Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7601 - 7650 OF 15656 RESULTS

MTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations
Cancer Letters, ISSN: 03043835 18727980
Ulka Vijapurkar; Liliane Robillard; Siqun Zhou; Michael Degtyarev; Kui Lin; Tom Truong; Jarrod Tremayne; Berry; Zhonghua Pei; Lori S. Friedman; Elizabeth M. Blackwood; Marcia Belvin
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TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer
Molecular Cell, ISSN: 10972765 10974164
François Gonzalvez; David Lawrence; Becky Yang; Sharon Fong Yee; Pitti; Scot A. Marsters; Victoria Pham; Jean-Philippe Stephan; Jennie R. Lill; Avi Ashkenazi
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Development of capillary size exclusion chromatography for the analysis of monoclonal antibody fragments extracted from human vitreous humor
Journal of Chromatography A, ISSN: 00219673 18733778
Jennifer C. Rea; Yun Lou; Joel Cuzzi; Yuhua Hu; Isabella de Jong; Yajun Jennifer Wang; Dell Farnan
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Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Michael F. T. Koehler; Philippe Bergeron; Elizabeth M. Blackwood; Krista K. Bowman; Yunghsiang Chen; Gauri Deshmukh; Xiao Ding; Jennifer A. Epler; Kevin Lau; Leslie Lee; Lichuan Liu; Cuong Q. Ly; Shiva Malek; Jim Nonomiya; Jason Oeh; Daniel F. Ortwine; Deepak Sampath; Steve Sideris; Lan Trinh; Tom Truong; Jiansheng Wu; Zhonghua Pei; Joseph P. Lyssikatos
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Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Michael T. Lipari; Wei Li; Paul Moran; Monica Kong-Beltran; Tao Sai; Joyce Lai; S. Jack Lin; Ganesh Kolumam; Jose Zavala-Solorio; Anita Izrael-Tomasevic; David Arnott; Jianyong Wang; Andrew S. Peterson; Daniel Kirchhofer
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The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily
Biochemistry, ISSN: 15204995 00062960
Goetz Parsiegla; Christophe Noguere; Santell; Lazarus; Yves Bourne
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LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Bernd Wranik; Erin Christensen; Gabriele Schaefer; Janet Jackman; Andrew C. Vendel; Dan L. Eaton
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Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators
PLoS ONE, ISSN: 19326203
Justin M. Scheer; Wendy N. Sandoval; J. Michael Elliott; Lily Shao; Luis; Sock-Cheng Lewin-Koh; Gabriele Schaefer; Richard L. Vandlen
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Dynamic randomization and a randomization model for clinical trials data
Statistics in Medicine, ISSN: 02776715 10970258
Lee D. Kaiser
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A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments
Statistics in Medicine, ISSN: 02776715 10970258
Kingshuk Roy Choudhury; Finbarr O'Sullivan; Ian Kasman; Greg D. Plowman
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Multiple secretoglobin 1A1 genes are differentially expressed in horses
BMC Genomics, ISSN: 14712164
Olivier Côté; Brandon N. Lillie; Michael Anthony Hayes; Mary Ellen Clark; Laura van den Bosch; Paula Katavolos; Laurent Viel; Dorothee Bienzle
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Studying dissolution with a model integrating solid-liquid interface kinetics and diffusion kinetics
Analytical Chemistry, ISSN: 00032700 15206882
Jeff Y. Gao
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Mutation Scanning Using MUT-MAP, a High-Throughput, Microfluidic Chip-Based, Multi-Analyte Panel
PLoS ONE, ISSN: 19326203
Rajesh Patel; Alison Tsan; Rachel Tam; Rupal Desai; Nancy Schoenbrunner; Thomas W. Myers; Keith Bauer; Edward Smith; Rajiv Raja
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Molecular pathways: Next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1
Clinical Cancer Research, ISSN: 10780432 15573265
Daniel S. Chen; Bryan Irving; F. Stephen Hodi
