Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7851 - 7900 OF 15656 RESULTS

Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma
American Journal of Neuroradiology, ISSN: 01956108 1936959X
Jose A. Carrillo; Albert Lai; Phioanh L. Nghiemphu; Kim; Phillips; Samir Kharbanda; Moftakhar; Lalaezari; William H. Yong; Benjamin M. Ellingson; Timothy Cloughesy; Whitney B. Pope
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Protein microarrays, biosensors, and cell-based methods for secretome-wide extracellular protein-protein interaction mapping
Methods, ISSN: 10462023 10959130
Lino C. Gonzalez Jr.
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Drug absorption interactions between oral targeted anticancer agents and PPIs: Is pH-dependent solubility the achilles heel of targeted therapy
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Nageshwar Budha; Adam Frymoyer; Gillian S. Smelick; Jin Y. Jin; Marc R. Yago; Mark J. Dresser; Scott N. Holden; Leslie Z. Benet; Joseph A. Ware
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Nanolitre-scale crystallization using acoustic liquid-transfer technology
Acta Crystallographica Section D: Biological Crystallography, ISSN: 09074449 13990047
Armando G. Villasẽor; April Wong; Ada Shao; Ankur Garg; Timothy J. Donohue; Andreas Kuglstatter; Seth F. Harris
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Identification of Asp isomerization in proteins by 18O labeling and tandem mass spectrometry
Methods in Molecular Biology, ISSN: 10643745
Jennifer Zhang; Viswanatham Katta
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Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function
Methods in Molecular Biology, ISSN: 10643745
Robert F. Kelley; Meng
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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
Nature, ISSN: 00280836 14764687
Wilson; Jane Fridlyand; Yibing Yan; Elicia M. Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Wang; Jeffrey A. Sosman; Antoni Ribas; Jiang Li; John Moffat; Daniel P. Sutherlin; Koeppen; Mark Merchant; Richard M. Neve; Jeffrey Settleman
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The development of small-molecule IAP antagonists for the treatment of cancer
Topics in Medicinal Chemistry, ISSN: 18622461 1862247X
Deshayes; Jeremy Murray; Domagoj Vucic
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Inefficiency of randomization methods that balance on stratum margins and improvements with permuted blocks and a sequential method
Statistics in Medicine, ISSN: 02776715 10970258
Lee D. Kaiser
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Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease
Blood, ISSN: 15280020 00064971
Pichika Chantrathammachart; Nigel Mackman; Erica Sparkenbaugh; Jian-Guo Wang; Leslie V. Parise; Daniel Kirchhofer; Nigel S. Key; Rafal Pawlinski
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CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Blood, ISSN: 15280020 00064971
Sebastian Willenborg; Tina Lucas; Geert Van Loo; Johanna A. Knipper; Thomas Krieg; Ingo Haase; Bent Brachvogel; Matthias Hammerschmidt; Andras Nagy; Napoleone Ferrara; Manolis Pasparakis; Sabine A. Eming
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Coarse-grained modeling of the self-association of therapeutic monoclonal antibodies
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Anuj Chaudhri; Isidro E. Zarraga; Tim J. Kamerzell; J. Paul Brandt; Thomas W. Patapoff; Steven J. Shire; Gregory A. Voth
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Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Edna F. Choo; Bruno Alicke; Xiao Ding; Hank La; Erin McNamara; Frank-Peter Theil; Jay Tibbitts; Lori S. Friedman; Cornelis E. Hop; Stephen Gould
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Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2
Cancer Research, ISSN: 00085472 15387445
Meilan He; Wei Zhang; Thomas Bakken; Melissa Schutten; Zsolt Toth; Jae U. Jung; Parkash Gill; Mark Cannon; Shou-Jiang Gao
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GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death In Vitro and In Vivo
