Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7251 - 7300 OF 15650 RESULTS

Characterization of the drug-to-antibody ratio distribution for antibody-drug conjugates in plasma/serum
Bioanalysis, ISSN: 17576180 17576199
Keyang Xu; Luna Liu; Randall Dere; Elaine Mai; Rebecca Erickson; Angela Hendricks; Kedan Lin; Jagath R. Junutula; Surinder Kaur
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Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Inna Y. Gong; Wendy A. Teft; Justin Ly; Yunghsiang Chen; Bruno Alicke; Richard B. Kim; Edna F. Choo
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Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steven T. Staben; Chudi O. Ndubaku; Nicole Blaquiere; Marcia Belvin; Richard J. Bull; Danette Dudley; Kyle A. Edgar; Daniel C. Gray; Robert Heald; Timothy P. Heffron; Graham Jones; Mark Jones; Aleksandr Kolesnikov; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Neville J. McLean; Jim Nonomiya; Alan G. Olivero; Rachel Ord; Jodie Pang; Stephen Price; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Jeffery J. Wallin; Lan Wang; Binqing Wei; Christian Weismann; Ping Wu
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A likelihood and resampling based approach to dichotomizing a continuous biomarker in medical research
Journal of Biopharmaceutical Statistics, ISSN: 10543406 15205711
Min Su; Liang Fang; Zheng Su
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8th annual european antibody congress 2012: November 27-28, 2012, Geneva, Switzerland
mAbs, ISSN: 19420862 19420870
Alain Beck; Paul J. Carter; Hans-Peter Gerber; Alexey A. Lugovskoy; Thierry Wurch; Jagath R. Junutula; Roland Kontermann; Robert Mabry
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Predictive value in retinal vein occlusions of early versus late or incomplete ranibizumab response defined by optical coherence tomography
Ophthalmology, ISSN: 01616420 15494713
Robert B. Bhisitkul; Peter A. Campochiaro; Howard Shapiro; Roman G. Rubio
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Safety of rituximab in combination with other biologic disease-modifying antirheumatic drugs in rheumatoid arthritis: An open-label study
Journal of Rheumatology, ISSN: 0315162X 14992752
William F. Rigby; Philip J. Mease; Ewa Olech; Ashby; Swati Tole
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Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
The Lancet Oncology, ISSN: 14702045 14745488
Sandra M. Swain; Sung-Bae Kim; Javier Cortés; Jungsil Ro; Vladimir Semiglazov; Mario Campone; Eva Ciruelos; Jean-Marc Ferrero; Andreas Schneeweiss; Adam Knott; Emma Clark; Graham Ross; Benyunes; Baselga
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Dr. Keystone, et al, reply
Journal of Rheumatology, ISSN: 0315162X 14992752
Edward Keystone; Stanley B. Cohen; Paul Emery; Joel M. Kremer; Maxime Dougados; James E. Loveless; Carol Y. Chung; Pamela Wong; Lehane; Helen Tyrrell
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Development of a new bioprocess scheme using frozen seed train intermediates to initiate CHO cell culture manufacturing campaigns
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Gargi Seth; Robert W. Hamilton; Stapp; Lisa Zheng; Angela Meier; Krista Petty; Stephenie Leung; Srikanth Chary
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Bioanalysis special focus issue on antibody-drug conjugates
Bioanalysis, ISSN: 17576180 17576199
Surinder Kaur
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Bioanalysis of antibody-drug conjugates: American Association of Pharmaceutical Scientists Antibody-Drug Conjugate Working Group position paper
Bioanalysis, ISSN: 17576180 17576199
Boris Gorovits; Stephen C. Alley; Sanela Bilic; Brian Booth; Surinder Kaur; Phillip Oldfield; Shobha Purushothama; Chetana Rao; Stacy Shord; Patricia Siguenza
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Data acquisition and data mining techniques for metabolite identification using LC coupled to high-resolution MS
