Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7151 - 7200 OF 15650 RESULTS

Developing Therapeutic Antibodies for Neurodegenerative Disease
Neurotherapeutics, ISSN: 19337213 18787479
Y. Joy Yu; Ryan J. Watts
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A novel visuospatial priming task for rats with relevance to Tourette syndrome and modulation of dopamine levels
Neuroscience and Biobehavioral Reviews, ISSN: 01497634 18737528
Nurith Amitai; Martin Weber; Neal R. Swerdlow; Richard F. Sharp; Michelle R. Breier; Adam L. Halberstadt; Jared W. Young
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Challenges of trial design for extended drug delivery: A virtual round table with industry
Retina Today, ISSN: 18250572
Ken Green; Yehia Hashad; Roman G. Rubio
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Estimating the survival functions for right-censored and interval-censored data with piecewise constant hazard functions
Contemporary Clinical Trials, ISSN: 15517144 15592030
Pei He; George Kong; Zheng Su
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Theoretical considerations and practical approaches to address the effect of anti-drug antibody (ADA) on quantification of biotherapeutics in circulation
AAPS Journal, ISSN: 15507416
Marian Kelley; Ago Ahene; Boris Gorovits; John Kamerud; Lindsay King; Thomas McIntosh; Yang
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Calcineurin inhibitor-free mycophenolate mofetil/sirolimus maintenance in liver transplantation: The randomized spare-the-nephron trial
Liver Transplantation, ISSN: 15276465 15276473
Lewis Teperman; Dilip Moonka; Anthony Sebastian; Linda Sher; Paul Marotta; Christopher Marsh; Baburao Koneru; John Goss; Dennis Preston; John P. Roberts
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Fibroblast growth factor receptor 3 is a rational therapeutic target in bladder cancer
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Kilian M. Gust; David J. McConkey; Shannon Awrey; Paul K. Hegarty; Jing Qing; Jolanta Bondaruk; Avi Ashkenazi; Bogdan Czerniak; Colin P. Dinney; Peter C. Black
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Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: The ITC evidence-based position
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Kalvass; Polli; Bourdet; Bo Feng; Huang; Liu; Smith; Zhang; Zamek-Gliszczynski
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At scale analysis and optimization of a cell culture harvest process-mitigating risk and optimizing performance
American Pharmaceutical Review, ISSN: 10998012
Michael Pohlscheidt; Goetz Lieser; Bjoern-Erec Bertermann; Horst Eberhardt; Stefan Herter; Hermann Tebbe
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DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-hodgkin lymphoma
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Dongwei Li; Kirsten Achilles Poon; Shang-Fan Yu; Randall Dere; MaryAnn Go; Jeffrey Lau; Bing Zheng; Kristi Elkins; Dimitry Danilenko; Katherine R. Kozak; Pamela Chan; Josefa Chuh; Xiaoyan Shi; Denise Nazzal; Franklin Fuh; Jacqueline McBride; Vanitha Ramakrishnan; Ruth De Tute; Andy Rawstron; Andrew S. Jack; Rong Deng; Yu-Waye Chu; David Dornan; Marna Williams; William Y. Ho; Allen Ebens; Saileta Prabhu; Andrew G. Polson
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Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell
Biotechnology Progress, ISSN: 87567938 15206033
Zhilan Hu; Donglin Guo; Shirley S. M. Yip; Dejin Zhan; Shahram Misaghi; John C. Joly; Snedecor; Amy Shen
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Optimization of drug-drug interaction study design: Comparison of minimal physiologically based pharmacokinetic models on prediction of CYP3A inhibition by ketoconazole
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Bing Han; Jialin Mao; Jenny Y. Chien; Stephen D. Hall
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Use of an anti-apoptotic CHO cell line for transient gene expression
Biotechnology Progress, ISSN: 87567938 15206033
Nichole F. Macaraeg; Dorothea Reilly; Athena W. Wong
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BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor
Nature Cell Biology, ISSN: 14657392 14764679
Brian Biehs; Jimmy Kuang-Hsien Hu; Nicolas B. Strauli; Eugenio Sangiorgi; Heekyung Jung; Ralf-Peter Heber; Sunita Ho; Alice F. Goodwin; Jeremy S. Dasen; Mario R. Capecchi; Ophir D. Klein
