Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7451 - 7500 OF 15797 RESULTS

High-resolution imaging of entire organs by 3-dimensional imaging of solvent cleared organs (3DISCO)
Experimental Neurology, ISSN: 00144886 10902430
Ali Ertürk; Frank Bradke
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A thematic analysis of quality of life in lung transplant: The existing evidence and implications for future directions
American Journal of Transplantation, ISSN: 16006135 16006143
Singer; Joan Chen; Paul D. Blanc; Leard; Kukreja; Hubert Chen
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Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models
Clinical Cancer Research, ISSN: 10780432 15573265
Jie Lin; Deepak Sampath; Michelle Nannini; Brian B. Lee; Michael Degtyarev; Jason Oeh; Heidi Savage; Zhengyu Guan; Rebecca Hong; Robert Kassees; Leslie Lee; Tyler Risom; Stefan Gross; Bianca M. Liederer; Koeppen; Nicholas J. Skelton; Jeffery J. Wallin; Marcia Belvin; Elizabeth A. Punnoose; Lori S. Friedman; Kui Lin
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The efficacy and tolerability of adriamycin, bleomycin, vinblastine, dacarbazine and Stanford V in older Hodgkin lymphoma patients: A comprehensive analysis from the North American intergroup trial E2496
British Journal of Haematology, ISSN: 00071048 13652141
Andrew M. Evens; Fangxin Hong; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Joseph M. Connors; Randy D. Gascoyne; Henry Wagner; Mary Gospodarowicz; Bruce D. Cheson; Patrick J. Stiff; Ranjana H. Advani; Thomas P. Miller; Richard T. Hoppe; Wojciech Jurczak; Sandra J. Horning
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A sequential testing approach to detecting multiple change points in the proportional hazards model
Statistics in Medicine, ISSN: 02776715 10970258
Pei He; Liang Fang; Zheng Su
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Generation of tumor-targeted antibody-CpG conjugates
Journal of Immunological Methods, ISSN: 00221759 18727905
Zhongjun Li; Julie K. Jang; Melissa G. Lechner; Peisheng Hu; Leslie A. Khawli; Christopher A. Scannell; Alan L. Epstein
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Development of a robust flow cytometry-based pharmacodynamic assay to detect phospho-protein signals for phosphatidylinositol 3-kinase inhibitors in multiple myeloma
Journal of Translational Medicine, ISSN: 14795876
Congfen Li; Chikara Takahashi; Liangxuan Zhang; Mahrukh Huseni; Basha Stankovich; Haider Mashhedi; Joanna Y. Lee; French; Jeffrey Eastham-Anderson; Doris Kim; Howell; Matthew J. Brauer; Marcin Kowanetz; Yibing Yan; Eric W. Humke; Allen Ebens; Garret M. Hampton; Lackner; Priti Hegde; Shidong Jia
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Phosphorylation of dishevelled by protein kinase RIPK4 regulates Wnt signaling
Science, ISSN: 10959203 00368075
Xiaodong Huang; James C. McGann; Bob Y. Liu; Rami N. Hannoush; Jennie R. Lill; Victoria Pham; Kim Newton; Michael Kakunda; Jinfeng Liu; Christine Yu; Sarah G. Hymowitz; Hongo; Anthony Wynshaw-Boris; Paul G. Polakis; Richard M. Harland; Vishva M. Dixit
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Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8+ T Cell Responses in the Lymph Node
Immunity, ISSN: 10747613 10974180
Wolfgang Kastenmüller; Marlene Brandes; Ze Wang; Jasmin Herz; Jackson G. Egen; Ronald N. Germain
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A safe synthesis of 1,5-disubstituted 3-amino-1 H-1,2,4-triazoles from 1,3,4-oxadiazolium hexafluorophosphates
Synthesis (Germany), ISSN: 00397881 1437210X
Brian Wong; Andreas Stumpf; Diane Carrera; Christine Gu; Haiming Zhang
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Biomarker results from the AVADO phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer
British Journal of Cancer, ISSN: 00070920 15321827
David W. Miles; Sanne De Haas; Luc Dirix; Romieu; Chan; Pivot; Tomczak; Provencher; Javier Cortés; Paul Delmar; Stefan J. Scherer
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Future Perspectives
Pharmacogenomics of Human Drug Transporters: Clinical Impacts,
Toshihisa Ishikawa; Joseph A. Ware
