Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7001 - 7050 OF 15650 RESULTS

October 15, 2013

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5- carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Xiaozhang Zheng; Kenneth W. Bair; Paul Bauer; Timm Baumeister; Krista K. Bowman; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Yezhen Feng; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Hong Li; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Justin Ly; Thomas O'Brien; Jason Oeh; Angela Oh; Dominic J. Reynolds; Deepak Sampath; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jarrod Tremayne; Leslie Wang; Weiru Wang; Zhongguo Wang; Hongxing Wu; Jiansheng Wu; Yang Xiao; Guangxing Yang; Po-Wai Yuen; Mark Zak; Peter Dragovich

October 1, 2013

New paradigms for process validation: A practical approach

BioProcess International, ISSN: 15426319

Mire-Sluis; Vijay Chiruvolu; Kelley; Linda Ng; Reb Russell; Chiang Syin; Victor Vinci; Mats Welin; Nathan McKnight; Bob Kuhn; Christian Klock; Ranjit Deshmukh; Siddharth Advant

October 1, 2013

Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Elizabeth M. Blackwood; Jennifer A. Epler; Ivana Yen; Michael Flagella; Thomas O'Brien; Marie Evangelista; Stephen Schmidt; Yang Xiao; Jonathan Choi; Kaska Kowanetz; Judi Ramiscal; Kenton Wong; Diana Jakubiak; Sharon Fong Yee; Cain; Lewis Gazzard; Karen Williams; Jason S Halladay; Peter K Jackson; Shiva Malek

October 1, 2013

A dual host vector for Fab phage display and expression of native IgG in mammalian cells

Protein Engineering, Design and Selection, ISSN: 17410126 17410134

Devin B. Tesar; Isidro Hötzel

October 1, 2013

SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Rebecca R. Pferdehirt; Barbara J. Meyer

October 1, 2013

Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins

PLoS Pathogens, ISSN: 15537366 15537374

Wouter L. W. Hazenbos; Kimberly K. Kajihara; Richard L. Vandlen; J. Hiroshi Morisaki; Sophie M. Lehar; Mark J. Kwakkenbos; Tim Beaumont; Arjen Q. Bakker; Qui Phung; Lee R. Swem; Satish Ramakrishnan; Janice Kim; Min Xu; Ishita M. Shah; Binh An Diep; Tao Sai; Andrew Sebrell; Yana Khalfin; Angela Oh; Christopher M. Koth; S. Jack Lin; Byoung-Chul Lee; Magnus Strandh; Klaus Koefoed; Peter S. Andersen; Hergen Spits; Eric J. Brown; Man-Wah Tan; Sanjeev Mariathasan

October 1, 2013

Considerations for the successful co-development of targeted cancer therapies and companion diagnostics

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Jane Fridlyand; Richard M. Simon; Jessica C. Walrath; Roach; Richard Buller; David P. Schenkein; Keith Flaherty; Jeff D. Allen; Ellen V. Sigal; Scher

October 1, 2013

Spray Drying of Monoclonal Antibodies: Investigating Powder-Based Biologic Drug Substance Bulk Storage

Drying Technology, ISSN: 07373937 15322300

Mayumi Bowen; Robert Turok; Maa

October 1, 2013

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

Journal of Clinical Investigation, ISSN: 00219738 15588238

Holly Martin; Raghuveer Singh Mali; Peilin Ma; Anindya Chatterjee; Baskar Ramdas; Emily Sims; Veerendra Munugalavadla; Joydeep Ghosh; Matringly; Valeria Visconte; Ramon V. Tiu; Cornelis P. Vlaar; Suranganie Dharmawardhane; Reuben Kapur

October 1, 2013

The anatomy of successful computational biology software

Nature Biotechnology, ISSN: 10870156 15461696

Stephen Altschul; Barry Demchak; Richard Durbin; Robert Gentleman; Martin Krzywinski; Heng Li; Anton Nekrutenko; James Robinson; Wayne Rasband; James Taylor; Cole Trapnell

October 1, 2013

A high-throughput functional complementation assay for classification of BRCA1 missense variants

Cancer Discovery, ISSN: 21598274 21598290

Peter Bouwman; Hanneke van der Gulden; Ingrid van der Heijden; Rinske Drost; Christiaan N. Klijn; Pramudita Prasetyanti; Mark Pieterse; Ellen Wientjens; Jost Seibler; Frans B.L. Hogervorst; Jos Jonkers

October 1, 2013

Mass spectrometry of antibody-drug conjugates in plasma and tissue in drug development

