Genentech: Publications

October 1, 2012

Genomic landscape of liver cancer

Nature Genetics, ISSN: 10614036 15461718

Zemin Zhang

October 1, 2012

Mycobacterium marinum SecA2 promotes stable granulomas and induces tumor necrosis factor alpha in Vivo

Infection and Immunity, ISSN: 00199567 10985522

Brigitte Y. Watkins; Shilpa A. Joshi; David A. Ball; Hadley Leggett; Summer Park; Janice Kim; Cary D. Austin; Andres Paler Martinez; Min Xu; Kenneth H. Downing; Eric J. Brown

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October 1, 2012

The genetics of type I interferon in systemic lupus erythematosus

Current Opinion in Immunology, ISSN: 09527915 18790372

Paola G. Bronson; Christina Chaivorapol; Ward Ortmann; Timothy W. Behrens; Robert R. Graham

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October 1, 2012

Risk of Significant Infection in Rheumatoid Arthritis Patients Switching Anti-Tumor Necrosis Factor-α Drugs

Seminars in Arthritis and Rheumatism, ISSN: 00490172 1532866X

Bao-Anh Nguyen-Khoa; Earl L. Goehring; Kimberly Alexander; Wei Dong; Pavel Napalkov; Judith K. Jones

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October 1, 2012

Cost utility of palivizumab prophylaxis among pre-term infants in the United States: A national policy perspective

Journal of Medical Economics, ISSN: 13696998 1941837X

Parthiv J. Mahadevia; Anthony Masaquel; Mark J. Polak; Leonard B. Weiner

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October 1, 2012

European genetic ancestry is associated with a decreased risk of lupus nephritis

Arthritis and Rheumatism, ISSN: 00043591 15290131

Ilana B. Richman; Kimberly E. Taylor; Sharon A. Chung; Laura Trupin; Michelle Petri; Edward Yelin; Robert R. Graham; Annette T. Lee; Timothy W. Behrens; Peter K. Gregersen; Michael F. Seldin; Lindsey A. Criswell

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October 1, 2012

Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials

Retina, ISSN: 0275004X 15392864

Neil M. Bressler; David S. Boyer; David F. Williams; Butler; Steve Francom; Benton Brown; Flavia Di Nucci; Timothy Cramm; Lisa Tuomi; Tsontcho Ianchulev; Roman G. Rubio

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October 1, 2012

Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications

Journal of Nanoscience and Nanotechnology, ISSN: 15334880 15334899

Po-Chang Chiang; Yuzhong Deng; Savita Ubhayakar; Hank La; Yong Cui; Kang-Jye Chou; Yingqing Ran; Harvey Wong

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October 1, 2012

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

Nature Genetics, ISSN: 10614036 15461718

Charles M. Rudin; Durinck; Eric Stawiski; John T. Poirier; Zora Modrusan; David S. Shames; Emily A. Bergbower; Yinghui Guan; James Shin; Joseph Guillory; Rivers; Catherine K. Foo; Deepali Bhatt; Stinson; Florian Gnad; Matthias Peter; Robert Gentleman; Subhra Chaudhuri; Vasantharajan Janakiraman; Bijay S. Jaiswal; Chaitali Parikh; Yuan; Zemin Zhang; Koeppen; Thomas D Wu; Howard M. Stern; Robert Yauch; Kenneth E. Huffman; Diego D. Paskulin; Peter B. Illei; Marileila Varella-Garcia; Adi Gazdar; Frederic J. De Sauvage; Richard Bourgon; Minna; Malcolm V. Brock; Somasekar Seshagiri

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October 1, 2012

Omalizumab and the risk of malignancy: Results from a pooled analysis

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

William W. Busse; Roland Buhl; Carlos Fernandez Vidaurre; Martin Blogg; Jin Zhu; Mark D. Eisner; Janice Canvin

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October 1, 2012

Hepatitis C virus induces epidermal growth factor receptor activation via CD81 binding for viral internalization and entry

Journal of Virology, ISSN: 0022538X 10985514

Jingyu Diao; Homer Pantua; Hai Ngu; László Kömüves; Laurie Diehl; Gabriele Schaefer; Sharookh B. Kapadia

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October 1, 2012

Studying host cell protein interactions with monoclonal antibodies using high throughput protein A chromatography

