Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7101 - 7150 OF 15796 RESULTS

Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development
Molecular Pharmaceutics, ISSN: 15438384 15438392
Gillian S. Smelick; Timothy P. Heffron; Laura Chu; Brian J. Dean; David A. West; Scott L. Duvall; Bert L. Lum; Nageshwar Budha; Scott N. Holden; Leslie Z. Benet; Adam Frymoyer; Mark J. Dresser; Joseph A. Ware
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Physical chemical drug-drug interactions from drug discovery to registration: New opportunities for the pharmaceutical scientist to impact drug development
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph A. Ware; Gena Dalziel
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Impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of GDC-0941 in healthy volunteers: Bench to bedside investigation of pH-dependent solubility
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph A. Ware; Gena Dalziel; Jin Y. Jin; Jackson D. Pellett; Gillian S. Smelick; David A. West; Laurent Salphati; Xiao Ding; Rebecca Sutton; Jane Fridyland; Mark J. Dresser; Glenn Morrisson; Scott N. Holden
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Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs - Reversing the effect of elevated gastric pH with betaine HCl
Molecular Pharmaceutics, ISSN: 15438384 15438392
Jodie Pang; Gena Dalziel; Brian J. Dean; Joseph A. Ware; Laurent Salphati
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More myths in ultrahigh-pressure liquid chromatography
LC-GC Europe, ISSN: 14716577
Michael W. Dong
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Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Journal of Experimental Medicine, ISSN: 00221007 15409538
Omar Abdel-Wahab; Jie Gao; Mazhar Adli; Anwesha Dey; Thomas Trimarchi; Young Rock Chung; Cem Kuscu; Todd Hricik; Delphine Ndiaye-Lobry; Lindsay M. LaFave; Richard Koche; Alan H. Shih; Olga A. Guryanova; Eunhee Kim; Sheng Li; Suveg Pandey; Joseph Y. Shin; Leon Telis; Jinfeng Liu; Parva K. Bhatt; Sebastien Monette; Xinyang Zhao; Christopher E Mason; Christopher Y. Park; Bradley E. Bernstein; Iannis Aifantis; Ross L. Levine
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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Nature Neuroscience, ISSN: 10976256 15461726
David V. Hansen; Jan H. Lui; Pierre Flandin; Kazuaki Yoshikawa; John L. R. Rubenstein; Arturo Alvarez-Buylla; Arnold R. Kriegstein
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Two-dimensional HPLC in pharmaceutical analysis
American Pharmaceutical Review, ISSN: 10998012
Kelly Zhang; Jennifer Wang; Midco Tsang; Larry Wigman; Nik P. Chetwyn
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Strategy for selecting disposable bags for cell culture media applications based on a root-cause investigation
Biotechnology Progress, ISSN: 87567938 15206033
Joseph Wood; Ekta Mahajan; Masaru Shiratori
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Clinical applications of palifermin: Amelioration of oral mucositis and other potential indications
Journal of Cellular and Molecular Medicine, ISSN: 15821838
Saroj Vadhan-Raj; Jenna D. Goldberg; Miguel-Angel Perales; Dietmar P. Berger; Marcel R.M. van den Brink
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Erratum: Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes (Journal of Inherited Metabolic Disease DOI: 10.1007/s10545-012-9561-3)
Journal of Inherited Metabolic Disease, ISSN: 01418955 15732665
Derek G. Burke; Ahad A. Rahim; Simon N. Waddington; Stefan Karlsson; Ida Enquist; Kailash Bhatia; Atul Mehta; Ashok Vellodi; Simon Heales
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Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct
Developmental Dynamics, ISSN: 10588388 10970177
Yoko Inès Nozawa; Erica Yao; Chuwen Lin; Jehn-Hsiahn Yang; Christopher W. Wilson; Rhodora Gacayan; Pao-Tien Chuang
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A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail
European Journal of Clinical Pharmacology, ISSN: 00316970 14321041
Peter N. Morcos; Linda Chang; Rohit Kulkarni; Mylene Giraudon; Nancy Shulman; Barbara J. Brennan; Patrick F. Smith; Jonathan Q. Tran
