Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6651 - 6700 OF 15796 RESULTS

March 5, 2014

Is SIRT2 required for necroptosis?

Nature, ISSN: 00280836 14764687

Kim Newton; Joanne M. Hildebrand; Zhirong Shen; Diego Rodriguez; Silvia Alvarez-Diaz; Sean Petersen; Saumil Shah; Dugger; Chunzi Huang; Johan Auwerx; Vandenabeele; Douglas R. Green; Avi Ashkenazi; Vishva M. Dixit; William J. Kaiser; Andreas Strasser; Alexei Degterev; John Silke

March 3, 2014

Assessment of the hepatic CYP reductase null mouse model and its potential application in drug discovery

Molecular Pharmaceutics, ISSN: 15438384 15438392

Jason Boggs; Cornelis E. Hop; Erin McNamara; Yuzhong Deng; Kirsten Messick; Kristina West; Edna F. Choo

March 1, 2014

The role of body mass index in survival outcome for lymphoma patients: US intergroup experience

Annals of Oncology, ISSN: 09237534 15698041

Fangxin Hong; Thomas M. Habermann; Leo I. Gordon; Hochster; Randy D. Gascoyne; Morrison; Richard I. Fisher; Nancy L. Bartlett; Patrick J. Stiff; Bruce D. Cheson; Michael Crump; Sandra J. Horning; Wojciech Jurczak

March 1, 2014

Discriminative motif analysis of high-throughput dataset

Bioinformatics, ISSN: 13674803 14602059

Zizhen Yao; Kyle L. Macquarrie; Abraham P. Fong; Stephen J. Tapscott; Walter L. Ruzzo; Robert Gentleman

March 1, 2014

DropArray™, a wall-less 96-well plate for uptake and immunofluorescence microscopy, confirms CD22 recycles

Traffic, ISSN: 13989219 16000854

Gladys S. Ingle; Suzie J. Scales

March 1, 2014

Investigations into the mechanisms of pyridine ring cleavage in vismodegibs

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

S. Cyrus Khojasteh; Qin Yue; Shuguang Ma; Georgette M. Castanedo; Jacob Z. Chen; Joseph P. Lyssikatos; Teresa Mulder; Ryan Takahashi; Justin Ly; Kirsten Messick; Wei Jia; Lichuan Liu; Cornelis E. Hop; Harvey Wong

March 1, 2014

Psoriasis-like skin lesions are dependent on IL-23 but develop in the absence of IL-22 in a model mouse

Journal of Dermatological Science, ISSN: 09231811 1873569X

Mikiro Takaishi; Kimiko Nakajima; Wenjun Ouyang; Shigetoshi Sano

March 1, 2014

Sequential C3 and C5 direct C-H arylation of imidazo[1,2-a]pyrazines with (Hetero)aryl bromides

European Journal of Organic Chemistry, ISSN: 1434193X 10990690

Brett M. Johnson; Malcolm P. Huestis

March 1, 2014

The role of body mass index in survival outcome for lymphoma patients: US intergroup experience

Annals of Oncology, ISSN: 09237534 15698041

Fangxin Hong; Thomas M. Habermann; Leo I. Gordon; Hochster; Randy D. Gascoyne; Morrison; Richard I. Fisher; Nancy L. Bartlett; Patrick J. Stiff; Bruce D. Cheson; Michael Crump; Sandra J. Horning; Brad Kahl

March 1, 2014

Solvent-based formulations for intravenous mouse pharmacokinetic studies: Tolerability and recommended solvent dose limits

Xenobiotica, ISSN: 00498254 13665928

Evan A Thackaberry; Xiaojing Wang; Michelle G. Schweiger; Kirsten Messick; Nicole R. Valle; Brian J. Dean; Amy Sambrone; Terri Bowman; Minli Xie

March 1, 2014

Metastatic basal cell carcinoma: Prognosis dependent on anatomic site and spread of disease

European Journal of Cancer, ISSN: 09598049 18790852

Margaret McCusker; Nicole Basset-Seguin; Reinhard Dummer; Karl Lewis; Dirk Schadendorf; Aleksandar Sekulic; Jeannie Hou; Lisa I. Wang; Huibin Yue; Axel Hauschild

March 1, 2014

Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis

Cancer Research, ISSN: 15387445 00085472

Xiang Liu; Chunhui Yi; Yunfei Wen; Prakash Radhakrishnan; Jarrod Tremayne; Thongtan Dao; Keith R. Johnson; Michael A. Hollingsworth

March 1, 2014

Analysis of safety data in clinical trials using a recurrent event approach

Pharmaceutical Statistics, ISSN: 15391604 15391612

Qi Gong; Barbara Tong; Alexander Strasak; Liang Fang

March 1, 2014

A Brief Overview of the 32nd Annual STP Symposium on the Toxicologic Pathology of the Digestive Tract and Pancreas

