Genentech: Publications

June 10, 2011

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

Science, ISSN: 00368075 10959203

Yonghao Yu; Sang-Oh Yoon; George Poulogiannis; Qian Yang; Xiaoju Max Ma; Judit Villén; Neil Kubica; Gregory R. Hoffman; Lewis C. Cantley; Steven P. Gygi; John Blenis

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June 9, 2011

VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1

Neuron, ISSN: 08966273 10974199

Carmen Ruiz de Almodovar; Pierre J. Fabre; Ellen Knevels; Cathy Coulon; Inmaculada Segura; Patrick C. G. Haddick; Liesbeth Aerts; Nicolas Delattin; Geraldine Strasser; Won-Jong Oh; Christian Lange; Stefan Vinckier; Jody Haigh; Coralie Fouquet; Chenghua Gu; Kari Alitalo; Valerie Castellani; Marc Tessier-Lavigne; Alain Chedotal; Frédéric Charron; Peter Carmeliet

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June 7, 2011

Structural basis of photosensitivity in a bacterial light-oxygen-voltage/ helix-turn-helix (LOV-HTH) DNA-binding protein

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Abigail I. Nash; Reginald McNulty; Mary Elizabeth Shillito; Trevor E. Swartz; Roberto A. Bogomolni; Hartmut Luecke; Kevin H. Gardner

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June 7, 2011

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Weiwei Chen; Tracy Tzu-Ling Tang; Jeffrey Eastham-Anderson; Debra Dunlap; Bruno Alicke; Michelle Nannini; Stephen Gould; Robert Yauch; Zora Modrusan; Kelly J. DuPree; Darbonne; Greg D. Plowman; Frederic J. De Sauvage; Christopher A. Callahana

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June 7, 2011

The arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions

Current Biology, ISSN: 09609822

Aakanksha Singhvi; Jerome Teuliere; Karla Talavera; Shaun Cordes; Guangshuo Ou; Ronald D. Vale; Brinda C. Prasad; Clark; Gian Garriga

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June 3, 2011

A high throughput approach to purifying chiral molecules using 3μm analytical chiral stationary phases via supercritical fluid chromatography

Journal of Chromatography A, ISSN: 00219673

Chris Hamman; Mengling Wong; Michael Hayes; Paul Gibbons

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June 2, 2011

Immunology: In command of commensals

Nature, ISSN: 00280836 14764687

Menno Van Lookeren Campagne; Vishva M. Dixit

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June 2, 2011

Improved synthesis of γ-lactones from cyclopropyl cyanoesters

Synthetic Communications, ISSN: 00397911 15322432

Nandini C. Patel; Jacob B. Schwarz; Khondaker Islam; Whitney Miller; Tuan P. Tran; Yunjing Wei

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June 1, 2011

Rituximab's new therapeutic target: The podocyte actin cytoskeleton

Science Translational Medicine, ISSN: 19466234 19466242

Andrew A. Chan

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June 1, 2011

Free versus total ligand-binding assays: Points to consider in biotherapeutic drug development

Bioanalysis, ISSN: 17576180 17576199

Yang; Quarmby

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June 1, 2011

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex

Journal of Neuroscience Research, ISSN: 03604012 10974547

Guoxin Wu; Sethu Sankaranarayanan; Sidney H.-K. Hsieh; Adam J. Simon; Mary J. Savage

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June 1, 2011

Absorption, distribution, metabolism, and excretion of [ 14C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: A unique metabolic pathway via pyridine ring opening

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Qin Yue; Yunghsiang Chen; Teresa Mulder; Alan Deese; Ryan Takahashi; Patrick J. Rudewicz; Mark E. Reynolds; Eric G. Solon; Cornelis E. Hop; Harvey Wong; S. Cyrus Khojasteh

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June 1, 2011

Randomized phase II study of bevacizumab in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer: Results from the SALUTE trial

Journal of Clinical Oncology, ISSN: 0732183X 15277755

David Spigel; Peter Townley; David M. Waterhouse; Liang Fang; Ibrahim Adiguzel; Jane E. Huang; David A. Karlin; Leonardo Faoro; Frank A. Scappaticci; Mark A. Socinski

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June 1, 2011

Antibody delivery of drugs and radionuclides: Factors influencing clinical pharmacology

Therapeutic Delivery, ISSN: 20415990 20416008

Saileta Prabhu; C. Andrew Boswell; Douglas Leipold; Leslie A. Khawli; Dongwei Li; Dan Lu; Frank-Peter Theil; Amita Joshi; Bert L. Lum

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June 1, 2011

Pharmacokinetic study of the phase III, randomized, double-blind, multicenter trial (TRIBUTE) of paclitaxel and carboplatin combined with erlotinib or placebo in patients with advanced Non-small Cell Lung Cancer (NSCLC)