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Reading speed improvements in retinal vein occlusion after ranibizumab treatment
JAMA Ophthalmology, ISSN: 21686165
Ivan J. Suñer; Neil M. Bressler; Rohit Varma; Paul P. Lee; Chantal M. Dolan; James Ward; Shoshana Colman; Roman G. Rubio
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In situ validation of an intestinal stem cell signature in colorectal cancer
Gut, ISSN: 00175749 14683288
Jennifer L. Ziskin; Debra Dunlap; Murat Yaylaoglu; Imola K. Fodor; William F. Forrest; Rajesh Patel; Nianfeng Ge; Gordon G. Hutchins; James K. Pine; Philip Quirke; Koeppen; Adrian M. Jubb
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Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactionss
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Harma Ellens; Shibing Deng; Joann Coleman; Joe Bentz; Mitchell E. Taub; Isabelle Ragueneau-Majlessi; Sophie P. Chung; Krisztina Herédi-Szabó; Sibylle Neuhoff; Johan Palm; Praveen Balimane; Lei Zhang; Masoud Jamei; Imad Hanna; Michael O'connor; Dallas Bednarczyk; Malin Forsgard; Xiaoyan Chu; Christoph Funk; Ailan Guo; Kathleen M. Hillgren; Libin Li; Anne Y. Pak; Elke S. Perloff; Ganesh Rajaraman; Laurent Salphati; Jan-Shiang Taur; Dietmar Weitz; Heleen M. Wortelboer; Cindy Q. Xia; Guangqing Xiao; Tetsuo Yamagata; Caroline A. Lee
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Authors' Response to Letter to the Editor on "Image Cytometry Protocols"
Journal of Histochemistry and Cytochemistry, ISSN: 00221554
Rosario Garrido; Tanja S. Zabka; Jianhua Tao; Mark Fielden; Adrian J. Fretland; Mudher Albassam
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T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Chaoran Li; Peter J. R. Ebert; Qi-Jing Li
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AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes
Nature, ISSN: 00280836 14764687
Ritu Kumar; Lauren Dimenna; Nadine Schrode; Ting-Chun Liu; Philipp Franck; Silvia Muñoz-Descalzo; Anna-Katerina Hadjantonakis; Ali A. Zarrin; Jayanta Chaudhuri; Olivier Elemento; Todd Evans
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Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Xiaozhang Zheng; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Jian Lin; Dominic J. Reynolds; Geeta Sharma; Chase C. Smith; Zhongguo Wang; Peter Dragovich; Angela Oh; Weiru Wang; Mark Zak; Janet Gunzner; Guiling Zhao; Po-Wai Yuen; Kenneth W. Bair
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Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor
Journal of Molecular Biology, ISSN: 10898638 00222836
Xiaolei Ma; Pierre A. Barthelemy; Lionel Rouge; Wiesmann; Sachdev S. Sidhu
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Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain
PLoS ONE, ISSN: 19326203
Rebecca A. Helmer; Oded Foreman; Janet S. Dertien; Marlyn Panchoo; Suhani M. Bhakta; Beverly S. Chilton
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Therapeutic protein drug-drug interactions: Navigating the knowledge gaps-highlights from the 2012 AAPS NBC roundtable and IQ Consortium/FDA workshop
AAPS Journal, ISSN: 15507416
Jane R. Kenny; Maggie M. Liu; Andrew T. Chow; Justin C. Earp; Raymond Evers; J. Greg Slatter; Diane D. Wang; Lei Zhang; Honghui Zhou
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Characterization of the guinea pig CMV gH/gL/GP129/GP131/GP133 complex in infection and spread
Virology, ISSN: 00426822 10960341
Marcy Auerbach; Donghong Yan; Ashley Fouts; Min Xu; Alberto Estevez; Cary D. Austin; Fernando Bazan; Becket Feierbach
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Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1
eLife, ISSN: 2050084X
Ling Luo; Hironori Uehara; Xiaohui Zhang; Subrata K. Das; Thomas Olsen; Derick Holt; Jacquelyn M. Simonis; Kyle Jackman; Nirbhai Singh; Tadashi R. Miya; Wei Huang; Faisal Ahmed; Ana Bastos-Carvalho; Yun Zheng Le; Christina Mamalis; Vince A. Chiodo; William W. Hauswirth; Judit Z. Baffi; Pedro M. Lacal; Angela Orecchia; Napoleone Ferrara; Guangping Gao; Kim Young-hee; Yingbin Fu; Leah Owen; Romulo J. C. Albuquerque; Wolfgang Baehr; Kirk Thomas; Dean Y. Li; Kakarla V. Chalam; Masabumi Shibuya; Salvatore Grisanti; David J. Wilson; Jayakrishna Ambati; Balamurali K. Ambati
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Adherence to dornase alfa treatment among commercially insured patients with cystic fibrosis
