Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8551 - 8600 OF 15656 RESULTS

May 12, 2011

Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Frederick Cohen; Philippe Bergeron; Elizabeth M. Blackwood; Krista K. Bowman; Huifen Chen; Antonio G. DiPasquale; Jennifer A. Epler; Michael F. T. Koehler; Kevin Lau; Lewis; Lichuan Liu; Cuong Q. Ly; Shiva Malek; Jim Nonomiya; Daniel F. Ortwine; Zhonghua Pei; Kirk D. Robarge; Steve Sideris; Lan Trinh; Tom Truong; Jiansheng Wu; Xianrui Zhao; Joseph P. Lyssikatos

May 12, 2011

Pyrazolopyridine inhibitors of B-RafV600E. Part 1: The development of selective, orally bioavailable, and efficacious inhibitors

ACS Medicinal Chemistry Letters, ISSN: 19485875

Steve Wenglowsky; Li Ren; Kateri Ahrendt; Ellen R. Laird; Ignacio Aliagas; Bruno Alicke; Alexandre J. Buckmelter; Edna F. Choo; Victoria Dinkel; Bainian Feng; Susan L. Gloor; Stephen Gould; Stefan Gross; Janet Gunzner; Joshua D. Hansen; Georgia Hatzivassiliou; Bonnie Liu; Kim Malesky; Simon Mathieu; Bradley J. Newhouse; Nicholas J. Raddatz; Yingqing Ran; Sumeet Rana; Nikole Randolph; Tyler Risom; Joachim Rudolph; Scott Savage; Leann T. Selby; Michael Shrag; Kyung Song; Hillary L. Sturgis; Walter C. Voegtli; Zhaoyang Wen; Brandon S. Willis; Richard D. Woessner; Wen-I. Wu; Wendy B. Young; Jonas Grina

May 11, 2011

Facile synthesis of spiro oxindoles, azaoxindoles, and dihydroisoquinolone

Synthetic Communications, ISSN: 00397911 15322432

Sharada Labadie; Christa Parmer

May 10, 2011

Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Pranav Parikh; Yuhan Hao; Mohsen Hosseinkhani; Shekhar B. Patil; George W. Huntley; Marc Tessier-Lavigne; Hongyan Zou

May 6, 2011

Comparing protein VEGF inhibitors: In vitro biological studies

Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104

Lanlan Yu; Xiao Huan Liang; Napoleone Ferrara

May 6, 2011

Bevacizumab treatment to progression after chemotherapy: Outcomes from a U.S. community practice network

Oncologist, ISSN: 10837159 1549490X

Eric Nadler; Elaine B. Yu; Arliene Ravelo; Amy Sing; Michael Forsyth; Stephen Gruschkus

May 6, 2011

Modulation of K11-linkage formation by variable loop residues within UbcH5A

Journal of Molecular Biology, ISSN: 00222836

Ivan Bosanac; Lilian Phu; Borlan Pan; Inna Zilberleyb; Brigitte Maurer; Vishva M. Dixit; Sarah G. Hymowitz; Donald S. Kirkpatrick

May 4, 2011

High affinity antigen recognition of the dual specific variants of Herceptin is entropy-driven in spite of structural plasticity

PLoS ONE, ISSN: 19326203

Jenny Bostrom; Lauric Haber; Patrick Koenig; Robert F. Kelley; Fuh

May 1, 2011

Studying the drift of in line pH measurements in cell culture

Biotechnology Progress, ISSN: 87567938 15206033

Victor Saucedo; Bradley Wolk; Adeyma Arroyo; Feng

May 1, 2011

Analysis of tumor burden versus progression-free survival for Phase II decision making

Contemporary Clinical Trials, ISSN: 15517144

Jane Fridlyand; Lee D. Kaiser; Gwendolyn Fyfe

May 1, 2011

Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2

Journal of Pharmacological and Toxicological Methods, ISSN: 10568719

Susan P. Rhodes; Jennifer N. Otten; Gary P. Hingorani; Dylan P. Hartley; Ronald B. Franklin