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The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma
International Journal of Cancer, ISSN: 00207136 10970215
Momen Elshazley; Sato; Tetsunari Hase; Ryo Yamashita; Kenya Yoshida; Shinya Toyokuni; Futoshi Ishiguro; Hirotaka Osada; Yoshitaka Sekido; Kohei Yokoi; Noriyasu Usami; David S. Shames; Masashi Kondo; Adi Gazdar; Minna; Yoshinori Hasegawa
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Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models
Clinical Cancer Research, ISSN: 10780432 15573265
Jill M. Spoerke; Carol O'Brien; Huw; Koeppen; Jane Fridlyand; Rainer Brachmann; Matthias Peter; Ajay Pandita; Sankar Mohan; Deepak Sampath; Lori S. Friedman; Berry; Garret M. Hampton; Lukas Amler; David S. Shames; Lackner
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Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Peter Dragovich; Kathy Barrett; Wade S. Blair; Philippe Bergeron; Christine Chang; Gauri Deshmukh; Eigenbrot; Nico Ghilardi; Paul Gibbons; Christopher A. Hurley; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Rohan Mendonca; Jeremy Murray; Rebecca Pulk; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Mark Zak
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miR-451 regulates dendritic cell cytokine responses to influenza infection
Journal of Immunology, ISSN: 00221767 15506606
Carrie M. Rosenberger; Rebecca L. Podyminogin; Garnet Navarro; Guo-Wei Zhao; Peter S. Askovich; Mitchell J. Weiss; Alan Aderem
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Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria
Immunity, ISSN: 10747613 10974180
Rajatava Basu; Darrell B. O'Quinn; Daniel J. Silberger; Trenton R. Schoeb; Lynette Fouser; Wenjun Ouyang; Robin D. Hatton; Casey T. Weaver
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A caspase cascade regulating developmental axon degeneration
Journal of Neuroscience, ISSN: 02706474 15292401
David J. Simon; Robby M. Weimer; Todd McLaughlin; Dara Y. Kallop; Karen Stanger; Jing Yang; Dennis D.M. O'Leary; Rami N. Hannoush; Marc Tessier-Lavigne
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Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
PLoS ONE, ISSN: 19326203
Christopher E. Heise; Jeremy Murray; Katherine E. Augustyn; Brandon Bravo; Preeti Chugha; Frederick Cohen; Anthony M. Giannetti; Paul Gibbons; Rami N. Hannoush; Brian R. Hearn; Priyadarshini Jaishankar; Cuong Q. Ly; Kinjalkumar Shah; Karen Stanger; Micah Steffek; Yinyan Tang; Xianrui Zhao; Joe Lewcock; Adam R. Renslo; Flygare; Michelle R. Arkin
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Author response: Validation of the national eye institute visual function questionnaire-25 (NEIVFQ-25) in age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Peggy Orr; Anne M. Rentz; Mary Kay Margolis; Dennis A. Revicki; Chantal M. Dolan; Shoshana Colman; Jennifer T. Fine; Neil M. Bressler
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Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Daisy J. Bustos; Corey Bakalarski; Yanling Yang; Junmin Peng; Donald S. Kirkpatrick
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Microwave-assisted protein staining, destaining, and in-gel/in-solution digestion of proteins
Methods in Molecular Biology, ISSN: 10643745
Jennie R. Lill; Victor J. Nesatyy
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Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
Journal of Cell Biology, ISSN: 00219525 15408140
Bryan Lo; Geraldine Strasser; Meredith Sagolla; Cary D. Austin; Melissa Junttila; Ira Mellman
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Phosphoproteome of Pristionchus pacificus provides insights into architecture of signaling networks in nematode models
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Nadine Borchert; Karsten Krug; Florian Gnad; Amit Sinha; Ralf J. Sommer; Boris Macek
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A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission
