Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6101 - 6150 OF 15796 RESULTS

Structural analysis of bacterial ABC transporter inhibition by an antibody fragment
Structure, ISSN: 18784186 09692126
Shivani Ahuja; Lionel Rouge; Danielle L. Swem; Jawahar Sudhamsu; Ping Wu; Russell; Mary Kate Alexander; Christine Tam; Mireille Nishiyama; Melissa A. Starovasnik; Christopher M. Koth
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Opposing activities of notch and wnt signaling regulate intestinal stem cells and gut homeostasis
Cell Reports, ISSN: 22111247
Hua Tian; Brian Biehs; Cecilia Chiu; Christian W. Siebel; Yan Wu; Michael Costa; Frederic J. De Sauvage; Ophir D. Klein
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MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas
PLoS ONE, ISSN: 19326203
Katja Schmitz; Koeppen; Elke Binot; Jana Fassunke; Helen Künstlinger; Michaela A. Ihle; Carina Heydt; Eva Wardelmann; Reinhard Büttner; Sabine Merkelbach-Bruse; Josef Rüschoff; Hans-Ulrich Schildhaus
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Development of orthogonally protected hypusine for solid-phase peptide synthesis
Journal of Organic Chemistry, ISSN: 15206904 00223263
Aimin Song; Jeffrey Tom; Zhiyong Yu; Victoria Pham; Dajin Tan; Dengxiong Zhang; Guoyong Fang; Tao Yu; Deshayes
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Using oxidation-reduction chemistry in sample preparation for sub-PPM quantitation by LC/MS
Journal of Liquid Chromatography and Related Technologies, ISSN: 1520572X 10826076
Mohammad Al-Sayah; Yong Liu; Roy Helmy; Peter M. Yehl
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Statistical methods for estimating the minimum thickness along a pipeline
Technometrics, ISSN: 15372723 00401706
Shiyao Liu; William Q. Meeker
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Reported consent processes and demographics: A substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial
HIV Medicine, ISSN: 14681293 14642662
Denning; Sharma; Smolskis; Touloumi; Walker; Babiker; Clewett; Ezekiel Emanuel; Florence; Papadopoulos; Sánchez; Jorge A. Tavel; Christine Grady
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Rituximab versus cyclophosphamide for ANCA-associated vasculitis with renal involvement
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Duvuru Geetha; Specks; John H. Stone; Merkel; Seo; Spiera; Langford; Hoffman; Cees Kallenberg; St.clair; Barri J. Fessler; Linna Ding; Tchao; Iklé; Brett Jepson; Paul Brunetta; Fervenza
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Risk factors for hemorrhagic cystitis in pediatric allogeneic hematopoietic stem cell transplant recipients
Transplant Infectious Disease, ISSN: 13993062 13982273
Hayden; Gu; Liu; Lovins; Kasow; Woodard; Srivastava; Leung
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Differential effects of tyrosine kinase inhibitors on normal and oncogenic EGFR signaling and downstream effectors
Molecular Cancer Research, ISSN: 15573125 15417786
Youngjoo Kim; Mihaela Apetri; Beibei Luo; Jeffrey Settleman; Karen S. Anderson
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Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Tobias Maile; Anita Izrael-Tomasevic; Tommy K. Cheung; Gulfem D. Guler; Charles Tindell; Alexandre Masselot; Jun Liang; Feng Zhao; Patrick Trojer; Marie Classon; David Arnott
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Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Melissa Mun; Stefanie Khoo; Aline Do Minh; James Dvornicky; Melody Trexler-Schmidt; Kao; Mike Laird
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Impact of age and medical comorbidity on adjuvant treatment outcomes for stage III colon cancer: A pooled analysis of individual patient data from four randomized, controlled trials
Annals of Oncology, ISSN: 15698041 09237534
Daniel Haller; Michael J O'Connell; Cartwright; Chris Twelves; Edward McKenna; Sun; Muhammad Saif; Lee; Greg Yothers; Hans-Joachim Schmoll
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cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection
