Genentech: Publications

January 1, 2015

Functional and structural abnormalities in deferoxamine retinopathy: A review of the literature

BioMed Research International, ISSN: 23146141 23146133

Maura Di Nicola; Giulio Barteselli; Laura Dell'Arti; Roberto Ratiglia; Francesco Viola

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January 1, 2015

Reply

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Aidan Long; Kenneth J. Rothman; Hubert Chen; Gillis Carrigan; Stanley J. Szefler

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January 1, 2015

Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study

Liver International, ISSN: 14783231 14783223

Edward J. Gane; Pockros; Stefan Zeuzem; Marcellin; Anna Shikhman; Coen A. Bernaards; Julian Zhou; Ellen S. Yetzer; Rosa Ballester; Cindy Dwyer; Xiao Tong; Nájera; Anne Bertasso; Janet Hammond; Amy Kindrick; Peter N. Morcos; Patrick F. Smith; Saray Stancic; Nancy Shulman

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January 1, 2015

Antibody isotype switching in vertebrates

Results and Problems in Cell Differentiation, ISSN: 18610412 00801844

Kate Senger; Jason A. Hackney; Jian Payandeh; Ali A. Zarrin

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January 1, 2015

Dual B cell immunotherapy is superior to individual Anti-CD20 depletion or baff blockade in murine models of spontaneous or accelerated lupus

Arthritis and Rheumatology, ISSN: 23265205 23265191

Wei Yu Lin; Dhaya Seshasayee; Wyne P. Lee; Patrick Caplazi; Sami McVay; Eric Suto; Allen Nguyen; Zhonghua Lin; Yonglian Sun; Laura DeForge; Mercedesz Balazs; Flavius Martin; Ali A. Zarrin

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January 1, 2015

MEK inhibitors beyond monotherapy: Current and future development

Current Opinion in Pharmacology, ISSN: 14714973 14714892

Ian E. Templeton; Luna Musib

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January 1, 2015

Predicting response to HER2 kinase inhibition

Oncotarget, ISSN: 19492553

Jeffrey Settleman

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January 1, 2015

Sequence variants and sequence variant analysis in biotherapeutic proteins

ACS Symposium Series, ISSN: 19475918 00976156

Oleg V. Borisov; Melissa Alvarez; James A. Carroll; Paul W. Brown

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January 1, 2015

Hamster phospholipase B-like 2 (PLBL2): A host-cell protein impurity in therapeutic monoclonal antibodies derived from chinese hamster ovary cells

BioProcess International, ISSN: 15426319

Vanderlaan; Wendy N. Sandoval; Peter S. Liu; Julie C. Nishihara; George Tsui; Margaret Lin; Feny Gunawan; Sara Parker; Robert Ming Wong; Justin Low; Xiangdan Wang; Yang; Karthik Veeravalli; McKay; X. Christopher Yu; O'Connell; Benjamin Tran; Rajesh Vij; Chris Fong; Kathleen Francissen; Judith Zhu-Shimoni; Quarmby; Denise C. Krawitz

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January 1, 2015

New stent leaves no polymer behind

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2015

Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1)

Clinical Cancer Research, ISSN: 15573265 10780432

Hirdesh Uppal; Estelle Doudement; Kaushiki Mahapatra; Darbonne; Daniela Bumbaca; Shen; Xiaoyan Du; Ola M. Saad; Kristin Harden; Steve Olsen; Gail L. Phillips; Dylan P. Hartley; Mark X. Sliwkowski; Sandhya Girish; Donna M. Dambach; Vanitha Ramakrishnan

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January 1, 2015

Induction dosing of peginterferon Alfa-2a (40KD) and/or high-dose ribavirin in genotype 1 CHC patients with difficult-to-treat characteristics: Pharmacokinetic and viral kinetic (PK/VK) assessment from progress

Hepato-Gastroenterology, ISSN: 01726390

Peter N. Morcos; Ruby Leong; James A. Thommes; Jean De Pamphilis; Joseph F. Grippo; Barbara J. Brennan

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January 1, 2015

The Patient-Reported Outcome (PRO) Consortium: Lessons Learned Along the Path to PRO Instrument Qualification

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

Risa P. Hayes; Steven I. Blum; Mark Forrest Gordon; Elisabeth Piault; Laurie B. Burke; Ashley F. Slagle; Stephen Joel Coons

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January 1, 2015

Quantification of tumor burden in a genetically engineered mouse model of lung cancer by micro-CT and automated analysis