Characterization of Protein Therapeutics using Mass Spectrometry,

Surinder Kaur; Keyang Xu; Ola M. Saad; Luna Liu; Tim Slattery; Randall Dere

October 1, 2013

Hepatitis C virus therapy is associated with lower health care costs not only in noncirrhotic patients but also in patients with end-stage liver disease

Alimentary Pharmacology and Therapeutics, ISSN: 02692813 13652036

Gordon; Hamzeh; Pockros; Hoop; Buikema; Korner; Terrault

October 1, 2013

Long-term outcomes of ranibizumab therapy for diabetic macular edema: The 36-month results from two phase III trials: RISE and RIDE

Ophthalmology, ISSN: 01616420 15494713

David M. Brown; Quan Dong Nguyen; Dennis Marcus; David S. Boyer; Sunil Patel; Leonard Feiner; Patricio G. Schlottmann; Amy Chen Rundle; Jiameng Zhang; Roman G. Rubio; Anthony P. Adamis; Jason S. Ehrlich; J. Jill Hopkins

October 1, 2013

Racial disparities in treatment patterns and clinical outcomes in patients with HER2-positive metastatic breast cancer

Breast Cancer Research and Treatment, ISSN: 01676806 15737217

Hope S. Rugo; Adam Brufsky; Marianne Ulcickas Yood; Debasish Tripathy; Peter A. Kaufman; Musa Mayer; Bongin Yoo; Oyewale Abidoye; Denise A. Yardley

October 1, 2013

Bevacizumab confers additional advantage to the combination of trastuzumab plus pertuzumab in trastuzumab-refractory breast cancer model

Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843

Yuliang Sun; Nandini Dey; Melissa Brammer; Pradip De; Brian R. Leyland-Jones

October 1, 2013

In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release

Nature Medicine, ISSN: 10788956 1546170X

Richard H. Scheller

October 1, 2013

B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes

Clinical and Experimental Immunology, ISSN: 00099104 13652249

Rajasekaran; Nan Wang; Hang; Macaubas; Rinderknecht; Beilhack; Shizuru; Mellins

September 27, 2013

The structure and regulation of magnesium selective ion channels

Biochimica et Biophysica Acta - Biomembranes, ISSN: 00052736 18792642

Jian Payandeh; Roland Pfoh; Emil F. Pai

September 26, 2013

The RosettaCon 2012 Special Collection: Code Writ on Water, Documentation Writ in Stone

PLoS ONE, ISSN: 19326203

Ingemar André; Jacob E. Corn

September 25, 2013

Influence of tumour micro-environment heterogeneity on therapeutic response

Nature, ISSN: 00280836 14764687

Melissa Junttila; Frederic J. De Sauvage

September 24, 2013

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Shahram Misaghi; Kate Senger; Tao Sai; Yan Qu; Yonglian Sun; Kajal Hamidzadeh; Allen Nguyen; Zhaoyu Jin; Meijuan Zhou; Donghong Yan; Wei Yu Lin; Zhonghua Lin; Maria N. Lorenzo; Andrew Sebrell; Jiabing Ding; Min Xu; Patrick Caplazi; Cary D. Austin; Mercedesz Balazs; Merone Roose-Girma; Laura DeForge; Søren Warming; Wyne P. Lee; Vishva M. Dixit; Ali A. Zarrin

September 23, 2013

Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies

Journal of Experimental Medicine, ISSN: 00221007 15409538

Kim; Avi Ashkenazi

September 23, 2013

Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control

BMC Genomics, ISSN: 14712164

Emanuele De Rinaldis; Patrycja Gazinska; Anca Mera; Zora Modrusan; Grazyna Fedorowicz; Brian Burford; Cheryl Gillett; Pierfrancesco Marra; Anita Grigoriadis; David Dornan; Lars Holmberg; Sarah Pinder; Andrew Tutt

September 20, 2013

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

Journal of Cell Biology, ISSN: 00219525 15408140

Sarah Huntwork-Rodriguez; Bei Wang; Trent A. Watkins; Arundhati Sengupta Ghosh; Christine D. Pozniak; Daisy J. Bustos; Kim Newton; Donald S. Kirkpatrick; Joe Lewcock

September 20, 2013

Using glucaminium-based ionic liquids for improving the separation of 2-aminopyrimidine-5-ylboronic acid and its pinacol ester by high performance liquid chromatography

Journal of Chromatography A, ISSN: 00219673 18733778

Manishkumar D. Joshi; Tianhao Li; Qiqing Zhong; Jared L. Anderson

September 20, 2013

Differential Host Response, Rather Than Early Viral Replication Efficiency, Correlates with Pathogenicity Caused by Influenza Viruses