Clinical Cancer Research, ISSN: 10780432 15573265
Jeffery J. Wallin; Zhengyu Guan; Wei Wei Prior; Leslie Lee; Berry; Lisa D. Belmont; Koeppen; Marcia Belvin; Lori S. Friedman; Deepak Sampath
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Structure and conservation of the periplasmic targeting factor Tic22 protein from plants and cyanobacteria
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Joanna Tripp; Alexander Hahn; Patrick Koenig; Nadine Flinner; Daniela Bublak; Eva M. Brouwer; Franziska Ertel; Oliver Mirus; Irmgard Sinning; Ivo Tews; Enrico Schleiff
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The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Youjun Chen; Cecile Chalouni; Christine Tan; Robyn Clark; Rayna Venook; Rachana Ohri; Helga Raab; Ron Firestein; William Mallet; Paul G. Polakis
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Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Mark Zak; Rohan Mendonca; Mercedesz Balazs; Kathy Barrett; Philippe Bergeron; Wade S. Blair; Christine Chang; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Chris Hamman; Emily J. Hanan; Eric Harstad; Peter R. Hewitt; Christopher A. Hurley; Tian Jin; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Janusz J. Kulagowski; Sharada Labadie; Jiangpeng Liao; Marya Liimatta; Zhonghua Lin; Patrick J. Lupardus; Robert J. Maxey; Jeremy Murray; Rebecca Pulk; Madeleine Rodriguez; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Ling Xiao; Yisong Xiao
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An effector-reduced anti-β-amyloid (Aβ) antibody with unique Aβ binding properties promotes neuroprotection and glial engulfment of Aβ
Journal of Neuroscience, ISSN: 02706474 15292401
Oskar Adolfsson; Maria Pihlgren; Nicolas Toni; Yvan Varisco; Anna Lucia Buccarello; Katia Antoniello; Sophie Lohmann; Kasia Piorkowska; Valerie Gafner; Jasvinder K. Atwal; Janice Maloney; Mark Chen; Alvin Gogineni; Robby M. Weimer; Deborah L. Mortensen; Michel Friesenhahn; Carole Ho; Robert Paul; Andrea Pfeifer; Andreas Muhs; Ryan J. Watts
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Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Taejin Yoon; Henriette Macmillan; Sarah E. Mortimer; Wei Jiang; Rinderknecht; Lawrence J. Stern; Mellins
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Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth
Cancer Cell, ISSN: 18783686 15356108
Nicholas S. Wilson; Annie Yang; Becky Yang; Suzana Couto; Howard M. Stern; Alvin Gogineni; Pitti; Scot A. Marsters; Robby M. Weimer; Mallika Singh; Avi Ashkenazi
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PiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Cell, ISSN: 10974172 00928674
Alyson Ashe; Alexandra Sapetschnig; Eva-Maria Weick; Jacinth Mitchell; Marloes P. Bagijn; Amy C. Cording; Anna-Lisa Doebley; Leonard D. Goldstein; Nicolas J. Lehrbach; Jérémie Le Pen; Greta Pintacuda; Aisa Sakaguchi; Peter Sarkies; Shawn Ahmed; Eric A. Miska
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A conserved role of IQGAP1 in regulating TOR complex 1
Journal of Cell Science, ISSN: 00219533 14779137
Yemsrach K. Tekletsadik; Robert Sonn; Mahasin A. Osman
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Weak interactions govern the viscosity of concentrated antibody solutions: High-throughput analysis using the diffusion interaction parameter
Biophysical Journal, ISSN: 00063495 15420086
Brian D. Connolly; Chris Petry; Sandeep Yadav; Barthélemy Demeule; Natalie Ciaccio; Jamie M. R. Moore; Steven J. Shire; Yatin Gokarn
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A novel method to calculate mean survival time for time-to-event data
Communications in Statistics: Simulation and Computation, ISSN: 03610918 15324141
Zheng Su; Liang Fang
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Considerations in the development of circulating tumor cell technology for clinical use
Journal of Translational Medicine, ISSN: 14795876