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Discovery and optimization of a novel series of potent mutant B-Raf V600E selective kinase inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Melissa M. Vasbinder; Brian Aquila; Martin Augustin; Huawei Chen; Tony Cheung; Donald Cook; Lisa Drew; Benjamin P. Fauber; Steve Glossop; Michael Grondine; Edward Hennessy; Jeffrey Johannes; Stephen Lee; Paul Lyne; Mario Mörtl; Charles Omer; Sangeetha Palakurthi; Timothy Pontz; Jon Read; Li Sha; Minhui Shen; Stefan Steinbacher; Haixia Wang; Allan Wu; Minwei Ye
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A Major Epigenetic Programming Mechanism Guided by piRNAs
Developmental Cell, ISSN: 15345807 18781551
Xiao A. Huang; Hang Yin; Sarah Sweeney; Debasish Raha; Michael Snyder; Haifan Lin
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One resin, multiple products: A green approach to purification
ACS Symposium Series, ISSN: 19475918 00976156
Ekta Mahajan; Jay Werber; Kapil Kothary; Tina M. Larson
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Biomarkers of Residual Disease, Disseminated Tumor Cells, and Metastases in the MMTV-PyMT Breast Cancer Model
PLoS ONE, ISSN: 19326203
Christian Franci; Jenny Zhou; Zhaoshi Jiang; Zora Modrusan; Zinaida Good; Erica L. Jackson; Hosein Kouros-Mehr
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Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria
EMBO Journal, ISSN: 02614189 14602075
Coenraad Kuijl; Manohar Pilli; Suresh K. Alahari; Hans Janssen; Poh-Sim Khoo; Karen E. Ervin; Monica Calero; Sobhanaditya Jonnalagadda; Richard H. Scheller; Jacques Neefjes; Jagath R. Junutula
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Treatment satisfaction is associated with improved quality of life in patients treated with inhaled treprostinil for pulmonary arterial hypertension
Health and Quality of Life Outcomes, ISSN: 14777525
Hubert Chen; Erika B. Rosenzweig; S Karl Gotzkowsky; Carl Arneson; Andrew C. Nelsen; Robert C. Bourge
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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Trent A. Watkins; Bei Wang; Sarah Huntwork-Rodriguez; Jing Yang; Zhiyu Jiang; Jeffrey Eastham-Anderson; Zora Modrusan; Joshua S. Kaminker; Marc Tessier-Lavigne; Joe Lewcock
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PI3K/AKT Activation and Response in Phase IB: AKT Inhibitor GDC-0068 with Docetaxel (D) Or MFOLFOX6 (F) in Refractory Solid Tumors
Annals of Oncology, ISSN: 15698041 09237534
Raymond D. Meng; Molife; De Mattos-Arruda; Antoine Hollebecque; Isakoff; Desamparados Roda; Yan; Andrés Cervantes; Jean-Charles Soria; Mateo; Guillem Argiles; Bendell
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PI3K/AKT Activation and Response in Phase IB: AKT Inhibitor GDC-0068 with Docetaxel (D) Or MFOLFOX6 (F) in Refractory Solid Tumors
Annals of Oncology, ISSN: 15698041 09237534
Meng; Molife; De Mattos-Arruda; Antoine Hollebecque; Isakoff; Roda; Yan; Andrés Cervantes; Jean-Charles Soria; Mateo; Guillem Argiles; Bendell
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Analysis of early hypertension and clinical outcome with bevacizumab: Results from seven phase III studies
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Pamela Douglas; John P. Middleton; George W. Sledge; David H. Johnson; David A. Reardon; Dafeng Chen; Oliver Rosen
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Thermodynamic and structural characterization of an antibody gel
mAbs, ISSN: 19420862 19420870
Osigwe Esue; Anna X. Xie; Tim J. Kamerzell; Thomas W. Patapoff
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Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels
Journal of Cell Biology, ISSN: 00219525 15408140
Nathalie Jurisch-Yaksi; Applonia J. Rose; Huiqi Lu; Tim Raemaekers; Sebastian Munck; Pieter Baatsen; Veerle Baert; Wendy Vermeire; Suzie J. Scales; Daphne Verleyen; Roel Vandepoel; Przemko Tylzanowski; Emre Yaksi; Thomy de Ravel; H. Joseph Yost; Guy Froyen; Cammon B. Arrington; Wim Annaert
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IL-22, not simply a Th17 cytokine
Immunological Reviews, ISSN: 01052896 1600065X
