Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6401 - 6450 OF 15796 RESULTS

Obinutuzumab (Gazyva®), a Novel Glycoengineered Type II CD20 Antibody for the Treatment of Chronic Lymphocytic Leukemia and Non-Hodgkin's Lymphoma
Handbook of Therapeutic Antibodies: Second Edition,
Christian Klein; Marina Bacac; Pablo Umaña; Michael Wenger
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Rituximab (Rituxan®)
Handbook of Therapeutic Antibodies: Second Edition,
Axel Böhnke; Michael Wenger
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Response to Biologic Disease-Modifying Anti-Rheumatic Drugs after Discontinuation of Anti-Tumor Necrosis Factor Alpha Agents for Rheumatoid Arthritis
Rheumatology and Therapy, ISSN: 21986584 21986576
Martin J. Bergman; Eric P. Elkin; Sarika Ogale; Tripthi V. Kamath; Max I. Hamburger
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Editorial
TrAC - Trends in Analytical Chemistry, ISSN: 18793142 01659936
Davy Guillarme; Michael W. Dong
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Comparison of survival and hospitalization rates between Medicare patients with advanced NSCLC treated with bevacizumab-carboplatin-paclitaxel and carboplatin-paclitaxel: A retrospective cohort study
Lung Cancer, ISSN: 18728332 01695002
Corey Langer; Arliene Ravelo; Sebastien J. Hazard; Annie Guérin; Raluca Ionescu-Ittu; Dominick Latremouille-Viau; Eric Q. Wu; Suresh Ramalingam
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Host cell protein testing by ELISAs and the use of orthogonal methods
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Judith Zhu-Shimoni; X. Christopher Yu; Julie C. Nishihara; Robert Ming Wong; Feny Gunawan; Margaret Lin; Denise C. Krawitz; Peter S. Liu; Wendy N. Sandoval; Vanderlaan
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Breast cancer resistance protein substrate and inhibition evaluation: Why, when, and how?
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Joseph A. Ware; Bradley L. Urquhart; Yuichi Sugiyama; Zamek-Gliszczynski
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A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Nature Medicine, ISSN: 1546170X 10788956
Monica K. Wetzel-Smith; Julie Hunkapiller; Tushar Bhangale; Karpagam Srinivasan; Janice Maloney; Jasvinder K. Atwal; Susan Sa; Murat Yaylaoglu; Oded Foreman; Ward Ortmann; Nisha Rathore; David V. Hansen; Marc Tessier-Lavigne; Richard Mayeux; Brian W. Kunkle; Jonathan L. Haines; Lindsay A. Farrer; Gerard D. Schellenberg; Alison M. Goate; Timothy W. Behrens; Paul K. Crane; Ryan J. Watts; Robert R. Graham
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Determination of cobimetinib in human plasma using protein precipitation extraction and high-performance liquid chromatography coupled to mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Yuzhong Deng; Luna Musib; Edna F. Choo; Matthew Chapple; Sarah Burke; James Johnson; Stephen M. Eppler; Brian J. Dean
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Monthly versus as-needed ranibizumab injections in patients with retinal vein occlusion: The SHORE study
Ophthalmology, ISSN: 15494713 01616420
Peter A. Campochiaro; Charles C. Wykoff; Michael Singer; Robert Johnson; Dennis Marcus; Linda Yau; Gary Sternberg
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Lupus nephritis susceptibility loci in women with systemic lupus erythematosus
