Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8251 - 8300 OF 15656 RESULTS

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice
Mucosal Immunology, ISSN: 19330219 19353456
Jennifer Cox; Noelyn Kljavin; Naruhisa Ota; Leonard; Merone Roose-Girma; Laurie Diehl; Wenjun Ouyang; Nico Ghilardi
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SpeCond: A method to detect condition-specific gene expression
Genome Biology, ISSN: 14747596 1474760X
Florence M.G. Cavalli; Richard Bourgon; Juan M. Vaquerizas; Nicholas M. Luscombe
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The A-MYSM Power of Deubiquitinases
Immunity, ISSN: 10747613 10974180
Ignacio A. Demarco; Harinder Singh
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Cancer immunotherapy comes of age
Nature, ISSN: 14764687 00280836
Ira Mellman; George Coukos; Glenn Dranoff
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The authors reply
New England Journal of Medicine, ISSN: 00284793 15334406
Joseph R. Arron; Jonathan Corren; Matthews
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Identification of surprisingly diverse type IV Pili, across a broad range of gram-positive bacteria
PLoS ONE, ISSN: 19326203
Saheed Imam; Zhongqiang Chen; David S. Roos; Mechthild Pohlschröder
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Workshop summary: Novel aspects of the functions of the TRAFs and cIAPs
Advances in Experimental Medicine and Biology, ISSN: 00652598
John Silke; Domagoj Vucic
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TRAF2 and cellular IAPs: A critical link in TNFR family signaling
Advances in Experimental Medicine and Biology, ISSN: 00652598
Domagoj Vucic
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Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
Science Translational Medicine, ISSN: 19466242
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Feng; Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David A. West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
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Influence of 17β-estradiol on gene expression of paracoccidioides during mycelia-to-yeast transition
PLoS ONE, ISSN: 19326203
Jata Shankar; Thomas D Wu; Karl V. Clemons; Jomar P. Monteiro; Laurence F. Mirels; David A. Stevens
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Metabolic disease: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
Science Translational Medicine, ISSN: 19466242 19466234
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Bo Feng; Li Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
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The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly
Cell, ISSN: 10974172 00928674
Jorge Z. Torres; Matthew K. Summers; David Peterson; Matthew J. Brauer; James Lee; Silvia Senese; Ankur A. Gholkar; Yu-Chen Lo; Xingye Lei; Kenneth Jung; David C. Anderson; David P. Davis; Lisa D. Belmont; Peter K Jackson
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Process validation challenges for technology transfer
Pharmaceutical Outsourcing, ISSN: 19453337
Judy H. Chang
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Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours
British Journal of Cancer, ISSN: 00070920 15321827
Pan; Xu; Peach; Huang; Branstetter; Novotny; Herbst; Gail Eckhardt; Holland
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Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Yifan Mao; Yonglei Shang; Victoria Pham; James A. Ernst; Jennie R. Lill; Suzie J. Scales; Jiping Zha
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Long-term safety, tolerability, and efficacy of vismodegib in two patients with metastatic basal cell carcinoma and basal cell nevus syndrome
Dermatology Reports, ISSN: 20367392 20367406
Glen J. Weiss; Raoul Tibes; Lisa Blaydorn; Gayle Jameson; Molly Downhour; Erica White; Ivor Caro; Daniel D. Von Hoff