Journal of Immunology, ISSN: 15506606 00221767
Kelly M. Storek; Nina A. Gertsvolf; Maikke B. Ohlson; Denise M. Monack
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Characteristics and temporal trends in patient registries: Focus on the life sciences industry, 1981-2012
Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569
Karin Travers; Rachel H. Sallum; Meghan D. Burns; Charles E. Barr; Beattie; Chris L. Pashos; Bryan R. Luce
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Breast Cancer Resistance Protein (ABCG2) in Clinical Pharmacokinetics and Drug Interactions: Practical Recommendations for Clinical Victim and Perpetrator Drug-Drug Interaction Study Design
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Caroline A. Lee; Meeghan A. O'connor; Tasha K. Ritchie; Aleksandra Galetin; Cook; Isabelle Ragueneau-Majlessi; Harma Ellens; Bo Feng; Mitchell E. Taub; Mary F. Paine; Polli; Joseph A. Ware; Zamek-Gliszczynski
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Functional analysis of protective IL1RL1 variants associated with asthma risk: To the editor
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Vladimir Ramirez-Carrozzi; Amy Dressen; Patrick J. Lupardus; Brian L. Yaspan; Rajita Pappu
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Contribution of metabolites to P450 inhibition-Based Drug-Drug interactions: Scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Hongbin Yu; Suresh K. Balani; Weichao Chen; Donghui Cui; Ling He; W. Griffith Humphreys; Jialin Mao; W. George Lai; Anthony J. Lee; Heng-Keang Lim; Christopher MacLauchlin; Chandra Prakash; Sekhar Surapaneni; Susanna Tse; Alana Upthagrove; Robert L. Walsky; Bo Wen; Zhaopie Zeng
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Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: The OLIVIA multinational randomised phase II trial
Annals of Oncology, ISSN: 15698041 09237534
Thomas Gruenberger; Bridgewater; Chau; Garcia Alfonso; Rivoire; Mudan; Susan F. Lasserre; Frank Hermann; Waterkamp; Adam
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The quintessence of immunogenicity reporting for biotherapeutics
Nature Biotechnology, ISSN: 15461696 10870156
Gopi Shankar; Arkin; Viswanath Devanarayan; Kromminga; Quarmby; Richards; Subramanyam; Steven J. Swanson
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Immunohistochemical Detection of FLAG-Tagged Endogenous Proteins in Knock-In Mice
Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554
Ron Ferrando; Kim Newton; Felix Chu; Webster; French
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Clinical outcomes in elderly patients with advanced non-small cell lung cancer: Results from ARIES, a bevacizumab observational cohortstudy
Clinical Oncology, ISSN: 14332981 09366555
Antoinette J. Wozniak; Michael Kosty; Mohammad Jahanzeb; Julie Brahmer; David Spigel; Larry Leon; Susan Fish; E. Dawn Flick; Sebastien J. Hazard; Thomas J. Lynch
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Feasibility and cardiac safety of trastuzumab emtansine after anthracycline-based chemotherapy as (neo)adjuvant therapy for human epidermal growth factor receptor 2-positive early-stage breast cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Ian E. Krop; Suter; Chau T. Dang; Luc Dirix; Romieu; Claudio Zamagni; Marc L. Citron; Mario Campone; Xu; Melanie Smitt; Luca Gianni
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Basal cells contribute to innate immunity of the airway epithelium through production of the antimicrobial protein RNase 7
Journal of Immunology, ISSN: 15506606 00221767
Gimano D. Amatngalim; Yolanda Van Wijck; Yvonne De Mooij-Eijk; Renate M. Verhoosel; Jürgen Harder; Annemarie N. Lekkerkerker; Richard A. J. Janssen; Pieter S. Hiemstra
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Incidence of liver injury among cancer patients receiving chemotherapy in an integrated health system
Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569
Marianne Ulcickas Yood; Michele Bortolini; Deborah Casso; Jean G. Beck; Susan A. Oliveria; Karen E. Wells; Kimberley J. Woodcroft; Lisa I. Wang