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Sharon A. Chung; Elizabeth E. Brown; Adrienne H. Williams; Paula S. Ramos; Celine C. Berthier; Tushar Bhangale; Marta E. Alarcón-Riquelme; Timothy W. Behrens; Lindsey A. Criswell; Deborah S. Cunninghame Graham; F. Yesim Demirci; Jeffrey C. Edberg; Patrick M. Gaffney; John B. Harley; Chaim O. Jacob; M. Ilyas Kamboh; Jennifer A. Kelly; Susan Manzi; Kathy L. Moser-Sivils; Laurie P. Russell; Michelle Petri; Betty P. Tsao; Timothy J. Vyse; Raphael Zidovetzki; Matthias Kretzler; Robert P. Kimberly; Barry I. Freedman; Robert R. Graham; Carl D. Langefeld
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PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition
Journal of Pathology, ISSN: 10969896 00223417
Wei Zhou; Adrian M. Jubb; Karen Lyle; Qian Xiao; Christy C. Ong; Rupal Desai; Ling Fu; Florian Gnad; Qinghua Song; Matthias Peter; Daniela Aust; Robert Grützmann; Mally Romero; Klara Totpal; Richard M. Neve; Yibing Yan; William F. Forrest; Wang; Rajiv Raja; Christian Pilarsky; Ana De Jesus-Acosta; Marcia Belvin; Lori S. Friedman; Mark Merchant; Elizabeth M. Jaffee; Lei Zheng; Koeppen; Klaus P. Hoeflich
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Treatment Patterns and Comparative Effectiveness in Elderly Diffuse Large B-Cell Lymphoma Patients: A Surveillance, Epidemiology, and End Results-Medicare Analysis
Oncologist, ISSN: 1549490X 10837159
Paul A. Hamlin; Sacha Satram-Hoang; Carolina Reyes; Khang Q. Hoang; Sridhar R. Guduru; Sandra Skettino
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SOX17 links gut endoderm morphogenesis and germ layer segregation
Nature Cell Biology, ISSN: 14764679 14657392
Manuel Viotti; Sonja Nowotschin; Anna-Katerina Hadjantonakis
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Proteome-wide light/dark modulation of thiol oxidation in cyanobacteria revealed by quantitative site-specific redox proteomics
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Jia Guo; Amelia Y. Nguyen; Ziyu Dai; Dian Su; Matthew J. Gaffrey; Ronald J. Moore; Jon M. Jacobs; Matthew E. Monroe; Richard D. Smith; David W. Koppenaal; Himadri B. Pakrasi; Wei-Jun Qian
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Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery
Future Medicinal Chemistry, ISSN: 17568927 17568919
Peter W. Fan; Yang Song; Leonid M. Berezhkovskiy; Jonathan Cheong; Emile G. Plise; S. Cyrus Khojasteh
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Visualization of protein sequence features using JavaScript and SVG with pViz.js
Bioinformatics, ISSN: 14602059 13674803
Kiran Mukhyalay; Alexandre Masselot
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Vision-related function after ranibizumab treatment for diabetic macular edema: Results from RIDE and RISE
Ophthalmology, ISSN: 15494713 01616420
Neil M. Bressler; Rohit Varma; Ivan J. Suñer; Chantal M. Dolan; James Ward; Jason S. Ehrlich; Shoshana Colman; Adam Turpcu
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Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular amd
British Journal of Ophthalmology, ISSN: 14682079 00071161
Robert L. Avery; Alessandro A. Castellarin; Nathan C. Steinle; Dilsher S. Dhoot; Dante Joseph Pieramici; Robert See; Stephen Couvillion; MA'An A. Nasir; Melvin D. Rabena; Kha Le; Mauricio Maia; Jennifer Visich
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2014 White Paper on recent issues in bioanalysis: A full immersion in bioanalysis (Part 3-LBA and immunogenicity)
Bioanalysis, ISSN: 17576199 17576180
