Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6301 - 6350 OF 15796 RESULTS

Clinical impact of chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care system
Journal of Managed Care Pharmacy, ISSN: 10834087
Nazia Rashid; Han A. Koh; Hilda C. Baca; Zhaoliang Li; Susan Malecha; Oyewale Abidoye; Anthony Masaquel
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Cell-specific aptamer characterization
Aptamers Selected by Cell-SELEX for Theranostics,
Tao Chen; Cuichen Wu; Weihong Tan
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Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Sharada Labadie; Peter Dragovich; Jinhua Chen; Benjamin P. Fauber; Jason Boggs; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Qunh Ho; Kwong Wah Lai; Shuguang Ma; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou
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Semiconductor-based sequencing of formalin-fixed, paraffin-embedded colorectal cancer samples
Oncologist, ISSN: 1549490X 10837159
Shidong Jia; Liangxuan Zhang; Gary J. Latham
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Onartuzumab with or without bevacizumab in combination with weekly paclitaxel does not prolong QTc or adversely affect other ECG parameters in patients with locally recurrent or metastatic triple-negative breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Marie T. Borin; Meng Chen; Mocci; Igor Rubets; Jason Chittenden; Wassim Aldairy; Mark Stroh
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Using lysine-reactive fluorescent dye for surface characterization of a mAb
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Ming Lei; Kao; Christian Schöneich
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Performance bounds for particle filters using the optimal proposal
Monthly Weather Review, ISSN: 15200493 00270644
Chris Snyder; Thomas Bengtsson; Mathias Morzfeld
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Excess of heme induces tissue factor-dependent activation of coagulation in mice
Haematologica, ISSN: 15928721 03906078
Erica Sparkenbaugh; Pichika Chantrathammachart; Shaobin Wang; Will Jonas; Daniel Kirchhofer; David Gailani; Andras Gruber; Raj Kasthuri; Nigel S. Key; Nigel Mackman; Rafal Pawlinski
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Clinical and economic burden of commercially insured patients with acromegaly in the United States: A retrospective analysis
Journal of Managed Care Pharmacy, ISSN: 10834087
Hilary Placzek; Yaping Xu; Yunming Mu; Susan M. Begelman; Maxine D. Fisher
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Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer
European Journal of Cancer, ISSN: 18790852 09598049
Gilles Vassal; Raphaël F. Rousseau; Patricia Blanc; Lucas Moreno; Gerlind Bode; Stefan Schwoch; Martin Schrappe; Jeffrey Skolnik; Bergmann; Mary Brigid Bradley-Garelik; Vaskar Saha; Andy Pearson; Heinz Zwierzina
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Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Yuan Chen; Divya Samineni; Sophie Mukadam; Harvey Wong; Shen; Dan Lu; Sandhya Girish; Cornelis E. Hop; Jin Y. Jin; Chunze Li
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IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Deepti R. Nagarkar; Vladimir Ramirez-Carrozzi; David F. Choy; Kevin Lee; Robert Soriano; Guiquan Jia; Abbas Alexander; Zora Modrusan; Rajita Pappu; Joseph R. Arron
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Strain engineering to prevent norleucine incorporation during recombinant protein production in Escherichia coli
Biotechnology Progress, ISSN: 15206033 87567938
Karthik Veeravalli; Mike Laird; Mark Fedesco; Yu Zhang; X. Christopher Yu