Clinical Cancer Research, ISSN: 10780432 15573265
Stanley B. Kaye; Louis Fehrenbacher; Robert Holloway; Amnon Amit; Beth Karlan; Brian Slomovitz; Paul Sabbatini; Ling Fu; Robert Yauch; Ilsung Chang; Josina C. Reddy
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GWASTools: An R/Bioconductor package for quality control and analysis of genome-wide association studies
Bioinformatics, ISSN: 13674803 14602059
Stephanie M. Gogarten; Tushar Bhangale; Matthew P. Conomos; Cecelia A. Laurie; Caitlin P. McHugh; Ian Painter; Xiuwen Zheng; David R. Crosslin; David Levine; Thomas Lumley; Sarah C. Nelson; Kenneth Rice; Jess Shen; Rohit Swarnkar; Bruce S. Weir; Cathy C. Laurie
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Fixed monthly versus less frequent ranibizumab dosing and predictors of visual response in exudative age-related macular degeneration
Journal of Ophthalmology, ISSN: 2090004X 20900058
Seenu M. Hariprasad; Lawrence S. Morse; Howard Shapiro; Pamela Wong; Lisa Tuomi
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Pooled analysis of individual patient data from capecitabine monotherapy clinical trials in locally advanced or metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Blum; Carlos H. Barrios; Nancy Feldman; Sunil Verma; Edward McKenna; Lee; Nana Scotto; Julie Gralow
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A case of semantic variant primary progressive aphasia with severe insular atrophy
Neurocase, ISSN: 13554794 14653656
Tiffany Chow; Links; Masterman; Mendez; Harry V. Vinters
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Project execution risk management in the biopharmaceutical industry - A life cycle approach
AACE International Transactions, ISSN: 15287106
Britton L. Wolf
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Adjuvant trials of targeted agents: The newest battleground in the war on cancer
Current Topics in Microbiology and Immunology, ISSN: 0070217X
Robert L. Cohen
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Prostate cancer- a biomarker perspective
Frontiers in Endocrinology, ISSN: 16642392
Yanqiu Liu; Priti Hegde; Fengmin Zhang; Garret M. Hampton; Shidong Jia
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Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events
Genome Research, ISSN: 10889051 15495469
Jinfeng Liu; William Lee; Zhaoshi Jiang; Zhongqiang Chen; Suchit Jhunjhunwala; Matthias Peter; Florian Gnad; Yinghui Guan; Houston N. Gilbert; Stinson; Christiaan N. Klijn; Joseph Guillory; Deepali Bhatt; Steffan Vartanian; Kimberly Walter; Jocelyn Chan; Thomas Holcomb; Gerrit J. P. Dijkgraaf; Stephanie Johnson; Julie Koeman; Minna; Adi Gazdar; Howard M. Stern; Klaus P. Hoeflich; Thomas D Wu; Jeffrey Settleman; Frederic J. De Sauvage; Robert Gentleman; Richard M. Neve; David Stokoe; Zora Modrusan; Somasekar Seshagiri; David S. Shames; Zemin Zhang
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Computerized extraction of electrocardiograms from continuous 12-lead holter recordings reduces measurement variability in a thorough QT study
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Samuel George; Ignacio Rodriguez; David Ipe; Philip T. Sager; Ihor Gussak; Branislav Vajdic
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Survival outcomes of bevacizumab beyond progression in metastatic colorectal cancer patients treated in us community oncology
Clinical Colorectal Cancer, ISSN: 15330028 19380674
Cartwright; Yeun Mi Yim; Elaine B. Yu; Hsingwen Chung; Melissa Halm; Michael Forsyth
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Risk of Mortality, Fatal Infection, and Fatal Malignancy Related to Use of Anti-Tumor Necrosis Factor-α Biologics by Rheumatoid Arthritis Patients
Seminars in Arthritis and Rheumatism, ISSN: 00490172 1532866X
Veena Thyagarajan; Heather Norman; Kimberly Alexander; Pavel Napalkov; Cheryl Enger
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Adult asthma and risk of coronary heart disease, cerebrovascular disease, and heart failure: A prospective study of 2 matched cohorts