Journal of Medical Economics, ISSN: 13696998 1941837X
Samya Z. Nasr; Will Chou; Kathleen F. Villa; Eunice Chang; Michael S. Broder
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Population pharmacokinetics of cyclosporine in transplant recipients
AAPS Journal, ISSN: 15507416
Kelong Han; Venkateswaran C. Pillai; Raman Venkataramanan
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Janet Gunzner; Guiling Zhao; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bang Fu; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Sophie Mukadam; Thomas O'Brien; Angela Oh; Dominic J. Reynolds; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jasleen K. Sodhi; Weiru Wang; Zhongguo Wang; Yang Xiao; Po-Wai Yuen; Mark Zak; Lei Zhang; Xiaozhang Zheng; Kenneth W. Bair; Peter Dragovich
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Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells
Cancer Research, ISSN: 00085472 15387445
Luis E. Arias-Romero; Olga Villamar-Cruz; Min Huang; Klaus P. Hoeflich; Jonathan Chernoff
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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Christopher A. Hurley; Wade S. Blair; Richard J. Bull; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Hazel J. Dyke; Rina Fong; Nico Ghilardi; Paul Gibbons; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Robert J. Maxey; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Savita Ubhayakar; Anne Van Abbema; Stuart I. Ward; Bohdan Waszkowycz; Mark Zak
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Previous myocardial infarction as a risk factor for in-hospital cardiovascular outcomes (from the National Registry of Myocardial Infarction 4 and 5)
American Journal of Cardiology, ISSN: 00029149 18791913
Quang T. Bui; Vanessa S. Reddy; Joan R. Jacobs; Susan M. Begelman; Paul D. Frederick; Dave P. Miller; William J. French
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Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria
New England Journal of Medicine, ISSN: 15334406 00284793
Marcus Maurer; Karin Rosén; Hsin-Ju Hsieh; Sarbjit S. Saini; Clive E. Grattan; Ana Gimenéz-Arnau; Sunil Agarwal; Ramona Doyle; Janice Canvin; Allen P. Kaplan; Thomas B. Casale
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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Mark Zak; Christopher A. Hurley; Stuart I. Ward; Philippe Bergeron; Kathy Barrett; Mercedesz Balazs; Wade S. Blair; Richard J. Bull; Paroma Chakravarty; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Charles Ellwood; Simon Gaines; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Gribling; Chris Hamman; Eric Harstad; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Sharada Labadie; Wyne P. Lee; Jiangpeng Liao; Marya Liimatta; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Austin Reeve; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Ignacio Aliagas; Barbara Avitabile-Woo; Yisong Xiao; Jing Yang; Janusz J. Kulagowski
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Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d ][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2- methylpropanamide (GDC-0032): A β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Chudi O. Ndubaku; Timothy P. Heffron; Steven T. Staben; Matthew Baumgardner; Nicole Blaquiere; Erin K. Bradley; Richard J. Bull; Steven Do; Jennafer Dotson; Danette Dudley; Kyle A. Edgar; Lori S. Friedman; Richard Goldsmith; Robert Heald; Aleksandr Kolesnikov; Leslie Lee; Lewis; Michelle Nannini; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Jeffery J. Wallin; Lan Wang; Binqing Wei; Deepak Sampath; Alan G. Olivero
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Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade S. Blair; Christine Chang; Donnie Delarosa; Jason Devoss; James Driscoll; Eigenbrot; Nico Ghilardi; Paul Gibbons; Jason S Halladay; Adam R. Johnson; Pawan Bir Kohli; Yingjie Lai; Yanzhou Liu; Joseph P. Lyssikatos; Priscilla Mantik; Kapil Menghrajani; Jeremy Murray; Ivan Peng; Amy Sambrone; Steven Shia; Young G. Shin; Jan Smith; Sue J. Sohn; Vickie Tsui; Ultsch; Lawren C. Wu; Yisong Xiao; Wenqian Yang; Judy Young; Birong Zhang; Bing-Yan Zhu; Steven Magnuson
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Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies
Journal of Molecular Biology, ISSN: 10898638 00222836
