part 2. Antisense Oligonucleotides
Toxicologic Pathology, ISSN: 15331601 01926233
Jeffery A. Engelhardt; Pierluigi Fant; Silvia Guionaud; Scott P. Henry; Michael W. Leach; Calvert Louden; Marshall S. Scicchitano; James L. Weaver; Tanja S. Zabka; Kendall S. Frazier
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Scientific and Regulatory Policy Committee Points-to-consider Paper∗: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part I. Biotherapeutics
Toxicologic Pathology, ISSN: 15331601 01926233
Kendall S. Frazier; Jeffery A. Engelhardt; Pierluigi Fant; Silvia Guionaud; Scott P. Henry; Michael W. Leach; Calvert Louden; Marshall S. Scicchitano; James L. Weaver; Tanja S. Zabka
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Understanding Particle Formation: Solubility of Free Fatty Acids as Polysorbate 20 Degradation Byproducts in Therapeutic Monoclonal Antibody Formulations
Molecular Pharmaceutics, ISSN: 15438392 15438384
Nidhi Doshi; Barthélemy Demeule; Sandeep Yadav
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Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism
Molecular Pharmaceutics, ISSN: 15438392 15438384
Anthony Tomlinson; Barthélemy Demeule; Baiwei Lin; Sandeep Yadav
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PTPRF Expression as a Potential Prognostic/Predictive Marker for Treatment with Erlotinib in Non-Small-Cell Lung Cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Denis Soulières; Fred R. Hirsch; Frances A. Shepherd; Walter Bordogna; Paul Delmar; David S. Shames; Barbara Klughammer
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Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions
Molecular Pharmaceutics, ISSN: 15438392 15438384
Mariya Pindrus; Steven J. Shire; Robert F. Kelley; Barthélemy Demeule; Wong; Yiren Xu; Sandeep Yadav
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Mouse Models of Rheumatoid Arthritis
Veterinary Pathology, ISSN: 15442217 03009858
Patrick Caplazi; Miriam Baca; Kai H. Barck; Richard A. D. Carano; Jason Devoss; Wyne P. Lee; Brad Bolon; Laurie Diehl
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A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis
Journal of Experimental Medicine, ISSN: 15409538 00221007
Ling Wu; Xing Chen; Junjie Zhao; Bradley Martin; Jarod A. Zepp; Jennifer S. Ko; Chunfang Gu; Gang Cai; Wenjun Ouyang; Ganes Sen; George R. Stark; Bing Su; Charlotte M. Vines; Cathy Tournier; Thomas A. Hamilton; Allison Vidimos; Brian Gastman; Caini Liu; Xiaoxia Li
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Simultaneous PET/MRI imaging during mouse cerebral hypoxia-ischemia
Journal of Visualized Experiments, ISSN: 1940087X
Yu Ouyang; Martin S. Judenhofer; Jeffrey H. Walton; Jan Marik; Simon P. Williams; Simon R. Cherry
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Comparative effectiveness and safety of rituximab versus subsequent anti-tumor necrosis factor therapy in patients with rheumatoid arthritis with prior exposure to anti-tumor necrosis factor therapies in the United States Corrona registry
Arthritis Research and Therapy, ISSN: 14786362 14786354
Leslie R. Harrold; Reed; Robert Magner; Ashwini Shewade; Ani John; Jeffrey D. Greenberg; Joel M. Kremer
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The staphylococcus aureus ABC-type manganese transporter MntABC is critical for reinitiation of bacterial replication following exposure to phagocytic oxidative burst
PLoS ONE, ISSN: 19326203
Alison Coady; Min Xu; Qui Phung; Tommy K. Cheung; Corey Bakalarski; Mary Kate Alexander; Sophie M. Lehar; Janice Kim; Summer Park; Man-Wah Tan; Mireille Nishiyama
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Parkinson's disease: From human genetics to clinical trials
Science Translational Medicine, ISSN: 19466242 19466234
Marcel P Van Der Brug; Andy Singleton; Thomas Gasser; Patrick A. Lewis
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Identification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer
British Journal of Cancer, ISSN: 15321827 00070920
O'Leary; Alice Shia; Cavicchioli; Haley; Comino; Merlano; Mauri; Kimberly Walter; Lackner; Wischnewsky; Crook; Lo Nigro; Schmid