American Journal of Epidemiology, ISSN: 00029262 14766256
Carlos Iribarren; Irina V. Tolstykh; Mary K. Miller; Erica Sobel; Mark D. Eisner
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Population pharmacokinetics of rituximab in patients with chronic lymphocytic leukemia
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Jing Li; Jianguo Zhi; Michael Wenger; Nancy Valente; Anna Dmoszynska; Tadeusz Robak; Ranvir Mangat; Amita Joshi; Jennifer Visich
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Phase Ib study of drozitumab combined with first-line mFOLFOX6 plus bevacizumab in patients with metastatic colorectal cancer
Cancer Investigation, ISSN: 07357907 15324192
Caio M. Rocha Lima; Soley Bayraktar; Aurea M. Flores; Jessica MacIntyre; Alberto Montero; Joaquina C. Baranda; John Wallmark; Chia C. Portera; Rajiv Raja; Howard M. Stern; Stephanie Royer-Joo; Lukas Amler
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Erratum: Phase i clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma (Investigational New Drugs DOI 10.1007/s10637-011-9765-7)
Investigational New Drugs, ISSN: 01676997 15730646
Jason Konner; Rachel N. Grisham; Jae Park; Owen A. O'Connor; Gillian Cropp; Robert Johnson; Alison L. Hannah; Martee L. Hensley; Paul Sabbatini; Svetlana Mironov; Samuel Danishefsky; David Hyman; David R. Spriggs; Jakob Dupont; Carol Aghajanian
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Cost-effectiveness of rituximab as maintenance therapy in patients with follicular non-Hodgkin lymphoma after responding to first-line rituximab plus chemotherapy
Leukemia and Lymphoma, ISSN: 10428194 10292403
John Hornberger; Rebecca Chien; Mark Friedmann; Leona Han; Ashwini Shewade; Sacha Satram-Hoang; Carolina Reyes
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A new scale-down membrane adsorber device for process development and validation
BioPharm International, ISSN: 1542166X 19391862
Nathalie Frau; Martin Leuthold; Amit Mehta; Kome Shomglin; Rene Faber
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Mouse mammary tumor virus suppresses apoptosis of mammary epithelial cells through ITAM-mediated signaling
Journal of Virology, ISSN: 0022538X 10985514
Hyoung H. Kim; Shannon M. Grande; John G. Monroe; Susan R. Ross
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A phase 1 study of weekly dosing of trastuzumab emtansine (T-DM1) in patients with advanced human epidermal growth factor 2-positive breast cancer
Cancer, ISSN: 0008543X 10970142
Muralidhar Beeram; Ian E. Krop; Howard A. Burris; Sandhya Girish; Wei Yu; Michael W. Lu; Scott N. Holden; Shanu Modi
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Factors associated with gastrointestinal perforation in a cohort of patients with rheumatoid arthritis
Arthritis Care and Research, ISSN: 2151464X 21514658
Jeffrey R. Curtis; Angel Lanas; Ani John; David A. Johnson; Kathy L. Schulman
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Advanced microscale bioreactor system: A representative scale-down model for bench-top bioreactors
Cytotechnology, ISSN: 09209069 15730778
Wei-Ting Hsu; Rigzen P. S. Aulakh; Donald L. Traul; Inn H. Yuk
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Multiple courses of rituximab produce sustained clinical and radiographic efficacy and safety in patients with rheumatoid arthritis and an inadequate response to 1 or more tumor necrosis factor inhibitors: 5-Year data from the REFLEX study
Journal of Rheumatology, ISSN: 0315162X 14992752
Edward Keystone; Stanley B. Cohen; Paul Emery; Joel M. Kremer; Maxime Dougados; James E. Loveless; Carol Y. Chung; Pamela Wong; Lehane; Helen Tyrrell
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GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling
Nature Neuroscience, ISSN: 10976256 15461726
Seung Min Shin; Nanyan Zhang; Jonathan Hansen; Nashaat Z. Gerges; Daniel T. S. Pak; Morgan Sheng; Sang H. Lee
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