PLoS ONE, ISSN: 19326203

Peter S. Askovich; Catherine J. Sanders; Carrie M. Rosenberger; Alan H. Diercks; Pradyot Dash; Garnet Navarro; Peter Vogel; Peter C. Doherty; Paul G. Thomas; Alan Aderem

September 16, 2013

Structural and biophysical insights into the role of CD4 and CD8 in T cell activation

Frontiers in Immunology, ISSN: 16643224

Yili Li; Yiyuan Yin; Roy A. Mariuzza

September 16, 2013

Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells

Nature Immunology, ISSN: 15292908 15292916

Kamalakannan Rajasekaran; Pawan Kumar; Kristina M. Schuldt; Erik J. Peterson; Bart Vanhaesebroeck; Vishva M. Dixit; Monica S. Thakar; Subramaniam Malarkannan

September 16, 2013

Peripherally induced Tregs-role in immune homeostasis and autoimmunity

Frontiers in Immunology, ISSN: 16643224

Mahesh Yadav; Stephen Stephan; Jeffrey A. Bluestone

September 15, 2013

SIR-nucleosome interactions: Structure-function relationships in yeast silent chromatin

Gene, ISSN: 03781119 18790038

Mariano Oppikofer; Stephanie Kueng; Susan M. Gasser

September 15, 2013

A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Wendy Lee; Daniel F. Ortwine; Philippe Bergeron; Kevin Lau; Lichuan Liu; Shiva Malek; Jim Nonomiya; Zhonghua Pei; Kirk D. Robarge; Stephen Schmidt; Steve Sideris; Joseph P. Lyssikatos

September 15, 2013

Onartuzumab (MetMab): Using nonclinical pharmacokinetic and concentration-effect data to support clinical development

Clinical Cancer Research, ISSN: 10780432 15573265

Hong Xiang; Brendan C. Bender; Arthur Reyes; Mark Merchant; Nelson L. Shasha Jumbe; Mally Romero; Teresa Davancaze; Ihsan Nijem; Elaine Mai; Judy Young; Amy Peterson; Lisa A. Damico

September 13, 2013

Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Christoph Spiess; Jack Bevers; Janet Jackman; Nancy Y. Chiang; Nakamura; Michael Dillon; Hongbin Liu; Patricia Molina; J. Michael Elliott; Whitney Shatz; Justin M. Scheer; Glen Giese; Josefine Persson; Yin Zhang; Dennis; James Giulianotti; Prateek Gupta; Dorothea Reilly; Enzo Palma; Jianyong Wang; Stefanich; Heleen Scheerens; Fuh; Lawren C. Wu

September 12, 2013

GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2

PLoS ONE, ISSN: 19326203

Nelson; Morgan Sheng

September 10, 2013

Multicenter Intestinal Current Measurements in Rectal Biopsies from CF and Non-CF Subjects to Monitor CFTR Function

PLoS ONE, ISSN: 19326203

John P. Clancy; Rhonda D. Szczesniak; Melissa A. Ashlock; Sarah E. Ernst; Lijuan Fan; Douglas B. Hornick; Philip H. Karp; Umer Khan; James Lymp; Alicia J. Ostmann; Amir Rezayat; Timothy D. Starner; Shajan P. Sugandha; Hongtao Sun; Nancy Quinney; Scott H. Donaldson; Steven M. Rowe; Sherif E. Gabriel

September 10, 2013

Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Song-Hua Lee; Rui-Rui Wong; Chui-Yoke Chin; Tian-Yeh Lim; Su-Anne Eng; Cin Kong; Nur Afifah Ijap; Ming-Seong Lau; Mei-Perng Lim; Yunn-Hwen Gan; Fang-Lian He; Man-Wah Tan; Sheila Nathan

September 9, 2013

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

Cancer Cell, ISSN: 18783686 15356108

Krishna P.L. Bhat; Veerakumar Balasubramaniyan; Brian Vaillant; Ravesanker Ezhilarasan; Karlijn Hummelink; Faith Hollingsworth; Khalida Wani; Lindsey Heathcock; Johanna D. James; Lindsey D. Goodman; Siobhan Conroy; Lihong Long; Nina Lelic; Suzhen Wang; Joy Gumin; Divya Raj; Yoshinori Kodama; Aditya Raghunathan; Adriana Olar; Kaushal Joshi; Christopher E. Pelloski; Amy Heimberger; SeHoon Kim; Daniel P. Cahill; Ganesh Rao; Wilfred F. A. DenDunnen; Hendrikus W.G.M. Boddeke; Phillips; Ichiro Nakano; Frederick F. Lang; Howard Colman; Erik P. Sulman; Kenneth D. Aldape

