Genentech: Publications

January 1, 2015

Cognitive deficits, changes in synaptic function, and brain pathology in a mouse model of normal aging

eNeuro, ISSN: 23732822

Martin Weber; Tiffany Wu; Jesse E. Hanson; Nazia M. Alam; Hilda Solanoy; Hai Ngu; Benjamin E. Lauffer; Han H. Lin; Sara L. Dominguez; Jens Reeder; Jennifer A. Tom; Pascal Steiner; Oded Foreman; Glen T. Prusky; Kimberly Scearce-Levie

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January 1, 2015

Manufacturing of High-Concentration Monoclonal Antibody Formulations via Spray Drying-the Road to Manufacturing Scale

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Benson Gikanga; Robert Turok; Ada Hui; Mayumi Bowen; Oliver B. Stauch; Maa

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January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun J. Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J. Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N. Kinch; Nick V Grishin; Matthias Peter; Bernard Chow; Julian S. Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

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January 1, 2015

Iridium(III)-catalyzed benzylic amine directed C-H sulfonamidation of arenes with sulfonyl azides

ChemCatChem, ISSN: 18673899 18673880

Heng Chen; Malcolm P. Huestis

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January 1, 2015

Separation science in drug development, part II: High-throughput characterization

LCGC North America, ISSN: 15275949

Baiwei Lin; Joseph H. Pease; Michael W. Dong

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January 1, 2015

Separation science in drug development, part I: High-throughput purification

LCGC North America, ISSN: 15275949

Joseph H. Pease; Brent Murphy; Mengling Wong; Michael W. Dong

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January 1, 2015

Analytical technologies for genotoxic impurities in pharmaceutical compounds

LCGC North America, ISSN: 15275949

Archana Kumar; Kelly Zhang; Larry Wigman

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January 1, 2015

The BioMart community portal: An innovative alternative to large, centralized data repositories

Nucleic Acids Research, ISSN: 13624962 03051048

Damian Smedley; Syed Haider; Durinck; Luca Pandini; Paolo Provero; James Allen; Olivier Arnaiz; Mohammad H.amza Awedh; Richard Baldock; Giulia Barbiera; Philippe Bardou; Tim Beck; Andrew Blake; Merideth Bonierbale; Anthony J. Brookes; Gabriele Bucci; Iwan Buetti; Sarah Burge; Cédric Cabau; Joseph W. Carlson; Claude Chelala; Charalambos Chrysostomou; Davide Cittaro; Olivier Collin; Raul Cordova; Rosalind J. Cutts; Erik Dassi; Alex Di Genova; Anis Djari; Anthony Esposito; Heather Estrella; Eduardo Eyras; Julio Fernandez-Banet; Simon Forbes; Robert C. Free; Takatomo Fujisawa; Emanuela Gadaleta; Jose M. Garcia-Manteiga; David Goodstein; Kristian Gray; José Afonso Guerra-Assunção; Bernard Haggarty; Dong-Jin Han; Byung Woo Han; Todd Harris; Jayson Harshbarger; Robert K. Hastings; Richard D. Hayes; Claire Hoede; Shen Hu; Zhi-Liang Hu; Lucie Hutchins; Zhengyan Kan; Hideya Kawaji; Aminah Keliet; Arnaud Kerhornou; Sunghoon Kim; Rhoda Kinsella; Christophe Klopp; Lei Kong; Daniel Lawson; Dejan Lazarevic; Ji-Hyun Lee; Thomas Letellier; Chuan-Yun Li; Pietro Lio; Chu-Jun Liu; Jie Luo; Alejandro Maass; Jerome Mariette; Thomas Maurel; Stefania Merella; Azza Mostafa Mohamed; Francois Moreews; Ibounyamine Nabihoudine; Nelson Ndegwa; Céline Noirot; Cristian Perez-Llamas; Michael Primig; Alessandro Quattrone; Hadi Quesneville; Davide Rambaldi; James Reecy; Michela Riba; Steven Rosanoff; Amna Ali Saddiq; Elisa Salas; Olivier Sallou; Rebecca Shepherd; Reinhard Simon; Linda Sperling; William Spooner; Daniel M. Staines; Delphine Steinbach; Kevin Stone; Elia Stupka; Jon W. Teague; Abu Z. Dayem Ullah; Jun Wang; Doreen Ware; Marie Wong-Erasmus; Ken Youens-Clark; Amonida Zadissa; Shi-Jian Zhang; Arek Kasprzyk