May 1, 2011

Aβ1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

Nature Neuroscience, ISSN: 10976256

Jihoon Jo; Daniel J. Whitcomb; Kimberly Moore Olsen; Talitha L. Kerrigan; Shih-Ching Lo; Gilles Bru-Mercier; Bryony Dickinson; Sarah Scullion; Morgan Sheng; Graham Collingridge; Kwangwook Cho

May 1, 2011

Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry

Analytical Biochemistry, ISSN: 10960309 00032697

Keyang Xu; Luna Liu; Ola M. Saad; Jakub Baudys; Lara Williams; Douglas Leipold; Shen; Helga Raab; Jagath R. Junutula; Amy H. Kim; Surinder Kaur

May 1, 2011

Validation of the national eye institute Visual Function Questionnaire-25 (NEI VFQ-25) in age-related macular degeneration

Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783

Peggy Orr; Anne M. Rentz; Mary Kay Margolis; Dennis A. Revicki; Chantal M. Dolan; Shoshana Colman; Jennifer T. Fine; Neil M. Bressler

May 1, 2011

A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

Nature Genetics, ISSN: 10614036 15461718

Trevor Hinkley; João Martins; Colombe Chappey; Mojgan Haddad; Eric Stawiski; Jeannette M. Whitcomb; Christos J. Petropoulos; Sebastian Bonhoeffer

May 1, 2011

Molecular determinants of origin discrimination by Orc1 initiators in archaea

Nucleic Acids Research, ISSN: 03051048 13624962

Erin C. Dueber; Alessandro Costa; Jacob E. Corn; Stephen D. Bell; James M. Berger

May 1, 2011

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Marcella Yu; Zhilan Hu; Efren Pacis; Natarajan Vijayasankaran; Amy Shen; Feng Li

May 1, 2011

Human prostate cancer stem cells: New features unveiled

Asian Journal of Andrology, ISSN: 1008682X 17457262

Yuting Sun; Gao

May 1, 2011

Effect of rituximab on physical function and quality of life in patients with rheumatoid arthritis previously untreated with methotrexate

Arthritis Care and Research, ISSN: 21514658 15290131

William F. Rigby; Gianfranco Ferraccioli; Maria Greenwald; Beatriz Zazueta-Montiel; Roy Fleischmann; Siegfried Wassenberg; Sarika Ogale; Gillian Armstrong; Angelika Jahreis; Laura Burke; Christopher Mela; Annie Chen

May 1, 2011

Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals

Molecular and Cellular Proteomics, ISSN: 15359476 15359484

Lilian Phu; Anita Izrael-Tomasevic; Marissa L. Matsumoto; Daisy J. Bustos; Jasmin N. Dynek; Anna V. Fedorova; Corey Bakalarski; David Arnott; Deshayes; Vishva M. Dixit; Robert F. Kelley; Domagoj Vucic; Donald S. Kirkpatrick

May 1, 2011

Gelatin capsule shell cross-linking

Pharmaceutical Technology Europe, ISSN: 01646826

Xiling Song; Yong Cul; Minli Xie

May 1, 2011

PHOENIX: A randomized controlled trial of peginterferon alfa-2a plus ribavirin as a prophylactic treatment after liver transplantation for hepatitis C virus

Liver Transplantation, ISSN: 15276465 15276473

Natalie Bzowej; David R. Nelson; Terrault; Gregory T. Everson; Lichen L. Teng; Avinash Prabhakar; Michael R. Charlton

May 1, 2011

Inhibitor of apoptosis proteins: Fascinating biology leads to attractive tumor therapeutic targets

Future Oncology, ISSN: 14796694 17448301

Eugene Varfolomeev; Domagoj Vucic

May 1, 2011

Journey forward: The new face of cancer survivorship care

American Journal of Managed Care, ISSN: 10880224

Jennifer Hausman; Patricia A. Ganz; Thomas P. Sellers; Joel Rosenquist

May 1, 2011

Journey Forward: The new face of cancer survivorship care

Journal of Oncology Practice, ISSN: 15547477 1935469X

Jennifer Hausman; Patricia A. Ganz; Thomas P. Sellers; Joel Rosenquist

May 1, 2011

Is this the end of painful injections?