Biotechnology Journal, ISSN: 18606768 18607314

Vikram N. Sisodiya; Joshua Lequieu; Maricel Rodriguez; Paul McDonald; Kathlyn P. Lazzareschi

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October 1, 2012

Improvements in health-related quality of life after treatment with tocilizumab in patients with rheumatoid arthritis refractory to tumour necrosis factor inhibitors: Results from the 24-week randomized controlled radiate study

Rheumatology, ISSN: 14620324 14620332

Vibeke Strand; Gerd R. Burmester; Sarika Ogale; Jenny Devenport; Ani John; Paul Emery

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September 28, 2012

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

Cell, ISSN: 10974172 00928674

Robert M. Samstein; Aaron Arvey; Steven Z. Josefowicz; Xiao Peng; Alex Reynolds; Richard Sandstrom; Shane Neph; Peter Sabo; Kim; Will Liao; Ming Li; Christina Leslie; John A. Stamatoyannopoulos; Alexander Y. Rudensky

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September 27, 2012

The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Timothy P. Heffron; Laurent Salphati; Bruno Alicke; Jonathan Cheong; Jennafer Dotson; Kyle A. Edgar; Richard Goldsmith; Stephen Gould; Leslie Lee; John Lesnick; Lewis; Chudi O. Ndubaku; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Emile G. Plise; Steve Sideris; Sean Trapp; Jeffery J. Wallin; Lan Wang; Xiaolin Zhang

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September 27, 2012

Cross-neutralization of influenza A viruses mediated by a single antibody loop

Nature, ISSN: 00280836 14764687

Damian C. Ekiert; Arun K. Kashyap; John Steel; Adam Rubrum; Gira Bhabha; Reza Khayat; Jeong Hyun Lee; Michael Dillon; Ryann E. O'Neil; Aleksandr M. Faynboym; Michael Horowitz; Lawrence Horowitz; Andrew B. Ward; Peter Palese; Richard Webby; Richard A. Lerner; Ramesh R. Bhatt; Ian A. Wilson

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September 27, 2012

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton

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September 27, 2012

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Blood, ISSN: 15280020 00064971

Raghuveer Singh Mali; Peilin Ma; Li-Fan Zeng; Holly Martin; Baskar Ramdas; Yantao He; Emily Sims; Sarah Nabinger; Joydeep Ghosh; Namit Sharma; Veerendra Munugalavadla; Anindya Chatterjee; Shuo Li; Sandusky; Andrew W. Craig; Kevin D. Bunting; Gen-Sheng Feng; Rebecca J. Chan; Zhong-Yin Zhang; Reuben Kapur

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September 27, 2012

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian B. Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton

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September 26, 2012

Spatially coordinated kinase signaling regulates local axon degeneration

Journal of Neuroscience, ISSN: 02706474 15292401

Mark Chen; Janice Maloney; Dara Y. Kallop; Jasvinder K. Atwal; Stephen Tam; Kristin Baer; Holger Kissel; Joshua S. Kaminker; Joe Lewcock; Robby M. Weimer; Ryan J. Watts

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September 21, 2012

Loss of the tumor suppressor BAP1 causes myeloid transformation

Science, ISSN: 10959203 00368075

Anwesha Dey; Dhaya Seshasayee; Rajkumar Noubade; French; Jinfeng Liu; Mira S. Chaurushiya; Donald S. Kirkpatrick; Victoria Pham; Jennie R. Lill; Corey Bakalarski; Jiansheng Wu; Lilian Phu; Paula Katavolos; Lindsay M. LaFave; Omar Abdel-Wahab; Zora Modrusan; Somasekar Seshagiri; Ken Dong; Zhonghua Lin; Mercedesz Balazs; Rowena Suriben; Kim Newton; Sarah G. Hymowitz; Guillermo Garcia-Manero; Flavius Martin; Ross L. Levine; Vishva M. Dixit

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September 20, 2012

Effectiveness of first-line management strategies for stage I follicular lymphoma: Analysis of the National Lymphocare Study

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Jonathan W. Friedberg; Michelle Byrtek; Brian K. Link; Christopher R. Flowers; Taylor; John Hainsworth; James R. Cerhan; Zelenetz; Jamie Hirata; Thomas P. Miller

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September 19, 2012

Childhood disorders of the synapse: Challenges and opportunities

Science Translational Medicine, ISSN: 19466234 19466242

Virginia Hughes; Morgan Sheng; Huda Y. Zoghbi

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September 18, 2012

Impact of hemodialysis catheter dysfunction on dialysis and other medical services: An observational cohort study

International Journal of Nephrology, ISSN: 2090214X 20902158

Robert I. Griffiths; Britt B. Newsome; Grace Leung; Geoffrey A. Block; Robert J. Herbert; Mark Danese

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September 17, 2012

Validity of cost and utility results?