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Phase 2 trial of linifanib (ABT-869) in patients with advanced renal cell cancer after sunitinib failure
European Journal of Cancer, ISSN: 09598049 18790852
Nizar M. Tannir; Yu-Ning Wong; Christian K. Kollmannsberger; Marc S. Ernstoff; David J. Perry; Leonard J. Appleman; Edwin M. Posadas; Daniel Cho; Toni K. Choueiri; Andrew Coates; Neeraj Gupta; Rajendra Pradhan; Jiang Qian; Jihong Chen; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Dror Michaelson
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Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration
Ophthalmology, ISSN: 01616420 15494713
Emmett T. Cunningham Jr.; Leonard Feiner; Carol Chung; Lisa Tuomi; Jason S. Ehrlich
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The Bcl-2/Bcl-X L/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Jun Chen; Sha Jin; Vivek Abraham; Xiaoli Huang; Bernard Liu; Michael J. Mitten; Paul M. Nimmer; Xiaoyu Lin; Morey L. Smith; Yu Shen; Alexander R. Shoemaker; Stephen K. Tahir; Haichao Zhang; Scott L. Ackler; Saul H. Rosenberg; Heather Maecker; Deepak Sampath; Joel D. Leverson; Chris Tse; Steven W. Elmore
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Preclinical assessment of novel BRAF inhibitors: Integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process
Xenobiotica, ISSN: 00498254 13665928
Edna F. Choo; Bruno Alicke; Jason Boggs; Victoria Dinkel; Stephen Gould; Jonas Grina; Kristina West; Kapil Menghrajani; Yingqing Ran; Joachim Rudolph; Steve Wenglowsky
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Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
Biochimica et Biophysica Acta - Proteins and Proteomics, ISSN: 15709639 18781454
David Meininger; Leeanne Zalameda; Yichin Liu; Lara P. Stepan; Luis Borges; John D. McCarter; Claire L. Sutherland
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Therapeutic promise and challenges of targeting DLL4/NOTCH1
Vascular Cell, ISSN: 2045824X
Minhong Yan
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Durable complete response of metastatic gastric cancer with anti-met therapy followed by resistance at recurrence
Cancer Discovery, ISSN: 21598274 21598290
Daniel V.T. Catenacci; Les Henderson; Shu-Yuan Xiao; Premal Patel; Robert Yauch; Priti Hegde; Jiping Zha; Ajay Pandita; Amy Peterson; Ravi Salgia
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Inflammation and autoantibody markers identify rheumatoid arthritis patients with enhanced clinical benefit following rituximab treatment
Arthritis and Rheumatism, ISSN: 00043591 15290131
Preeti Lal; Zheng Su; Cécile T.J. Holweg; Gregg J. Silverman; Sergio Schwartzman; Ariella Kelman; Simon J. Read; Spaniolo; John G. Monroe; Timothy W. Behrens; Michael J. Townsend
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Phase I study evaluating the safety and pharmacokinetics of MDX-1303, a fully human monoclonal antibody against Bacillus anthracis protective antigen, in healthy volunteers
Clinical and Vaccine Immunology, ISSN: 15566811 1556679X
Valerie Riddle; Phillip Leese; Diann Blanset; Melany Adamcio; Matthew Meldorf; Israel Lowy
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Towards BioDBcore: A community-defined information specification for biological databases
Database, ISSN: 17580463
Pascale Gaudet; Amos Bairoch; Dawn Field; Susanna-Assunta Sansone; Chris Taylor; Teresa K. Attwood; Alex Bateman; Judith A. Blake; Carol J. Bult; J. Michael Cherry; Rex L. Chisholm; Guy Cochrane; Charles E. Cook; Janan T. Eppig; Michael Y. Galperin; Robert Gentleman; Carole A. Goble; Takashi Gojobori; John M. Hancock; Douglas G. Howe; Tadashi Imanishi; Janet Kelso; David Landsman; Suzanna E. Lewis; Ilene Karsch-Mizrachi; Sandra Orchard; B.F. Francis Ouellette; Shoba Ranganathan; Lorna Richardson; Philippe Rocca-Serra; Paul N. Schofield; Damian Smedley; Christopher Southan; Tin W. Tan; Tatiana Tatusova; Patricia L. Whetzel; Owen White; Chisato Yamasaki
