Genentech: Publications

August 1, 2014

Combined administration of RG7652, a recombinant human monoclonal antibody against PCSK9, and atorvastatin does not result in reduction of immune function

Toxicological Sciences, ISSN: 10960929

Thomas R. Gelzleichter; Wendy Halpern; Roy Erwin; Amos Baruch; Maya Leabman; Abigail S. Forrest; Christina Satterwhite; Kun Peng; Jennifer Chilton; Dale Stevens

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July 17, 2014

PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia

Blood, ISSN: 15280020 00064971

Martin Weisser; Ru-Fang Yeh; Guillemette Duchateau-Nguyen; Palermo; Tri Quang Nguyen; Xiaoyan Shi; Susanna Y. Stinson; Nancy Yu; Annika Dufour; Tadeusz Robak; Galina Salogub; Anna Dmoszynska; Philippe Solal-Celigny; Krzysztof Warzocha; Javier Loscertales; John Catalano; Loree Larratt; Viktor A. Rossiev; Isabelle Bence-Bruckler; Christian H. Geisler; Marco Montillo; Kirsten Fischer; Anna-Maria Fink; Michael Hallek; Johannes Bloehdorn; Raymonde Busch; Axel Benner; Hartmut Doḧner; Nancy Valente; Michael Wenger; Stephan Stilgenbauer; David Dornan

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July 16, 2014

Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons

Neuron, ISSN: 10974199 08966273

Yelin Chen; Yuanyuan Wang; Ali Ertürk; Dara Y. Kallop; Zhiyu Jiang; Robby M. Weimer; Joshua S. Kaminker; Morgan Sheng

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July 16, 2014

Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains

PLoS ONE, ISSN: 19326203

Travis W. Bainbridge; Venita I. DeAlmeida; Anita Izrael-Tomasevic; Cecile Chalouni; Borlan Pan; Joshua Goldsmith; Alia P. Schoen; Gabriel Quinones; Ryan Kelly; Jennie R. Lill; Wendy N. Sandoval; Michael Costa; Paul G. Polakis; David Arnott; Bonnee Rubinfeld; James A. Ernst

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July 16, 2014

Statistical modeling of the drug load distribution on trastuzumab emtansine (Kadcyla), a lysine-linked antibody drug conjugate

Bioconjugate Chemistry, ISSN: 15204812 10431802

Michael Kim; Yan Chen; Joseph C. Marhoul; Fred Jacobson

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July 15, 2014

PILRα negatively regulates mouse inflammatory arthritis

Journal of Immunology, ISSN: 15506606 00221767

Yonglian Sun; Patrick Caplazi; Juan Zhang; Anita Mazloom; Sarah K. Kummerfeld; Gabriel Quinones; Kate Senger; Justin Lesch; Ivan Peng; Andrew Sebrell; Wilman Luk; Yanmei Lu; Zhonghua Lin; Kai H. Barck; Judy Young; Mariela Del Rio; Sophie M. Lehar; Vida Asghari; Wei Yu Lin; Sanjeev Mariathasan; Jason Devoss; Shahram Misaghi; Mercedesz Balazs; Tao Sai; Benjamin Haley; Hass; Min Xu; Wenjun Ouyang; Flavius Martin; Wyne P. Lee; Ali A. Zarrin

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July 15, 2014

VariantAnnotation: A Bioconductor package for exploration and annotation of genetic variants

Bioinformatics, ISSN: 14602059 13674803

Valerie Obenchain; Michael Lawrence; Vincent J. Carey; Stephanie M. Gogarten; Paul Shannon; Martin Morgan

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July 15, 2014

MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein

Genes and Development, ISSN: 15495477 08909369

Monica S. Guo; Taylor B. Updegrove; Emily Gogol; Svetlana A. Shabalina; Carol A. Gross; Gisela Storz

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July 15, 2014

Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex

Journal of Neurophysiology, ISSN: 15221598 00223077

Justin Elstrott; Kelly B. Clancy; Haani Jafri; Igor Akimenko; Daniel E. Feldman

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July 10, 2014

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible t-cell kinase inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Jason D. Burch; Kevin Lau; John J. Barker; Frederick A. Brookfield; Yong Chen; Yuan Chen; Eigenbrot; Claire Ellebrandt; Moulay Hicham Alaoui Ismaili; Adam R. Johnson; Daniel Kordt; Colin H. Mackinnon; Paul A. McEwan; Daniel F. Ortwine; Daniel B. Stein; Xiaolu Wang; Dirk Winkler; Po-Wai Yuen; Yamin Zhang; Ali A. Zarrin; Zhonghua Pei

