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Publications

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DISPLAYING 7301 - 7350 OF 15797 RESULTS

Fibroblast growth factor receptor 3 is a rational therapeutic target in bladder cancer
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Kilian M. Gust; David J. McConkey; Shannon Awrey; Paul K. Hegarty; Jing Qing; Jolanta Bondaruk; Avi Ashkenazi; Bogdan Czerniak; Colin P. Dinney; Peter C. Black
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Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: The ITC evidence-based position
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Kalvass; Polli; Bourdet; Bo Feng; Huang; Liu; Smith; Zhang; Zamek-Gliszczynski
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At scale analysis and optimization of a cell culture harvest process-mitigating risk and optimizing performance
American Pharmaceutical Review, ISSN: 10998012
Michael Pohlscheidt; Goetz Lieser; Bjoern-Erec Bertermann; Horst Eberhardt; Stefan Herter; Hermann Tebbe
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DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-hodgkin lymphoma
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Dongwei Li; Kirsten Achilles Poon; Shang-Fan Yu; Randall Dere; MaryAnn Go; Jeffrey Lau; Bing Zheng; Kristi Elkins; Dimitry Danilenko; Katherine R. Kozak; Pamela Chan; Josefa Chuh; Xiaoyan Shi; Denise Nazzal; Franklin Fuh; Jacqueline McBride; Vanitha Ramakrishnan; Ruth De Tute; Andy Rawstron; Andrew S. Jack; Rong Deng; Yu-Waye Chu; David Dornan; Marna Williams; William Y. Ho; Allen Ebens; Saileta Prabhu; Andrew G. Polson
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Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell
Biotechnology Progress, ISSN: 87567938 15206033
Zhilan Hu; Donglin Guo; Shirley S. M. Yip; Dejin Zhan; Shahram Misaghi; John C. Joly; Snedecor; Amy Shen
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Optimization of drug-drug interaction study design: Comparison of minimal physiologically based pharmacokinetic models on prediction of CYP3A inhibition by ketoconazole
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Bing Han; Jialin Mao; Jenny Y. Chien; Stephen D. Hall
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Use of an anti-apoptotic CHO cell line for transient gene expression
Biotechnology Progress, ISSN: 87567938 15206033
Nichole F. Macaraeg; Dorothea Reilly; Athena W. Wong
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BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor
Nature Cell Biology, ISSN: 14657392 14764679
Brian Biehs; Jimmy Kuang-Hsien Hu; Nicolas B. Strauli; Eugenio Sangiorgi; Heekyung Jung; Ralf-Peter Heber; Sunita Ho; Alice F. Goodwin; Jeremy S. Dasen; Mario R. Capecchi; Ophir D. Klein
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Reading speed improvements in retinal vein occlusion after ranibizumab treatment
JAMA Ophthalmology, ISSN: 21686165
Ivan J. Suñer; Neil M. Bressler; Rohit Varma; Paul P. Lee; Chantal M. Dolan; James Ward; Shoshana Colman; Roman G. Rubio
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In situ validation of an intestinal stem cell signature in colorectal cancer
Gut, ISSN: 00175749 14683288
Jennifer L. Ziskin; Debra Dunlap; Murat Yaylaoglu; Imola K. Fodor; William F. Forrest; Rajesh Patel; Nianfeng Ge; Gordon G. Hutchins; James K. Pine; Philip Quirke; Koeppen; Adrian M. Jubb
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Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactionss
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Harma Ellens; Shibing Deng; Joann Coleman; Joe Bentz; Mitchell E. Taub; Isabelle Ragueneau-Majlessi; Sophie P. Chung; Krisztina Herédi-Szabó; Sibylle Neuhoff; Johan Palm; Praveen Balimane; Lei Zhang; Masoud Jamei; Imad Hanna; Michael O'connor; Dallas Bednarczyk; Malin Forsgard; Xiaoyan Chu; Christoph Funk; Ailan Guo; Kathleen M. Hillgren; Libin Li; Anne Y. Pak; Elke S. Perloff; Ganesh Rajaraman; Laurent Salphati; Jan-Shiang Taur; Dietmar Weitz; Heleen M. Wortelboer; Cindy Q. Xia; Guangqing Xiao; Tetsuo Yamagata; Caroline A. Lee
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Authors' Response to Letter to the Editor on "Image Cytometry Protocols"
Journal of Histochemistry and Cytochemistry, ISSN: 00221554
Rosario Garrido; Tanja S. Zabka; Jianhua Tao; Mark Fielden; Adrian J. Fretland; Mudher Albassam
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T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Chaoran Li; Peter J. R. Ebert; Qi-Jing Li
