Genentech: Publications

March 1, 2011

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

Nature Structural and Molecular Biology, ISSN: 15459993 15459985

Aimee Shen; Patrick J. Lupardus; Malte M. Gersch; Aaron W. Puri; Victoria E. Albrow; Garcia; Matthew Bogyo

March 1, 2011

Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions

Protein Science, ISSN: 09618368 1469896X

Yatin Gokarn; R. Matthew Fesinmeyer; Atul Saluja; Vladimir Razinkov; Susan F. Chase; Thomas M. Laue; David N. Brems

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March 1, 2011

Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: A re-evaluation of P450 isoform selectivity

European Journal of Drug Metabolism and Pharmacokinetics, ISSN: 03787966 21070180

S. Cyrus Khojasteh; Saileta Prabhu; Jane R. Kenny; Jason S Halladay; Anthony Y. H. Lu

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March 1, 2011

Can modeling of health outcomes facilitate regulatory decision making? The benefit-risk tradeoff for rosiglitazone in 1999 vs. 2007

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Cross; David L. Veenstra; Gardner; Louis P. Garrison Jr.

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March 1, 2011

Treatment of growth hormone-deficient infants with recombinant human growth hormone to near-adult height: Patterns of growth

Hormone Research in Paediatrics, ISSN: 16632818 16632826

Allen W. Root; Ken Dana; Barbara M. Lippe

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March 1, 2011

Engaging neuroscience to advance translational research in brain barrier biology

Nature Reviews Neuroscience, ISSN: 1471003X 14710048

Edward A. Neuwelt; Björn Bauer; Christoph Fahlke; Gert Fricker; Constantino Iadecola; Damir Janigro; Luc Leybaert; Zoltán Molnár; Martha E. O'Donnell; John T. Povlishock; Norman R. Saunders; Frank Sharp; Danica Stanimirovic; Ryan J. Watts; Lester R. Drewes

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March 1, 2011

Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Yuan Chen; Liling Liu; Khanh Nguyen; Adrian J. Fretland

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March 1, 2011

Ultra-High-Pressure LC (UHPLC) for therapeutic protein characterization

American Pharmaceutical Review, ISSN: 10998012

Justin Jeong; Taylor Zhang; Jennifer Zhang; Kao

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February 28, 2011

Identification of IgG1 variants with increased affinity to FcΓRIIIa and unaltered affinity to FcΓRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays

Journal of Immunological Methods, ISSN: 00221759

Yanmei Lu; Jean-Michel Vernes; Nancy Y. Chiang; Qinglin Ou; Jiabing Ding; Adams; Kyu Hong; Bao-Tran Truong; Domingos Ng; Amy Shen; Nakamura; Qian Gong; Presta; Beresini; Bob Kelley; Henry B. Lowman; Wai Lee T. Wong; Meng

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February 20, 2011

Clinical immunogenicity specificity assessments: A platform evaluation

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Kun Peng; Ketevan A. Siradze; Quarmby; Saloumeh Kadkhodayan Fischer

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February 18, 2011

Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines

Journal of Organic Chemistry, ISSN: 00223263 15206904

Georgette M. Castanedo; Pamela S. Seng; Nicole Blaquiere; Sean Trapp; Steven T. Staben

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February 17, 2011

NFKBIA deletion in glioblastomas

New England Journal of Medicine, ISSN: 15334406 00284793

Markus Bredel; Denise M. Scholtens; Ajay K. Yadav; Angel A. Alvarez; Jaclyn J. Renfrow; James P. Chandler; Irene L. Y. Yu; Maria S. Carro; Fangping Dai; Michael J. Tagge; Roberto Ferrarese; Claudia Bredel; Phillips; Paul J. Lukac; Pierre A. Robe; Astrid Weyerbrock; Hannes Vogel; Steven Dubner; Bret Mobley; Xiao-Lin He; Adrienne C. Scheck; Branimir I. Sikic; Kenneth D. Aldape; Arnab Chakravarti; Griffith R. Harsh IV

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February 17, 2011

HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells

Blood, ISSN: 15280020 00064971

David Favre; Cheryl A. Stoddart; Brinda Emu; Rebecca Hoh; Jeffrey N. Martin; Frederick M. Hecht; Steven G. Deeks; Joseph M. McCune

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February 15, 2011

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

Molecular Biology of the Cell, ISSN: 10591524 19394586

Chih-Wen Chu; Fajian Hou; Junmei Zhang; Lilian Phu; Alexander V. Loktev; Donald S. Kirkpatrick; Peter K Jackson; Yingming Zhao; Hui Zou

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February 15, 2011

Non-oxime inhibitors of B-RafV600E kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Li Ren; Steve Wenglowsky; Greg Miknis; Bryson Rast; Alexandre J. Buckmelter; Robert J. Ely; Stephen Schlachter; Ellen R. Laird; Nikole Randolph; Michele Callejo; Matthew Martinson; Sarah Galbraith; Barbara J. Brandhuber; Guy Vigers; Tony Morales; Walter C. Voegtli; Joseph P. Lyssikatos