Homer Pantua; Jingyu Diao; Ultsch; Meredith Hazen; Mary Mathieu; Krista McCutcheon; Kentaro Takeda; Shailesh V. Date; Tommy K. Cheung; Qui Phung; Hass; David Arnott; Hongo; Matthews; Alex Brown; Arvind H. Patel; Robert F. Kelley; Eigenbrot; Sharookh B. Kapadia
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miR-221/222 Targets Adiponectin Receptor 1 to Promote the Epithelial-to-Mesenchymal Transition in Breast Cancer
PLoS ONE, ISSN: 19326203
Michael S. Hwang; Nancy Yu; Susanna Y. Stinson; Peng Yue; Robert J. Newman; Bernard B. Allan; David Dornan
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Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant
Chemical Communications, ISSN: 1364548X 13597345
Laura M. Dornan; Qun Cao; James C.A. Flanagan; James J. Crawford; Matthew J. Cook; Mark J. Muldoon
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Evaluation of tumor-size response metrics to predict overall survival in Western and Chinese patients with first-line metastatic colorectal cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Laurent Claret; Manish Gupta; Kelong Han; Amita Joshi; Nenad Sarapa; Jing He; Bob Powell; Rene Bruno
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The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD41 T-cell recovery: A randomized trial
Blood, ISSN: 15280020 00064971
Peter W. Hunt; Nancy Shulman; Timothy L. Hayes; Viktor Dahl; Ma Somsouk; Nicholas T. Funderburg; Bridget McLaughlin; Alan L. Landay; Oluwatoyin Adeyemi; Lee E. Gilman; Brian Clagett; Benigno Rodriguez; Jeffrey N. Martin; Timothy W. Schacker; Barbara L. Shacklett; Sarah Palmer; Michael M. Lederman; Steven G. Deeks
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Early effects of tocilizumab in the treatment of moderate to severe active rheumatoid arthritis: A one-week sub-study of a randomised controlled trial (Rapid Onset and Systemic Efficacy [ROSE] Study)
Clinical and Experimental Rheumatology, ISSN: 0392856X 1593098X
Yazici; Jeffrey R. Curtis; Ince; Baraf; Lepley; Jenny Devenport; Arthur Kavanaugh
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Turning on lanthanide luminescence via nanoencapsulation
Inorganic Chemistry, ISSN: 00201669 1520510X
Boris Makhinson; Alexandra K. Duncan; Ashley R. Elam; Ana De Bettencourt-Dias; Colin D. Medley; Joshua E. Smith; Eric J. Werner
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MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
Journal of Experimental Medicine, ISSN: 00221007 15409538
Jaehak Oh; Nan Wu; Günther Baravalle; Benjamin Cohn; Jessica K. Ma; Bryan Lo; Ira Mellman; Satoshi Ishido; Mark S. Anderson; Jeoung-Sook Shin
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Drug products for biological medicines: Novel delivery devices, challenging formulations, and combination products, part 2
BioProcess International, ISSN: 15426319
Mire-Sluis; Donna French; Jennifer Mercer; Gerd Kleemann; John Dougherty
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On assay robustness: the importance of early determination and science-driven decision-making
Bioanalysis, ISSN: 17576180 17576199
Kyra J. Cowan
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Assessment and significance of protein-protein interactions during development of protein biopharmaceuticals
Biophysical Reviews, ISSN: 18672469 18672450
Sandeep Yadav; Jun Liu; Thomas M. Scherer; Yatin Gokarn; Barthélemy Demeule; Sonoko Kanai; Andya; Steven J. Shire
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Anti-inflammatory strategies for plaque stabilization after acute coronary syndromes topical collection on vascular biology
Current Atherosclerosis Reports, ISSN: 15346242 15233804
Amos Baruch; Nicholas Van Bruggen; Juyong Brian Kim; Joshua E. Lehrer-Graiwer
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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Peter Dragovich; Benjamin P. Fauber; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Yichin Liu; Shiva Malek; Borlan Pan; David Peterson; Keith Pitts; Hans E. Purkey; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang
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Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
Molecular Cancer Research, ISSN: 15417786 15573125
Sato; Larsen; Woochang Lee; Han Sun; David S. Shames; Maithili P. Dalvi; Ruben D. Ramirez; Hao Tang; John Michael DiMaio; Boning Gao; Yang Xie; Ignacio I. Wistuba; Adi Gazdar; Jerry W. Shay; Minna
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