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Age distribution of patients with advanced non-melanoma skin cancer in the United States
Archives of Dermatological Research, ISSN: 03403696 1432069X
Stacey Dacosta Byfield; Diana M. Chen; Yeun Mi Yim; Carolina Reyes
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Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Bradley J. Newhouse; Steve Wenglowsky; Jonas Grina; Ellen R. Laird; Walter C. Voegtli; Li Ren; Kateri Ahrendt; Alexandre J. Buckmelter; Susan L. Gloor; Nathalie Klopfenstein; Joachim Rudolph; Zhaoyang Wen; Xianfeng Li; Bainian Feng
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A two-stage Bayesian design with sample size reestimation and subgroup analysis for phase II binary response trials
Contemporary Clinical Trials, ISSN: 15517144 15592030
Wei Zhong; Joseph S. Koopmeiners; Bradley P. Carlin
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Using registries to identify adverse events in rheumatic diseases
Pediatrics, ISSN: 00314005 10984275
Geraldina Lionetti; Yukiko Kimura; Laura E. Schanberg; Timothy Beukelman; Carol A. Wallace; Norman T. Ilowite; Jane Winsor; Kathleen Fox; Marc Natter; John S. Sundy; Eric Brodsky; Jeffrey R. Curtis; Vincent Del Gaizo; Solomon Iyasu; Angelika Jahreis; Ann Meeker-O'connell; Barbara B. Mittleman; Bernard M. Murphy; Eric D. Peterson; Sandra C. Raymond; Soko Setoguchi; Jeffrey N. Siegel; Rachel E. Sobel; Daniel Solomon; Taunton R. Southwood; Richard Vesely; Patience H. White; Nico M. Wulffraat; Christy I. Sandborg
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Population pharmacokinetic analysis from phase i and phase ii studies of the humanized monovalent antibody, onartuzumab (metmab), in patients with advanced solid tumors
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Yan Xin; Denise Jin; Stephen M. Eppler; Lisa A. Damico; Amita Joshi; John Davis; Surinder Kaur; Ihsan Nijem; John Bothos; Amy Peterson; Premal Patel; Shuang Bai
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Sample size and threshold estimation for clinical trials with predictive biomarkers
Contemporary Clinical Trials, ISSN: 15517144 15592030
Howard M. Mackey; Thomas Bengtsson
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Absence of pharmacokinetic drug-drug interaction of pertuzumab with trastuzumab and docetaxel
Anti-Cancer Drugs, ISSN: 09594973 14735741
Javier Cortés; Sandra M. Swain; Iveta Kudaba; Maik Hauschild; Taral Patel; Elza Grincuka; Norikazu Masuda; Virginia McNally; Graham Ross; Michael Brewster; Jean-François Marier; My My Trinh; Amit Garg; Ihsan Nijem; Jennifer Visich; Bert L. Lum; Baselga
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Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells
Acta Neuropathologica, ISSN: 00016322 14320533
Annegret Kathagen; Alexander Schulte; Gerd Balcke; Phillips; Tobias Martens; Jakob Matschke; Hauke S. Günther; Robert Soriano; Zora Modrusan; Thomas Sandmann; Carsten Kuhl; Alain Tissier; Mareike Holz; Lutz A. Krawinkel; Markus Glatzel; Manfred Westphal; Katrin Lamszus
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Porcine circovirus (PCV) removal by Q sepharose fast flow chromatography
Biotechnology Progress, ISSN: 87567938 15206033
Bin Yang; Hua Wang; Cintia Ho; Philip M. Lester; Qi Chen; Florian Neske; Sally A. Baylis; Johannes Blümel
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Maximizing kinetic performance in supercritical fluid chromatography using state-of-the-art instruments
Journal of Chromatography A, ISSN: 18733778 00219673
Alexandre Grand-Guillaume Perrenoud; Chris Hamman; Meenakshi Goel; Jean-Luc Veuthey; Davy Guillarme; Szabolcs Fekete
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Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
Journal of Experimental Medicine, ISSN: 00221007 15409538
Christine D. Pozniak; Arundhati Sengupta Ghosh; Alvin Gogineni; Jesse E. Hanson; Seung-Hye Lee; Jessica L. Larson; Hilda Solanoy; Daisy J. Bustos; Hong Li; Hai Ngu; Adrian M. Jubb; Gai Ayalon; Jiansheng Wu; Kimberly Scearce-Levie; Qiang Zhou; Robby M. Weimer; Donald S. Kirkpatrick; Joe Lewcock
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ATLAS: Randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Bruce E. Johnson; Fairooz F. Kabbinavar; Louis Fehrenbacher; John Hainsworth; Saifuddin Kasubhai; Bruce Kressel; Chin-Yu Lin; Thomas Marsland; Taral Patel; Jonathan Polikoff; Mark Rubin; Leonard White; James Chih-Hsin Yang; Chris J. Bowden; Vincent A. Miller