Investigational New Drugs, ISSN: 01676997

Hai T. Tran; Ralph G. Zinner; George R. Blumenschein; Yun W. Oh; Vassiliki A. Papadimitrakopoulou; Edward S. Kim; Charles Lu; Mubashira Malik; Bert L. Lum; Roy S. Herbst

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June 1, 2011

Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation

Journal of Immunology, ISSN: 00221767 15506606

Yan Qu; Shahram Misaghi; Kim Newton; Laurie L. Gilmour; Salina Louie; James Cupp; George R. Dubyak; David Hackos; Vishva M. Dixit

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June 1, 2011

Intercompany study to evaluate the robustness of capillary isoelectric focusing technology for the analysis of monoclonal antibodies

Chromatographia, ISSN: 00095893 16121112

Oscar Salas-Solano; Kunnel Babu; Park; Xinfeng Zhang; Li Zhang; Zoran Sosic; Boris Boumajny; Ming Zeng; Cheng; Angelia Reed-Bogan; Stacey Cummins-Bitz; David A. Michels; Monica Parker; Pauline Bonasia; Mingfang Hong; Steven Cook; Margaret Ruesch; David Lamb; Dora Bolyan; Steffen Kiessig; Darren Allender; Brian Nunnally

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June 1, 2011

Glycosylation of therapeutic proteins: Current understanding of structure-function relationships

BioProcess International, ISSN: 15426319

Joseph Siemiatkoski; Stacey Ma; Jun Park; Kurt Brorson; Patrick Swann; Lorna McLeod

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June 1, 2011

Regulation of hemocytes in Drosophila requires dappled cytochrome b5

Biochemical Genetics, ISSN: 00062928 15734927

Kurt Kleinhesselink; Corinna Conway; David Sholer; Irvin Huang; Deborah A. Kimbrell

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June 1, 2011

Non-oxime pyrazole based inhibitors of B-Raf kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Bradley J. Newhouse; Joshua D. Hansen; Jonas Grina; Michael Welch; George Topalov; Nicole Littman; Michele Callejo; Matthew Martinson; Sarah Galbraith; Ellen R. Laird; Barbara J. Brandhuber; Guy Vigers; Tony Morales; Richard D. Woessner; Nikole Randolph; Joseph P. Lyssikatos; Alan G. Olivero

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June 1, 2011

Clinical use of dornase alfa is associated with a slower rate of FEV 1 decline in cystic fibrosis

Pediatric Pulmonology, ISSN: 87556863 10990496

Michael W. Konstan; Wagener; David J. Pasta; Stefanie J. Millar; Joan R. Jacobs; Ashley Yegin; Morgan

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June 1, 2011

The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians

Clinical Endocrinology, ISSN: 03000664 13652265

Anand Vaidya; Bei Sun; Forman; Paul N. Hopkins; Nancy J. Brown; Nikheel S. Kolatkar; Gordon H. Williams; Jonathan S. Williams

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June 1, 2011

B cell immunotherapy in autoimmunity - 2010 update

Molecular Immunology, ISSN: 01615890 18729142

Andrew A. Chan

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June 1, 2011

Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab

Neuro-Oncology, ISSN: 15228517 15235866

Jeffrey S. Wefel; Timothy Cloughesy; James L. Zazzali; Maoxia Zheng; Michael D. Prados; Patrick Y. Wen; Tom Mikkelsen; David Schiff; Lauren E. Abrey; Alfred Yung; Nina Paleologos; Martin K. Nicholas; Randy Jensen; James Vredenburgh; Asha Das; Henry S. Friedman

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June 1, 2011

Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER)

Lupus, ISSN: 09612033 14770962

Merrill; Jill P. Buyon; Richard A. Furie; Latinis; Gordon; Hsin-Ju Hsieh; Paul Brunetta

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June 1, 2011

Sustained release formulations of rhVEGF165 produce a durable response in a murine model of peripheral angiogenesis

European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 09396411

Daugherty; Linda Rangell; Eckert; Jose Zavala-Solorio; Franklin V. Peale Jr.; Mrsny

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June 1, 2011

Estimated cases of legal blindness and visual impairment avoided using ranibizumab for choroidal neovascularization: Non-hispanic white population in the United States with age-related macular degeneration

Archives of Ophthalmology, ISSN: 00039950 15383601

Neil M. Bressler; Quan V. Doan; Rohit Varma; Paul P. Lee; Ivan J. Suñer; Chantal M. Dolan; Mark Danese; Elaine B. Yu; Irwin Tran; Shoshana Colman

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June 1, 2011

Treatment of chronic hepatitis C patients with the NS3/4A protease inhibitor danoprevir (ITMN-191/RG7227) leads to robust reductions in viral RNA: A phase 1b multiple ascending dose study