PharmacoEconomics, ISSN: 11707690 11792027

Alex Diamantopoulos; Laura Sawyer; Sarika Ogale; Fred Dejonckheere

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September 17, 2012

Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging

PLoS ONE, ISSN: 19326203

Amrita Kamath; Simon P. Williams; Sherron Bullens; Kyra J. Cowan; Yvonne Stenberg; Simon R. Cherry; Stephen Rendig; David L. Kukis; Chris Griesemer; Lisa A. Damico; Bunting

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September 15, 2012

Ras inhibition via direct Ras binding - Is there a path forward?

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Weiru Wang; Guowei Fang; Joachim Rudolph

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September 13, 2012

Potent and highly selective benzimidazole inhibitors of PI3-kinase delta

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Jeremy Murray; Zachary K. Sweeney; Bryan K. Chan; Mercedesz Balazs; Erin K. Bradley; Georgette M. Castanedo; Christine Chabot; David Chantry; Michael Flagella; David M. Goldstein; Rama Kondru; John Lesnick; Jun Li; Matthew C. Lucas; Jim Nonomiya; Jodie Pang; Stephen Price; Laurent Salphati; Brian S. Safina; Pascal P. A. Savy; Eileen Seward; Ultsch; Daniel P. Sutherlin

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September 13, 2012

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

Nature, ISSN: 00280836 14764687

David Vilchez; Ianessa Morantte; Zheng Liu; Peter M. Douglas; Carsten Merkwirth; Ana P. C. Rodrigues; Gerard Manning; Andrew Dillin

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September 10, 2012

A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Ian E. Krop; Patricia M. LoRusso; Kathy Miller; Shanu Modi; Denise A. Yardley; Gladys Rodriguez; Ellie Guardino; Michael W. Lu; Maoxia Zheng; Sandhya Girish; Lukas Amler; Eric P. Winer; Hope S. Rugo

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September 6, 2012

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production

Blood, ISSN: 15280020 00064971

Jonathan N. Thon; Matthew T. Devine; Antonija Jurak Begonja; Jay Tibbitts; Joseph E. Italiano Jr.

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September 6, 2012

Structural transitions of transmembrane helix 6 in the formation of Metarhodopsin i

Journal of Physical Chemistry B, ISSN: 15205207 15206106

Markus Eilers; Joseph A. Goncalves; Shivani Ahuja; Colleen Kirkup; Amiram Hirshfeld; Carlos Simmerling; Philip J. Reeves; Mordechai Sheves; Steven O. Smith

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September 6, 2012

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

Blood, ISSN: 15280020 00064971

Bithi Chatterjee; Anna Smed-Sörensen; Lillian Cohn; Cecile Chalouni; Richard L. Vandlen; Byoung-Chul Lee; Jenifer Widger; Tibor Keler; Lélia Delamarre; Ira Mellman

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September 6, 2012

Dr. Sekulic and colleagues reply

New England Journal of Medicine, ISSN: 15334406 00284793

Aleksandar Sekulic; Josina C. Reddy; Axel Hauschild

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September 5, 2012

Binding mechanism of metalṡNTP substrates and stringent-response alarmones to bacterial DnaG-type primases

Structure, ISSN: 18784186 09692126

Richard U. Rymer; Francisco A. Solorio; Ashley K. Tehranchi; Clement Chu; Jacob E. Corn; James L. Keck; Jue D. Wang; James M. Berger

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September 4, 2012

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

Journal of Clinical Investigation, ISSN: 00219738 15588238

Yanqiu Liu; Agnes D. Berendsen; Shidong Jia; Sutada Lotinun; Roland Baron; Napoleone Ferrara; Bjorn R. Olsen

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September 4, 2012

Molecular basis for negative regulation of the glucagon receptor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christopher M. Koth; Jeremy Murray; Susmith Mukund; Azadeh Madjidi; Alexandra Minn; Holly J. Clarke; Wong; Vicki Chiang; Luis; Alberto Estevez; Jesus Rondon; Yingnan Zhang; Isidro Hötzel; Bernard B. Allan

