Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6701 - 6750 OF 15796 RESULTS

February 1, 2014

Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss

Ophthalmology, ISSN: 01616420 15494713

Stephanie J. Loomis; Jae H. Kang; Robert N. Weinreb; Brian L. Yaspan; Jessica Cooke Bailey; Douglas Gaasterland; Terry Gaasterland; Richard K. Lee; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Peter Kraft; Kang Zhang; R. Rand Allingham; Brian W. Kunkle; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Louis R. Pasquale; Janey L. Wiggs

January 29, 2014

Novel quantitative autophagy analysis by organelle flow cytometry after cell sonication

PLoS ONE, ISSN: 19326203

Michael Degtyarev; Mike Reichelt; Kui Lin

January 22, 2014

Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

Tetrahedron Letters, ISSN: 00404039 18733581

Olivier René; Benjamin P. Fauber

January 17, 2014

Practical nonazide synthesis of a D-amino acid oxidase inhibitor via a sequential erlenmeyer-plöchl reaction and ligand-free copper(I) amination protocol

Organic Process Research and Development, ISSN: 1520586X 10836160

Hang Zhao; Stefan G. Koenig; John W. Dankwardt; Surendra P. Singh

January 17, 2014

An efficient catalytic asymmetric synthesis of a β2-amino acid on multikilogram scale

Organic Process Research and Development, ISSN: 1520586X 10836160

Travis Remarchuk; Srinivasan Babu; Jeffrey Stults; Antonio Zanotti-Gerosa; Stephen Roseblade; Shaohui Yang; Ping Huang; Chunbo Sha; Youchu Wang

January 16, 2014

The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma

Oncogene, ISSN: 09509232 14765594

Veerendra Munugalavadla; Sanjeev Mariathasan; Dionysos S. Slaga; Du; Berry; Geoffrey Del Rosario; Yibing Yan; Boe; Liping L. Sun; Lori S. Friedman; Chesi; P. Lief Bergsagel; Allen Ebens

January 16, 2014

Th17 cells at the crossroads of autoimmunity, inflammation, and atherosclerosis

Immunity, ISSN: 10747613 10974180

Nicholas Vanbruggen; Wenjun Ouyang

January 15, 2014

Chk1 inhibition in p53 deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death

Cell Cycle, ISSN: 15514005 15384101

Christopher J. Del Nagro; Jonathan Choi; Yang Xiao; Linda Rangell; Sankar Mohan; Ajay Pandita; Jiping Zha; Peter K Jackson; Thomas O'Brien

January 15, 2014

Dual targeting of HER2-positive cancer with trastuzumab emtansine and pertuzumab: Critical role for neuregulin blockade in antitumor response to combination therapy

Clinical Cancer Research, ISSN: 10780432 15573265

Gail L. Phillips; Carter Fields; Guangmin Li; Dowbenko; Gabriele Schaefer; Kathy Miller; Fabrice Andre; Howard A. Burris; Kathy S. Albain; Nadia Harbeck; Diéras; Diana Crivellari; Liang Fang; Ellie Guardino; Steve Olsen; Lisa Crocker; Mark X. Sliwkowski

January 15, 2014

Inhibition of c-kit is not required for reversal of hyperglycemia by imatinib in NOD mice

PLoS ONE, ISSN: 19326203

Janet Lau; Qiang Zhou; Susan E. Sutton; Ann E. Herman; Christian Schmedt; Richard Glynne

January 15, 2014

Future directions in idiopathic pulmonary fibrosis research an NHLBI workshop report

American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970

Timothy S. Blackwell; Andrew M. Tager; Zea Borok; Bethany B. Moore; David A. Schwartz; Kevin J. Anstrom; Ziv Bar-Joseph; Peter Bitterman; Michael R. Blackburn; Williamson Bradford; Kevin K. Brown; Harold A. Chapman; Harold R. Collard; Gregory P. Cosgrove; Robin Deterding; Ramona Doyle; Kevin R. Flaherty; Christine Kim Garcia; James S. Hagood; Craig A. Henke; Erica Herzog; Cory M. Hogaboam; Jeffrey C. Horowitz; Talmadge E. King Jr.; James E. Loyd; William E. Lawson; Clay B. Marsh; Paul W. Noble; Imre Noth; Dean Sheppard; Julie Olsson; Luis A. Ortiz; Thomas G. O'Riordan; Tim D. Oury; Ganesh Raghu; Jesse Roman; Patricia J. Sime; Thomas H. Sisson; Daniel Tschumperlin; Shelia M. Violette; Timothy E. Weaver; Rebecca G. Wells; Eric S. White; Naftali Kaminski; Fernando J. Martinez; Thomas A. Wynn; Victor J. Thannickal; Jerry P. Eu