Translational Oncology, ISSN: 19365233

Kai H. Barck; Hani Bou-Reslan; Ujjawal Rastogi; Timothy Sakhuja; Jason E. Long; Rafael Molina; Anthony Lima; Patricia Hamilton; Melissa Junttila; Leisa Johnson; Richard A. D. Carano

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January 1, 2015

Mixed-effects modeling of clinical DCE-MRI Data: Application to colorectal liver metastases treated with bevacizumab

Journal of Magnetic Resonance Imaging, ISSN: 15222586 10531807

Gregory Z. Ferl; James P.B. O'Connor; Geoff J. M. Parker; Richard A. D. Carano; Shiv J. Acharya; Gordon C. Jayson; Ruediger E. Port

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January 1, 2015

First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) Inhibitor, in patients with advanced solid tumors

Clinical Cancer Research, ISSN: 15573265 10780432

Debashis Sarker; Joo Ern Ang; Richard Baird; Rebecca Kristeleit; Krunal Shah; Victor Moreno; Paul A. Clarke; Florence I. Raynaud; Gallia Levy; Joseph A. Ware; Kathryn Mazina; Ray Lin; Jenny Q. Wu; Jill Fredrickson; Jill M. Spoerke; Lackner; Yibing Yan; Lori S. Friedman; Stanley B. Kaye; Mika K. Derynck; Paul Workman; De Bono

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January 1, 2015

Applying green chemistry principles in biologics drug development

RSC Drug Discovery Series, ISSN: 20413211 20413203

Kristi L. Budzinski

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January 1, 2015

Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization

Nature Communications, ISSN: 20411723

Nadia Martinez-Martin; Abel Viejo-Borbolla; Rocío Martín; Soledad Blanco; Jeffrey L. Benovic; Marcus Thelen; Antonio Alcamí

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January 1, 2015

Lack of a pharmacokinetic interaction between trastuzumab and carboplatin in the presence of docetaxel: Results from a phase Ib study in patients with HER2-positive metastatic or locally advanced inoperable solid tumors

Anti-Cancer Drugs, ISSN: 14735741 09594973

Stephen M. Eppler; Michael S. Gordon; Charles H. Redfern; Caroline Trudeau; Xu; Kelong Han; Bert L. Lum

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January 1, 2015

Diagnostic pathways to Alzheimer disease costs incurred in a medicare population

Alzheimer Disease and Associated Disorders, ISSN: 08930341

Daniel M. Gilden; Joanna M. Kubisiak; Khaled Sarsour; Craig A. Hunter

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January 1, 2015

Getting the most value from your screens: Advances in hardware, software, and methodologies to enhance surface plasmon resonance based fragment screening and hit-to-lead support

RSC Drug Discovery Series, ISSN: 20413211 20413203

Anthony M. Giannetti; Houston N. Gilbert; Donald P. Huddler; Mac Reiter; Chris Strande; Keith Pitts; Brandon Bravo

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January 1, 2015

Asthma biomarkers: What constitutes a 'gold standard'?

Thorax, ISSN: 14683296 00406376

Joseph R. Arron; Kenji Izuhara

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January 1, 2015

Implications of understanding the signaling, cellular, and cytotoxic mechanisms afforded by afucosylated antibodies

OncoImmunology, ISSN: 2162402X 21624011

Scot D. Liu; John Lowe

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January 1, 2015

John T. Stults

The Encyclopedia of Mass Spectrometry: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry,

Stults

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January 1, 2015

Metal ion interactions with mAbs: Part 1 pH and conformation modulate copper-mediated site-specific fragmentation of the IgG1 hinge region

mAbs, ISSN: 19420870 19420862

Zephania Kwong Glover; Basa; Benjamin Moore; Jennifer S. Laurence; Alavattam Sreedhara

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January 1, 2015

Symptoms and toxicity of rituximab maintenance relative to observation following immunochemotherapy in patients with follicular Lymphoma

Hematology, ISSN: 16078454 10245332

Zhou; Jianmin Wang; Jessica Zhang; Catherine Copley-Merriman; Yasuhiro Torigoe; Carolina Reyes; John F. Seymour; Fritz C. Offner; Marek Trneny; Gilles Salles