David R. Parkinson; Nicholas Dracopoli; Brenda G. Petty; Carolyn Compton; Massimo Cristofanilli; Albert Deisseroth; Daniel F. Hayes; Gordon Kapke; Prasanna Kumar; Jerry S.H. Lee; Minetta C. Liu; Robert McCormack; Stanislaw Mikulski; Larry Nagahara; Klaus Pantel; Sonia Pearson-White; Elizabeth A. Punnoose; Lori T. Roadcap; Andrew E. Schade; Scher; Caroline C. Sigman; Gary J. Kelloff
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Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease
Journal of Clinical Investigation, ISSN: 00219738 15588238
Azeb Tadesse Argaw; Linnea Asp; Jingya Zhang; Kristina Navrazhina; Trinh Pham; John N. Mariani; Sean Mahase; Dipankar J. Dutta; Jeremy Seto; Elisabeth G. Kramer; Napoleone Ferrara; Michael V. Sofroniew; Gareth R. John
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Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
Nature Biotechnology, ISSN: 10870156 15461696
Mallika Singh; Napoleone Ferrara
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A Randomized, phase II trial of standard triweekly compared with dose-dense biweekly capecitabine plus oxaliplatin plus bevacizumab as first-line treatment for metastatic colorectal cancer: XELOX-A-DVS (dense versus standard)
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Edith Mitchell; Thomas Cartwright; Ambrose Kwok; Hu; Edward McKenna; Yehuda Z. Patt
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Regulation of epithelial immunity by IL-17 family cytokines
Trends in Immunology, ISSN: 14714906 14714981
Rajita Pappu; Sascha Rutz; Wenjun Ouyang
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The transcription factor ZNF217 Is a prognostic biomarker and therapeutic target during breast cancer progression
Cancer Discovery, ISSN: 21598274 21598290
Laurie E. Littlepage; Adam S. Adler; Hosein Kouros-Mehr; Guiqing Huang; Jonathan Chou; Sheryl R. Krig; Obi L. Griffith; James E. Korkola; Kun Qu; Devon A. Lawson; Qing Xue; Mark D. Sternlicht; Gerrit J. P. Dijkgraaf; Paul Yaswen; Hope S. Rugo; Colleen A. Sweeney; Colin C. Collins; Joe W. Gray; Howard Y. Chang; Zena Werb
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A single-dose study of denosumab in patients with various degrees of renal impairment
Journal of Bone and Mineral Research, ISSN: 08840431 15234681
Geoffrey A. Block; Henry G. Bone; Liang Fang; Edward Lee; Desmond Padhi
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Generation of a cholesterol-independent, non-GS NS0 cell line through chemical treatment and application for high titer antibody production
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Jincai Li; Wei Gu; Diane G. Edmondson; Connie Lu; Natarajan Vijayasankaran; Bruno Figueroa; Dave Stevenson; Thomas Ryll; Feng Li
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Lack of a meaningful effect of anacetrapib on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
British Journal of Clinical Pharmacology, ISSN: 03065251 13652125
Rajesh Krishna; Daria Stypinski; Melissa Ali; Amit Garg; Josee Cote; Andrea Maes; Bruce Degroot; Yang Liu; Susie Li; Sandra M. Connolly; John A. Wagner; S. Aubrey Stoch
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Simultaneous, sequential quantitative achiral-chiral analysis by two-dimensional liquid chromatography
Journal of Separation Science, ISSN: 16159306 16159314
Venkatramani; Larry Wigman; Kavita Mistry; Nicholas Chetwyn
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Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Daniel P. Sutherlin; Stewart Baker; Angelina Bisconte; Paul M. Blaney; Anthony Brown; Bryan K. Chan; David Chantry; Georgette M. Castanedo; Paul Depledge; Paul Goldsmith; David M. Goldstein; Timothy Hancox; Jasmit Kaur; David Knowles; Rama Kondru; John Lesnick; Matthew C. Lucas; Lewis; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Brian S. Safina; Laurent Salphati; Steven T. Staben; Eileen Seward; Stephen Shuttleworth; Sukhjit Sohal; Zachary K. Sweeney; Ultsch; Bohdan Waszkowycz; Binqing Wei
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Drug-drug interaction potential of marketed oncology drugs: In vitro assessment of time-dependent cytochrome P450 inhibition, reactive metabolite formation and drug-drug interaction prediction