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Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody
Nature Communications, ISSN: 20411723
Sumana Chandramouli; Claudio Ciferri; Pavel A. Nikitin; Stefano Caló; Rachel Gerrein; Kara Balabanis; James Monroe; Christy M. Hebner; Anders E. Lilja; Ethan C. Settembre; Andrea Carfi
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A charged aerosol detector/chemiluminescent nitrogen detector/liquid chromatography/mass spectrometry system for regular and fragment compound analysis in drug discovery
Journal of Chromatography A, ISSN: 18733778 00219673
Yutao Jiang; Daniel Hascall; Delia Li; Joseph H. Pease
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The Hippo pathway promotes cell survival in response to chemical stress
Cell Death and Differentiation, ISSN: 14765403 13509047
Di Cara; Tobias Maile; Parsons; Magico; Basu; Tapon; King-Jones
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Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Anthony A. Estrada; Zachary K. Sweeney
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Integrated risk assessment of suicidal ideation and behavior in drug development
Drug Discovery Today, ISSN: 18785832 13596446
Patrick Y. Muller; Donna M. Dambach; Brian Gemzik; Andreas Hartmann; Sian Ratcliffe; Christian Trendelenburg; Laszlo Urban
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Identification of Subvisible Particles in Biopharmaceutical Formulations Using Raman Spectroscopy Provides Insight into Polysorbate 20 Degradation Pathway
Pharmaceutical Research, ISSN: 1573904X 07248741
Miguel Saggu; Jun Liu; Ankit Patel
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Predicting the Agitation-Induced Aggregation of Monoclonal Antibodies Using Surface Tensiometry
Molecular Pharmaceutics, ISSN: 15438392 15438384
Ian C. Shieh; Ankit Patel
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Deep sequencing-guided design of a high affinity dual specificity antibody to target two angiogenic factors in neovascular age-related macular degeneration
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Patrick Koenig; Chingwei V. Lee; Sarah Sanowar; Ping Wu; Stinson; Seth F. Harris; Fuh
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A phase II trial of RCHOP followed by radioimmunotherapy for early stage (stages I/II) diffuse large B-cell non-Hodgkin lymphoma: ECOG3402
British Journal of Haematology, ISSN: 13652141 00071048
Witzig; Fangxin Hong; Ivana N. Micallef; Randy D. Gascoyne; Ahmet Dogan; Henry Wagner; Wojciech Jurczak; Ranjana H. Advani; Sandra J. Horning
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Uniting small-molecule and biologic drug perspectives: Analytical characterization and regulatory considerations for antibody-drug conjugates
BioProcess International, ISSN: 15426319
Jon Harris; Fred Jacobson; Claudia Jochheim; Godfrey Amphlett; Kathleen Francissen; Lorna McLeod
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Challenges and opportunities for quantitative clinical pharmacology in cancer immunotherapy: Something old, something new, something borrowed, and something blue
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Mark Stroh; David J. Carlile; Chi-Chung Li; Wagg; Ribba; Ramanujan; Jin Y. Jin; Jian Xu; Jean-Eric Charoin; Xhu; Peter N. Morcos; John Davis; Phipps
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Deriving healthbased exposure limits in the pharmaceutical industry
Contract Pharma, ISSN: 23806559 15443469
Patricia A. Weideman; Joel P. Bercu; Callis; Dolan; Ellen C. Faria; Flueckiger; Gould; Hayes; Robert A. Jolly; Ester Lovsin Barle; Luo; Molnar; Eric Morinello; Naumann; Olson; Pfister; Sandhu; Sargent; Seaman; Sehner; Bryan K. Shipp; Stanard; Streeter; Sussman; Walsh; Willis; Maier
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Challenges and opportunities for quantitative clinical pharmacology in cancer immunotherapy: Something old, something new, something borrowed, and something blue