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January 1, 2015

Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425

Translational and Clinical Pharmacology, ISSN: 22890882

Young G. Shin; Henri Meijering; Fred H. van Heuveln; Jaap Wieling; Jason S Halladay; Srikumar Sahasranaman; Cornelis E. Hop

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January 1, 2015

Safety, virology and pharmacokinetics of oseltamivir in infants with laboratory-confirmed influenza: A Phase I/II, prospective, open-label, multicentre clinical trial

Antiviral Therapy, ISSN: 20402058 13596535

Barbara A. Rath; Jerzy Brzostek; Sara Guillén; Vis Niranjan; Colombe Chappey; Craig R. Rayner; Barry Clinch

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January 1, 2015

Anemia Predicts Sustained Virological Response in Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C Treated with Peginterferon Alfa-2a and Ribavirin

Current Hepatitis Reports, ISSN: 15410706 15403416

Reau; Korner; Jian Han; Donald Jensen

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January 1, 2015

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

Oncotarget, ISSN: 19492553

Nitu Bansal; Prasun J. Mishra; Mark Stein; Robert S. DiPaola; Joseph R. Bertino

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January 1, 2015

Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants

Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642

Dwight R. Stoll; Eric S. Talus; David C. Harmes; Kelly Zhang

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January 1, 2015

Predictors of early discontinuation of pegylated interferon for reasons other than lack of efficacy in United States veterans with chronic hepatitis c

Gastroenterology Nursing, ISSN: 15389766 1042895X

Joanne Lafleur; Hoop; Korner; Scott L. Duvall; Timothy Morgan; Prashant K. Pandya; Jian Han; Kristin Knippenberg; Richard E. Nelson

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January 1, 2015

First million-dollar syringe could be a sight for sore eyes

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2015

Development and implementation of a double-blind corticosteroid-tapering regimen for a clinical trial

International Journal of Rheumatology, ISSN: 16879279 16879260

Neil Collinson; Katie Tuckwell; Frank Habeck; Monique Chapman; Micki Klearman; John H. Stone

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January 1, 2015

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: Addressing methodologic issues of plasma membrane isolation and expression-activity relationship

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Vineet Kumar; Bhagwat Prasad; Gabriela Patilea; Anshul Gupta; Laurent Salphati; Raymond Evers; Cornelis E. Hop; Jashvant D. Unadkat

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January 1, 2015

A biopharmaceutical industry perspective on single-use sensors for biological process applications

BioPharm International, ISSN: 19391862 1542166X

Bradley H. Diehl; Mark A. Lapack; Tony Y. Wang; Robert E. Kottmeier; Stacey M. Kaneshiro; Michael C. Brandenstein; Yongchun Zhang; Yuk Chun Chiu; Seongkyu Yoon; Victor Saucedo

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January 1, 2015

The authors explore and define common industry approaches and practices when applying GMPs in early development

Pharmaceutical Technology, ISSN: 21507376 15432521

Q. Chan Li; Jackson D. Pellett; Michael Szulc; Mark D. Trone; Kirby Wong-Moon

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January 1, 2015

Creating a specialist protein resource network: A meeting report for the protein bioinformatics and community resources retreat

Database, ISSN: 17580463

Patricia C. Babbitt; Pantelis G. Bagos; Amos Bairoch; Alex Bateman; Arnaud Chatonnet; Mark J. Chen; David J. Craik; Robert D. Finn; David Gloriam; Daniel H. Haft; Bernard Henrissat; Gemma L. Holliday; Vignir Isberg; Quentin Kaas; David Landsman; Nicolas Lenfant; Gerard Manning; Nozomi Nagano; Narayanaswamy Srinivasan; Claire O'Donovan; Kim D. Pruitt; Ramanathan Sowdhamini; Neil D. Rawlings; Milton H. Saier Jr.; Joanna L. Sharman; Michael Spedding; Konstantinos D. Tsirigos; Ake Vastermark; Gerrit Vriend