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AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes
Nature, ISSN: 00280836 14764687
Ritu Kumar; Lauren Dimenna; Nadine Schrode; Ting-Chun Liu; Philipp Franck; Silvia Muñoz-Descalzo; Anna-Katerina Hadjantonakis; Ali A. Zarrin; Jayanta Chaudhuri; Olivier Elemento; Todd Evans
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Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Xiaozhang Zheng; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Jian Lin; Dominic J. Reynolds; Geeta Sharma; Chase C. Smith; Zhongguo Wang; Peter Dragovich; Angela Oh; Weiru Wang; Mark Zak; Janet Gunzner; Guiling Zhao; Po-Wai Yuen; Kenneth W. Bair
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Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor
Journal of Molecular Biology, ISSN: 10898638 00222836
Xiaolei Ma; Pierre A. Barthelemy; Lionel Rouge; Wiesmann; Sachdev S. Sidhu
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Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain
PLoS ONE, ISSN: 19326203
Rebecca A. Helmer; Oded Foreman; Janet S. Dertien; Marlyn Panchoo; Suhani M. Bhakta; Beverly S. Chilton
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Therapeutic protein drug-drug interactions: Navigating the knowledge gaps-highlights from the 2012 AAPS NBC roundtable and IQ Consortium/FDA workshop
AAPS Journal, ISSN: 15507416
Jane R. Kenny; Maggie M. Liu; Andrew T. Chow; Justin C. Earp; Raymond Evers; J. Greg Slatter; Diane D. Wang; Lei Zhang; Honghui Zhou
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Characterization of the guinea pig CMV gH/gL/GP129/GP131/GP133 complex in infection and spread
Virology, ISSN: 00426822 10960341
Marcy Auerbach; Donghong Yan; Ashley Fouts; Min Xu; Alberto Estevez; Cary D. Austin; Fernando Bazan; Becket Feierbach
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Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1
eLife, ISSN: 2050084X
Ling Luo; Hironori Uehara; Xiaohui Zhang; Subrata K. Das; Thomas Olsen; Derick Holt; Jacquelyn M. Simonis; Kyle Jackman; Nirbhai Singh; Tadashi R. Miya; Wei Huang; Faisal Ahmed; Ana Bastos-Carvalho; Yun Zheng Le; Christina Mamalis; Vince A. Chiodo; William W. Hauswirth; Judit Z. Baffi; Pedro M. Lacal; Angela Orecchia; Napoleone Ferrara; Guangping Gao; Kim Young-hee; Yingbin Fu; Leah Owen; Romulo J. C. Albuquerque; Wolfgang Baehr; Kirk Thomas; Dean Y. Li; Kakarla V. Chalam; Masabumi Shibuya; Salvatore Grisanti; David J. Wilson; Jayakrishna Ambati; Balamurali K. Ambati
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Adherence to dornase alfa treatment among commercially insured patients with cystic fibrosis
Journal of Medical Economics, ISSN: 13696998 1941837X
Samya Z. Nasr; Will Chou; Kathleen F. Villa; Eunice Chang; Michael S. Broder
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Population pharmacokinetics of cyclosporine in transplant recipients
AAPS Journal, ISSN: 15507416
Kelong Han; Venkateswaran C. Pillai; Raman Venkataramanan
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Janet Gunzner; Guiling Zhao; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bang Fu; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Sophie Mukadam; Thomas O'Brien; Angela Oh; Dominic J. Reynolds; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jasleen K. Sodhi; Weiru Wang; Zhongguo Wang; Yang Xiao; Po-Wai Yuen; Mark Zak; Lei Zhang; Xiaozhang Zheng; Kenneth W. Bair; Peter Dragovich
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Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells
Cancer Research, ISSN: 00085472 15387445
Luis E. Arias-Romero; Olga Villamar-Cruz; Min Huang; Klaus P. Hoeflich; Jonathan Chernoff
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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Christopher A. Hurley; Wade S. Blair; Richard J. Bull; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Hazel J. Dyke; Rina Fong; Nico Ghilardi; Paul Gibbons; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Robert J. Maxey; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Savita Ubhayakar; Anne Van Abbema; Stuart I. Ward; Bohdan Waszkowycz; Mark Zak
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Previous myocardial infarction as a risk factor for in-hospital cardiovascular outcomes (from the National Registry of Myocardial Infarction 4 and 5)
American Journal of Cardiology, ISSN: 00029149 18791913
Quang T. Bui; Vanessa S. Reddy; Joan R. Jacobs; Susan M. Begelman; Paul D. Frederick; Dave P. Miller; William J. French