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Mark Stroh; David J. Carlile; Chi-Chung Li; Wagg; Ribba; Ramanujan; Jin Y. Jin; Xu; Jean-Eric Charoin; Xhu; Peter N. Morcos; John Davis; Phipps
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Improved assembly of bispecific antibodies from knob and hole half-antibodies
Biotechnology Progress, ISSN: 15206033 87567938
Ambrose Jon Williams; Glen Giese; Josefine Persson
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A novel immunoassay to measure total serum lymphotoxin-α levels in the presence of an anti-LTα therapeutic antibody
Journal of Immunological Methods, ISSN: 18727905 00221759
Judy Young; Allen Nguyen; Zhihua Julia Qiu; Yong Ying; Xiaoying Gao; Chae Reed; Anan Chuntharapai; Rong Deng; Jeff Lutman; Jane L. Grogan; Wai Lee T. Wong; Laura DeForge
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Significance of the hyperautofluorescent ring associated with choroidal neovascularisation in eyes undergoing anti-VEGF therapy for wet age-related macular degeneration
British Journal of Ophthalmology, ISSN: 14682079 00071161
Natalia Camacho; Giulio Barteselli; Joseph T. Nezgoda; Sharif El-Emam; Lingyun Cheng; Dirk-Uwe Bartsch; William R. Freeman
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Genetic modifiers of age at onset in carriers of the G206A mutation in PSEN1 with familial Alzheimer disease among Caribbean hispanics
JAMA Neurology, ISSN: 21686157 21686149
Joseph H. Lee; Rong Cheng; Badri N. Vardarajan; Rafael Lantigua; Dolly Reyes-Dumeyer; Ward Ortmann; Robert R. Graham; Tushar Bhangale; Timothy W. Behrens; Martin Medrano; Ivonne Z. Jiménez-Velázquez; Richard Mayeux
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Mass spectrometry in small molecule drug development
American Pharmaceutical Review, ISSN: 10998012
Christine Gu; Baiwei Lin; Joseph H. Pease; Nicholas Chetwyn; Peter M. Yehl
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Randomized, phase II, placebo-controlled trial of onartuzumab and/or bevacizumab in combination with weekly paclitaxel in patients with metastatic triple-negative breast cancer
Annals of Oncology, ISSN: 15698041 09237534
Diéras; Mario Campone; Denise A. Yardley; Romieu; Vicente Valero; Isakoff; Koeppen; Wilson; Yuanyuan Xiao; David S. Shames; Mocci; Meng Chen; Schmid
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Longitudinal commercial claims-based cost analysis of diabetic retinopathy screening patterns
American Health and Drug Benefits, ISSN: 19422970 19422962
Kathryn Fitch; Thomas Weisman; Tyler Engel; Adam Turpcu; Helen Blumen; Yamina Rajput; Purav Dave
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Trastuzumab emtansine (T-DM1) in patients With HER2-positive metastatic breast cancer previously treated with chemotherapy and 2 or more HER2-targeted agents: Results from the T-PAS expanded access study
Cancer Journal (United States), ISSN: 1540336X 15289117
Denise A. Yardley; Ian E. Krop; Patricia M. LoRusso; Musa Mayer; Brian Barnett; Bongin Yoo; Edith A. Perez
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Ability of interleukin-33- and immune complex-triggered activation of human mast cells to down-regulate monocyte-mediated immune responses
Arthritis and Rheumatology, ISSN: 23265205 23265191
Felice Rivellese; Jolien Suurmond; Kim Habets; Annemarie L. Dorjée; Nandhini Ramamoorthi; Michael J. Townsend; Amato De Paulis; Gianni Marone; Tom W. J. Huizinga; Costantino Pitzalis; Toes
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Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes
Journal of Thrombosis and Haemostasis, ISSN: 15387836 15387933
Østerud; Dusten Unruh; Olsen; Daniel Kirchhofer; A. Phillip Owens III; Vladimir Y. Bogdanov
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Reliability and validity of the Advanced Basal Cell Carcinoma Index (aBCCdex)
British Journal of Dermatology, ISSN: 13652133 00070963
Susan D. Mathias; Mary-Margaret Chren; Ross D. Crosby; Hilary H. Colwell; Yeun Mi Yim; Carolina Reyes; Diana M. Chen; Scott W. Fosko
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Similar Efficacy with Omalizumab in Chronic Idiopathic/Spontaneous Urticaria Despite Different Background Therapy