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Dissecting cancer heterogeneity
Nature Biotechnology, ISSN: 10870156 15461696
David Dornan; Jeffrey Settleman
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Single-versus dual-infusion of B-cell-depleting antibody ocrelizumab in rheumatoid arthritis: Results from the phase III FEATURE trial
International Journal of Clinical Rheumatology, ISSN: 17584272 17584280
Joseph E. Huffstutter; James Taylor; Joy Schechtman; Piotr Leszczynski; Marek Brzosko; Farhad Sedarati; Dalia Moawad; Amy V. Kapp; Rebecca Sudlow; Wolfgang Dummer
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An introduction to wnt signaling
Targeting the Wnt Pathway in Cancer,
Paul G. Polakis
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Kilogram-scale asymmetric ruthenium-catalyzed hydrogenation of a tetrasubstituted fluoroenamide
Advanced Synthesis and Catalysis, ISSN: 16154150 16154169
Andreas Stumpf; Mark E. Reynolds; Daniel P. Sutherlin; Srinivasan Babu; Erhard Bappert; Felix Spindler; Michael Welch; John J. Gaudino
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Concomitant asthma medication use by patients receiving omalizumab 20032008
Journal of Asthma, ISSN: 02770903 15324303
Michael S. Broder; James L. Zazzali; Eunice Chang; Ashley Yegin
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GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Jeffery J. Wallin; Kyle A. Edgar; Zhengyu Guan; Megan Berry; Wei Wei Prior; Leslie Lee; John Lesnick; Lewis; Jim Nonomiya; Jodie Pang; Laurent Salphati; Alan G. Olivero; Daniel P. Sutherlin; Carol O'Brien; Jill M. Spoerke; Sonal Patel; Letitia Lensun; Robert Kassees; Berry; Lackner; Deepak Sampath; Marcia Belvin; Lori S. Friedman
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Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3- dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery
Nanoscale Research Letters, ISSN: 19317573 1556276X
Po-Chang Chiang; Yingqing Ran; Kang-Jye Chou; Yong Cui; Harvey Wong
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Identification of aberrant pathway and network activity from high-throughput data-workshop introduction
Pacific Symposium on Biocomputing 2011, PSB 2011,
Ochs; Karchin; Ressom; Robert Gentleman
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Lack of an effect of anacetrapib on the pharmacokinetics of digoxin in healthy subjects
Biopharmaceutics and Drug Disposition, ISSN: 01422782 1099081X
Rajesh Krishna; Daria Stypinski; Melissa Ali; Amit Garg; Isaias Noel Gendrano III; Andrea Maes; Bruce Degroot; Yang Liu; Susie Li; Sandra M. Connolly; John A. Wagner; S. Aubrey Stoch
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Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human
Xenobiotica, ISSN: 00498254 13665928
Laurent Salphati; Jodie Pang; Emile G. Plise; Bilin Chou; Jason S Halladay; Alan G. Olivero; Patrick J. Rudewicz; Qingping Tian; Susan C. Wong; Xiaolin Zhang
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Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans
Psychopharmacology, ISSN: 00333158 14322072
William Cho; Paul Maruff; John Connell; Cindy Gargano; Nicole Calder; Scott Doran; Sabrina Fox-Bosetti; Aizza Hassan; John Renger; Gary Herman; Christopher Lines; Ajay Verma
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Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Albert Lai; Samir Kharbanda; Whitney B. Pope; Anh Tran; Orestes E. Solis; Franklin V. Peale Jr.; William F. Forrest; Kanan Pujara; Jose A. Carrillo; Ajay Pandita; Benjamin M. Ellingson; Chauncey W. Bowers; Robert Soriano; Nils-Ole Schmidt; Sankar Mohan; William H. Yong; Somasekar Seshagiri; Zora Modrusan; Zhaoshi Jiang; Kenneth D. Aldape; Paul S. Mischel; Linda M. Liau; Cameron J. Escovedo; Weidong Chen; Phioanh L. Nghiemphu; C. David James; Michael D. Prados; Manfred Westphal; Katrin Lamszus; Timothy Cloughesy; Phillips