Journal of Hepatology, ISSN: 01688278 01688278

Nicole Forestier; Dominique Larrey; Dominique Guyader; Marcellin; Régine Rouzier; Alain Patat; Patrick F. Smith; Williamson Bradford; Steven Porter; Lawrence Blatt; Scott D. Seiwert; Stefan Zeuzem

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June 1, 2011

Streamlining downstream process development

BioProcess International, ISSN: 15426319

Brian Kluck; Binh Thai; Jim Furey; Dennis Annarelli

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June 1, 2011

Characterization of xenobiotic-induced hepatocellular enzyme induction in rats: Anticipated thyroid effects and unique pituitary gland findings

Toxicologic Pathology, ISSN: 01926233 15331601

Tanja S. Zabka; Mark Fielden; Rosario Garrido; Jianhua Tao; Adrian J. Fretland; Jennifer Fretland; Mudher Albassam; Thomas Singer; Kolaja

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June 1, 2011

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

Biochemical Journal, ISSN: 02646021 14708728

Mislav Oreb; Anja Höfle; Patrick Koenig; Maik S. Sommer; Irmgard Sinning; Fei Wang; Ivo Tews; Danny J. Schnell; Enrico Schleiff

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June 1, 2011

Ubiquitylation in apoptosis: A post-translational modification at the edge of life and death

Nature Reviews Molecular Cell Biology, ISSN: 14710072 14710080

Domagoj Vucic; Vishva M. Dixit; Ingrid E. Wertz

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May 30, 2011

Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse

Journal of Cell Biology, ISSN: 00219525 00219525

Deanna G. Wilson; Khanhky Phamluong; Li Li; Mei Sun; Tim C. Cao; Peter S. Liu; Zora Modrusan; Wendy N. Sandoval; Linda Rangell; Richard A. D. Carano; Andrew S. Peterson; Mark J. Solloway

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May 27, 2011

Intravital Imaging Reveals Limited Antigen Presentation and T Cell Effector Function in Mycobacterial Granulomas

Immunity, ISSN: 10747613 10974180

Jackson G. Egen; Antonio Gigliotti Rothfuchs; Carl G. Feng; Marcus A. Horwitz; Alan Sher; Ronald N. Germain

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May 27, 2011

Murine Insulin Growth Factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Adrian A. Lobito; Sree R. Ramani; Irene Tom; J.Fernando Bazan; Luis; Wayne J. Fairbrother; Wenjun Ouyang; Lino C. Gonzalez Jr.

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May 26, 2011

Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions

Blood, ISSN: 15280020 00064971

David Yao; Yuanshuai Huang; Xiaoran Huang; Weihuan Wang; Quanjian Yan; Lebing L. Wei; Wei Xin; Stanton Gerson; Pamela Stanley; John Lowe; Lan Zhou

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May 25, 2011

A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

Science Translational Medicine, ISSN: 19466234 19466242

Jasvinder K. Atwal; Yongmei Chen; Cecilia Chiu; Deborah L. Mortensen; William J. Meilandt; Yichin Liu; Christopher E. Heise; Kwame Hoyte; Wilman Luk; Yanmei Lu; Kun Peng; Ping Wu; Lionel Rouge; Yingnan Zhang; Lazarus; Kimberly Scearce-Levie; Weiru Wang; Yan Wu; Marc Tessier-Lavigne; Ryan J. Watts

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May 25, 2011

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

Science Translational Medicine, ISSN: 19466234 19466242

Y. Joy Yu; Yin Zhang; Margaret Kenrick; Kwame Hoyte; Wilman Luk; Yanmei Lu; Jasvinder K. Atwal; J. Michael Elliott; Saileta Prabhu; Ryan J. Watts; Dennis

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May 20, 2011

Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry

Molecular Cell, ISSN: 10972765 10974164

Xiaodong Huang; Matthew K. Summers; Victoria Pham; Jennie R. Lill; Jinfeng Liu; Gwanghee Lee; Donald S. Kirkpatrick; Peter K Jackson; Guowei Fang; Vishva M. Dixit

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May 16, 2011

Crystal structures of two aminoglycoside kinases bound with a Eukaryotic protein kinase inhibitor

PLoS ONE, ISSN: 19326203

Desiree H. Fong; Bing Xiong; Jiyoung Hwang; Albert M. Berghuis

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May 15, 2011

Toward understanding molecular heterogeneity of polysorbates by application of liquid chromatography-mass spectrometry with computer-aided data analysis

Analytical Chemistry, ISSN: 00032700

Oleg V. Borisov; Junyan A. Ji; Y. John Wang; Felix Vega; Victor Ling

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May 15, 2011

Targeting superficial or nodular basal cell carcinoma with topically formulated small molecule inhibitor of smoothened