January 15, 2014

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Biochemical Journal, ISSN: 02646021 14708728

James M. Murphy; Qingwei Zhang; Samuel N. Young; Michael L. Reese; Fiona P. Bailey; Patrick A. Eyers; Daniela Ungureanu; Henrik Hammaren; Olli Silvennoinen; Leila N. Varghese; Kelan Chen; Anne Tripaydonis; Natalia Jura; Koichi Fukuda; Jun Qin; Zachary Nimchuk; Mary Beth Mudgett; Sabine Elowe; Christine L. Gee; Ling Liu; Roger J. Daly; Gerard Manning; Jeffrey J. Babon; Isabelle S. Lucet

January 10, 2014

Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Yingnan Zhang; Eigenbrot; Lijuan Zhou; Steven Shia; Wei Li; Quan; Jeffrey Tom; Paul Moran; Paola Di Lello; Nicholas J. Skelton; Monica Kong-Beltran; Andrew S. Peterson; Daniel Kirchhofer

January 9, 2014

Small molecule disruptors of the Glucokinase-Glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Kate S. Ashton; Kristin L. Andrews; Marian C. Bryan; Jie Chen; Kui Chen; Michelle Chen; Samer Chmait; Michael Croghan; Rod Cupples; Christopher Fotsch; Joan Helmering; Steve R. Jordan; Robert J. M. Kurzeja; Klaus Michelsen; Lewis D. Pennington; Steve F. Poon; Glenn Sivits; Gwyneth Van; Steve L. Vonderfecht; Robert C. Wahl; Jiandong Zhang; David J. Lloyd; Clarence Hale; David J. St. Jean

January 7, 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Nature, ISSN: 00280836 14764687

Yukinori Okada; Di Wu; Gosia Trynka; Towfique Raj; Chikashi Terao; Katsunori Ikari; Yuta Kochi; Koichiro Ohmura; Akari Suzuki; Shinji Yoshida; Robert R. Graham; Arun Manoharan; Ward Ortmann; Tushar Bhangale; Joshua C. Denny; Robert J. Carroll; Anne E. Eyler; Greenberg; Joel M. Kremer; Dimitrios A. Pappas; Lei Jiang; Jian Yin; Lingying Ye; Ding-Feng Su; Jian Yang; Gang Xie; Edward Keystone; Harm-Jan Westra; Toñu Esko; Andres Metspalu; Xuezhong Zhou; Namrata Gupta; Daniel B. Mirel; Eli A. Stahl; Dorothée Diogo; Jing Cui; Katherine P. Liao; Michael H. Guo; Keiko Myouzen; Takahisa Kawaguchi; Marieke J.H. Coenen; Piet L.C.M. Van Riel; Mart A. F. J. Van De Laar; Henk-Jan Guchelaar; Tom W. J. Huizinga; Philippe Dieudé; Xavier Mariette; S. Louis Bridges Jr.; Alexandra Zhernakova; Toes; Paul P. Tak; Corinne Miceli-Richard; So-Young Bang; Hye-Soon Lee; Javier Martin; Miguel A. Gonzalez-Gay; Luis Rodriguez-Rodriguez; Solbritt Rantapää-Dahlqvist; Lisbeth Ärlestig; Hyon Choi; Yoichiro Kamatani; Pilar Galan; Mark Lathrop; Steve Eyre; John Bowes; Anne Barton; Niek De Vries; Larry W. Moreland; Lindsey A. Criswell; Elizabeth W. Karlson; Atsuo Taniguchi; Ryo Yamada; Michiaki Kubo; Jun S. Liu; Sang-Cheol Bae; Jane Worthington; Leonid Padyukov; Lars Klareskog; Peter K. Gregersen; Soumya Raychaudhuri; Barbara E. Stranger; Philip L. De Jager; Lude Franke; Peter M. Visscher; Matthew A. Brown; Hisashi Yamanaka; Tsuneyo Mimori; Atsushi Takahashi; Huji Xu; Timothy W. Behrens; Katherine A. Siminovitch; Shigeki Momohara; Fumihiko Matsuda; Kazuhiko Yamamoto; Robert M. Plenge

January 7, 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Nature, ISSN: 00280836 14764687