Lauren Stevenson; Lakshmi Amaravadi; Heather Myler; Laura Salazar-Fontana; Boris Gorovits; Susan Kirshner; Li Xue; Fabio Garofolo; Stephen C. Alley; Theingi Thway; Alison Joyce; Surendra Bansal; Chris Beaver; Annik Bergeron; Xiao-Yan Cai; Laura Cojocaru; Binodh DeSilva; Isabelle Dumont; Eric Fluhler; Stephanie Fraser; Dominique Gouty; Swati Gupta; Sam Haidar; Roger Hayes; Benno Ingelse; Akiko Ishii-Watabe; Surinder Kaur; Lindsay King; Omar Laterza; Sheldon Leung; Ann Lévesque; Mark Ma; Corinne Petit-Frere; Renuka Pillutla; Mark Rose; Gary Schultz; John Smeraglia; Steven J. Swanson; Albert Torri; Faye Vazvaei; Jason Wakelin-Smith; Amanda Wilson; Eric Woolf; Tong-Yuan Yang
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Impact of symptom burden on work-related abilities in patients with locally recurrent or metastatic breast cancer: Results from a substudy of the VIRGO observational cohort study
Breast, ISSN: 15323080 09609776
Charles S. Cleeland; Musa Mayer; Nancy A. Dreyer; Yeun Mi Yim; Elaine B. Yu; Zhaohui Su; Yong Mun; Jeff A. Sloan; Peter A. Kaufman
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2014 White Paper on recent issues in bioanalysis: A full immersion in bioanalysis (Part 2-hybrid LBA/LCMS, ELN & regulatory agencies' input)
Bioanalysis, ISSN: 17576199 17576180
Dawn Dufield; Hendrik Neubert; Fabio Garofolo; Leo Kirkovsky; Lauren Stevenson; Isabelle Dumont; Surinder Kaur; Keyang Xu; Stephen C. Alley; Matthew Szapacs; Mark Arnold; Surendra Bansal; Sam Haidar; Jan Welink; Olivier Le Blaye; Jason Wakelin-Smith; Emma Whale; Akiko Ishii-Watabe; Mark Bustard; Noriko Katori; Lakshmi Amaravadi; Anne-Françoise Aubry; Chris Beaver; Annik Bergeron; Xiao-Yan Cai; Laura Cojocaru; Binodh DeSilva; Jeff Duggan; Eric Fluhler; Boris Gorovits; Swati Gupta; Roger Hayes; Stacy Ho; Benno Ingelse; Lindsay King; Ann Lévesque; Steve Lowes; Mark Ma; Adrien Musuku; Heather Myler; Timothy Olah; Shefali Patel; Mark Rose; Gary Schultz; John Smeraglia; Steven J. Swanson; Albert Torri; Faye Vazvaei; Amanda Wilson; Eric Woolf; Li Xue; Tong-Yuan Yang
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Complement inhibition in cynomolgus monkeys by anti-factor D antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565
Kelly M. Loyet; Jeremy Good; Teresa Davancaze; Lizette Sturgeon; Xiangdan Wang; Yang; Kha Le; Maureen Wong; Hass; Menno Van Lookeren Campagne; Peter Haughney; Alyssa M. Morimoto; Lisa A. Damico; Laura DeForge
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Willingness to pay to avoid metastatic breast cancer treatment side effects: results from a conjoint analysis
SpringerPlus, ISSN: 21931801
Deepa Lalla; Rashad Carlton; Eduardo Santos; Thomas Bramley; Anna D’Souza
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A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease
PLoS ONE, ISSN: 19326203
Kareem L. Graham; Jian V. Zhang; Susanna Lewén; Thomas M. Burke; Ton Dang; Maria Zoudilova; Raymond A. Sobel; Eugene C. Butcher; Brian A. Zabel
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TNFR1-activated NF-κB signal transduction: Regulation by the ubiquitin/proteasome system
Current Opinion in Chemical Biology, ISSN: 18790402 13675931
Ingrid E. Wertz
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Ultra-high-pressure liquid chromatography (UHPLC) in method development
TrAC - Trends in Analytical Chemistry, ISSN: 18793142 01659936
Michael W. Dong; Kelly Zhang
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Backbone cyclization of a recombinant cystine-knot peptide by engineered Sortase A
FEBS Letters, ISSN: 18733468 00145793
Karen Stanger; Till Maurer; Harini Kaluarachchi; Mary Coons; Yvonne Franke; Rami N. Hannoush
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Single-cell in situ imaging of palmitoylation in fatty-acylated proteins