Clinical Cancer Research, ISSN: 10780432 15573265

Tracy Tzu-Ling Tang; Jean Y. Tang; Dongwei Li; Mike Reich; Christopher Callahan; Ling Fu; Robert Yauch; Frank Wang; Karen Kotkow; Kris Chang; Elana Shpall; Angela Wu; Lee L. Rubin; James C. Marsters Jr.; Ervin H. Epstein Jr.; Ivor Caro; Frederic J. De Sauvage

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May 15, 2011

Changes in18F-fluorodeoxyglucose and 18F-fluorodeoxythymidine positron emission tomography imaging in patients with non-small cell lung cancer treated with erlotinib

Clinical Cancer Research, ISSN: 10780432 15573265

Linda Mileshkin; Rodney Hicks; Brett Hughes; Paul Mitchell; Veena Charu; Barbara Gitlitz; David Macfarlane; Benjamin Solomon; Lukas Amler; Wei Yu; Andrea Pirzkall; Bernard M. Fine

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May 13, 2011

AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β(GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Li Zhang; Francois Jouret; Jesse Rinehart; Jeff Sfakianos; Ira Mellman; Richard P. Lifton; Lawrence H. Young; Michael J. Caplan

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May 13, 2011

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways

Cell, ISSN: 00928674

Liyun Sang; Julie J. Miller; Kevin C. Corbit; Rachel H. Giles; Matthew J. Brauer; Edgar A. Otto; Lisa M. Baye; Xiaohui Wen; Suzie J. Scales; Mandy Kwong; Erik G. Huntzicker; Mindan K. Sfakianos; Wendy N. Sandoval; J.Fernando Bazan; Priya Kulkarni; Francesc R. Garcia-Gonzalo; Allen D. Seol; John F. O'Toole; Susanne Held; Heiko M. Reutter; William Lane; Muhammad Arshad Rafiq; Abdul Noor; Muhammad Ansar; Akella Radha Rama Devi; Val C. Sheffield; Diane C. Slusarski; John B. Vincent; Daniel A. Doherty; Friedhelm Hildebrandt; Jeremy Reiter; Peter K Jackson

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May 13, 2011

Computational design of proteins targeting the conserved stem region of influenza hemagglutinin

Science, ISSN: 00368075 10959203

Sarel J. Fleishman; Timothy A. Whitehead; Damian C. Ekiert; Cyrille Dreyfus; Jacob E. Corn; Eva-Maria Strauch; Ian A. Wilson; David Baker

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May 12, 2011

Pyrazolopyridine inhibitors of B-RafV600E. Part 1: The development of selective, orally bioavailable, and efficacious inhibitors

ACS Medicinal Chemistry Letters, ISSN: 19485875

Steve Wenglowsky; Li Ren; Kateri Ahrendt; Ellen R. Laird; Ignacio Aliagas; Bruno Alicke; Alexandre J. Buckmelter; Edna F. Choo; Victoria Dinkel; Bainian Feng; Susan L. Gloor; Stephen Gould; Stefan Gross; Janet Gunzner; Joshua D. Hansen; Georgia Hatzivassiliou; Bonnie Liu; Kim Malesky; Simon Mathieu; Bradley J. Newhouse; Nicholas J. Raddatz; Yingqing Ran; Sumeet Rana; Nikole Randolph; Tyler Risom; Joachim Rudolph; Scott Savage; Leann T. Selby; Michael Shrag; Kyung Song; Hillary L. Sturgis; Walter C. Voegtli; Zhaoyang Wen; Brandon S. Willis; Richard D. Woessner; Wen-I. Wu; Wendy B. Young; Jonas Grina

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May 12, 2011

Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Frederick Cohen; Philippe Bergeron; Elizabeth M. Blackwood; Krista K. Bowman; Huifen Chen; Antonio G. DiPasquale; Jennifer A. Epler; Michael F. T. Koehler; Kevin Lau; Lewis; Lichuan Liu; Cuong Q. Ly; Shiva Malek; Jim Nonomiya; Daniel F. Ortwine; Zhonghua Pei; Kirk D. Robarge; Steve Sideris; Lan Trinh; Tom Truong; Jiansheng Wu; Xianrui Zhao; Joseph P. Lyssikatos

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May 12, 2011

TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma

PLoS ONE, ISSN: 19326203

Kui Lin; James R. Taylor Jr.; Thomas D Wu; Johnny Gutierrez; J. Michael Elliott; Jean-Michel Vernes; Koeppen; Phillips; Frederic J. De Sauvage; Meng

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May 11, 2011

Facile synthesis of spiro oxindoles, azaoxindoles, and dihydroisoquinolone

Synthetic Communications, ISSN: 00397911 15322432

Sharada Labadie; Christa Parmer

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