Veterinary Pathology, ISSN: 03009858 15442217

Dimitry Danilenko; Prashant R. Nambiar; Mark F. Cesta

March 1, 2014

Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy

Virology, ISSN: 00426822 10960341

John R. Teijaro; Kevin B. Walsh; James P. Long; Kevin P. Tordoff; Gregory V. Stark; Amie J. Eisfeld; Yoshihiro Kawaoka; Hugh Rosen; Michael B.A. Oldstone

March 1, 2014

The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections

Infection and Immunity, ISSN: 00199567 10985522

Shrinivas Bishu; Nydiaris Herna´ndez-Santos; Michelle R. Simpson-Abelson; Anna R. Huppler; Heather R. Conti; Nico Ghilardi; Anna J. Mamo; Sarah L. Gaffen

March 1, 2014

Patient-reported outcomes from EMILIA, a randomized phase 3 study of trastuzumab emtansine (T-DM1) versus capecitabine and lapatinib in human epidermal growth factor receptor 2-positive locally advanced or metastatic breast cancer

Cancer, ISSN: 0008543X 10970142

Manfred Welslau; Diéras; Joo-Hyuk Sohn; Sara A. Hurvitz; Deepa Lalla; Liang Fang; Betsy Althaus; Ellie Guardino; David W. Miles

February 25, 2014

Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: Retrospective testing of specimens from the EURTAC trial

PLoS ONE, ISSN: 19326203

Susana Benlloch; Maria F. Botero; Jordi Beltran-Alamillo; Clara Mayo; Ana Gimenez-Capitán; Itziar De Aguirre; Cristina Queralt; Jose Luis Ramirez; Santiago Ramón Y Cajal; Barbara Klughammer; Mariette Schlegel; Walter Bordogna; David Chen; Guili Zhang; Barbara Kovach; Felice Shieh; John F. Palma; Lin Wu; H. Jeffrey Lawrence; Miquel Taron

February 21, 2014

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3

Nature, ISSN: 00280836 14764687

Aditya Murthy; Yun Li; Ivan Peng; Mike Reichelt; Anand K. Katakam; Rajkumar Noubade; Merone Roose-Girma; Jason Devoss; Laurie Diehl; Robert R. Graham; Menno Van Lookeren Campagne

February 20, 2014

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

Immunity, ISSN: 10747613 10974180

Judith Behnsen; Stefan Jellbauer; Christina P. Wong; Robert A. Edwards; Michael D. George; Wenjun Ouyang; Manuela Raffatellu

February 20, 2014

Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues

Immunity, ISSN: 10747613 10974180

Tetsuya Honda; Jackson G. Egen; Tim Lämmermann; Wolfgang Kastenmüller; Parizad Torabi-Parizi; Ronald N. Germain

February 19, 2014

The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth

Nature Communications, ISSN: 20411723

Hyunjoo Kim; Ho-June Lee; Yumin Oh; Seon-Guk Choi; Se-Hoon Hong; Hyo-Jin Kim; Song-Yi Lee; Ji-Woo Choi; Deog Su Hwang; Key-Sun Kim; Hyo-Joon Kim; Jianke Zhang; Hyun-Jo Youn; Dong-Young Noh; Yong-Keun Jung

February 19, 2014

Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer

New England Journal of Medicine, ISSN: 15334406 00284793

Sandra M. Swain; Baselga; Sung-Bae Kim; Jungsil Ro; Vladimir Semiglazov; Mario Campone; Eva Ciruelos; Jean-Marc Ferrero; Andreas Schneeweiss; Sarah Heeson; Emma Clark; Graham Ross; Benyunes; Javier Cortés

February 18, 2014

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Monica Gostissa; Bjoern Schwer; Amelia Chang; Junchao Dong; Robin M. Meyers; Gregory T. Marecki; Vivian W. Choi; Roberto Chiarle; Ali A. Zarrin; Frederick W. Alt

February 18, 2014

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters

Tetrahedron, ISSN: 00404020 14645416

Brian Wong; Xin Linghu; James J. Crawford; Joy Drobnick; Wendy Lee; Haiming Zhang

February 18, 2014

Further insights into the effects of pre-organizing the BimBH3 Helix

ACS Chemical Biology, ISSN: 15548937 15548929

Toru Okamoto; David Segal; Zobel; Anna V. Fedorova; Hong Yang; Wayne J. Fairbrother; David C.S. Huang; Brian J. Smith; Deshayes; Czabotar

February 15, 2014

Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung

Journal of Immunology, ISSN: 00221767 15506606

Parizad Torabi-Parizi; Nienke Vrisekoop; Wolfgang Kastenmüller; Michael Y. Gerner; Jackson G. Egen; Ronald N. Germain