Pharmaceutical Research, ISSN: 07248741 1573904X
Jane R. Kenny; Sophie Mukadam; Chenghong Zhang; Suzanne Tay; Carol Collins; Aleksandra Galetin; S. Cyrus Khojasteh
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Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans
mAbs, ISSN: 19420862 19420870
Marcella Yu; Darren Brown; Chae Reed; Shan Chung; Jeff Lutman; Stefanich; Anne Wong; Jean-Philippe Stephan; Robert Bayer
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The effect of fellow eye visual acuity on visual acuity of study eyes receiving ranibizumab for age-related macular degeneration
Retina, ISSN: 0275004X 15392864
Sandrine A. Zweifel; Namrata Saroj; Howard Shapiro; K. Bailey Freund
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Ultrasensitive detection of cellular protein interactions using bioluminescence resonance energy transfer quantum dot-based nanoprobes
Journal of Cellular Biochemistry, ISSN: 07302312 10974644
Gabriel Quinones; Steven C. Miller; Sukanta Bhattacharyya; Daniel Sobek; Jean-Philippe Stephan
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Androgen hormone action in prostatic carcinogenesis: Stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis
Carcinogenesis, ISSN: 01433334 14602180
Emily A. Ricke; Karin Williams; Yi-Fen Lee; Suzana Couto; Yuzhuo Wang; Simon W. Hayward; Gerald R. Cunha; William A. Ricke
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The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients
British Journal of Pharmacology, ISSN: 00071188 14765381
Andrew G. Polson; Reina N. Fuji
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Antibodies against the gh/gl/UL128/UL130/UL131 complex comprise the majority of the anti-cytomegalovirus (Anti-CMV) neutralizing antibody response in CMV hyperimmune globulin
Journal of Virology, ISSN: 0022538X 10985514
Ashley Fouts; Pamela Chan; Jean-Philippe Stephan; Richard L. Vandlen; Becket Feierbach
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Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis
Journal of Cystic Fibrosis, ISSN: 15691993 18735010
Clement L. Ren; Michael W. Konstan; Ashley Yegin; Lawrence Rasouliyan; Benjamin L. Trzaskoma; Morgan; Warren E. Regelmann
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Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC
Nature Immunology, ISSN: 15292908 15292916
Jianming Xie; Johannes B. Huppa; Evan W. Newell; Jun Huang; Peter J. R. Ebert; Qi-Jing Li; Mark M. Davis
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Collective action of hematopoietic cell subsets mediates anti-IL10R1 and CpG tumor immunity
Cancer Immunology, Immunotherapy, ISSN: 03407004 14320851
Meng-Yun Chou; Cary D. Austin; Kim
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Quantification of antiangiogenic and antivascular drug activity by kinetic analysis of DCE-MRI data
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Gregory Z. Ferl; Ruediger E. Port
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Reply to "On the differentiation of mouse IgE + cells"
Nature Immunology, ISSN: 15292908 15292916
Oezcan Talay; Donghong Yan; Hans D. Brightbill; Elizabeth E. M. Straney; Meijuan Zhou; Ena Ladi; Wyne P. Lee; Jackson G. Egen; Cary D. Austin; Min Xu; Lawren C. Wu
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The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Hans Erickson; Gail L. Phillips; Douglas Leipold; Carmela A. Provenzano; Elaine Mai; Holly A. Johnson; Bert Gunter; Charlene A. Audette; Manish Gupta; Jan Pinkas; Jay Tibbitts
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ERK inhibition overcomes acquired resistance to MEK Inhibitors
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Georgia Hatzivassiliou; Bonnie Liu; Carol O'Brien; Jill M. Spoerke; Klaus P. Hoeflich; Matthias Peter; Robert Soriano; William F. Forrest; Sherry Heldens; Huifen Chen; Toy; Connie Ha; Wei Zhou; Kyung Song; Lori S. Friedman; Lukas Amler; Garret M. Hampton; John Moffat; Marcia Belvin; Lackner
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