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July 7, 2014

Imaging cleared intact biological systems at a cellular level by 3DISCO

Journal of Visualized Experiments, ISSN: 1940087X

Ali Ertürk; Daniel Lafkas; Cecile Chalouni

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July 3, 2014

Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides

Organic Letters, ISSN: 15237052 15237060

Olivier René; Benjamin P. Fauber; Sushant Malhotra; Herbert M. Yajima

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July 3, 2014

Comparative efficacy of biologics as monotherapy and in combination with methotrexate on patient reported outcomes (PROs) in rheumatoid arthritis patients with an inadequate response to conventional DMARDs - a systematic review and network meta-analysis

Health and Quality of Life Outcomes, ISSN: 14777525

Jeroen P. Jansen; Felicity Buckley; Fred Dejonckheere; Sarika Ogale

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July 2, 2014

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Science Translational Medicine, ISSN: 19466242 19466234

Gauvreau; Harris; Boulet; Heleen Scheerens; Fitzgerald; Wendy Putnam; Cockcroft; Davis; Richard Leigh; Zheng; Barbro Dahlén; Yehong Wang; Romeo MacIuca; Mayers; X. Charlene Liao; Lawren C. Wu; Matthews; O'Byrne

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July 1, 2014

The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation

Cancer Research, ISSN: 15387445 00085472

Debasish Raha; Wilson; Jing Peng; David Peterson; Peng Yue; Marie Evangelista; Catherine Wilson; Mark Merchant; Jeffrey Settleman

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July 1, 2014

Development of a comprehensive near infrared spectroscopy calibration model for rapid measurements of moisture content in multiple pharmaceutical products

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X

Dipak Mainali; Jane Li; Peter M. Yehl; Nicholas Chetwyn

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July 1, 2014

Asymmetric stereodivergent strategy towards aminocyclitols

Chemistry - A European Journal, ISSN: 15213765 09476539

Barry M. Trost; Sushant Malhotra

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July 1, 2014

Balancing benefit and risk of medicines: A systematic review and classification of available methodologies

Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569

Shahrul Mt-Isa; Christine Hallgreen; Nan Wang; Georgy Genov; Ian Hirsch; Davide Luciani; Lawrence D. Phillips; George Quartey; Sinan B. Sarac; Isabelle Stoeckert; Ioanna Tzoulaki; Alain Micaleff; Deborah Ashby; Billy Amzal; Simon Ashworth; Alex Asiimwe; Johan Bring; Torbjorn Callreus; Edmond Kakit Chan; Christoph Dierig; Gerald Downey; David Gelb; Alesia Goginsky; Richard Hermann; Steve Hobbiger; Kimberley S. Hockley; Diana Hughes; Juhaeri Juhaeri; Silvia Kuhls; Alfons Lieftucht; Marilyn Metcalf; Jeremiah Mwangi; Richard Nixon; Rebecca Noel; John Pears; Ruth Peters; Lawrence Phillips; Susan Shepherd; Elizabeth Swain J.; Andrew Thomson; Laurence Titeux; Rianne van den Ham; Tjeerd van Staa; Edward Waddingham; Lesley Wise

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July 1, 2014

Predicting Discontinuation of Pegylated Interferon as a Result of Lack of Efficacy in United States Veterans With Chronic Hepatitis C on Dual Therapy

Annals of Pharmacotherapy, ISSN: 15426270 10600280

Richard E. Nelson; Hoop; Korner; Scott L. Duvall; Candace Hayden; Kristin Knippenberg; Timothy Morgan; Prashant K. Pandya; Jian Han; Joanne Lafleur

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July 1, 2014

Endogenously expressed IL-13Rα2 attenuates IL-13- mediated responses but does not activate signaling in human lung fibroblasts

Journal of Immunology, ISSN: 15506606 00221767

Sanjay Chandriani; Daryle J. DePianto; Elsa N. N'Diaye; Abbas Alexander; Janet Jackman; Jack Bevers; Vladimir Ramirez-Carrozzi; Rajita Pappu; Steven E. Kauder; Toy; Connie Ha; Zora Modrusan; Lawren C. Wu; Harold R. Collard; Paul J. Wolters; Jackson G. Egen; Joseph R. Arron

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July 1, 2014

Treatment emergent suicidal ideation and behavior

Suicide: Phenomenology and Neurobiology,

Sian Ratcliffe; Phillip B. Chappell; Janel Boyce-Rustay; Svetlana Gloukhova; Denise M. Oleske

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July 1, 2014

Rituximab and three dexamethasone cycles provide responses similar to splenectomy in women and those with immune thrombocytopenia of less than two years duration

Haematologica, ISSN: 15928721 03906078

James B. Bussel; Christina S. Lee; Caroline Seery; Allison A. Imahiyerobo; Michaela V. Thompson; Diane Catellier; Ithamar G. Turenne; Vivek L. Patel; Paul A. Basciano; Rebecca Elstrom; Waleed Ghanima