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February 15, 2011

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Alexandre J. Buckmelter; Li Ren; Ellen R. Laird; Bryson Rast; Greg Miknis; Steve Wenglowsky; Stephen Schlachter; Michael Welch; Eugene Tarlton; Jonas Grina; Joseph P. Lyssikatos; Barbara J. Brandhuber; Tony Morales; Nikole Randolph; Guy Vigers; Matthew Martinson; Michele Callejo

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February 15, 2011

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christopher J. Westlake; Lisa M. Baye; Maxence V. Nachury; Kevin J. Wright; Karen E. Ervin; Lilian Phu; Cecile Chalouni; John S. Beck; Donald S. Kirkpatrick; Diane C. Slusarski; Val C. Sheffield; Richard H. Scheller; Peter K Jackson

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February 14, 2011

Population pharmacokinetic evaluation with external validation and bayesian estimator of voriconazole in liver transplant recipients

Clinical Pharmacokinetics, ISSN: 03125963 11791926

Kelong Han; Robert Bies; Heather Johnson; Blair Capitano; Raman Venkataramanan

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February 11, 2011

Menadione degrades the optical quality and mitochondrial integrity of bovine crystalline lenses

Molecular Vision, ISSN: 10900535

Kenneth W. Olsen; Vlad Bantseev; Vivan Choh

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February 10, 2011

A general asymmetric synthesis of phenylglycinols

Tetrahedron Asymmetry, ISSN: 09574166 1362511X

Xingang Pan; Liangbin Jia; Xuejian Liu; Haikuo Ma; Wenqian Yang; Jacob B. Schwarz

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February 10, 2011

Do we need to optimize plasma protein and tissue binding in drug discovery?

Current Topics in Medicinal Chemistry, ISSN: 15680266

Xingrong Liu; Cuiping Chen; Cornelis E. Hop

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February 9, 2011

Tree pruner: An efficient tool for selecting data from a biased genetic database

BMC Bioinformatics, ISSN: 14712105

Mohan Krishnamoorthy; Pragneshkumar Patel; Mira Dimitrijevic; Jonathan Dietrich; Margaret Green; Catherine Macken

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February 9, 2011

Differences in reversion of resistance mutations to wild- type under structured treatment interruption and related increase in replication capacity

PLoS ONE, ISSN: 19326203

Agnes C. Paquet; John Baxter; Jodi Weidler; Yolanda S. Lie; Jody Lawrence; Rose Kim; Michael Bates; Eoin Coakley; Colombe Chappey

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February 3, 2011

Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay

PLoS ONE, ISSN: 19326203

Rajiv Dua; Jianhuan Zhang; Gordon Parry; Elicia M. Penuel

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February 1, 2011

TRAPing a new gene for autoimmunity

Nature Genetics, ISSN: 10614036 15461718

Timothy W. Behrens; Robert R. Graham

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February 1, 2011

TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro

PLoS ONE, ISSN: 19326203

Christina Menke; Tatiana Goncharov; Lubna Qamar; Christopher Korch; Heide L. Ford; Kian Behbakht; Andrew Thorburn

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February 1, 2011

Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells

Prostate, ISSN: 02704137 10970045

Manisha Tripathi; Alka A. Potdar; Hironobu Yamashita; Brandy Weidow; Peter T. Cummings; Daniel Kirchhofer; Vito Quaranta

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February 1, 2011

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling

Developmental Dynamics, ISSN: 10588388 10970177

Sangho Yu; Dianna Crawford; Takatoshi Tsuchihashi; Timothy W. Behrens; Deepak Srivastava

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February 1, 2011

A new regulatory switch in a JAK protein kinase

Proteins: Structure, Function and Bioinformatics, ISSN: 08873585 10970134

Vickie Tsui; Paul Gibbons; Ultsch; Kyle Mortara; Christine Chang; Wade S. Blair; Rebecca Pulk; Mark S. Stanley; Melissa A. Starovasnik; David Williams; Maria Lamers; Phillip Leonard; Steven Magnuson; Jun Liang; Eigenbrot

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February 1, 2011

Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms

Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642

Craig J. Goergen; Junya Azuma; Kyla N. Barr; Lars Magdefessel; Dara Y. Kallop; Alvin Gogineni; Amarjeet Grewall; Robby M. Weimer; Andrew J. Connolly; Ronald L. Dalman; Charles A. Taylor; Philip S. Tsao; Joan M. Greve

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February 1, 2011

Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab

Neurology, ISSN: 00283878 1526632X

Whitney B. Pope; Qi Xia; Virginia Paton; Asha Das; Julie Hambleton; Kim; Huo; Brown; Goldin; Timothy Cloughesy

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February 1, 2011

From the authors

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Mark D. Eisner

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February 1, 2011

Paper Covers Rock: In Search of the e-record Model

Law and Critique, ISSN: 09578536 15728617

Jacques Mourrain

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February 1, 2011

Budget impact of erlotinib for maintenance therapy in advanced non-small cell lung cancer