Cecilia M. Lindgren; Di Wu; Gosia Trynka; Towfique Raj; Chikashi Terao; Katsunori Ikari; Yuta Kochi; Koichiro Ohmura; Akari Suzuki; Shinji Yoshida; Robert R. Graham; Arun Manoharan; Ward Ortmann; Tushar Bhangale; Joshua C. Denny; Robert J. Carroll; Anne E. Eyler; Greenberg; Joel M. Kremer; Dimitrios A. Pappas; Lei Jiang; Jian Yin; Lingying Ye; Ding-Feng Su; Jian Yang; Gang Xie; Edward Keystone; Harm-Jan Westra; Toñu Esko; Andres Metspalu; Xuezhong Zhou; Namrata Gupta; Daniel B. Mirel; Eli A. Stahl; Dorothée Diogo; Jing Cui; Katherine P. Liao; Michael H. Guo; Keiko Myouzen; Takahisa Kawaguchi; Marieke J.H. Coenen; Piet L.C.M. Van Riel; Mart A. F. J. Van De Laar; Henk-Jan Guchelaar; Tom W. J. Huizinga; Philippe Dieudé; Xavier Mariette; S. Louis Bridges Jr.; Alexandra Zhernakova; Toes; Paul P. Tak; Corinne Miceli-Richard; So-Young Bang; Hye-Soon Lee; Javier Martin; Miguel A. Gonzalez-Gay; Luis Rodriguez-Rodriguez; Solbritt Rantapää-Dahlqvist; Lisbeth Ärlestig; Hyon Choi; Yoichiro Kamatani; Pilar Galan; Mark Lathrop; Steve Eyre; John Bowes; Anne Barton; Niek De Vries; Larry W. Moreland; Lindsey A. Criswell; Elizabeth W. Karlson; Atsuo Taniguchi; Ryo Yamada; Michiaki Kubo; Jun S. Liu; Sang-Cheol Bae; Jane Worthington; Leonid Padyukov; Lars Klareskog; Peter K. Gregersen; Soumya Raychaudhuri; Barbara E. Stranger; Philip L. De Jager; Lude Franke; Peter M. Visscher; Matthew A. Brown; Hisashi Yamanaka; Tsuneyo Mimori; Atsushi Takahashi; Huji Xu; Timothy W. Behrens; Katherine A. Siminovitch; Shigeki Momohara; Fumihiko Matsuda; Kazuhiko Yamamoto; Robert M. Plenge

January 7, 2014

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Allen A. Thomas; Kevin W. Hunt; Matthew Volgraf; Ryan J. Watts; Xingrong Liu; Guy Vigers; Darin Smith; Douglas Sammond; Tony P. Tang; Susan P. Rhodes; Andrew T. Metcalf; Karin D. Brown; Jennifer N. Otten; Michael Burkard; April Cox; Mary K. Geck Do; Darrin Dutcher; Sumeet Rana; Robert K. Delisle; Kelly Regal; Albion D. Wright; Robert Groneberg; Kimberly Scearce-Levie; Michael Siu; Hans E. Purkey; Joseph P. Lyssikatos; Indrani W. Gunawardana

January 6, 2014

Diagnosis-driven individualization of cancer care

The Bethesda Handbook of Clinical Oncology: Fourth Edition,

Philippe C. Bishop; Chris J. Bowden; Garret M. Hampton; Lukas Amler

January 6, 2014

Defining the ligand specificity of the Deleted in Colorectal Cancer (DCC) receptor

PLoS ONE, ISSN: 19326203

Patrick C. G. Haddick; Irene Tom; Luis; Gabriel Quinones; Bernd Wranik; Sree R. Ramani; Jean-Philippe Stephan; Marc Tessier-Lavigne; Lino C. Gonzalez Jr.

January 6, 2014

Discovery of potential anti-infectives against Staphylococcus aureus using a Caenorhabditis elegans infection model

BMC Complementary and Alternative Medicine, ISSN: 14726882

Cin Kong; Wageeh A. Yehye; Noorsaadah Abd Rahman; Man-Wah Tan; Sheila Nathan

January 5, 2014

Long-term depression: A cell biological view

Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN: 14712970 09628436

Morgan Sheng; Ali Ertürk

January 2, 2014

A versatile annulation route to primary-amino-substituted naphthyridine esters

Synlett, ISSN: 09365214 14372096

Jinhua Chen; Zijin Xu; Tao Wang; Joseph P. Lyssikatos; Chudi O. Ndubaku

January 2, 2014

Depressive, functional status, and neuropsychiatric symptom trajectories before an Alzheimer's disease diagnosis

Aging and Mental Health, ISSN: 13607863 13646915

Joseph E. Gaugler; Martha Hovater; David L. Roth; Joseph A. Johnston; Robert L. Kane; Khaled Sarsour