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Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria
New England Journal of Medicine, ISSN: 15334406 00284793
Marcus Maurer; Karin Rosén; Hsin-Ju Hsieh; Sarbjit S. Saini; Clive E. Grattan; Ana Gimenéz-Arnau; Sunil Agarwal; Ramona Doyle; Janice Canvin; Allen P. Kaplan; Thomas B. Casale
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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Mark Zak; Christopher A. Hurley; Stuart I. Ward; Philippe Bergeron; Kathy Barrett; Mercedesz Balazs; Wade S. Blair; Richard J. Bull; Paroma Chakravarty; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Charles Ellwood; Simon Gaines; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Gribling; Chris Hamman; Eric Harstad; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Sharada Labadie; Wyne P. Lee; Jiangpeng Liao; Marya Liimatta; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Austin Reeve; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Ignacio Aliagas; Barbara Avitabile-Woo; Yisong Xiao; Jing Yang; Janusz J. Kulagowski
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Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d ][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2- methylpropanamide (GDC-0032): A β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Chudi O. Ndubaku; Timothy P. Heffron; Steven T. Staben; Matthew Baumgardner; Nicole Blaquiere; Erin K. Bradley; Richard J. Bull; Steven Do; Jennafer Dotson; Danette Dudley; Kyle A. Edgar; Lori S. Friedman; Richard Goldsmith; Robert Heald; Aleksandr Kolesnikov; Leslie Lee; Lewis; Michelle Nannini; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Jeffery J. Wallin; Lan Wang; Binqing Wei; Deepak Sampath; Alan G. Olivero
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Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade S. Blair; Christine Chang; Donnie Delarosa; Jason Devoss; James Driscoll; Eigenbrot; Nico Ghilardi; Paul Gibbons; Jason S Halladay; Adam R. Johnson; Pawan Bir Kohli; Yingjie Lai; Yanzhou Liu; Joseph P. Lyssikatos; Priscilla Mantik; Kapil Menghrajani; Jeremy Murray; Ivan Peng; Amy Sambrone; Steven Shia; Young G. Shin; Jan Smith; Sue J. Sohn; Vickie Tsui; Ultsch; Lawren C. Wu; Yisong Xiao; Wenqian Yang; Judy Young; Birong Zhang; Bing-Yan Zhu; Steven Magnuson
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Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies
Journal of Molecular Biology, ISSN: 10898638 00222836
Homer Pantua; Jingyu Diao; Ultsch; Meredith Hazen; Mary Mathieu; Krista McCutcheon; Kentaro Takeda; Shailesh V. Date; Tommy K. Cheung; Qui Phung; Hass; David Arnott; Hongo; Matthews; Alex Brown; Arvind H. Patel; Robert F. Kelley; Eigenbrot; Sharookh B. Kapadia
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miR-221/222 Targets Adiponectin Receptor 1 to Promote the Epithelial-to-Mesenchymal Transition in Breast Cancer
PLoS ONE, ISSN: 19326203
Michael S. Hwang; Nancy Yu; Susanna Y. Stinson; Peng Yue; Robert J. Newman; Bernard B. Allan; David Dornan
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Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant
Chemical Communications, ISSN: 1364548X 13597345
Laura M. Dornan; Qun Cao; James C.A. Flanagan; James J. Crawford; Matthew J. Cook; Mark J. Muldoon
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Evaluation of tumor-size response metrics to predict overall survival in Western and Chinese patients with first-line metastatic colorectal cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Laurent Claret; Manish Gupta; Kelong Han; Amita Joshi; Nenad Sarapa; Jing He; Bob Powell; Rene Bruno
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The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD41 T-cell recovery: A randomized trial
Blood, ISSN: 15280020 00064971
Peter W. Hunt; Nancy Shulman; Timothy L. Hayes; Viktor Dahl; Ma Somsouk; Nicholas T. Funderburg; Bridget McLaughlin; Alan L. Landay; Oluwatoyin Adeyemi; Lee E. Gilman; Brian Clagett; Benigno Rodriguez; Jeffrey N. Martin; Timothy W. Schacker; Barbara L. Shacklett; Sarah Palmer; Michael M. Lederman; Steven G. Deeks
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Early effects of tocilizumab in the treatment of moderate to severe active rheumatoid arthritis: A one-week sub-study of a randomised controlled trial (Rapid Onset and Systemic Efficacy [ROSE] Study)
Clinical and Experimental Rheumatology, ISSN: 0392856X 1593098X