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January 1, 2015

A comprehensive transcriptional portrait of human cancer cell lines

Nature Biotechnology, ISSN: 15461696 10870156

Christiaan N. Klijn; Durinck; Eric Stawiski; Matthias Peter; Zhaoshi Jiang; Hanbin Liu; Jeremiah D. Degenhardt; Oleg Mayba; Florian Gnad; Jinfeng Liu; Gregoire Pau; Jens Reeder; Yi Cao; Kiran Mukhyala; Suresh K Selvaraj; Mamie Yu; Gregory J Zynda; Matthew J. Brauer; Thomas D Wu; Robert Gentleman; Gerard Manning; Robert Yauch; Richard Bourgon; David Stokoe; Zora Modrusan; Richard M. Neve; Frederic J. De Sauvage; Jeffrey Settleman; Somasekar Seshagiri; Zemin Zhang

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January 1, 2015

Recommendations for adaptation and validation of commercial kits for biomarker quantification in drug development

Bioanalysis, ISSN: 17576199 17576180

Masood U. Khan; Ronald Bowsher; Mark Cameron; Viswanath Devanarayan; Steve Keller; Lindsay King; Jean W. Lee; Alyssa M. Morimoto; Paul Rhyne; Laurie Stephen; Yuling Wu; Tim Wyant; D Richard Lachno

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December 30, 2014

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

T. Justin Rettenmaier; Jack D. Sadowsky; Nathan D. Thomsen; Steven C. Chen; Allison K. Doak; Michelle R. Arkin; James A. Wells

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December 30, 2014

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Vikas Sharma; Thomas W. Patapoff; Bruce Kabakoff; Satyan Pai; Eric Hilario; Boyan Zhang; Charlene Li; Oleg V. Borisov; Robert F. Kelley; Ilya Chorny; Joe Zhongxiang Zhou; Ken A. Dill; Trevor E. Swartz

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December 26, 2014

Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Giovanni Cervi; Paola Magnaghi; Daniela Asa; Nilla Avanzi; Alessandra Badari; Daniela Borghi; Michele Caruso; Alessandra Cirla; Liviana Cozzi; Eduard Felder; Arturo Galvani; Fabio Gasparri; Antonio Lomolino; Steven Magnuson; Beatrice Malgesini; Ilaria Motto; Maurizio Pasi; Simona Rizzi; Barbara Salom; Graziella Sorrentino; Sonia Troiani; Barbara Valsasina; Thomas O'Brien; Antonella Isacchi; Daniele Donati; Roberto D'Alessio

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December 20, 2014

Identification of the WNT1 residues required for palmitoylation by Porcupine

FEBS Letters, ISSN: 18733468 00145793

Miranda; Lisa M. Galli; Enriquez; Linda A. Szabo; Xinxin Gao; Rami N. Hannoush; Laura W. Burrus

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December 19, 2014

Synthesis of Akt inhibitor ipatasertib. part 2. Total synthesis and first kilogram scale-up

Organic Process Research and Development, ISSN: 1520586X 10836160

Travis Remarchuk; Frederic St-Jean; Diane Carrera; Scott Savage; Herbert M. Yajima; Brian Wong; Srinivasan Babu; Alan Deese; Jeffrey Stults; Michael W. Dong; David Askin; Jonathan W. Lane; Keith L. Spencer

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December 19, 2014

Synthesis of Akt inhibitor ipatasertib. part 1. Route scouting and early process development of a challenging cyclopentylpyrimidine intermediate

Organic Process Research and Development, ISSN: 1520586X 10836160

Jonathan W. Lane; Keith L. Spencer; Sagar R. Shakya; Nicholas C. Kallan; Peter J. Stengel; Travis Remarchuk

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December 19, 2014

Depletion of the Central Metabolite NAD leads to oncosismediated cell death

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Christopher J. Del Nagro; Yang Xiao; Linda Rangell; Mike Reichelt; Thomas O'Brien

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December 18, 2014

Preclinical efficacy of MEK inhibition in NRAS-mutant AML

Blood, ISSN: 15280020 00064971

Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li

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December 18, 2014

Preclinical efficacy of MEK inhibition in NRAS-mutant AML

Blood, ISSN: 15280020 00064971

Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott C. Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li

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December 16, 2014

Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: Omeprazole and ranitidine

Anti-Cancer Drugs, ISSN: 14735741 09594973

Heidemarie Kletzl; Mylene Giraudon; Patricia Sanwald Ducray; Markus Abt; Marta Hamilton; Bert L. Lum