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January 1, 2015

Enhancing efficiency of trace metals analysis using a validated generic ICP-OES method

American Pharmaceutical Review, ISSN: 10998012

Ila Patel; Venkatramani; Colin D. Medley; Kavita Mistry; Larry Wigman; Nik P. Chetwyn

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January 1, 2015

United States comparative costs and absenteeism of diabetic ophthalmic conditions

Postgraduate Medicine, ISSN: 19419260 00325481

Richard A. Brook; Nathan L. Kleinman; Sunil Patel; Jim E. Smeeding; Ian A. Beren; Adam Turpcu

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January 1, 2015

Expanded change protocols: Benefits, cost considerations, and regulatory views

BioProcess International, ISSN: 15426319

Nadine Ritter; Julia Edwards; Stefanie Pluschkell; Suzanne Stella; Rebekah Logan; Chana Fuchs; Wassim Nashabeh; Rohin Mahtre

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January 1, 2015

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

Immunity, ISSN: 10974180 10747613

Natalia B. Pikor; Jillian L. Astarita; Leslie Summers-Deluca; Georgina Galicia; Joy Qu; Lesley A. Ward; Susan Armstrong; Claudia X. Dominguez; Deepali Malhotra; Brendan Heiden; Robert Kay; Valera Castanov; Hanane Touil; Louis Boon; Paul O'Connor; Amit Bar-Or; Alexandre Prat; Valeria Ramaglia; Samuel Ludwin; Shannon J. Turley; Jennifer L. Gommerman

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January 1, 2015

Orchestrating high-throughput genomic analysis with Bioconductor

Nature Methods, ISSN: 15487105 15487091

Wolfgang Huber; Vincent J. Carey; Robert Gentleman; Simon Anders; Marc Carlson; Benilton S. Carvalho; Hector Corrada Bravo; Sean Davis; Laurent Gatto; Thomas Girke; Raphael Gottardo; Florian Hahne; Kasper D. Hansen; Rafael A. Irizarry; Michael Lawrence; Michael I. Love; James MacDonald; Valerie Obenchain; Andrzej K. Oles̈; Hervé Pagès; Alejandro Reyes; Paul Shannon; Gordon K. Smyth; Dan Tenenbaum; Levi Waldron; Martin Morgan

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January 1, 2015

Solid state considerations for early development

American Pharmaceutical Review, ISSN: 10998012

Jeffrey Stults

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January 1, 2015

Effect of individual fc methionine oxidation on FcRn binding: Met252 oxidation impairs fcrn binding more profoundly than Met428 oxidation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Xuan Gao; Junyan A. Ji; Karthik Veeravalli; Y. John Wang; Taylor Zhang; William Mcgreevy; Kai Zheng; Robert F. Kelley; Mike Laird; Jun Liu; Cromwell

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January 1, 2015

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

Journal of Chromatography A, ISSN: 18733778 00219673

Lulu Dai; Larry Wigman; Kelly Zhang

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January 1, 2015

Oxidative degradation of polysorbate surfactants studied by liquid chromatography-mass spectrometry

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Oleg V. Borisov; Junyan A. Ji; Y. John Wang

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January 1, 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yi Zhang; Xiaohui Wei; Gaurav Bajaj; Jeffrey S. Barrett; Bernd Meibohm; Amita Joshi; Manish Gupta

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January 1, 2015

Separation methods and orthogonal techniques

ACS Symposium Series, ISSN: 19475918 00976156

David A. Michels; Anna Y. Ip; Thomas M. Dillon; Kurt Brorson; Scott Lute; Brittany Chavez; Ken M. Prentice; Lowell J. Brady; Karen J. Miller

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January 1, 2015

Characterizing monoclonal antibody structure by carboxyl group footprinting

mAbs, ISSN: 19420870 19420862

Parminder Kaur; Sara Tomechko; Janna Kiselar; Wuxian Shi; Galahad Deperalta; Aaron T. Wecksler; Giridharan Gokulrangan; Victor Ling; Mark R. Chance

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January 1, 2015

Quorum sensing regulates the osmotic stress response in Vibrio harveyi

Journal of Bacteriology, ISSN: 10985530 00219193

Julia C. Van Kessel; Steven T. Rutherford; Jian-Ping Cong; Sofia Quinodoz; James Healy; Bonnie L. Bassler