February 13, 2014

Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors

Cell, ISSN: 10974172 00928674

Diego O. Croci; Juan P. Cerliani; Tomas Dalotto-Moreno; Santiago P. Méndez-Huergo; Ivan D. Mascanfroni; Sebastián Dergan-Dylon; Marta A. Toscano; Julio J. Caramelo; Juan J. García-Vallejo; Jing Ouyang; Enrique A. Mesri; Melissa Junttila; Carlos Bais; Margaret A. Shipp; Mariana Salatino; Gabriel A. Rabinovich

February 13, 2014

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type i 1/2 kinase inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Steven T. Staben; Jianwen A. Feng; Karen Lyle; Marcia Belvin; Jason Boggs; Jason D. Burch; Ching-Ching Chua; Haifeng Cui; Antonio G. DiPasquale; Lori S. Friedman; Christopher E. Heise; Koeppen; Adrian Kotey; Robert Mintzer; Angela Oh; David Allen Roberts; Lionel Rouge; Joachim Rudolph; Christine Tam; Weiru Wang; Yisong Xiao; Amy Young; Yamin Zhang; Klaus P. Hoeflich

February 13, 2014

Fragment-based identification of amides derived from trans-2-(pyridin-3-yl) cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Anthony M. Giannetti; Xiaozhang Zheng; Nicholas J. Skelton; Weiru Wang; Brandon Bravo; Kenneth W. Bair; Timm Baumeister; Eric Cheng; Lisa Crocker; Yezhen Feng; Janet Gunzner; Yen-Ching Ho; Rongbao Hua; Bianca M. Liederer; Yongbo Liu; Xiaolei Ma; Thomas O'Brien; Jason Oeh; Deepak Sampath; Youming Shen; Chengcheng Wang; Leslie Wang; Hongxing Wu; Yang Xiao; Po-Wai Yuen; Mark Zak; Guiling Zhao; Qiang Zhao; Peter Dragovich

February 12, 2014

Integrative biology approach identifies cytokine targeting strategies for psoriasis

Science Translational Medicine, ISSN: 19466242 19466234

Gayathri K. Perera; Chrysanthi Ainali; Ekaterina Semenova; Christian Hundhausen; Guillermo Barinaga; Deepika Kassen; Andrew E. Williams; Muddassar M. Mirza; Mercedesz Balazs; Xiaoting Wang; Robert Sanchez Rodriguez; Andrej Alendar; Jonathan Barker; Sophia Tsoka; Wenjun Ouyang; Frank Nestle

February 10, 2014

Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers

PLoS ONE, ISSN: 19326203

Erica Schleifman; Rupal Desai; Jill M. Spoerke; Yuanyuan Xiao; Cheryl Wong; Ilma Abbas; Carol O'Brien; Rajesh Patel; Teiko Sumiyoshi; Ling Fu; Rachel Tam; Koeppen; Wilson; Rajiv Raja; Garret M. Hampton; Lackner

February 10, 2014

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Journal of Experimental Medicine, ISSN: 00221007 15409538

Nga Bien-Ly; Y. Joy Yu; Daniela Bumbaca; Justin Elstrott; C. Andrew Boswell; Yin Zhang; Wilman Luk; Yanmei Lu; Dennis; Robby M. Weimer; Inhee Chung; Ryan J. Watts

February 6, 2014

Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration

Cell Stem Cell, ISSN: 19345909 18759777

Ciara Metcalfe; Noelyn Kljavin; Ryan Ybarra; Frederic J. De Sauvage

February 6, 2014

Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc)

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Benjamin P. Fauber; Steven Magnuson

February 4, 2014

A general approach to site-specific antibody drug conjugates

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Feng Tian; Yingchun Lu; Anthony Manibusan; Aaron Sellers; Hon Tran; Ying Sun; Trung Phuong; Richard Barnett; Brad Hehli; Frank Song; Michael J. DeGuzman; Semsi Ensari; Jason K. Pinkstaff; Lorraine M. Sullivan; Sandra L. Biroc; Ho Cho; Peter G. Schultz; John Di Joseph; Maureen Dougher; Dangshe Ma; Russell Dushin; Mauricio Leal; Lioudmila Tchistiakova; Eric Feyfant; Hans-Peter Gerber; Puja Sapra

February 1, 2014

Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

Nature Reviews Immunology, ISSN: 14741733 14741741

Marcus R. Clark; Malay Mandal; Kyoko Ochiai; Harinder Singh

February 1, 2014

Continued benefit of tocilizumab plus disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis and inadequate clinical responses by week 8 of treatment