Bioanalysis, ISSN: 17576180 17576199
Shuguang Ma; Swapan K. Chowdhury
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Newer developments in HPLC impacting pharmaceutical analysis: A brief review
American Pharmaceutical Review, ISSN: 10998012
Michael W. Dong; Davy Guillarme
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Recapitulating human cancer in a mouse
Nature Biotechnology, ISSN: 10870156 15461696
Lynda Chin; Frederic J. De Sauvage; Mikala Egeblad; Kenneth P. Olive; David Tuveson; William Weiss
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Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
Science Translational Medicine, ISSN: 19466234 19466242
Jessica A. Couch; Y. Joy Yu; Yin Zhang; Jacqueline M. Tarrant; Reina N. Fuji; William J. Meilandt; Hilda Solanoy; Raymond K. Tong; Kwame Hoyte; Wilman Luk; Yanmei Lu; Kapil Gadkar; Saileta Prabhu; Benjamin A. Ordonia; Quyen Nguyen; Yuwen L. Lin; Zhonghua Lin; Mercedesz Balazs; Kimberly Scearce-Levie; James A. Ernst; Dennis; Ryan J. Watts
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Strategies to address drug interaction potential for antibody-drug conjugates in clinical development
Bioanalysis, ISSN: 17576180 17576199
Dan Lu; Srikumar Sahasranaman; Yi Zhang; Sandhya Girish
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Structural basis of signaling blockade by anti-IL-13 antibody Lebrikizumab
Journal of Molecular Biology, ISSN: 10898638 00222836
Ultsch; Jack Bevers; Nakamura; Richard L. Vandlen; Robert F. Kelley; Lawren C. Wu; Eigenbrot
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EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS
PLoS ONE, ISSN: 19326203
Claire E. Le Pichon; Sara L. Dominguez; Hilda Solanoy; Hai Ngu; Nicholas Lewin-Koh; Mark Chen; Jeffrey Eastham-Anderson; Ryan J. Watts; Kimberly Scearce-Levie
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Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: From hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Kevin W. Hunt; Adam W. Cook; Ryan J. Watts; Christopher T. Clark; Guy Vigers; Darin Smith; Andrew T. Metcalf; Indrani W. Gunawardana; Michael Burkard; April Cox; Mary K. Geck Do; Darrin Dutcher; Allen A. Thomas; Sumeet Rana; Nicholas C. Kallan; Robert K. Delisle; James P. Rizzi; Kelly Regal; Douglas Sammond; Robert Groneberg; Michael Siu; Hans E. Purkey; Joseph P. Lyssikatos; Allison Marlow; Xingrong Liu; Tony P. Tang
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Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Simon Allen; Julia M. Richardson; Angela Mehlert; Michael A. J. Ferguson
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Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1
FEBS Letters, ISSN: 00145793 18733468
Elizabeth Helgason; Qui Phung; Erin C. Dueber
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OTUB1 modulates c-IAP1 stability to regulate signalling pathways
EMBO Journal, ISSN: 02614189 14602075
Tatiana Goncharov; Kyle Niessen; Maria Cristina De Almagro; Anita Izrael-Tomasevic; Anna V. Fedorova; Eugene Varfolomeev; David Arnott; Deshayes; Donald S. Kirkpatrick; Domagoj Vucic
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Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases
Science Signaling, ISSN: 19450877 19379145
Guanglei Zhuang; Kebing Yu; Zhaoshi Jiang; Alicia S Chung; Jenny Yao; Connie Ha; Toy; Robert Soriano; Benjamin Haley; Elizabeth M. Blackwood; Deepak Sampath; Carlos Bais; Jennie R. Lill; Napoleone Ferrara
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Science signaling podcast: 16 April 2013
Science Signaling, ISSN: 19450877 19379145
Guanglei Zhuang; Napoleone Ferrara; Annalisa M. VanHook
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Exploring the effects of omalizumab in allergic asthma: An analysis of biomarkers in the EXTRA study
American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970