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Effects of intravitreal ranibizumab on retinal hard exudate in diabetic macular edema: Findings from the RIDE and RISE phase III clinical trials
Ophthalmology, ISSN: 15494713 01616420
Amitha Domalpally; Michael S. Ip; Jason S. Ehrlich
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Does patient rurality predict quality colon cancer care?: A population-based study
Diseases of the Colon and Rectum, ISSN: 15300358 00123706
Christopher J. Chow; Waddah B. Al-Refaie; Anasooya Abraham; Abraham Markin; Wei Zhong; David A. Rothenberger; Mary R. Kwaan; Elizabeth B. Habermann
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Dulanermin with rituximab in patients with relapsed indolent B-cell lymphoma: an open-label phase 1b/2 randomised study
The Lancet Haematology, ISSN: 23523026
Chan Yoon Cheah; David Belada; Michelle A. Fanale; Andrea Janikova; Myron S. Czucman; Ian Flinn; Amy V. Kapp; Avi Ashkenazi; Kelley; Gordon L. Bray; Scott N. Holden; John F. Seymour
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Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse
Molecular Biology of the Cell, ISSN: 19394586 10591524
Anne Reversat; Maria-Isabel Yuseff; Danielle Lankar; Odile Malbec; Dorian Obino; Mathieu Maurin; Naga Venkata Gayathri Penmatcha; Alejandro Amoroso; Lucie Sengmanivong; Gregg G. Gundersen; Ira Mellman; François Darchen; Claire Desnos; Paolo Pierobon; Ana-Maria Lennon-Duménil
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Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing
Journal of Molecular Biology, ISSN: 10898638 00222836
Thomas Van Blarcom; Andrea Rossi; Davide Foletti; Purnima Sundar; Steven Pitts; Christine Bee; Jody Melton Witt; Zea Melton; Adela Hasa-Moreno; Lee Shaughnessy; Dilduz Telman; Lora Zhao; Wai Ling Cheung; Jan Berka; Wenwu Zhai; Pavel Strop; Javier Chaparro-Riggers; David L. Shelton; Jaume Pons; Arvind Rajpal
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MAP4K4 regulates integrin-FERM binding to control endothelial cell motility
Nature, ISSN: 14764687 00280836
Philip Vitorino; Stacey Yeung; Ailey Crow; Jesse Bakke; Tanya Smyczek; Kristina West; Erin McNamara; Jeffrey Eastham-Anderson; Stephen Gould; Seth F. Harris; Chudi O. Ndubaku; Weilan Ye
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Atom-Atom-Path similarity and Sphere Exclusion clustering: Tools for prioritizing fragment hits
Journal of Cheminformatics, ISSN: 17582946
Alberto Gobbi; Anthony M. Giannetti; Huifen Chen; Man-Ling Lee
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Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues
PLoS ONE, ISSN: 19326203
Scott D. Patterson; John M. Rossi; Katherine L. Paweletz; Dan Fitzpatrick; C. Glenn Begley; Leigh Busse; Steve Elliott; Ian McCaffery
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A novel Respiratory Syncytial Virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models
PLoS ONE, ISSN: 19326203
Stacie L. Lambert; Shahin Aslam; Elizabeth Stillman; Mia MacPhail; Christine Nelson; Bodrey Ro; Rosemary Sweetwood; Yuk Man Lei; Jennifer C. Woo; Roderick S. Tang
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An industry statistician's perspective on personalized health care drug development
Design and Analysis of Clinical Trials for Predictive Medicine,
Jane Fridlyand; Ru-Fang Yeh; Howard M. Mackey; Thomas Bengtsson; Paul Delmar; Spaniolo; Lieberman
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Regulation of the oncoprotein Smoothened by small molecules
Nature Chemical Biology, ISSN: 15524469 15524450
Hayley J. Sharpe; Weiru Wang; Rami N. Hannoush; Frederic J. De Sauvage
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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Science Translational Medicine, ISSN: 19466242 19466234
