Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8801 - 8850 OF 15805 RESULTS

March 1, 2011

Characteristics of patients losing vision after 2 years of monthly dosing in the phase III ranibizumab clinical trials

Ophthalmology, ISSN: 01616420

Philip J. Rosenfeld; Howard Shapiro; Lisa Tuomi; Mary Webster; Julee Elledge; Barbara A. Blodi

March 1, 2011

American college of rheumatology/European league against rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials

Arthritis and Rheumatism, ISSN: 00043591 15290131

David T. Felson; Josef S. Smolen; George Wells; Bin Zhang; Lilian H.D. Van Tuyl; Julia Funovits; Daniel Aletaha; Allaart; Joan Bathon; Stefano Bombardieri; Peter Brooks; Andrew Brown; Marco Matucci-Cerinic; Hyon Choi; Bernard Combe; Maarten De Wit; Maxime Dougados; Paul Emery; Daniel E. Furst; Juan Gomez-Reino; Gillian Hawker; Edward Keystone; Dinesh Khanna; John Kirwan; Tore K. Kvien; Robert Landewé; Joachim Listing; Kaleb Michaud; Emilio Martin-Mola; Pamela Montie; Theodore Pincus; Pamela Richards; Jeffrey N. Siegel; Lee S. Simon; Tuulikki Sokka; Vibeke Strand; Peter Tugwell; Alan Tyndall; Desirée Van Der Heijde; Suzan Verstappen; Barbara White; Frederick Wolfe; Angela Zink; Maarten Boers

March 1, 2011

Challenges in developing bioanalytical assays for characterization of antibody-drug conjugates

Bioanalysis, ISSN: 17576180 17576199

Jean-Philippe Stephan; Katherine R. Kozak; Wai Lee T. Wong

March 1, 2011

The minimum L2 distance estimator for Poisson mixture models

Journal of Statistical Planning and Inference, ISSN: 03783758

Ian R. Harris; Shuyi Shen

March 1, 2011

DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression

Neuro-Oncology, ISSN: 15228517 15235866

Shichun Zheng; E. Andres Houseman; Zachary Morrison; Margaret R. Wrensch; Joseph S. Patoka; Christian Ramos; Daphne A. Haas-Kogan; Sean McBride; Carmen J. Marsit; Brock C. Christensen; Heather H. Nelson; David Stokoe; Joseph L. Wiemels; Susan Chang; Michael D. Prados; Tarik Tihan; Scott R. VandenBerg; Karl T. Kelsey; Mitchel S. Berger; John K. Wiencke

February 28, 2011

Identification of IgG1 variants with increased affinity to FcΓRIIIa and unaltered affinity to FcΓRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays

Journal of Immunological Methods, ISSN: 00221759

Yanmei Lu; Jean-Michel Vernes; Nancy Y. Chiang; Qinglin Ou; Jiabing Ding; Adams; Kyu Hong; Bao-Tran Truong; Domingos Ng; Amy Shen; Nakamura; Qian Gong; Presta; Beresini; Bob Kelley; Henry B. Lowman; Wai Lee T. Wong; Meng

February 20, 2011

Clinical immunogenicity specificity assessments: A platform evaluation

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Kun Peng; Ketevan A. Siradze; Quarmby; Saloumeh Kadkhodayan Fischer

February 18, 2011

Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines

Journal of Organic Chemistry, ISSN: 00223263 15206904

Georgette M. Castanedo; Pamela S. Seng; Nicole Blaquiere; Sean Trapp; Steven T. Staben

February 17, 2011

HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells

Blood, ISSN: 15280020 00064971

David Favre; Cheryl A. Stoddart; Brinda Emu; Rebecca Hoh; Jeffrey N. Martin; Frederick M. Hecht; Steven G. Deeks; Joseph M. McCune