Nicola A. Hanania; Sally E. Wenzel; Karin Rosén; Hsin-Ju Hsieh; Mosesova; David F. Choy; Preeti Lal; Joseph R. Arron; Harris; William W. Busse
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Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type i serine proteases Fromtransmembrane anchors
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Kavita Raman; Neil N. Trivedi; Wilfred W. Raymond; Rajkumar Ganesan; Daniel Kirchhofer; George M. Verghese; Charles S. Craik; Eric L. Schneider; Shilpa Nimishakavi; George H. Caughey
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Kilogram synthesis of (S)-3-aminopyran from l -glutamic acid
Synlett, ISSN: 09365214 14372096
Scott Savage; Srinivasan Babu; Mark Zak; Zhongping Mao; Jianhua Cao; Yonghui Ge; Dongxu Ma; Guoqiang Jiang
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Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR)
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Anthony A. Estrada; Daniel G. Shore; Elizabeth M. Blackwood; Yunghsiang Chen; Gauri Deshmukh; Xiao Ding; Antonio G. DiPasquale; Jennifer A. Epler; Lori S. Friedman; Michael F. T. Koehler; Lichuan Liu; Shiva Malek; Jim Nonomiya; Daniel F. Ortwine; Zhonghua Pei; Steve Sideris; Frederic St-Jean; Lan Trinh; Tom Truong; Joseph P. Lyssikatos
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The role of the FcGRIIIa polymorphism in modifying the association between treatment and outcome in patients with rheumatoid arthritis treated with rituximab versus TNF-α antagonist therapies
Clinical and Experimental Rheumatology, ISSN: 0392856X 1593098X
Khaled Sarsour; Greenberg; Joseph A. Johnston; David R. Nelson; Lee A. O'Brien; Carole Oddoux; Harry Ostrer; Alex Pearlman; Reed
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In Vitro and In Vivo Assays
Drug Discovery: Practices, Processes, and Perspectives,
Adam R. Johnson
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Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Vernon T. Phan; Xiumin Wu; Jason H. Cheng; Rebecca X. Sheng; Alicia S Chung; Guanglei Zhuang; Christopher Tran; Qinghua Song; Marcin Kowanetz; Amy Sambrone; Martha Tan; Meng; Erica L. Jackson; Franklin V. Peale Jr.; Melissa Junttila; Napoleone Ferrara
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Comparison of endogenous and overexpressed MyoD shows enhanced binding of physiologically bound sites
Skeletal Muscle, ISSN: 20445040
Zizhen Yao; Abraham P. Fong; Yi Cao; Walter L. Ruzzo; Robert Gentleman; Stephen J. Tapscott
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Micro-volume wall-less immunoassays using patterned planar plates
Lab on a Chip - Miniaturisation for Chemistry and Biology, ISSN: 14730189 14730197
Katherine R. Kozak; Jianyong Wang; Melvin Lye; Josefa Chuh; Rashi Takkar; Namyong Kim; Hyunjae Lee; Noo Li Jeon; Kedan Lin; Crystal Zhang; Wai Lee T. Wong; Laura DeForge
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Histone deacetylase 2 cell autonomously suppresses excitatory and enhances inhibitory synaptic function in CA1 pyramidal neurons
Journal of Neuroscience, ISSN: 02706474 15292401
Jesse E. Hanson; Lunbin Deng; David Hackos; Shih-Ching Lo; Benjamin E. Lauffer; Pascal Steiner; Qiang Zhou
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Pharmacokinetics of ranibizumab in patients with neovascular age-related macular degeneration: A population approach
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Lu Xu; Tong Lu; Lisa Tuomi; Nelson L'ntshotsholé Jumbe; Jian-Feng Lu; Stephen M. Eppler; Peter Kuebler; Lisa A. Damico; Amita Joshi
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Drug products for biological medicines
BioProcess International, ISSN: 15426319
Mire-Sluis; Donna French; Jennifer Mercer; Gerd Kleemann; John Dougherty
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Development of advanced fermentor control applications for use in an industrial automation environment
Journal of Laboratory Automation, ISSN: 22110690 22110682