Journal of Rheumatology, ISSN: 0315162X 14992752

Edward Keystone; Andrew Anisfeld; Sarika Ogale; Jenny Devenport; Jeffrey R. Curtis

February 1, 2014

Hexyl glucoside and hexyl maltoside inhibit light-induced oxidation of tryptophan

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yilma T. Adem; Patricia Molina; Hongbin Liu; Thomas W. Patapoff; Alavattam Sreedhara; Osigwe Esue

February 1, 2014

Efficacy and safety of danoprevir-ritonavir plus peginterferon alfa-2a-ribavirin in hepatitis C virus genotype 1 prior null responders

Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596

Edward J. Gane; Régine Rouzier; Alicja Wiercinska-Drapalo; Dominique Larrey; Peter N. Morcos; Barbara J. Brennan; Sophie Le Pogam; Nájera; Rosemary Petric; Jonathan Q. Tran; Rohit Kulkarni; Ying Zhang; Patrick F. Smith; Ellen S. Yetzer; Nancy Shulman

February 1, 2014

Ready-to-use cryopreserved primary cells: A novel solution for QC lot release potency assays

BioProcess International, ISSN: 15426319

Hélène Gazzano-Santoro; Linda G. Chan; Mimmi S. Ballard; Judy Young

February 1, 2014

Disconnect between sputum neutrophils and other measures of airway inflammation in asthma

European Respiratory Journal, ISSN: 09031936 13993003

Joseph R. Arron; David F. Choy; Laviolette; Steven G. Kelsen; Ammar Hatab; Richard Leigh; Neil C. Thomson; Eugene R. Bleecker; Ron Olivenstein; Pedro C. Avila; Jarjour; Mario Castro; Gauvreau; James T. Good; Joel N. Kline; Adel Mansur; Mayers; Liam G. Heaney; Qutayba Hamid; Harris

February 1, 2014

Underuse of the health care system by persons with diabetes mellitus and diabetic macular edema in the United States

JAMA Ophthalmology, ISSN: 21686165

Neil M. Bressler; Rohit Varma; Quan V. Doan; Michelle Gleeson; Mark Danese; Julie K. Bower; Elizabeth Selvin; Chantal M. Dolan; Jennifer T. Fine; Shoshana Colman; Adam Turpcu

February 1, 2014

Interview: Experiences targeting B cells for the treatment of multiple sclerosis

Immunotherapy, ISSN: 1750743X 17507448

Andrew A. Chan; Albert Jan Schutte

February 1, 2014

Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Peter Dragovich; Guiling Zhao; Timm Baumeister; Brandon Bravo; Anthony M. Giannetti; Yen-Ching Ho; Rongbao Hua; Guangkun Li; Xiaorong Liang; Xiaolei Ma; Thomas O'Brien; Angela Oh; Nicholas J. Skelton; Chengcheng Wang; Weiru Wang; Yunli Wang; Yang Xiao; Po-Wai Yuen; Mark Zak; Qiang Zhao; Xiaozhang Zheng

February 1, 2014

Nonclinical evaluation of the serum pharmacodynamic biomarkers HGF and shed MET following dosing with the anti-MET monovalent monoclonal antibody onartuzumab

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Elaine Mai; Zhong Zheng; Youjun Chen; Jing Peng; Christophe Severin; Ellen H. Filvaroff; Mally Romero; William Mallet; Surinder Kaur; Thomas R. Gelzleichter; Ihsan Nijem; Mark Merchant; Judy Young

February 1, 2014

A phase ia dose-escalation study of the anti-factor D monoclonal antibody fragment FCFD4514S in patients with geographic atrophy

Retina, ISSN: 0275004X 15392864

Diana V. Do; Dante Joseph Pieramici; Menno Van Lookeren Campagne; Tatiana Beres; Michel Friesenhahn; Yi Zhang; Erich C. Strauss

February 1, 2014

Exploring concepts of in vitro time-dependent CYP inhibition assays

Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607

David M Stresser; Jialin Mao; Jane R. Kenny; Barry C Jones; Kenneth Grime

February 1, 2014

Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model

Journal of General Virology, ISSN: 00221317 14652099

Carrie M. Rosenberger; Rebecca L. Podyminogin; Peter S. Askovich; Garnet Navarro; Shari M. Kaiser; Catherine J. Sanders; Jennifer L. McClaren; Vincent C. Tam; Pradyot Dash; Jhoanna G. Noonan; Bart G. Jones; Sherri L. Surman; Jacques J. Peschon; Alan H. Diercks; Julia L. Hurwitz; Peter C. Doherty; Paul G. Thomas; Alan Aderem

February 1, 2014

The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Edna F. Choo; Jason Boggs; Chunqiang Zhu; Joseph W. Lubach; Nathaniel D. Catron; Gary Jenkins; Andrew J. Souers; Richard Voorman

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