Nature Protocols, ISSN: 17502799 17542189
Xinxin Gao; Rami N. Hannoush
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Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
Nature, ISSN: 14764687 00280836
Mahesh Yadav; Suchit Jhunjhunwala; Qui Phung; Patrick J. Lupardus; Josh Tanguay; Stephanie M. Bumbaca; Christian Franci; Tommy K. Cheung; Jens Fritsche; Toni Weinschenk; Zora Modrusan; Ira Mellman; Jennie R. Lill; Lélia Delamarre
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MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
Nature, ISSN: 14764687 00280836
Thomas Powles; Joseph Paul Eder; Gregg D. Fine; Fadi S. Braiteh; Yohann Loriot; Cristina Cruz; Joaquim Bellmunt; Howard A. Burris; Petrylak; Siew-Leng Teng; Xiaodong Shen; Zachary Boyd; Priti Hegde; Daniel S. Chen; Nicholas J. Vogelzang
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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
Nature, ISSN: 14764687 00280836
Roy S. Herbst; Jean-Charles Soria; Marcin Kowanetz; Gregg D. Fine; Omid Hamid; Michael S. Gordon; Jeffrey A. Sosman; David McDermott; John D. Powderly; Scott Gettinger; Holbrook E. K. Kohrt; Leora Horn; Donald Lawrence; Sandra Rost; Maya Leabman; Yuanyuan Xiao; Ahmad Mokatrin; Koeppen; Priti Hegde; Ira Mellman; Daniel S. Chen; F. Stephen Hodi
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Molecular simulations of the pairwise interaction of monoclonal antibodies
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Mauro Lapelosa; Thomas W. Patapoff; Isidro E. Zarraga
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The blood-brain barrier's gut check
Science Translational Medicine, ISSN: 19466242 19466234
Nga Bien-Ly; Ryan J. Watts
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Evaluating Source Data Verification as a Quality Control Measure in Clinical Trials
Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790
Nicole Sheetz; Brett Wilson; Joanne Benedict; Esther Huffman; Andy Lawton; Mark Travers; Patrick Nadolny; Stephen Young; Kyle Given; Lawrence Florin
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Drugs for macular degeneration
JAMA - Journal of the American Medical Association, ISSN: 15383598 00987484
Ivaylo Stoilov; Anne E. Fung; Roman G. Rubio
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Quantification of residual solvents in antibody drug conjugates using gas chromatography
Analytica Chimica Acta, ISSN: 18734324 00032670
Colin D. Medley; Jacob Kay; Yi Li; Jason Gruenhagen; Peter M. Yehl; Nik P. Chetwyn
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Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Shan-Shan Wang; Yi-Feng Gu; Nicholas Wolff; Karoliina Stefanius; Alana Christie; Anwesha Dey; Robert E. Hammer; Xian-Jin Xie; Dinesh Rakheja; Ivan Pedrosa; Thomas Carroll; Renée M. McKay; Payal Kapur; James Brugarolas
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A microRNA upregulated in asthma airway T cells promotes T H 2 cytokine production
Nature Immunology, ISSN: 15292916 15292908
Laura J. Simpson; Sana Patel; Nirav R. Bhakta; David F. Choy; Hans D. Brightbill; Xin Ren; Yanli Wang; Heather H. Pua; Dirk Baumjohann; Misty M. Montoya; Marisella Panduro; Kelly A. Remedios; Xiaozhu Huang; John V. Fahy; Joseph R. Arron; Prescott G. Woodruff; K. Mark Ansel
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Combined vemurafenib and cobimetinib in BRAF-mutated melanoma
New England Journal of Medicine, ISSN: 15334406 00284793