September 9, 2013

Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region

Journal of Molecular Biology, ISSN: 10898638 00222836

Kittichoat Tiyanont; Thomas E. Wales; Christian W. Siebel; John R. Engen; Stephen C. Blacklow

September 5, 2013

CD8+ T-cell epitope mapping for pneumonia virus of mice in H-2b mice

Journal of Virology, ISSN: 0022538X 10985514

Kevin B. Walsh; John Sidney; Megan J. Welch; Daniel M. Fremgen; Alessandro Sette; Michael B.A. Oldstone

September 5, 2013

A Role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway

Cell Stem Cell, ISSN: 19345909 18759777

Kai Kessenbrock; Gerrit J. P. Dijkgraaf; Devon A. Lawson; Laurie E. Littlepage; Payam Shahi; Ursula Pieper; Zena Werb

September 4, 2013

A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb

Journal of General Physiology, ISSN: 00221295 15407748

Tamer M. Gamal El-Din; Gilbert Q. Martinez; Jian Payandeh; Todd Scheuer; William A. Catterall

September 3, 2013

Protein microarrays for identification of novel extracellular protein-protein interactions

Current protocols in protein science / editorial board, John E. Coligan ... [et al.], ISSN: 19343655 19343663

Irene Tom; Nicholas Lewin-Koh; Sree R. Ramani; Lino C. Gonzalez Jr.

September 3, 2013

NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition

Oncogenesis, ISSN: 21579024

Osborne; Larsen; Gonzales; David S. Shames; Sato; Ignacio I. Wistuba; Girard; Minna; Cobb

September 3, 2013

Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy

Journal of Clinical Investigation, ISSN: 15588238 00219738

Leisa Johnson; Mahrukh Huseni; Tanya Smyczek; Anthony Lima; Stacey Yeung; Jason H. Cheng; Rafael Molina; David Kan; Ann De Mazière; Judith Klumperman; Ian Kasman; Yin Zhang; Dennis; Jeffrey Eastham-Anderson; Adrian M. Jubb; Olivia Hwang; Rupal Desai; Maike Schmidt; Michelle Nannini; Kai H. Barck; Richard A. D. Carano; William F. Forrest; Qinghua Song; Daniel S. Chen; Louie Naumovski; Mallika Singh; Weilan Ye; Priti Hegde

September 1, 2013

Go with the flow

Innovations in Pharmaceutical Technology, ISSN: 14717204

Juan Colberg; Stefan G. Koenig; David Leahy; Peter Poechlauer

September 1, 2013

Pharmacokinetics of a three-way drug interaction between danoprevir, ritonavir and the organic anion transporting polypeptide (OATP) inhibitor ciclosporin

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Barbara J. Brennan; Sebastian A. Moreira; Peter N. Morcos; Mercidita T. Navarro; Jiney Asthappan; Petra Goelzer; Paul Weigl; Patrick F. Smith

September 1, 2013

Analysis of pharmaceutical impurities using multi-heartcutting 2D LC coupled with UV-charged aerosol MS detection

Journal of Separation Science, ISSN: 16159306 16159314

Kelly Zhang; Yi Li; Midco Tsang; Nik P. Chetwyn

September 1, 2013

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

Nature Immunology, ISSN: 15292908 15292916

Ansuman T. Satpathy; Carlos G. Briseño; Jacob S. Lee; Dennis Ng; Nicholas A. Manieri; Wumesh Kc; Xiaodi Wu; Stephanie R. Thomas; Wan-Ling Lee; Mustafa Turkoz; Keely G. McDonald; Matthew M. Meredith; Christina Song; Cynthia J. Guidos; Rodney D. Newberry; Wenjun Ouyang; Theresa L. Murphy; Thaddeus S. Stappenbeck; Jennifer L. Gommerman; Michel Nussenzweig; Marco Colonna; Raphael Kopan; Kenneth M. Murphy

September 1, 2013

Efficacy and safety of ocrelizumab in active proliferative lupus nephritis: Results from a randomized, double-blind, phase III study

Arthritis and Rheumatism, ISSN: 15290131 00043591

Eduardo F. Mysler; Alberto J. Spindler; Renato Guzman; Marc Bijl; David Jayne; Richard A. Furie; Frédéric A. Houssiau; Jorn Drappa; David Close; Romeo MacIuca; Kajal Rao; Saba Shahdad; Paul Brunetta

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