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December 15, 2014

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Lewis Gazzard; Brent A. Appleton; Kerry Chapman; Huifen Chen; Clark; Joy Drobnick; Simon Goodacre; Jason S Halladay; Joseph P. Lyssikatos; Stephen Schmidt; Steve Sideris; Wiesmann; Karen Williams; Ping Wu; Ivana Yen; Shiva Malek

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December 15, 2014

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Benjamin P. Fauber; Peter Dragovich; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Sharada Labadie; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Steve Sideris; Ultsch; Binqing Wei; Ivana Yen; Qin Yue; Aihe Zhou

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December 15, 2014

Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Giancarlo Trani; John J. Barker; Steven M. Bromidge; Frederick A. Brookfield; Jason D. Burch; Yuan Chen; Eigenbrot; Alexander Heifetz; Moulay Hicham Alaoui Ismaili; Adam R. Johnson; Thomas M. Krülle; Colin H. Mackinnon; Rosemary Maghames; Paul A. McEwan; Christian A.G.N. Montalbetti; Daniel F. Ortwine; Yolanda Pérez-Fuertes; Darshan G. Vaidya; Xiaolu Wang; Ali A. Zarrin; Zhonghua Pei

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December 15, 2014

A reversed sulfonamide series of selective RORc inverse agonists

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Monique B. Van Niel; Benjamin P. Fauber; Matthew W. Cartwright; Simon Gaines; Jonathan C. Killen; Olivier René; Stuart I. Ward; Gladys De Leon Boenig; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Emanuela Gancia; Arunima Ganguli; Alberto Gobbi; Julie Hawkins; Adam R. Johnson; James R. Kiefer; Hank La; Peter Lockey; Maxine Norman; Wenjun Ouyang; Ann R. Qin; Nicole Wakes; Bohdan Waszkowycz; Harvey Wong

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December 15, 2014

MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Xiangnan Du; Benjamin C. Lin; Qian-Rena Wang; Hao Li; Ellen Ingalla; Janet Y. Tien; Isabelle Rooney; Avi Ashkenazi; Elicia M. Penuel; Jing Qing

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December 11, 2014

Internal motions prime cIAP1 for rapid activation

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Aaron H. Phillips; Allyn J. Schoeffler; Tsutomu Matsui; Thomas M. Weiss; John W. Blankenship; Zobel; Anthony M. Giannetti; Erin C. Dueber; Wayne J. Fairbrother

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December 11, 2014

The IL-20 subfamily of cytokines-from host defence to tissue homeostasis

Nature Reviews Immunology, ISSN: 14741741 14741733

Sascha Rutz; Xiaoting Wang; Wenjun Ouyang

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December 11, 2014

Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Emily J. Hanan; Eigenbrot; Marian C. Bryan; Burdick; Bryan K. Chan; Yuan Chen; Jennafer Dotson; Robert Heald; Philip Jackson; Hank La; Michael Lainchbury; Shiva Malek; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Christine Tam; Shumei Wang; Siew Kuen Yeap; Ivana Yen; Jianping Yin; Christine Yu; Inna Zilberleyb; Timothy P. Heffron

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December 11, 2014

8-tetrahydropyran-2-yl chromans: Highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Allen A. Thomas; Kevin W. Hunt; Bradley J. Newhouse; Ryan J. Watts; Xingrong Liu; Guy Vigers; Darin Smith; Susan P. Rhodes; Karin D. Brown; Jennifer N. Otten; Michael Burkard; April Cox; Mary K. Geck Do; Darrin Dutcher; Sumeet Rana; Robert K. Delisle; Kelly Regal; Albion D. Wright; Robert Groneberg; Jiangpeng Liao; Kimberly Scearce-Levie; Michael Siu; Hans E. Purkey; Joseph P. Lyssikatos

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December 10, 2014

A septin-dependent diffusion barrier at dendritic spine necks

PLoS ONE, ISSN: 19326203

Helge Ewers; Tomoko Tada; Jennifer D. Petersen; Bence Racz; Morgan Sheng; Daniel Choquet

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December 8, 2014

The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function

Cancer Cell, ISSN: 18783686 15356108

Robert J. Johnston; Laetitia Comps-Agrar; Jason A. Hackney; Xin Yu; Mahrukh Huseni; Yagai Yang; Summer Park; Vincent Javinal; Chiu; Bryan Irving; Dan L. Eaton; Jane L. Grogan

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December 5, 2014

Gutsy moves in mice: Cellular and molecular dynamics of endoderm morphogenesis

Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN: 14712970 09628436

Manuel Viotti; Ann C. Foley; Anna-Katerina Hadjantonakis

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