Sascha Rutz; Celine Eidenschenk; Wenjun Ouyang
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Comparative Effectiveness of Chemotherapy in Elderly Patients with Metastatic Colorectal Cancer
Journal of Gastrointestinal Cancer, ISSN: 19416636 19416628
Sacha Satram-Hoang; Lee; Shui Yu; Sridhar R. Guduru; Ashokvardhan R. Gunuganti; Carolina Reyes; Edward McKenna
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Evaluating the impact of bevacizumab maintenance therapy on overall survival in advanced non-small-cell lung cancer
Clinical Lung Cancer, ISSN: 15257304 19380690
George Dranitsaris; Nancy Beegle; Arliene Ravelo; Traci Kalberer; Elaine B. Yu; Sachdev Thomas
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Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations
mAbs, ISSN: 19420862 19420870
Ekaterine Kortkhonjia; Relly Brandman; Joe Zhongxiang Zhou; Vincent A. Voelz; Ilya Chorny; Bruce Kabakoff; Thomas W. Patapoff; Ken A. Dill; Trevor E. Swartz
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Quality of life of young adult survivors of hematologic malignancies
Cancer Nursing, ISSN: 0162220X 15389804
Marlana R. Mattson; Regan K. Demshar; Barbara J. Daly
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Meeting report: PDA virus and TSE safety forum
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124
Hannelore Willkommen; Johannes Blümel; Kurt Brorson; Dayue Chen; Qi Chen; Albrecht Gröner; Thomas R. Kreil; James S. Robertson; Michel Ruffing; Sol Ruiz
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Freely turning over palmitate in erythrocyte membrane proteins is not responsible for the anchoring of lipid rafts to the spectrin skeleton: A study with bio-orthogonal chemical probes
Biochimica et Biophysica Acta - Biomembranes, ISSN: 00052736 18792642
Annarita Ciana; Cesare Achilli; Rami N. Hannoush; Angela Risso; Cesare Balduini; Giampaolo Minetti
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Cardiac tolerability of pertuzumab plus trastuzumab plus docetaxel in patients with HER2-positive metastatic breast cancer in CLEOPATRA: A randomized, double-blind, placebo-controlled phase III study
Oncologist, ISSN: 10837159 1549490X
Sandra M. Swain; Michael S. Ewer; Javier Cortés; Dino Amadori; David W. Miles; Adam Knott; Emma Clark; Benyunes; Graham Ross; Baselga
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Analysis of dermatologic events in vemurafenib-treated patients with melanoma
Oncologist, ISSN: 10837159 1549490X
Mario E. Lacouture; Madeleine Duvic; Axel Hauschild; Victor G. Prieto; Caroline Robert; Dirk Schadendorf; Caroline C. Kim; Christopher J. McCormack; Patricia L. Myskowski; Olivia Spleiss; Kerstin Trunzer; Fei Su; Betty Nelson; Keith B. Nolop; Joseph F. Grippo; Richard J. Lee; Matthew J. Klimek; James L. Troy; Andrew K. Joe
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Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice
Arthritis and Rheumatism, ISSN: 00043591 15290131
Rajasekaran; Nan Wang; Phi Truong; Rinderknecht; Macaubas; Beilhack; Shizuru; Mellins
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Meeting report - Workshop on virus removal by filtration: Trends and new developments
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124
Hannelore Willkommen; Johannes Blümel; Kurt Brorson; Dayue Chen; Qi Chen; Albrecht Gröner; Thomas R. Kreil; James S. Robertson; Michel Ruffing; Sol Ruiz
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Antimalarial chemoprophylaxis and the risk of neuropsychiatric disorders
Travel Medicine and Infectious Disease, ISSN: 14778939 18730442
Cornelia Schneider; Miriam Adamcova; Susan S. Jick; Patricia Schlagenhauf; Mary K. Miller; Hans-Georg Rhein; Christoph R. Meier
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PAR-1 contributes to the innate immune response during viral infection
Journal of Clinical Investigation, ISSN: 00219738 15588238
Silvio Antoniak; A. Phillip Owens III; Martin Baunacke; Julie C. Williams; Rebecca D. Lee; Alice Weithäuser; Patricia A. Sheridan; Ronny Malz; James P. Luyendyk; Denise A. Esserman; Jo Ann Trejo; Daniel Kirchhofer; Burns C. Blaxall; Rafal Pawlinski; Melinda A. Beck; Ursula Rauch; Nigel Mackman