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Thomas B. Casale; Jonathan A. Bernstein; Marcus Maurer; Sarbjit S. Saini; Benjamin L. Trzaskoma; Hubert Chen; Clive E. Grattan; Ana Gimenéz-Arnau; Allen P. Kaplan; Karin Rosén
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A phase II trial of RCHOP followed by radioimmunotherapy for early stage (stages I/II) diffuse large B-cell non-Hodgkin lymphoma: ECOG3402
British Journal of Haematology, ISSN: 13652141 00071048
Witzig; Fangxin Hong; Ivana N. Micallef; Randy D. Gascoyne; Ahmet Dogan; Henry Wagner; Brad Kahl; Ranjana H. Advani; Sandra J. Horning
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The minimal important difference for measures of urticaria disease activity: Updated findings
Allergy and Asthma Proceedings, ISSN: 15396304 10885412
Susan D. Mathias; Ross D. Crosby; Karin Rosén; James L. Zazzali
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Interlaboratory study to evaluate the robustness of capillary electrophoresis-mass spectrometry for peptide mapping
Journal of Separation Science, ISSN: 16159314 16159306
Christian Wenz; Coral Barbas; Ángeles Lõpez-Gonzálvez; Antonia Garcia; Fernando Benavente; Victoria Sanz-Nebot; Tim Blanc; Gordon Freckleton; Philip Britz-McKibbin; Meera Shanmuganathan; Francois De L'Escaille; Johann Far; Rob Haselberg; Sean Huang; Carolin Huhn; Martin Pattky; David A. Michels; Si Mou; Feng Yang; Christian Neusuess; Nora Tromsdorf; Edward E.K. Baidoo; Jay D. Keasling; Park
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Large-scale interlaboratory study to develop, analytically validate and apply highly multiplexed, quantitative peptide assays to measure cancer-relevant proteins in plasma
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Susan E. Abbatiello; Birgit Schilling; Mani; Lisa J. Zimmerman; Steven C. Hall; Brendan MacLean; Matthew Albertolle; Simon Allen; Michael Burgess; Michael P. Cusack; Mousumi Gosh; Victoria Hedrick; Jason M. Held; H. Dorota Inerowicz; Angela Jackson; Hasmik Keshishian; Christopher R. Kinsinger; John Lyssand; Lee Makowski; Mehdi Mesri; Henry Rodriguez; Paul Rudnick; Pawel Sadowski; Nell Sedransk; Kent Shaddox; Stephen J. Skates; Eric Kuhn; Derek Smith; Jeffery R. Whiteaker; Corbin Whitwell; Shucha Zhang; Christoph H. Borchers; Susan J. Fisher; Bradford W. Gibson; Daniel C. Liebler; Michael J. MacCoss; Thomas A. Neubert; Amanda G. Paulovich; Fred E. Regnier; Paul Tempst; Steve A. Carr
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Synthesis of Tricyclic 1,2,3-Triazolopyridines
Synthesis (Germany), ISSN: 1437210X 00397881
Jessica J. Frick; Cuong Q. Ly; Jacob B. Schwarz
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Antitumor effects of MEHD7945A, a dual-specific antibody against EGFR and HER3, in combination with radiation in lung and head and neck cancers
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Chunrong Li; Shyhmin Huang; Eric A. Armstrong; David M. Francis; Lauryn R. Werner; Mark X. Sliwkowski; Albert Van Der Kogel; Paul M. Harari
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Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab
Protein Science, ISSN: 1469896X 09618368
Brigitte Maurer; Ivan Bosanac; Steven Shia; Mandy Kwong; Corpuz; Richard L. Vandlen; Kerstin N. Schmidt; Eigenbrot
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Estimated Life-Years Saved in Women with HER2-Positive Metastatic Breast Cancer Receiving First-Line Trastuzumab and Pertuzumab in the United States
Value in Health, ISSN: 15244733 10983015
Mark Danese; Anthony Masaquel; Eduardo Santos; Melissa Brammer; Abraham Lee; Deepa Lalla
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The incidence of metastatic basal cell carcinoma (mBCC) in Denmark, 1997-2010
European Journal of Dermatology, ISSN: 19524013 11671122
Mary Nguyen-Nielsen; Lisa I. Wang; Lars Pedersen; Anne Braae Olesen; Jeannie Hou; Howard M. Mackey; Margaret McCusker; Nicole Basset-Seguin; Jon Fryzek; Mogens Vyberg
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