January 1, 2014

A20-a bipartite ubiquitin editing enzyme with immunoregulatory potential

Advances in Experimental Medicine and Biology, ISSN: 22148019 00652598

Ingrid E. Wertz; Vishva M. Dixit

January 1, 2014

Bevacizumab and cyclosphosphamide, doxorubicin, vincristine and prednisone in combination for patients with peripheral T-cell or natural killer cell neoplasms: An Eastern Cooperative Oncology Group study (E2404)

Leukemia and Lymphoma, ISSN: 10292403 10428194

Kristen Ganjoo; Fangxin Hong; Sandra J. Horning; Randy D. Gascoyne; Yasodha Natkunam; Lode J. Swinnen; Thomas M. Habermann; Wojciech Jurczak; Ranjana H. Advani

January 1, 2014

A phase I study of PRO131921, a novel anti-CD20 monoclonal antibody in patients with relapsed/refractory CD20+ indolent NHL: Correlation between clinical responses and AUC pharmacokinetics

Clinical Immunology, ISSN: 15217035 15216616

Carla Casulo; Julie Vose; William Y. Ho; Wojciech Jurczak; Mark Brunvand; Andre Goy; Yvette Kasamon; Bruce D. Cheson; Jonathan W. Friedberg

January 1, 2014

Phase 2 study of VcR-CVAD with maintenance rituximab for untreated mantle cell lymphoma: An Eastern Cooperative Oncology Group study (E1405)

Blood, ISSN: 15280020 00064971

Julie E. Chang; Hailun Li; Smith; Randy D. Gascoyne; Elisabeth M. Paietta; David T. Yang; Ranjana H. Advani; Sandra J. Horning; Wojciech Jurczak

January 1, 2014

The rheumatoid arthritis treat-to-target trial: A cluster randomized trial within the Corrona rheumatology network

BMC Musculoskeletal Disorders, ISSN: 14712474

Leslie R. Harrold; Reed; J. Timothy Harrington; Christine J. Barr; Katherine C. Saunders; Allan Gibofsky; Jeffrey D. Greenberg; Ani John; Jenny Devenport; Joel M. Kremer

January 1, 2014

Mechanistic studies of the cationic binding pocket of CYP2C9 in vitro and in silico: Metabolism of nonionizable analogs of tienilic acid

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Suzanne Tay; Hoa Le; Kevin A. Ford; Sidney D. Nelson; S. Cyrus Khojasteh; Peter M. Rademacher

January 1, 2014

Dichotomizing a Continuous Baseline Covariate in Randomized Clinical Trials with Binary Outcomes

Communications in Statistics: Simulation and Computation, ISSN: 15324141 03610918

Boan Zhang; Yunzhi Lin; Zheng Su

January 1, 2014

Steric and electronic factors influence regio-isomeric thiazole formations between substituted benzothioamides and ethyl bromopyruvate

Journal of Heterocyclic Chemistry, ISSN: 19435193 0022152X

Jun Liang; Valerie Dorman Soucy; Vickie Tusi; Yanzhou Liu; Birong Zhang; Yingjie Lai; Steven Magnuson; Bing-Yan Zhu; Fangdao Wang; Jinghao Gu; Qingfen Zhang; Yuan Wu; Wei Deng; Wenqian Yang

January 1, 2014

Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: Quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Bhagwat Prasad; Raymond Evers; Anshul Gupta; Cornelis E. Hop; Laurent Salphati; Suneet Shukla; Suresh V. Ambudkar; Jashvant D. Unadkat

January 1, 2014

Molecular beacons for intracellular analysis: Challenges and successes

Molecular Beacons,

Colin D. Medley; Zhi Zhu

January 1, 2014

Reference standards for therapeutic proteins

BioProcess International, ISSN: 15426319

Mire-Sluis; Nadine Ritter; Barry Cherney; Dieter Schmalzing; Markus Blümel

January 1, 2014

Reference standards for therapeutic proteins

BioProcess International, ISSN: 15426319

Mire-Sluis; Nadine Ritter; Barry Cherney; Dieter Schmalzing; Markus Blümel

January 1, 2014

Etrolizumab as induction therapy for ulcerative colitis: A randomised, controlled, phase 2 trial