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July 1, 2014

The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation

Cancer Research, ISSN: 15387445 00085472

Debasish Raha; Wilson; Jing Peng; David Peterson; Peng Yue; Marie Evangelista; Catherine Wilson; Mark Merchant; Jeffrey Settleman

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June 30, 2014

Estimated cases of blindness and visual impairment from neovascular age-related macular degeneration avoided in Australia by ranibizumab treatment

PLoS ONE, ISSN: 19326203

Paul Mitchell; Neil M. Bressler; Quan V. Doan; Chantal M. Dolan; Alberto Ferreira; Aaron Osborne; Elena Rochtchina; Mark Danese; Shoshana Colman; Andrew K. Wong

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June 25, 2014

Direct reprogramming of human fibroblasts to hepatocyte-like cells by synthetic modified mRNAs

PLoS ONE, ISSN: 19326203

Kamen P. Simeonov; Hirdesh Uppal

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June 20, 2014

Development of a semi-automated high throughput transient transfection system

Journal of Biotechnology, ISSN: 18734863 01681656

Aaron B. Bos; Joseph N. Duque; Sunil Bhakta; Farzam Farahi; Lindsay A. Chirdon; Jagath R. Junutula; Peter D. Harms; Athena W. Wong

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June 19, 2014

Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis

PLoS ONE, ISSN: 19326203

Sarah L. May; Qing Zhou; Mitzi Lewellen; Cristan M. Carter; David Coffey; Steven L. Highfill; Christoph M. Bucher; Ilze Matise; Herbert C. Morse Iii; M. Gerard O'Sullivan; Melissa Schutten; Charles Johnson; Donald Bellgrau; Bruce R. Blazar; Jaime F. Modiano

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June 19, 2014

Designer proteins to trigger cell death

Cell, ISSN: 10974172 00928674

Wayne J. Fairbrother; Avi Ashkenazi

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June 19, 2014

E-Cadherin Couples Death Receptors to the Cytoskeleton to Regulate Apoptosis

Molecular Cell, ISSN: 10974164 10972765

Min Lu; Scot A. Marsters; Ye; Luis; Lino C. Gonzalez Jr.; Avi Ashkenazi

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June 19, 2014

From cancer genomics to precision oncology - Tissue's still an issue

Cell, ISSN: 10974172 00928674

Robert L. Cohen; Jeffrey Settleman

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June 18, 2014

β-Amyloid inhibits E-S potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition

Neuron, ISSN: 10974199 08966273

Adrienne L. Orr; Jesse E. Hanson; Dong Li; Adam Klotz; Sarah Wright; Dale Schenk; Peter Seubert; Daniel V. Madison

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June 16, 2014

B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas

Cancer Cell, ISSN: 18783686 15356108

Nesrine I. Affara; Brian Ruffell; Terry R. Medler; Andrew J. Gunderson; Magnus Johansson; Sophia Bornstein; Emily Bergsland; Martin Steinhoff; Yijin Li; Qian Gong; Ma; Jane F. Wiesen; Melissa H. Wong; Molly Kulesz-Martin; Bryan Irving; Lisa Coussens

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June 15, 2014

The use and effectiveness of rituximab maintenance in patients with follicular lymphoma diagnosed between 2004 and 2007 in the United States

Cancer, ISSN: 10970142 0008543X

Loretta J. Nastoupil; Sinha; Michelle Byrtek; Zhou; Taylor; Jonathan W. Friedberg; Brian K. Link; James R. Cerhan; Keith Dawson; Christopher R. Flowers

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June 15, 2014

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

James F. Blake; John J. Gaudino; Jason De Meese; Peter Mohr; Mark Chicarelli; Hongqi Tian; Rustam Garrey; Allen A. Thomas; Christopher S. Siedem; Michael Welch; Gabrielle Kolakowski; Robert Kaus; Michael Burkard; Matthew Martinson; Huifen Chen; Brian J. Dean; Danette Dudley; Stephen Gould; Patricia Pacheco; Sheerin Shahidi-Latham; Weiru Wang; Kristina West; Jianping Yin; John Moffat; Jacob B. Schwarz

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June 12, 2014

Structure-guided rescaffolding of selective antagonists of BCL-X L

ACS Medicinal Chemistry Letters, ISSN: 19485875

Michael F. T. Koehler; Philippe Bergeron; Edna F. Choo; Kevin Lau; Chudi O. Ndubaku; Danette Dudley; Paul Gibbons; Brad E Sleebs; Carl S. Rye; George Nikolakopoulos; Chinh Bui; Sanji Kulasegaram; Wilhelmus J A Kersten; Brian J. Smith; Czabotar; Colman; David C.S. Huang; Jonathan B Baell; Keith G Watson; Lisa Hasvold; Zhi-Fu Tao; Le Wang; Andrew J. Souers; Steven W. Elmore; Flygare; Wayne J. Fairbrother; Guillaume Lessene