Journal of Medical Economics, ISSN: 13696998

Josh J. Carlson; Wong; David L. Veenstra; Carolina Reyes

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February 1, 2011

Bleeding events in bevacizumab-treated cancer patients who received full-dose anticoagulation and remained on study

British Journal of Cancer, ISSN: 00070920 15321827

Natasha Leighl; Bennouna; Jing Yi; Moore; Julie Hambleton; Herbert Hurwitz

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February 1, 2011

The transcriptional diversity of 25 Drosophila cell lines

Genome Research, ISSN: 10889051 15495469

Lucy Cherbas; Aarron T. Willingham; Dayu Zhang; Li Yang; Yi Zou; Brian D. Eads; Joseph W. Carlson; Jane M. Landolin; Philipp Kapranov; Jacqueline Dumais; Anastasia Samsonova; Jeong-Hyeon Choi; Johnny Roberts; Carrie A. Davis; Haixu Tang; Marijke J. Van Baren; Srinka Ghosh; Alexander Dobin; Kim Bell; Wei Lin; Laura Langton; Michael O. Duff; Aaron E. Tenney; Chris Zaleski; Michael R. Brent; Roger A. Hoskins; Thomas C. Kaufman; Justen Andrews; Brenton R. Graveley; Norbert Perrimon; Susan E. Celniker; Thomas R. Gingeras; Peter Cherbas

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February 1, 2011

Resurrection of a clinical antibody: Template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin-α antibody

Proteomics, ISSN: 16159853 16159861

Natalie E. Castellana; Krista McCutcheon; Victoria Pham; Kristin Harden; Allen Nguyen; Judy Young; Adams; Kurt A. Schroeder; David Arnott; Vineet Bafna; Jane L. Grogan; Jennie R. Lill

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February 1, 2011

A method for removing the brain and spinal cord as one unit from adult mice and rats

Lab Animal, ISSN: 00937355 15484475

Heather S. Kennedy; Floresita Puth; Marjie Van Hoy; Claire E. Le Pichon

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February 1, 2011

Harnessing dendritic cells for immunotherapy

Seminars in Immunology, ISSN: 10445323

Lélia Delamarre; Ira Mellman

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February 1, 2011

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Protein Science, ISSN: 09618368 1469896X

Andreas Kuglstatter; April Wong; Stan Tsing; Simon W. Lee; Yan Lou; Armando G. Villaseñor; J. Michael Bradshaw; David Shaw; Jim W. Barnett; Michelle F. Browner

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February 1, 2011

Effect of electrostatic spray on human pulmonary epithelial cells

Journal of Electrostatics, ISSN: 03043886

Michelle G. Zeles-Hahn; Yvonne Lentz; Thomas J. Anchordoquy; Corinne S. Lengsfeld

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February 1, 2011

Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Sunaga; David S. Shames; Girard; Michael Peyton; Larsen; Imai; Junichi Soh; Sato; Noriko Yanagitani; Kaira; Yang Xie; Adi Gazdar; Mori; Minna

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February 1, 2011

Effects of omalizumab on changes in pulmonary function induced by controlled cat room challenge

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Jonathan Corren; Robert A. Wood; Deepen Patel; Jin Zhu; Ashley Yegin; Gitika Dhillon; James E. Fish

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February 1, 2011

Advances in the assessment and control of the effector functions of therapeutic antibodies

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Xu-Rong Jiang; An Song; Svetlana Bergelson; Thomas Arroll; Bhavin S. Parekh; Kimberly May; Shan Chung; Robert Strouse; Mire-Sluis; Mark Schenerman

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February 1, 2011

Translational pharmacokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase i study

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Zheng; Heleen Scheerens; John C. Davis; Rong Deng; Saloumeh Kadkhodayan Fischer; Cynthia Woods; Fielder; Stefanich

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February 1, 2011

Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways

Journal of Immunology, ISSN: 00221767 15506606

David F. Choy; Barmak Modrek; Abbas Alexander; Sarah K. Kummerfeld; Hilary F. Clark; Lawren C. Wu; Grazyna Fedorowicz; Zora Modrusan; John V. Fahy; Prescott G. Woodruff; Joseph R. Arron

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February 1, 2011

Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes

PLoS Genetics, ISSN: 15537390 15537404

Kimberly E. Taylor; Sharon A. Chung; Robert R. Graham; Ward Ortmann; Annette T. Lee; Carl D. Langefeld; Chaim O. Jacob; M. Ilyas Kamboh; Marta E. Alarcón-Riquelme; Betty P. Tsao; Kathy L. Moser; Patrick M. Gaffney; John B. Harley; Michelle Petri; Manzi; Peter K. Gregersen; Timothy W. Behrens; Lindsey A. Criswell

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February 1, 2011

The quality product steward model: The genentech approach

BioPharm International, ISSN: 1542166X

Zhengyu Dong; Sharon Ma; Feuerhelm

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February 1, 2011

Extractables and leachables

BioProcess International, ISSN: 15426319

Mire-Sluis; Stacey Ma; Ingrid Markovic; Lorna McLeod

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January 30, 2011