Managed Care, ISSN: 10623388

Thomas Morrow

May 1, 2011

Gelatin Capsule Shell Cross-Linking: Tier II Dissolution Method Development in the Presence of Sodium Lauryl Sulfate

Pharmaceutical Technology, ISSN: 15432521 21507376

Xiling Song; Yong Cui; Minli Xie

May 1, 2011

Investigation of the HIN200 Locus in UK SLE Families Identifies Novel Copy Number Variants

Annals of Human Genetics, ISSN: 00034800 14691809

Michelle M.A. Fernando; Adam J. de Smith; Lachlan Coin; David L. Morris; Philippe Froguel; Jonathan Mangion; Alexandra I. F. Blakemore; Robert R. Graham; Timothy W. Behrens; Timothy J. Vyse

April 29, 2011

Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3

Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104

Chang-Young Jang; Judith A. Coppinger; John R. Yates; Guowei Fang

April 28, 2011

Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449)

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Anthony M. Giannetti; Harvey Wong; Gerrit J. P. Dijkgraaf; Erin C. Dueber; Daniel F. Ortwine; Brandon Bravo; Stephen Gould; Emile G. Plise; Bert L. Lum; Vikram Malhi; Richard A. Graham

April 27, 2011

PSD-95 is required to sustain the molecular organization of the postsynaptic density

Journal of Neuroscience, ISSN: 02706474 15292401

Xiaobing Chen; Nelson; Xiang Li; Christine A. Winters; Rita Azzam; Alioscka A. Sousa; Richard D. Leapman; Harold Gainer; Morgan Sheng; Thomas S. Reese

April 26, 2011

[Targeted cytotoxic drugs emerging for cancer therapy]. Vasta-aineisiin konjugoidut solunsalpaajat tulossa syövän hoitoon.

Duodecim; lääketieteellinen aikakauskirja, ISSN: 00127183

Teemu T. Junttila; Minna Tanner; Jorma Isola

April 26, 2011

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christy C. Ong; Adrian M. Jubb; Matthias Peter; Wei Zhou; Victoria Tran; Tom Truong; Helen Turley; Thomas O'Brien; Domagoj Vucic; Adrian L. Harris; Marcia Belvin; Lori S. Friedman; Elizabeth M. Blackwood; Koeppen; Klaus P. Hoeflich

April 23, 2011

Regulation and functions of the IL-10 family of cytokines in inflammation and disease

Annual Review of Immunology, ISSN: 07320582

Wenjun Ouyang; Sascha Rutz; Natasha K Crellin; Patricia A. Valdez; Sarah G. Hymowitz

April 21, 2011

Jürg Tschopp (1951-2011).

Nature, ISSN: 14764687

Vishva M. Dixit

April 20, 2011

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases

Journal of Biotechnology, ISSN: 01681656

Meixia Zhou; Yongping Crawford; Domingos Ng; Jack Tung; Abigail F.J. Pynn; Angela Meier; Inn H. Yuk; Natarajan Vijayasankaran; Kimberly D. Leach; John C. Joly; Snedecor; Amy Shen

April 15, 2011

Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime

Analytical Biochemistry, ISSN: 10960309 00032697

Sandeep Yadav; Thomas M. Scherer; Steven J. Shire; Devendra S. Kalonia

April 15, 2011

Pharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: The role of alpha-1-acid glycoprotein binding

Clinical Cancer Research, ISSN: 10780432 15573265

Richard A. Graham; Bert L. Lum; Sravanthi Cheeti; Jin Y. Jin; Karin Jorga; Daniel D. Von Hoff; Charles M. Rudin; Josina C. Reddy; Low; Patricia M. LoRusso

April 15, 2011

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors

Clinical Cancer Research, ISSN: 10780432 15573265

Patricia M. LoRusso; Charles M. Rudin; Josina C. Reddy; Raoul Tibes; Glen J. Weiss; Mitesh J. Borad; Christine L. Hann; Julie Brahmer; Ilsung Chang; Darbonne; Richard A. Graham; Kenn Zerivitz; Low; Daniel D. Von Hoff