February 17, 2011

NFKBIA deletion in glioblastomas

New England Journal of Medicine, ISSN: 15334406 00284793

Markus Bredel; Denise M. Scholtens; Ajay K. Yadav; Angel A. Alvarez; Jaclyn J. Renfrow; James P. Chandler; Irene L. Y. Yu; Maria S. Carro; Fangping Dai; Michael J. Tagge; Roberto Ferrarese; Claudia Bredel; Phillips; Paul J. Lukac; Pierre A. Robe; Astrid Weyerbrock; Hannes Vogel; Steven Dubner; Bret Mobley; Xiao-Lin He; Adrienne C. Scheck; Branimir I. Sikic; Kenneth D. Aldape; Arnab Chakravarti; Griffith R. Harsh IV

February 15, 2011

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christopher J. Westlake; Lisa M. Baye; Maxence V. Nachury; Kevin J. Wright; Karen E. Ervin; Lilian Phu; Cecile Chalouni; John S. Beck; Donald S. Kirkpatrick; Diane C. Slusarski; Val C. Sheffield; Richard H. Scheller; Peter K Jackson

February 15, 2011

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Alexandre J. Buckmelter; Li Ren; Ellen R. Laird; Bryson Rast; Greg Miknis; Steve Wenglowsky; Stephen Schlachter; Michael Welch; Eugene Tarlton; Jonas Grina; Joseph P. Lyssikatos; Barbara J. Brandhuber; Tony Morales; Nikole Randolph; Guy Vigers; Matthew Martinson; Michele Callejo

February 15, 2011

Non-oxime inhibitors of B-RafV600E kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Li Ren; Steve Wenglowsky; Greg Miknis; Bryson Rast; Alexandre J. Buckmelter; Robert J. Ely; Stephen Schlachter; Ellen R. Laird; Nikole Randolph; Michele Callejo; Matthew Martinson; Sarah Galbraith; Barbara J. Brandhuber; Guy Vigers; Tony Morales; Walter C. Voegtli; Joseph P. Lyssikatos

February 15, 2011

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

Molecular Biology of the Cell, ISSN: 10591524 19394586

Chih-Wen Chu; Fajian Hou; Junmei Zhang; Lilian Phu; Alexander V. Loktev; Donald S. Kirkpatrick; Peter K Jackson; Yingming Zhao; Hui Zou

February 14, 2011

Population pharmacokinetic evaluation with external validation and bayesian estimator of voriconazole in liver transplant recipients

Clinical Pharmacokinetics, ISSN: 03125963 11791926

Kelong Han; Robert Bies; Heather Johnson; Blair Capitano; Raman Venkataramanan

February 11, 2011

Menadione degrades the optical quality and mitochondrial integrity of bovine crystalline lenses

Molecular Vision, ISSN: 10900535

Kenneth W. Olsen; Vlad Bantseev; Vivan Choh

February 10, 2011

Do we need to optimize plasma protein and tissue binding in drug discovery?

Current Topics in Medicinal Chemistry, ISSN: 15680266

Xingrong Liu; Cuiping Chen; Cornelis E. Hop

February 10, 2011

A general asymmetric synthesis of phenylglycinols

Tetrahedron Asymmetry, ISSN: 09574166 1362511X

Xingang Pan; Liangbin Jia; Xuejian Liu; Haikuo Ma; Wenqian Yang; Jacob B. Schwarz

February 9, 2011

Differences in reversion of resistance mutations to wild- type under structured treatment interruption and related increase in replication capacity

PLoS ONE, ISSN: 19326203

Agnes C. Paquet; John Baxter; Jodi Weidler; Yolanda S. Lie; Jody Lawrence; Rose Kim; Michael Bates; Eoin Coakley; Colombe Chappey

February 9, 2011

Tree pruner: An efficient tool for selecting data from a biased genetic database

BMC Bioinformatics, ISSN: 14712105

Mohan Krishnamoorthy; Pragneshkumar Patel; Mira Dimitrijevic; Jonathan Dietrich; Margaret Green; Catherine Macken