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September 4, 2012

FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice

Journal of Clinical Investigation, ISSN: 00219738 15588238

Sunyoung Lee; Roland Meier; Saori Furuta; Marc E. Lenburg; Paraic A. Kenny; Ren Xu; Mina J. Bissell

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September 1, 2012

Anti-neuropilin-1 (MNRP1685A): Unexpected pharmacokinetic differences across species, from preclinical models to humans

Pharmaceutical Research, ISSN: 07248741 1573904X

Yan Xin; Shuang Bai; Lisa A. Damico; Denise Jin; Wei-Ching Liang; Yan Wu; Frank-Peter Theil; Amita Joshi; Yanmei Lu; John Lowe; Mauricio Maia; Rainer Brachmann; Hong Xiang

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September 1, 2012

Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): An Emphasis on preclinical and clinical catabolism

Current Drug Metabolism, ISSN: 13892002 18755453

Shen; Daniela Bumbaca; Ola M. Saad; Qin Yue; Cinthia V Pastuskovas; S. Cyrus Khojasteh; Jay Tibbitts; Surinder Kaur; Wang; Yu-Waye Chu; Patricia M. LoRusso; Sandhya Girish

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September 1, 2012

Pharmacokinetic considerations for antibody drug conjugates

Pharmaceutical Research, ISSN: 07248741 1573904X

Kedan Lin; Jay Tibbitts

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September 1, 2012

Psychometric evaluation of the cystic fibrosis questionnaire-revised in a national sample

Quality of Life Research, ISSN: 09629343

Alexandra L. Quittner; Gregory S. Sawicki; Ann McMullen; Lawrence Rasouliyan; David J. Pasta; Ashley Yegin; Michael W. Konstan

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September 1, 2012

A role for Th17 cells in the regulation of tertiary lymphoid follicles

European Journal of Immunology, ISSN: 00142980 15214141

Jane L. Grogan; Wenjun Ouyang

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September 1, 2012

Tissue distribution studies of protein therapeutics using molecular probes: Molecular imaging

AAPS Journal, ISSN: 15507416

Simon P. Williams

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September 1, 2012

Dyslipidemia and changes in lipid profiles associated with rheumatoid arthritis and initiation of anti-tumor necrosis factor therapy

Arthritis Care and Research, ISSN: 2151464X 21514658

Jeffrey R. Curtis; Ani John; Onur Baser

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September 1, 2012

Drug interaction potential of trastuzumab emtansine (T-DM1) combined with pertuzumab in patients with HER2-positive metastatic breast cancer

Current Drug Metabolism, ISSN: 13892002 18755453

Dan Lu; Howard A. Burris; Wang; E. Claire Dees; Javier Cortés; Amita Joshi; Manish Gupta; Joo-Hee Yi; Yu-Waye Chu; Ted Shih; Liang Fang; Sandhya Girish

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September 1, 2012

Diagnosis and management of childhood obstructive sleep apnea syndrome

Pediatrics, ISSN: 00314005 10984275

Carole L. Marcus; Lee Jay Brooks; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Michael S. Schechter; Stephen Howard Sheldon; Karen Spruyt; Sally Davidson Ward; Christopher Lehmann; Richard N. Shiffman

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September 1, 2012

Diagnosis and management of childhood obstructive sleep apnea syndrome

Pediatrics, ISSN: 00314005 10984275

Carole L. Marcus; Lee Jay Brooks; Sally Davidson Ward; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Christopher Lehmann; Michael S. Schechter; Stephen Howard Sheldon; Richard N. Shiffman; Karen Spruyt

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September 1, 2012

Compartmental tissue distribution of antibody therapeutics: Experimental approaches and interpretations

AAPS Journal, ISSN: 15507416

C. Andrew Boswell; Daniela Bumbaca; Fielder; Leslie A. Khawli

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September 1, 2012

Differential effects of predosing on tumor and tissue uptake of an 111in-labeled anti-TENB2 antibody-drug conjugate

Journal of Nuclear Medicine, ISSN: 01615505

C. Andrew Boswell; Eduardo E. Mundo; Crystal Zhang; Shannon Stainton; Shang-Fan Yu; Jennifer A. Lacap; Mao; Katherine R. Kozak; Aimee Fourie-O'Donohue; Paul G. Polakis; Leslie A. Khawli; Kedan Lin

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