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Antibody-drug conjugates for the treatment of B-cell non-Hodgkin's lymphoma and leukemia
Future Oncology, ISSN: 14796694 17448301
Yu-Waye Chu; Andrew G. Polson
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Characterization of the long-term pharmacokinetics of bevacizumab following last dose in patients with resected stage II and III carcinoma of the colon
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Jing Li; Manish Gupta; Denise Jin; Yan Xin; Jennifer Visich; David E. Allison
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Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver
Xenobiotica, ISSN: 00498254 13665928
Hoa Le; Kevin A. Ford; S. Cyrus Khojasteh; Peter W. Fan
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Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Sara A. Hurvitz; Luc Dirix; Judit Kocsis; Giulia V. Bianchi; Janice Lu; Jeferson Vinholes; Ellie Guardino; Chunyan Song; Barbara Tong; Vivian W. Ng; Yu-Waye Chu; Edith A. Perez
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Markers of response for the antiangiogenic agent bevacizumab
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Diether Lambrechts; Heinz-Josef Lenz; Sanne De Haas; Peter Carmeliet; Stefan J. Scherer
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The degrabase: A database of proteolysis in healthy and apoptotic human cells
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Emily D. Crawford; Julia E. Seaman; Nick Agard; Gerald W. Hsu; Olivier Julien; Sami Mahrus; Huy Nguyen; Kazutaka Shimbo; Hikari A.I. Yoshihara; Min Zhuang; Robert J. Chalkley; James A. Wells
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Cosolute effects on the chemical potential and interactions of an IgG1 monoclonal antibody at high concentrations
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Thomas M. Scherer
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Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma
Cell, ISSN: 10974172 00928674
Matija Snuderl; Ana Batista; Nathaniel D. Kirkpatrick; Carmen Ruiz de Almodovar; Lars Riedemann; Elisa C. Walsh; Rachel Anolik; Yuhui Huang; John D. Martin; Walid Kamoun; Ellen Knevels; Thomas Schmidt; Christian T. Farrar; Benjamin J. Vakoc; Nishant Mohan; Euiheon Chung; Sylvie Roberge; Teresa Peterson; Carlos Bais; Boryana H. Zhelyazkova; Stephen Yip; Martin Hasselblatt; Claudia Rossig; Elisabeth Niemeyer; Napoleone Ferrara; Michael Klagsbrun; Dan G. Duda; Dai Fukumura; Lei Xu; Peter Carmeliet; Rakesh K. Jain
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High Heregulin Expression Is Associated with Activated HER3 and May Define an Actionable Biomarker in Patients with Squamous Cell Carcinomas of the Head and Neck
PLoS ONE, ISSN: 19326203
David S. Shames; Juliet Carbon; Kimberly Walter; Adrian M. Jubb; Cleopatra Kozlowski; Thomas Januario; An Do; Ling Fu; Yuanyuan Xiao; Rajiv Raja; Brittany Jiang; Ashi Malekafzali; Howard M. Stern; Jeffrey Settleman; Wilson; Garret M. Hampton; Robert Yauch; Andrea Pirzkall; Lukas Amler
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Particle shape enhances specificity of antibody-displaying nanoparticles
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Sutapa Barua; Jin-Wook Yoo; Poornima Kolhar; Aditya A. Wakankar; Yatin Gokarn; Samir Mitragotri
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EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells
PLoS ONE, ISSN: 19326203
Eugene Y. Chiang; Robert J. Johnston; Jane L. Grogan
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Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia
PLoS ONE, ISSN: 19326203
Ai-Luen Wu; Bo Feng; Mark Chen; Ganesh Kolumam; Jose Zavala-Solorio; Shelby K. Wyatt; Vineela D. Gandham; Richard A. D. Carano; Junichiro Sonoda
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Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner
Oncogene, ISSN: 09509232 14765594
Wagner; Marschall; Karl; Cristofanon; Zobel; Deshayes; Domagoj Vucic; Debatin; Fulda
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