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Exposure-response analysis of pertuzumab in HER2-positive metastatic breast cancer: Absence of effect on QTc prolongation and other ECG parameters
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Amit Garg; Jing Li; Emma Clark; Adam Knott; Timothy J. Carrothers; Jean-François Marier; Javier Cortés; Michael Brewster; Jennifer Visich; Bert L. Lum
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Purification of antibodies by precipitating impurities using Polyethylene Glycol to enable a two chromatography step process
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X
Glen Giese; Adam Myrold; Gorrell; Josefine Persson
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Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Kathy Barrett; Wade S. Blair; Christine Chang; Gauri Deshmukh; Eigenbrot; Paul Gibbons; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Marya Liimatta; Patrick J. Lupardus; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Mark Zak
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Vehicle selection for nonclinical oral safety studies
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607
Evan A Thackaberry
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IL-2 Immunotherapy Reveals Potential for Innate Beta Cell Regeneration in the Non-Obese Diabetic Mouse Model of Autoimmune Diabetes
PLoS ONE, ISSN: 19326203
Yaiza Diaz-de-Durana; Janet Lau; Deborah Knee; Christophe Filippi; Marco Londei; Peter McNamara; Marc Nasoff; Michael Didonato; Richard Glynne; Ann E. Herman
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Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)
Tetrahedron Letters, ISSN: 00404039 18733581
Malcolm P. Huestis; Wendy Liu; Matthew Volgraf; Hans E. Purkey; Christine Yu; Weiru Wang; Darin Smith; Guy Vigers; Darrin Dutcher; Kevin W. Hunt; Michael Siu
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Methylglyoxal Evokes Pain by Stimulating TRPA1
PLoS ONE, ISSN: 19326203
David A. Andersson; Clive Gentry; Emily Light; Nisha Vastani; Julie Vallortigara; Angelika Bierhaus; Thomas Fleming; Stuart Bevan
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Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism
Journal of Experimental Medicine, ISSN: 00221007 15409538
Nathan E. Welty; Christopher Staley; Nico Ghilardi; Michael J. Sadowsky; Botond Z. Igyártó; Daniel H. Kaplan
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Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells
Journal of Cell Science, ISSN: 00219533 14779137
Abitha Jacob; Jian Jing; James Lee; Pepper Schedin; Simon M. Gilbert; Andrew A. Peden; Jagath R. Junutula; Rytis Prekeris
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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
Journal of Experimental Medicine, ISSN: 00221007 15409538
Adriana Soler; Helena Serra; Wayne Pearce; Ana Angulo; Julie Guillermet-Guibert; Lori S. Friedman; Francesc Viñals; Holger Gerhardt; Oriol Casanovas; Mariona Graupera; Bart Vanhaesebroeck
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Incidence of catheter-related complications in patients with central venous or hemodialysis catheters: A health care claims database analysis
BMC Cardiovascular Disorders, ISSN: 14712261
Pavel Napalkov; Diana M. Felici; Laura Chu; Joan R. Jacobs; Susan M. Begelman
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Dynamical modelling of phenotypes in a genome-wide RNAi live-cell imaging assay
BMC Bioinformatics, ISSN: 14712105
Gregoire Pau; Thomas Walter; Beate Neumann; Jean-Karim Hériché; Jan Ellenberg; Wolfgang Huber
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Investigation into temperature-induced aggregation of an antibody drug conjugate
Bioconjugate Chemistry, ISSN: 15204812 10431802
Nia S. Beckley; Kathlyn P. Lazzareschi; Hung-Wei Chih; Vikas Sharma; Heather Flores
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Managing technologies in a global drug substance biotech manufacturing network - A case study
Pharmaceutical Outsourcing, ISSN: 19453337
Michael Pohlscheidt; Eric Fallon; David Chang; Dan Stark; Frank Trach