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Neurodegeneration in type 2 diabetes: Evidence from spectral-domain optical coherence tomography
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Jay Chhablani; Apoorva Sharma; Abhilash Goud; Hari Kumar Peguda; Harsha L. Rao; Viquar Unnisa Begum; Giulio Barteselli
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Retinal ganglion cells thinning in eyes with nonproliferative idiopathic macular telangiectasia type 2A
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Jay Chhablani; Abhilash Goud; Ganesh Babu Jonnadulla
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HSP105 recruits protein phosphatase 2A To dephosphorylate ß-catenin
Molecular and Cellular Biology, ISSN: 10985549 02707306
Nancy Yu; Michael Kakunda; Victoria Pham; Jennie R. Lill; Pan Du; Matthew Wongchenko; Yibing Yan; Ron Firestein; Xiaodong Huang
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Clinical outcomes and medication adherence in acute coronary syndrome patients with and without type 2 diabetes mellitus: A longitudinal analysis 2006-2011
Journal of Managed Care Pharmacy, ISSN: 10834087
Mark J. Cziraky; Vanessa S. Reddy; Rakesh Luthra; Yaping Xu; Kenneth Wilhelm; Thomas P. Power; Maxine D. Fisher
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Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Melissa Junttila; Vidusha Devasthali; Jason H. Cheng; Joseph Castillo; Ciara Metcalfe; Anne C. Clermont; Doug Den Otter; Emily Chan; Hani Bou-Reslan; Tim C. Cao; William F. Forrest; Michelle Nannini; French; Richard A. D. Carano; Mark Merchant; Klaus P. Hoeflich; Mallika Singh
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Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
Cell Death and Disease, ISSN: 20414889
Joel D. Leverson; Haichao Zhang; Jun Chen; Stephen K. Tahir; Darren C. Phillips; John Xue; Paul M. Nimmer; Sha Jin; Morey L. Smith; Yu Xiao; Peter J. Kovar; Tanaka; Bruncko; Sheppard; Le Wang; Sarah Gierke; Kategaya; Daniel J Anderson; Wong; Jeffrey Eastham-Anderson; Ludlam; Deepak Sampath; Wayne J. Fairbrother; Ingrid E. Wertz; Saul H. Rosenberg; Chris Tse; Steven W. Elmore; Andrew J. Souers
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Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on h 1 antihistamines: A randomized, placebo-controlled study
Journal of Investigative Dermatology, ISSN: 15231747 0022202X
Sarbjit S. Saini; Carsten Bindslev-Jensen; Marcus Maurer; Jean-Jacques Grob; Emel Bülbül Baskan; Mary S. Bradley; Janice Canvin; Abdelkader Rahmaoui; Panayiotis Georgiou; Oral Alpan; Sheldon Spector; Karin Rosén
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Gas-wall partitioning of oxygenated organic compounds: Measurements, structure-activity relationships, and correlation with gas chromatographic retention factor
Aerosol Science and Technology, ISSN: 15217388 02786826
Geoffrey K. Yeh; Paul J. Ziemann
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Sorbitol crystallization-induced aggregation in frozen mAb formulations
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Deirdre Murphy Piedmonte; Alison Hair; Priti Baker; Lejla Brych; Karthik Nagapudi; Hong Lin; Wenjin Cao; Susan Hershenson; Gayathri Ratnaswamy
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Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: A retrospective, exploratory analysis in EMILIA
Annals of Oncology, ISSN: 15698041 09237534
Ian E. Krop; Lin; Kimberly Blackwell; Ellie Guardino; Huober; Michael W. Lu; David W. Miles; Meghna Samant; Manfred Welslau; Diéras
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Adventitious Agent Testing of Biologicals: Changing to a New Frontier of Technology, Cell-Based to Nucleic Acid-Based Detection
ACS Symposium Series, ISSN: 19475918 00976156
Ivar Kljavin; Kevin McCarthy; Dieter Schmalzing