The Lancet, ISSN: 1474547X 01406736

Séverine Vermeire; Sharon O'Byrne; Mary E. Keir; Marna Williams; Timothy T. Lu; John C Mansfield; Christopher A. Lamb; Brian G. Feagan; Julián Panés; Azucena Salas; Daniel C. Baumgart; Stefan Schreiber; Iris Dotan; William J. Sandborn; Tew; Diana Luca; Meina Tao Tang; Laurie Diehl; Jeffrey Eastham-Anderson; Gert De Hertogh; Clementine Perrier; Jackson G. Egen; John A. Kirby; Gert Van Assche; Paul J. Rutgeerts

January 1, 2014

Multiplexed ion beam imaging of human breast tumors

Nature Medicine, ISSN: 1546170X 10788956

Michael Angelo; Sean C. Bendall; Rachel Finck; Matthew B. Hale; Chuck Hitzman; Alexander D. Borowsky; Richard M. Levenson; John Lowe; Scot D. Liu; Shuchun Zhao; Yasodha Natkunam; Garry P. Nolan

January 1, 2014

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Heidi J. A. Wallweber; Christine Tam; Yvonne Franke; Melissa A. Starovasnik; Patrick J. Lupardus

January 1, 2014

Model-based meta-analysis for quantifying paclitaxel dose response in cancer patients

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Dan Lu; Amita Joshi; Li; Nancy Zhang; Melanie Ren; Yuying Gao; Russell D. Wada; Jin Y. Jin

January 1, 2014

Byproducts of commonly used coupling reagents: Origin, toxicological evaluation and methods for determination

American Pharmaceutical Review, ISSN: 10998012

Larry Wigman; Travis Remarchuk; Stephen Gomez; Archana Kumar; Michael W. Dong; Colin D. Medley; Nik P. Chetwyn

January 1, 2014

New FDA draft guidance on immunogenicity

AAPS Journal, ISSN: 15507416

Ashwin Parenky; Heather Myler; Lakshmi Amaravadi; Karoline Bechtold-Peters; Amy Rosenberg; Susan Kirshner; Quarmby

January 1, 2014

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: Metabolite structure, kinetics, inducibility, and interindividual variability

Endocrinology, ISSN: 19457170 00137227

Zhican Wang; Timothy Wong; Takanori Hashizume; Leslie Dickmann; Michele Scian; Nicholas J. Koszewski; Jesse P. Goff; Ronald L. Horst; Amarjit S. Chaudhry; Erin G. Schuetz; Kenneth E. Thummel

January 1, 2014

Change notifications for single use components: Criteria from an end user perspective

Pharmaceutical Engineering, ISSN: 02738139

Sally Kline; Ekta Mahajan; Darrell Morrow; Bob Steininger; Nancy Sweeney; Russell Wong

January 1, 2014

Sleeping our Alzheimer's risk away

Journal of Experimental Medicine, ISSN: 15409538 00221007

Ryan J. Watts

January 1, 2014

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

Science, ISSN: 10959203 00368075

Kim Newton; Dugger; Katherine E. Wickliffe; Neeraj Kapoor; Maria Cristina De Almagro; Domagoj Vucic; László Kömüves; Ron Ferrando; French; Webster; Merone Roose-Girma; Søren Warming; Vishva M. Dixit

January 1, 2014

Evaluation of two commercial omalizumab/free IgE immunoassays: Implications of use during therapy

Current Medical Research and Opinion, ISSN: 14734877 03007995

Baker; Kun Peng; Melissa Cheu; Saloumeh Kadkhodayan Fischer

January 1, 2014

CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis

Mucosal Immunology, ISSN: 19353456 19330219

Moshkovits; Shik; Itan; Karo-Atar; Bernshtein; Hershko; Menno Van Lookeren Campagne; Munitz

January 1, 2014

Administration of Anti-CD20 mAb Is Highly Effective in Preventing but Ineffective in Treating Chronic Graft-Versus-Host Disease While Preserving Strong Graft-Versus-Leukemia Effects

Biology of Blood and Marrow Transplantation, ISSN: 15236536 10838791

Heather F. Johnston; Yajing Xu; Jeremy J. Racine; Kaniel Cassady; Xiong Ni; Tao Wu; Andrew A. Chan; Stephen Forman; Defu Zeng

January 1, 2014

A mechanistic systems pharmacology model for prediction of LDL cholesterol lowering by PCSK9 antagonism in human dyslipidemic populations

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Kapil Gadkar; Nageshwar Budha; Amos Baruch; John Davis; Fielder; Ramanujan

January 1, 2014

When assay format matters: A case study on the evaluation of three assay formats to support a clinical pharmacokinetic study

AAPS Journal, ISSN: 15507416

Kun Peng; Baker; Suzanne Brignoli; Janis Cabuhat; Saloumeh Kadkhodayan Fischer

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