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IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis
BMJ Open, ISSN: 20446055
Jianmei Wang; Adam Platt; Ruchi Upmanyu; Søren Germer; Guiyuan Lei; Christina Rabe; Ryma Benayed; Andrew Kenwright; Andrew Hemmings; Mitchell Martin; Olivier Harari
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Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
C. Andrew Boswell; Jan Marik; Michael J. Elowson; Noe A. Reyes; Sheila Ulufatu; Daniela Bumbaca; Victor Yip; Eduardo E. Mundo; Nicholas Majidy; Marjie Van Hoy; Saritha N. Goriparthi; Anthony Trias; Herman S. Gill; Simon P. Williams; Jagath R. Junutula; Fielder; Leslie A. Khawli
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EGFR-activating mutations correlate with a fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity
Cancer Research, ISSN: 00085472 15387445
Heike N. Pfaäffle; Meng Wang; Liliana Gheorghiu; Natalie Ferraiolo; Patricia Greninger; Kerstin Borgmann; Jeffrey Settleman; Cyril H. Benes; Lecia V. Sequist; Lee Zou; Henning Willers
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Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Benjamin P. Fauber; Peter Dragovich; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Yichin Liu; Yingchun Liu; Shiva Malek; David Peterson; Keith Pitts; Steve Sideris; Ultsch; Erica Vanderporten; Jing Wang; Binqing Wei; Ivana Yen; Qin Yue
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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5- carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Xiaozhang Zheng; Kenneth W. Bair; Paul Bauer; Timm Baumeister; Krista K. Bowman; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Yezhen Feng; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Hong Li; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Justin Ly; Thomas O'Brien; Jason Oeh; Angela Oh; Dominic J. Reynolds; Deepak Sampath; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jarrod Tremayne; Leslie Wang; Weiru Wang; Zhongguo Wang; Hongxing Wu; Jiansheng Wu; Yang Xiao; Guangxing Yang; Po-Wai Yuen; Mark Zak; Peter Dragovich
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New paradigms for process validation: A practical approach
BioProcess International, ISSN: 15426319
Mire-Sluis; Vijay Chiruvolu; Kelley; Linda Ng; Reb Russell; Chiang Syin; Victor Vinci; Mats Welin; Nathan McKnight; Bob Kuhn; Christian Klock; Ranjit Deshmukh; Siddharth Advant
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Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Elizabeth M. Blackwood; Jennifer A. Epler; Ivana Yen; Michael Flagella; Thomas O'Brien; Marie Evangelista; Stephen Schmidt; Yang Xiao; Jonathan Choi; Kaska Kowanetz; Judi Ramiscal; Kenton Wong; Diana Jakubiak; Sharon Fong Yee; Cain; Lewis Gazzard; Karen Williams; Jason S Halladay; Peter K Jackson; Shiva Malek
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A dual host vector for Fab phage display and expression of native IgG in mammalian cells
Protein Engineering, Design and Selection, ISSN: 17410126 17410134
Devin B. Tesar; Isidro Hötzel
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SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Rebecca R. Pferdehirt; Barbara J. Meyer
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Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins
PLoS Pathogens, ISSN: 15537366 15537374
Wouter L. W. Hazenbos; Kimberly K. Kajihara; Richard L. Vandlen; J. Hiroshi Morisaki; Sophie M. Lehar; Mark J. Kwakkenbos; Tim Beaumont; Arjen Q. Bakker; Qui Phung; Lee R. Swem; Satish Ramakrishnan; Janice Kim; Min Xu; Ishita M. Shah; Binh An Diep; Tao Sai; Andrew Sebrell; Yana Khalfin; Angela Oh; Christopher M. Koth; S. Jack Lin; Byoung-Chul Lee; Magnus Strandh; Klaus Koefoed; Peter S. Andersen; Hergen Spits; Eric J. Brown; Man-Wah Tan; Sanjeev Mariathasan
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Considerations for the successful co-development of targeted cancer therapies and companion diagnostics
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Jane Fridlyand; Richard M. Simon; Jessica C. Walrath; Roach; Richard Buller; David P. Schenkein; Keith Flaherty; Jeff D. Allen; Ellen V. Sigal; Scher
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