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Design and pharmacokinetic characterization of novel antibody formats for ocular therapeutics
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Kapil Gadkar; Cinthia V Pastuskovas; Jennifer Le Couter; J. Michael Elliott; Jianhuan Zhang; Chingwei V. Lee; Sarah Sanowar; Fuh; Hok Seon Kim; T. Noelle Lombana; Christoph Spiess; Makia Nakamura; Hass; Whitney Shatz; Meng; Justin M. Scheer
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Biophysical techniques for characterizing the higher order structure and interactions of monoclonal antibodies
ACS Symposium Series, ISSN: 19475918 00976156
Yatin Gokarn; Sanjeev Agarwal; Kelly Arthur; Alexander Bepperling; Eric S. Day; Dana I. Filoti; Daniel G. Greene; David Hayes; Rachel Kroe-Barrett; Thomas M. Laue; Jasper C. Lin; Brian McGarry; Vladimir Razinkov; Sanjaya Singh; Rosalynn Taing; Sathyadevi Venkataramani; William Weiss; Danlin Yang; Isidro E. Zarraga
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Nanomedicine based on nucleic acids: Pharmacokinetic and pharmacodynamic perspectives
Current Pharmaceutical Biotechnology, ISSN: 18734316 13892010
Chenguang Zhou; Zhaogang Yang; Lesheng Teng
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89Zr-Bevacizumab PET visualizes heterogeneous tracer accumulation in tumor lesions of renal cell carcinoma patients and differential effects of antiangiogenic treatment
Journal of Nuclear Medicine, ISSN: 01615505
Sjoukje F. Oosting; Adrienne H. Brouwers; Suzanne C. Van Es; Wouter B. Nagengast; Thijs H. Oude Munnink; Marjolijn N. Lub-de Hooge; Harry Hollema; Johan R. De Jong; Igle J. De Jong; Sanne De Haas; Stefan J. Scherer; Wim J. Sluiter; Rudi A. Dierckx; Alfons H.H. Bongaerts; Jourik A. Gietema; Elisabeth G. E. De Vries
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Erlotinib therapy after initial platinum doublet therapy in patients with EGFR wild type non-small cell lung cancer: Results of a combined patient-level analysis of the NCIC CTG BR.21 and SATURN trials
Translational Lung Cancer Research, ISSN: 22264477 22186751
Raymond U. Osarogiagbon; Federico Cappuzzo; Tudor Ciuleanu; Larry Leon; Barbara Klughammer
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Derivation of phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 1: Modeling optimal treatment duration and sustained virologic response rates
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Xiaodong Wang; Matthew Hruska; Phyllis Chan; Alaa Ahmad; Jeremy Freeman; Maria Arantxa Horga; Jan Hillson; Vikram Kansra; Juan-Carlos Lopez-Talavera
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Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma
Oncotarget, ISSN: 19492553
Lindi Chen; Raphaël F. Rousseau; Steven A. Middleton; Gwen L. Nichols; David R. Newell; John Lunec; Deborah A. Tweddle
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Separation science in drug development, part 1: High-throughput purification
LC-GC Europe, ISSN: 14716577
Mengling Wong; Brent Murphy; Joseph H. Pease; Michael W. Dong
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Toward an era of utilizing methionine overproducing hosts for recombinant protein production in Escherichia coli
Bioengineered, ISSN: 21655987 21655979
Karthik Veeravalli; Mike Laird
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Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked toll-like receptor 8
Frontiers in Immunology, ISSN: 16643224
Gabrielle McDonald; Nicholas Cabal; Augustin Vannier; Benjamin Umiker; Raymund H. Yin; Arturo V. Orjalo; Hans E. Johansson; Jin-Hwan Han; Thereza Imanishi-Kari
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Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?