Ryan Hamilton; Krishna Tamminana; John Boyd; Gen Sasaki; Alex Toda; Sid Haskell; Elizabeth Danbe
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A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer
Biopharmaceutics and Drug Disposition, ISSN: 01422782 1099081X
Sravanthi Cheeti; Nageshwar Budha; Sharmila Rajan; Mark J. Dresser; Jin Y. Jin
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Predictive DMPK: In silico ADME predictions in drug discovery
Molecular Pharmaceutics, ISSN: 15438384 15438392
Jane R. Kenny
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Physicochemical and DMPK in silico models: Facilitating their use by medicinal chemists
Molecular Pharmaceutics, ISSN: 15438384 15438392
Daniel F. Ortwine; Ignacio Aliagas
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The efficacy and tolerability of adriamycin, bleomycin, vinblastine, dacarbazine and Stanford V in older Hodgkin lymphoma patients: A comprehensive analysis from the North American intergroup trial E2496
British Journal of Haematology, ISSN: 00071048 13652141
Andrew M. Evens; Fangxin Hong; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Joseph M. Connors; Randy D. Gascoyne; Henry Wagner; Mary Gospodarowicz; Bruce D. Cheson; Patrick J. Stiff; Ranjana H. Advani; Thomas P. Miller; Richard T. Hoppe; Brad Kahl; Sandra J. Horning
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Chromatographic peak alignment using derivative dynamic time warping
Biotechnology Progress, ISSN: 87567938 15206033
Christopher Bork; Kenneth Ng; Yinhan Liu; Alex Yee; Michael Pohlscheidt
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Functional limitations due to axial and peripheral joint impairments in patients with ankylosing spondylitis: Are focused measures more informative?
Arthritis Care and Research, ISSN: 2151464X 21514658
Siddharth Bethi; Abhijit Dasgupta; Michael H. Weisman; Thomas J. Learch; Lianne S. Gensler; John C. Davis; John D. Reveille; Michael M. Ward
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Role of electrostatic potential in the in silico prediction of molecular bioactivation and mutagenesis
Molecular Pharmaceutics, ISSN: 15438384 15438392
Kevin A. Ford
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Population-based efficacy modeling of omalizumab in patients with severe allergic asthma inadequately controlled with standard therapy
AAPS Journal, ISSN: 15507416
Rui Zhu; Zheng; Wendy Putnam; Jennifer Visich; Mark D. Eisner; Matthews; Karin Rosén; David Z. D'Argenio
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Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models
Clinical Cancer Research, ISSN: 10780432 15573265
Jie Lin; Deepak Sampath; Michelle Nannini; Brian Lee; Michael Degtyarev; Jason Oeh; Heidi Savage; Zhengyu Guan; Rebecca Hong; Robert Kassees; Leslie Lee; Tyler Risom; Stefan Gross; Bianca M. Liederer; Koeppen; Nicholas J. Skelton; Jeffery J. Wallin; Marcia Belvin; Elizabeth A. Punnoose; Lori S. Friedman; Kui Lin
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Analyzing binomial data in a split-plot design: Classical approach or modern techniques?
Communications in Statistics: Simulation and Computation, ISSN: 03610918 15324141
Liang Fang; Thomas M. Loughin
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Simultaneous pharmacokinetic model for rolofylline and both M1-trans and M1-cis metabolites
AAPS Journal, ISSN: 15507416
Mark Stroh; Matthew M. Hutmacher; Jianmei Pang; Ryan Lutz; Hiroshi Magara; Julie Stone
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In vitro and in vivo evaluation of amorphous solid dispersions generated by different bench-scale processes, using griseofulvin as a model compound
AAPS Journal, ISSN: 15507416
Po-Chang Chiang; Yong Cui; Yingqing Ran; Joseph W. Lubach; Kang-Jye Chou; Linda Bao; Wei Jia; Hank La; Jonathan Hau; Amy Sambrone; Ann R. Qin; Yuzhong Deng; Harvey Wong
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