James Larkin; Paolo A. Ascierto; Brigitte Dréno; Victoria Atkinson; Gabriella Liszkay; Michele Maio; Mario Mandala; Lev Demidov; Daniil Stroyakovskiy; Luc Thomas; Luis De La Cruz-Merino; Caroline Dutriaux; Claus Garbe; Mika A. Sovak; Ilsung Chang; Nicholas Choong; Stephen P. Hack; McArthur; Antoni Ribas
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Regulation of neuronal gene expression and survival by basal NMDA receptor activity: A role for histone deacetylase 4
Journal of Neuroscience, ISSN: 15292401 02706474
Yelin Chen; Yuanyuan Wang; Zora Modrusan; Morgan Sheng; Joshua S. Kaminker
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Direct medical costs and resource use for treating central and branch retinal vein occlusion in commercially insured working-age and medicare populations
Retina, ISSN: 15392864 0275004X
Ivan J. Suñer; Jay Margolis; Kimberly Ruiz; Irwin Tran; Paul P. Lee
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Collateral vessel presence in branch and central retinal vein occlusions and their impact on visual acuity and anatomical gains: A retrospective analysis
Retina, ISSN: 15392864 0275004X
Rishi Singh; Tamara Lee; Linda Yau; Roman G. Rubio
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HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme
Developmental Cell, ISSN: 18781551 15345807
Marco Osterwalder; Dario Speziale; Malak Shoukry; Rajiv Mohan; Robert Ivanek; Manuel Kohler; Christian Beisel; Xiaohui Wen; Suzie J. Scales; Vincent M. Christoffels; Axel Visel; Javier Lopez-Rios; Rolf Zeller
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Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Wilson; Yuanyuan Xiao; Jill M. Spoerke; Jane Fridlyand; Koeppen; Eloisa Fuentes; Huw; Ilma Abbas; Arjan Gower; Erica Schleifman; Rupal Desai; Ling Fu; Teiko Sumiyoshi; Joyce A. O’Shaughnessy; Garret M. Hampton; Lackner
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Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Janice Maloney; Travis W. Bainbridge; Amy Gustafson; Shuo Zhang; Roxanne Kyauk; Pascal Steiner; Marcel P Van Der Brug; Yichin Liu; James A. Ernst; Ryan J. Watts; Jasvinder K. Atwal
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Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Science Translational Medicine, ISSN: 19466242 19466234
Y. Joy Yu; Jasvinder K. Atwal; Yin Zhang; Raymond K. Tong; Kristin R. Wildsmith; Christine Tan; Nga Bien-Ly; Maria Hersom; Janice Maloney; William J. Meilandt; Daniela Bumbaca; Kapil Gadkar; Kwame Hoyte; Wilman Luk; Yanmei Lu; James A. Ernst; Kimberly Scearce-Levie; Jessica A. Couch; Dennis; Ryan J. Watts
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Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib
Molecular Pharmaceutics, ISSN: 15438392 15438384
Edna F. Choo; Justin Ly; Jocelyn Chan; Sheerin Shahidi-Latham; Kirsten Messick; Emile G. Plise; Cristine Quiason; Lulu Yang
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Subcutaneous Tocilizumab Versus Placebo in Combination With Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis
Arthritis Care and Research, ISSN: 21514658 2151464X
Alan Kivitz; Ewa Olech; Michael Borofsky; Beatriz M. Zazueta; Federico Navarro-Sarabia; Sebastião C. Radominski; Merrill; Lucy Rowell; Clare Nasmyth-Miller; Bao; Stephen Wright; Janet E. Pope
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Associations Between Preterm Birth, Low Birth Weight, andPostpartum Health in a Predominantly Hispanic WICPopulation
Journal of Nutrition Education and Behavior, ISSN: 14994046
Stephanie A. Leonard; Denise Gee; Yuda Zhu; Catherine M. Crespi; Shannon E. Whaley
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