Scientific World Journal, ISSN: 1537744X 23566140
Savita V. Dandapani; Ying Zhang; Richard Jennelle; Yvonne G. Lin
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Neoadjuvant breast cancer treatment as a sensitive setting for trastuzumab biosimilar development and extrapolation
Future Oncology, ISSN: 17448301 14796694
Christian Jackisch; Frank A. Scappaticci; Dominik Heinzmann; Fabio Bisordi; Thomas Schreitmüller; Gunter Von Minckwitz; Javier Cortés
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Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis
Thorax, ISSN: 14683296 00406376
Daryle J. DePianto; Sanjay Chandriani; Abbas Alexander; Guiquan Jia; Elsa N. N'Diaye; Patrick Caplazi; Steven E. Kauder; Sabyasachi Biswas; Satyajit K. Karnik; Connie Ha; Zora Modrusan; Michael A. Matthay; Kukreja; Harold R. Collard; Jackson G. Egen; Paul J. Wolters; Joseph R. Arron
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Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control
Journal of Neuroscience, ISSN: 15292401 02706474
Shih-Ching Lo; Yuanyuan Wang; Martin Weber; Jessica L. Larson; Kimberly Scearce-Levie; Morgan Sheng
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The VEGF receptor family
Receptor Tyrosine Kinases: Family and Subfamilies,
Guanglei Zhuang; Napoleone Ferrara
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Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma
Genes and Cancer, ISSN: 19476027 19476019
Chen; James Lee; Noelyn Kljavin; Benjamin Haley; Anneleen Daemen; Leisa Johnson; Yuxin Liang
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Tocilizumab in rheumatoid arthritis: A case study of safety evaluations of a large postmarketing data set from multiple data sources
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Jeffrey R. Curtis; Susana Perez-Gutthann; Samy Suissa; Pavel Napalkov; Natasha Singh; Liz Thompson; Benjamin Porter-Brown
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Randomized study of danoprevir/ritonavir-based therapy for HCV genotype 1 patients with prior partial or null responses to peginterferon/ribavirin
Journal of Hepatology, ISSN: 16000641 01688278
Jordan J. Feld; Ira M. Jacobson; Donald Jensen; Graham R. Foster; Stanislas Pol; Edward Tam; Maciej Jablkowski; Hanna Berak; John M. Vierling; Eric Yoshida; Héctor R. Perez-Gomez; Astrid Scalori; Gregory J. Hooper; Jorge A. Tavel; Mercidita T. Navarro; Saba Shahdad; Rohit Kulkarni; Sophie Le Pogam; Nájera; Simon Eng; Chin Yin Lim; Nancy Shulman; Ellen S. Yetzer
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Dusp5 negatively regulates IL-33-mediated eosinophil survival and function
EMBO Journal, ISSN: 14602075 02614189
Derek A. Holmes; Jung-Hua Yeh; Donghong Yan; Min Xu; Andrew A. Chan
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Derivation of phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 2: Exposure-response analyses for efficacy and safety variables
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Matthew Hruska; Xiaodong Wang; Phyllis Chan; Alaa Ahmad; Jeremy Freeman; Maria Arantxa Horga; Jan Hillson; Vikram Kansra; Juan-Carlos Lopez-Talavera
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Prediction of Drug Distribution in Subcutaneous Xenografts of Human Tumor Cell Lines and Healthy Tissues in Mouse: Application of the Tissue Composition-Based Model to Antineoplastic Drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Patrick Poulin; Yunghsiang Chen; Xiao Ding; Stephen Gould; Cornelis E. Hop; Kirsten Messick; Jason Oeh; Bianca M. Liederer
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100% Container closure integrity testing of lyophilized drug products by the oxygen head space analysis methodology
Pharmazeutische Industrie, ISSN: 0031711X
Tobias Posset; Misael Schleger; Fred Lim; Mumenthaler; Sebastian Schneider; Thomas Kaiser
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Ocular angiogenesis: Vascular endothelial growth factor and other factors
Developments in Ophthalmology, ISSN: 16622790 02503751
Roman G. Rubio; Anthony P. Adamis
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Antibody engineering & therapeutics 2015: The antibody society’s annual meeting december 7–10, 2015, San Diego, CA
mAbs, ISSN: 19420870 19420862
Paul W. H. I. Parren; Dennis R. Burton; Andrew Bradbury; James S. Huston; Paul J. Carter; Trudi Veldman; Kerry A. Chester; James W. Larrick; Mark R. Alfenito; Jamie K. Scott; Louis M. Weiner; Gregory P. Adams; Janice M. Reichert
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Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with 89Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts
Oncotarget, ISSN: 19492553
Eva J. ter Weele; Anton G.T. Terwisscha van Scheltinga; Jos G.W. Kosterink; Linda Pot; Silke R. Vedelaar; Laetitia E. Lamberts; Simon P. Williams; Marjolijn N. Lub-de Hooge; Elisabeth G. E. De Vries
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CMC considerations when a drug development project is assigned breakthrough therapy status
Pharmaceutical Engineering, ISSN: 02738139
Earl S. Dye; John Groskoph; Kelley; George Millili; Moheb Nasr; Christopher J. Potter; Eric Thostesen; Hans Vermeersch
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