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June 9, 2014

Pannexin-1 is blocked by its C-terminus through a delocalized non-specific interaction surface

PLoS ONE, ISSN: 19326203

Michelle Dourado; Evera Wong; David Hackos

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June 6, 2014

Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics

Molecular Neurodegeneration, ISSN: 17501326

Kristin R. Wildsmith; Stephen P. Schauer; Ashley Smith; David Arnott; Yuda Zhu; Joshua Haznedar; Surinder Kaur; W Rodney Mathews; Lee Honigberg

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June 4, 2014

AB3 building blocks for the synthesis of polyester dendrimers

Tetrahedron Letters, ISSN: 18733581 00404039

Jean-D'Amour K. Twibanire; Malcolm P. Huestis; T. Bruce Grindley

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June 4, 2014

Genomic characterization of Salmonella Cerro ST367, an emerging Salmonella subtype in cattle in the United States

BMC Genomics, ISSN: 14712164

Lorraine D. Rodriguez-Rivera; Andrea I. Moreno Switt; Lovorka Degoricija; Rixun Fang; Craig A. Cummings; Manohar Furtado; Martin Wiedmann; Henk C. Den Bakker

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June 3, 2014

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Patrick J. Lupardus; Ultsch; Heidi J. A. Wallweber; Pawan Bir Kohli; Adam R. Johnson; Eigenbrot

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June 3, 2014

Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Ashley Fouts; Laetitia Comps-Agrar; Katharina F. Stengel; Diego Ellerman; Allyn J. Schoeffler; Søren Warming; Dan L. Eaton; Becket Feierbach

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June 1, 2014

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Matthew Volgraf; Lina Chan; Malcolm P. Huestis; Hans E. Purkey; Michael Burkard; Mary K. Geck Do; Julie Harris; Kevin W. Hunt; Xingrong Liu; Joseph P. Lyssikatos; Sumeet Rana; Allen A. Thomas; Guy Vigers; Michael Siu

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June 1, 2014

Comparative oncogenomics identifies psmb4 and shmt2 as potential cancer driver genes

Cancer Research, ISSN: 15387445 00085472

Genee Y. Lee; Matthias Peter; Li Li; Noelyn Kljavin; Richard Bourgon; James Lee; Howard M. Stern; Zora Modrusan; Somasekar Seshagiri; Zemin Zhang; David P. Davis; David Stokoe; Jeffrey Settleman; Frederic J. De Sauvage; Richard M. Neve

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June 1, 2014

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Richard Pastor; Jason D. Burch; Steven Magnuson; Daniel F. Ortwine; Yuan Chen; Kelly De La Torre; Xiao Ding; Eigenbrot; Adam R. Johnson; Marya Liimatta; Yichin Liu; Steven Shia; Xiaolu Wang; Lawren C. Wu; Zhonghua Pei

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May 26, 2014

Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase

ChemBioChem, ISSN: 14397633 14394227

Angela Oh; Yen-Ching Ho; Mark Zak; Yongbo Liu; Xukun Chen; Po-Wai Yuen; Xiaozhang Zheng; Yichin Liu; Peter Dragovich; Weiru Wang

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May 24, 2014

Safety of infusing rituximab at a more rapid rate in patients with rheumatoid arthritis: Results from the RATE-RA study

BMC Musculoskeletal Disorders, ISSN: 14712474

Charles H Pritchard; Maria Greenwald; Joel M. Kremer; Norman B. Gaylis; William F. Rigby; Steve Zlotnick; Carol Y. Chung; Birgit Jaber; William Reiss

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May 23, 2014

Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: A randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer

Breast Cancer Research, ISSN: 1465542X 14655411

Edith A. Perez; Sara A. Hurvitz; Lukas Amler; Kirsten E. Mundt; Vivian W. Ng; Ellie Guardino; Luca Gianni

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May 22, 2014

Mechanisms and functions of inflammasomes

Cell, ISSN: 10974172 00928674

Lamkanfi; Vishva M. Dixit

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May 21, 2014

Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation

F1000Research, ISSN: 1759796X 20461402

Chih-Cheng Yang; Alicia S Chung; Chia-Yu Ku; Laurence M. Brill; Roy Williams; Dieter A. Wolf

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May 20, 2014

Characterization and stability study of polysorbate 20 in therapeutic monoclonal antibody formulation by multidimensional ultrahigh-performance liquid chromatography-charged aerosol detection-mass spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Yi Li; Daniel Hewitt; Yvonne Lentz; Junyan A. Ji; Taylor Zhang; Kelly Zhang

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