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January 1, 2015

Group I Paks as therapeutic targets in NF2-deficient meningioma

Oncotarget, ISSN: 19492553

Hoi Yee Chow; Biao Dong; Sergio G. Duron; David Campbell; Christy C. Ong; Klaus P. Hoeflich; Long-Sheng Chang; D. Bradley Welling; Zeng-Jie Yang; Jonathan Chernoff

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January 1, 2015

p21-activated kinase 2 regulates endothelial development and function through the Bmk1/Erk5 pathway

Molecular and Cellular Biology, ISSN: 10985549 02707306

Maria Radu; Karen Lyle; Klaus P. Hoeflich; Olga Villamar-Cruz; Koeppen; Jonathan Chernoff

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January 1, 2015

Effects of copper on CHO cells: Cellular requirements and product quality considerations

Biotechnology Progress, ISSN: 15206033 87567938

Inn H. Yuk; Stephen Russell; Yun Tang; Wei-Ting Hsu; Brad Mauger; Rigzen P. S. Aulakh; Jun Luo; Martin Gawlitzek; John C. Joly

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January 1, 2015

TRPA1 as a drug target - Promise and challenges

Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN: 14321912 00281298

Jun Chen; David Hackos

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January 1, 2015

Separation science in drug development, Part 2: High‑throughput characterization

LC-GC Europe, ISSN: 14716577

Baiwei Lin; Joseph H. Pease; Michael W. Dong

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January 1, 2015

The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+ T cell responses

OncoImmunology, ISSN: 2162402X 21624011

Robert J. Johnston; Xin Yu; Jane L. Grogan

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January 1, 2015

DUBs, the regulation of cell identity and disease

Biochemical Journal, ISSN: 14708728 02646021

Johanna Heideker; Ingrid E. Wertz

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January 1, 2015

Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice

Gastroenterology, ISSN: 15280012 00165085

Nikè V.J.A. Büller; Sanne L. Rosekrans; Ciara Metcalfe; Jarom Heijmans; Willemijn A. Van Dop; Evelyn Fessler; Marnix Jansen; Christina Ahn; Jacqueline L.M. Vermeulen; B. Florien Westendorp; Els C. Robanus-Maandag; G. Johan Offerhaus; Jan Paul Medema; Geert R.A.M. D'Haens; Manon E. Wildenberg; Frederic J. De Sauvage; Vanesa Muncan; Gijs R. Van Den Brink

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January 1, 2015

Principles and techniques in molecular biology

Rheumatology: Sixth Edition,

Elaine F. Remmers; Michael J. Ombrello; Richard M. Siegel

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January 1, 2015

Biosimilars in rheumatology

Rheumatology: Sixth Edition,

Jeffrey N. Siegel

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January 1, 2015

Cytokines

Rheumatology: Sixth Edition,

John J. O'Shea; Massimo Gadina; Richard M. Siegel; Joshua Farber

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January 1, 2015

Analytical Ultracentrifugation and Its Role in Development and Research of Therapeutical Proteins

Methods in Enzymology, ISSN: 15577988 00766879

Jun Liu; Sandeep Yadav; Andya; Barthélemy Demeule; Steven J. Shire

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January 1, 2015

Single-molecule optical methods analyzing receptor tyrosine kinase activation in living cells

Receptor Tyrosine Kinases: Methods and Protocols, ISSN: 10643745

Inhee Chung; Ira Mellman

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January 1, 2015

Stromal infrastructure of the lymph node and coordination of immunity

Trends in Immunology, ISSN: 14714981 14714906

Jonathan Chang; Shannon J. Turley

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January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric W. Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N Kinch; Nick V Grishin; Peter M. Haverty; Bernard Chow; Julian S Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

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January 1, 2015

miRNAs in Transitions: EMT, MET, and EndoMT

MicroRNA in Regenerative Medicine,

Sato; David S. Shames; Yoshinori Hasegawa

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January 1, 2015

New HPLC systems and products introduced at Pittcon 2015: A brief review

LC-GC Europe, ISSN: 14716577

Michael W. Dong

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