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Comparative performance of cell life span and cell transit models for describing erythropoietic drug effects
AAPS Journal, ISSN: 15507416
Nageshwar Budha; Andreas Kovar; Bernd Meibohm
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The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors
Endocrinology, ISSN: 00137227 19457170
Erik R. Nelson; Carolyn D. DuSell; Xiaojuan Wang; Matthew K. Howe; Glenda Evans; Ryan D. Michalek; Michihisa Umetani; Jeffrey C. Rathmell; Sundeep Khosla; Diane Gesty-Palmer; Donald P. McDonnell
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A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
PLoS Genetics, ISSN: 15537390 15537404
Paula S. Ramos; Lindsey A. Criswell; Kathy L. Moser; Mary E. Comeau; Adrienne H. Williams; Nicholas M. Pajewski; Sharon A. Chung; Robert R. Graham; Raphael Zidovetzki; Jennifer A. Kelly; Kenneth M. Kaufman; Chaim O. Jacob; Timothy J. Vyse; Betty P. Tsao; Robert P. Kimberly; Patrick M. Gaffney; Marta E. Alarcón-Riquelme; John B. Harley; Carl D. Langefeld
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It takes two to tango: A new couple in the family of ubiquitin-editing complexes
Nature Immunology, ISSN: 15292908 15292916
Ingrid E. Wertz
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Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T H17 cells
Nature Immunology, ISSN: 15292908 15292916
Sascha Rutz; Rajkumar Noubade; Celine Eidenschenk; Naruhisa Ota; Wenwen Zeng; Yan Zheng; Jason A. Hackney; Jiabing Ding; Harinder Singh; Wenjun Ouyang
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Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration
Ophthalmology, ISSN: 01616420 15494713
Emmett T. Cunningham Jr.; Leonard Feiner; Carol Y. Chung; Lisa Tuomi; Jason S. Ehrlich
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Proposal for a new protein therapeutic immunogenicity titer assay cutpoint
Bioanalysis, ISSN: 17576180 17576199
Eric Wakshull; Robert Hendricks; Caroline Amaya; Daniel A. Coleman
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IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
Nature Immunology, ISSN: 15292908 15292916
Vladimir Ramirez-Carrozzi; Arivazhagan Sambandam; Luis; Zhongua Lin; Surinc Er Jeet; Justin Lesch; Jason A. Hackney; Janice Kim; Meijuan Zhou; Joyce Lai; Zora Modrusan; Tao Sai; Wyne P. Lee; Min Xu; Patrick Caplazi; Laurie Diehl; Jason De Voss; Mercedesz Balazs; Lino C. Gonzalez Jr.; Harinder Singh; Wenjun Ouyang; Rajita Pappu
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The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus
Genes and Immunity, ISSN: 14664879 14765470
Paola G. Bronson; Goldstein; Ramsay; Beckman; Janelle A. Noble; Lane; Michael F. Seldin; Jennifer A. Kelly; John B. Harley; Kathy L. Moser; Patrick M. Gaffney; Timothy W. Behrens; Lindsey A. Criswell; Lisa F. Barcellos
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Role of MetMAb (OA-5D5) in c-MET active lung malignancies
Expert Opinion on Biological Therapy, ISSN: 14712598
Mosmi Surati; Premal Patel; Amy Peterson; Ravi Salgia
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On-line characterization of monoclonal antibody variants by liquid chromatography-mass spectrometry operating in a two-dimensional format
Analytical Biochemistry, ISSN: 10960309 00032697
Melissa Alvarez; Guillaume Tremintin; Jennifer Wang; Eng; Kao; Justin Jeong; Victor Ling; Oleg V. Borisov
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Different mechanisms for resistance to trastuzumab versus lapatinib in HER2- positive breast cancers -- role of estrogen receptor and HER2 reactivation
Breast Cancer Research, ISSN: 14655411 1465542X
Yen-Chao Wang; Gladys Morrison; Ryan Gillihan; Jun Guo; Robin M. Ward; Xiaoyong Fu; Maria F. Botero; Nuala A. Healy; Susan G. Hilsenbeck; Gail L. Phillips; Gary C. Chamness; Mothaffar F. Rimawi; C.Kent Osborne; Rachel Schiff
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