April 15, 2011

DDA3 associates with MCAK and controls chromosome congression

Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104

Chang-Young Jang; Guowei Fang

April 15, 2011

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Rui Xu; Anna L. Banka; James F. Blake; Ian S. Mitchell; Eli M. Wallace; Josef R. Bencsik; Nicholas C. Kallan; Keith L. Spencer; Susan L. Gloor; Matthew Martinson; Tyler Risom; Stefan Gross; Tony Morales; Wen-I. Wu; Guy Vigers; Barbara J. Brandhuber; Nicholas J. Skelton

April 15, 2011

Discovery and SAR of spirochromane Akt inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Nicholas C. Kallan; Keith L. Spencer; James F. Blake; Rui Xu; Justin Heizer; Josef R. Bencsik; Ian S. Mitchell; Susan L. Gloor; Matthew Martinson; Tyler Risom; Stefan Gross; Tony Morales; Wen-I. Wu; Guy Vigers; Barbara J. Brandhuber; Nicholas J. Skelton

April 15, 2011

Mixed-mode and reversed-phase liquid chromatography-tandem mass spectrometry methodologies to study composition and base hydrolysis of polysorbate 20 and 80

Journal of Chromatography A, ISSN: 00219673

Daniel Hewitt; Melissa Alvarez; Kathryn Robinson; Junyan A. Ji; Y. John Wang; Kao; Taylor Zhang

April 15, 2011

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Xiaohua Wu; Shi Chen; Selina A. Orlando; Jin Yuan; Edward T. Kim; Veerendra Munugalavadla; Raghuveer Singh Mali; Reuben Kapur; Feng-Chun Yang

April 14, 2011

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S

Blood, ISSN: 15280020 00064971

Felicity N. E. Gavins; Janice Russell; Elena L. Senchenkova; Lidiana De Almeida Paula; Amílcar S. Damazo; Charles T. Esmon; Daniel Kirchhofer; Robert P. Hebbel; D. Neil Granger

April 11, 2011

Genome-wide survey of post-meiotic segregation during yeast recombination

Genome Biology, ISSN: 14747596 1474760X

Eugenio Mancera; Richard Bourgon; Wolfgang Huber; Lars M. Steinmetz

April 4, 2011

A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells

Journal of Cell Biology, ISSN: 00219525 00219525

Stephen S. Francis; Jeff Sfakianos; Bryan Lo; Ira Mellman

April 1, 2011

Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK Inhibitors in BRAF mutant cancers

Oncotarget, ISSN: 19492553

Ryan B. Corcoran; Jeffrey Settleman; Jeff A. Engelman

April 1, 2011

A candidate gene study of the type i interferon pathway implicates IKBKE and IL8 as risk loci for SLE

European Journal of Human Genetics, ISSN: 10184813 14765438

Johanna K. Sandling; Sophie Garnier; Snaevar Sigurdsson; Chuan Wang; Gunnel Nordmark; Iva Gunnarsson; Elisabet Svenungsson; Leonid Padyukov; Gunnar Sturfelt; Andreas Jönsen; Anders A. Bengtsson; Lennart Truedsson; Catharina Eriksson; Solbritt Rantapää-Dahlqvist; Anders Mälarstig; Rona J. Strawbridge; Anders Hamsten; Lindsey A. Criswell; Robert R. Graham; Timothy W. Behrens; Maija-Leena Eloranta; Gunnar Alm; Lars Rönnblom; Ann-Christine Syvänen

April 1, 2011

Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial

Journal of Rheumatology, ISSN: 0315162X 14992752

Jin-Shei Lai; Jennifer L. Beaumont; Sarika Ogale; Paul Brunetta; Cella

Join Our Team

The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.

Two Scientists Walk Into a Bar

Two Scientists Walk Into a Bar

Listen to our podcast, where researchers talk about their work answering the toughest questions in human biology.