Yazici; Jeffrey R. Curtis; Ince; Baraf; Lepley; Jenny Devenport; Arthur Kavanaugh
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Turning on lanthanide luminescence via nanoencapsulation
Inorganic Chemistry, ISSN: 00201669 1520510X
Boris Makhinson; Alexandra K. Duncan; Ashley R. Elam; Ana De Bettencourt-Dias; Colin D. Medley; Joshua E. Smith; Eric J. Werner
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MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
Journal of Experimental Medicine, ISSN: 00221007 15409538
Jaehak Oh; Nan Wu; Günther Baravalle; Benjamin Cohn; Jessica K. Ma; Bryan Lo; Ira Mellman; Satoshi Ishido; Mark S. Anderson; Jeoung-Sook Shin
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Drug products for biological medicines: Novel delivery devices, challenging formulations, and combination products, part 2
BioProcess International, ISSN: 15426319
Mire-Sluis; Donna French; Jennifer Mercer; Gerd Kleemann; John Dougherty
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On assay robustness: the importance of early determination and science-driven decision-making
Bioanalysis, ISSN: 17576180 17576199
Kyra J. Cowan
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Assessment and significance of protein-protein interactions during development of protein biopharmaceuticals
Biophysical Reviews, ISSN: 18672469 18672450
Sandeep Yadav; Jun Liu; Thomas M. Scherer; Yatin Gokarn; Barthélemy Demeule; Sonoko Kanai; Andya; Steven J. Shire
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Anti-inflammatory strategies for plaque stabilization after acute coronary syndromes topical collection on vascular biology
Current Atherosclerosis Reports, ISSN: 15346242 15233804
Amos Baruch; Nicholas Van Bruggen; Juyong Brian Kim; Joshua E. Lehrer-Graiwer
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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Peter Dragovich; Benjamin P. Fauber; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Yichin Liu; Shiva Malek; Borlan Pan; David Peterson; Keith Pitts; Hans E. Purkey; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang
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Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
Molecular Cancer Research, ISSN: 15417786 15573125
Sato; Larsen; Woochang Lee; Han Sun; David S. Shames; Maithili P. Dalvi; Ruben D. Ramirez; Hao Tang; John Michael DiMaio; Boning Gao; Yang Xie; Ignacio I. Wistuba; Adi Gazdar; Jerry W. Shay; Minna
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The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
Nature Reviews Cancer, ISSN: 1474175X 14741768
Morgan O'Hayre; José Vázquez-Prado; Irina Kufareva; Eric Stawiski; Tracy M. Handel; Somasekar Seshagiri; J. Silvio Gutkind
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Evaluation of food effect on pharmacokinetics of vismodegib in advanced solid tumor patients
Clinical Cancer Research, ISSN: 10780432 15573265
Manish R. Sharma; Theodore G. Karrison; Bethany Kell; Kehua Wu; Michelle Turcich; David Geary; S. Peter Kang; Naoko Takebe; Richard A. Graham; Michael Maitland; Richard L. Schilsky; Ratain; Ezra E W Cohen
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Next generation therapeutics
Current Opinion in Chemical Biology, ISSN: 13675931 18790402
Paul J. Carter; Daria Hazuda; James A. Wells
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Structure-guided design of a selective BCL-XL inhibitor
Nature Chemical Biology, ISSN: 15524450 15524469
Guillaume Lessene; Czabotar; Brad E Sleebs; Zobel; Kym N Lowes; Jerry M Adams; Jonathan B Baell; Colman; Deshayes; Wayne J. Fairbrother; Flygare; Paul Gibbons; Wilhelmus J A Kersten; Sanji Kulasegaram; Rebecca M Moss; John P Parisot; Brian J. Smith; Ian P Street; Hong Yang; David C.S. Huang; Keith G Watson
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Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas
Cancer Letters, ISSN: 03043835 18727980
Nadia Lounnas; Célia Rosilio; Marielle Nebout; Didier Mary; Emmanuel Griessinger; Zouhour Neffati; Johanna Chiche; Hergen Spits; Thijs Hagenbeek; Vahid Asnafi; Sally-Ann Poulsen; Claudiu T. Supuran; Jean-François Peyron; Véronique Imbert
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GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior
Neuropsychopharmacology, ISSN: 0893133X 1740634X
Jesse E. Hanson; Martin Weber; William J. Meilandt; Tiffany Wu; Tom Luu; Lunbin Deng; Mehrdad Shamloo; Morgan Sheng; Kimberly Scearce-Levie; Qiang Zhou
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