Joel D. Leverson; Darren C. Phillips; Michael J. Mitten; Erwin R. Boghaert; Dolores Diaz; Stephen K. Tahir; Lisa D. Belmont; Paul M. Nimmer; Yu Xiao; Xiaoju Max Ma; Kym N Lowes; Peter J. Kovar; Jun Chen; Sha Jin; Morey L. Smith; John Xue; Haichao Zhang; Anatol Oleksijew; Terrance J. Magoc; Kedar S. Vaidya; Daniel H. Albert; Jacqueline M. Tarrant; Nghi La; Le Wang; Zhi-Fu Tao; Michael D. Wendt; Deepak Sampath; Saul H. Rosenberg; Chris Tse; David C.S. Huang; Wayne J. Fairbrother; Steven W. Elmore; Andrew J. Souers
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GPU-accelerated compartmental modeling analysis of DCE-MRI data from glioblastoma patients treated with bevacizumab
PLoS ONE, ISSN: 19326203
Yu-Han H. Hsu; Ziyin Huang; Gregory Z. Ferl; Chee Ng
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Transient blockade of delta-like notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation
Journal of Immunology, ISSN: 15506606 00221767
Sherri Wood; Jiane Feng; Jooho Chung; Vedran Radojcic; Ashley R. Sandy-Sloat; Ann Friedman; Amy Shelton; Minhong Yan; Christian W. Siebel; D. Keith Bishop; Ivan Maillard
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A probabilistic method to report predictions from a human liver microsomes stability QSAR model: A practical tool for drug discovery
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Ignacio Aliagas; Alberto Gobbi; Timothy P. Heffron; Man-Ling Lee; Daniel F. Ortwine; Mark Zak; S. Cyrus Khojasteh
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Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Steven L. Gallion; Sarah G. Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; C. Gregory Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie
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TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation
Journal of Immunology, ISSN: 15506606 00221767
Jarod A. Zepp; Ling Wu; Wen Qian; Wenjun Ouyang; Mark Aronica; Serpil Erzurum; Xiaoxia Li
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Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology, ISSN: 19353456 19330219
Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl
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Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology, ISSN: 19353456 19330219
Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl
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Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology, ISSN: 19353456 19330219
Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Scot D. Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl
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Effect of a Modified Saquinavir/Ritonavir Dosing Regimen with Lower Dose Lead-In Phase on QTc Interval, Pharmacokinetics, Antiviral Activity and Safety in Treatment-Naïve HIV-1-Infected Patients
Drugs in R and D, ISSN: 11796901 11745886
Marta Boffito; Akil Jackson; Anton Pozniak; Mylene Giraudon; Rohit Kulkarni; Maria Connie Abelardo; Indravadan H. Patel; Peter N. Morcos
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Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Jacomijn P. Dijksterhuis; Bolormaa Baljinnyam; Karen Stanger; Hakki O. Sercan; Yun Ji; Osler Andres; Jeffrey S. Rubin; Rami N. Hannoush; Gunnar Schulte
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Rapid antidepressants stimulate the decoupling of GABA B receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η
Molecular Psychiatry, ISSN: 14765578 13594184
Workman; Patrick C. G. Haddick; Bush; Dilly; Niere; Zemelman; Raab-Graham
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Considerations on Immunogenicity
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,
Thomas R. Gelzleichter; Eric Wakshull
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Minor structural change to tertiary sulfonamide RORC ligands led to opposite mechanisms of action
ACS Medicinal Chemistry Letters, ISSN: 19485875
Olivier René; Benjamin P. Fauber; Gladys De Leon Boenig; Brenda Burton; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah G. Hymowitz; Adam R. Johnson; James R. Kiefer; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Heidi J. A. Wallweber; Harvey Wong
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