February 3, 2011

Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay

PLoS ONE, ISSN: 19326203

Rajiv Dua; Jianhuan Zhang; Gordon Parry; Elicia M. Penuel

February 1, 2011

Extractables and leachables

BioProcess International, ISSN: 15426319

Mire-Sluis; Stacey Ma; Ingrid Markovic; Lorna McLeod

February 1, 2011

The quality product steward model: The genentech approach

BioPharm International, ISSN: 1542166X

Zhengyu Dong; Sharon Ma; Feuerhelm

February 1, 2011

Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes

PLoS Genetics, ISSN: 15537390 15537404

Kimberly E. Taylor; Sharon A. Chung; Robert R. Graham; Ward Ortmann; Annette T. Lee; Carl D. Langefeld; Chaim O. Jacob; M. Ilyas Kamboh; Marta E. Alarcón-Riquelme; Betty P. Tsao; Kathy L. Moser; Patrick M. Gaffney; John B. Harley; Michelle Petri; Manzi; Peter K. Gregersen; Timothy W. Behrens; Lindsey A. Criswell

February 1, 2011

Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways

Journal of Immunology, ISSN: 00221767 15506606

David F. Choy; Barmak Modrek; Abbas Alexander; Sarah K. Kummerfeld; Hilary F. Clark; Lawren C. Wu; Grazyna Fedorowicz; Zora Modrusan; John V. Fahy; Prescott G. Woodruff; Joseph R. Arron

February 1, 2011

Translational pharmacokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase i study

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Zheng; Heleen Scheerens; John C. Davis; Rong Deng; Saloumeh Kadkhodayan Fischer; Cynthia Woods; Fielder; Stefanich

February 1, 2011

Advances in the assessment and control of the effector functions of therapeutic antibodies

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Xu-Rong Jiang; An Song; Svetlana Bergelson; Thomas Arroll; Bhavin S. Parekh; Kimberly May; Shan Chung; Robert Strouse; Mire-Sluis; Mark Schenerman

February 1, 2011

Effects of omalizumab on changes in pulmonary function induced by controlled cat room challenge

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Jonathan Corren; Robert A. Wood; Deepen Patel; Jin Zhu; Ashley Yegin; Gitika Dhillon; James E. Fish

February 1, 2011

Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Sunaga; David S. Shames; Girard; Michael Peyton; Larsen; Imai; Junichi Soh; Sato; Noriko Yanagitani; Kaira; Yang Xie; Adi Gazdar; Mori; Minna

February 1, 2011

Effect of electrostatic spray on human pulmonary epithelial cells

Journal of Electrostatics, ISSN: 03043886

Michelle G. Zeles-Hahn; Yvonne Lentz; Thomas J. Anchordoquy; Corinne S. Lengsfeld

February 1, 2011

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Protein Science, ISSN: 09618368 1469896X

Andreas Kuglstatter; April Wong; Stan Tsing; Simon W. Lee; Yan Lou; Armando G. Villaseñor; J. Michael Bradshaw; David Shaw; Jim W. Barnett; Michelle F. Browner

February 1, 2011

Harnessing dendritic cells for immunotherapy

Seminars in Immunology, ISSN: 10445323

Lélia Delamarre; Ira Mellman

February 1, 2011

A method for removing the brain and spinal cord as one unit from adult mice and rats

Lab Animal, ISSN: 00937355 15484475

Heather S. Kennedy; Floresita Puth; Marjie Van Hoy; Claire E. Le Pichon

February 1, 2011

Resurrection of a clinical antibody: Template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin-α antibody

Proteomics, ISSN: 16159853 16159861

Natalie E. Castellana; Krista McCutcheon; Victoria Pham; Kristin Harden; Allen Nguyen; Judy Young; Adams; Kurt A. Schroeder; David Arnott; Vineet Bafna; Jane L. Grogan; Jennie R. Lill

February 1, 2011

The transcriptional diversity of 25 Drosophila cell lines

Genome Research, ISSN: 10889051 15495469

Lucy Cherbas; Aarron T. Willingham; Dayu Zhang; Li Yang; Yi Zou; Brian D. Eads; Joseph W. Carlson; Jane M. Landolin; Philipp Kapranov; Jacqueline Dumais; Anastasia Samsonova; Jeong-Hyeon Choi; Johnny Roberts; Carrie A. Davis; Haixu Tang; Marijke J. Van Baren; Srinka Ghosh; Alexander Dobin; Kim Bell; Wei Lin; Laura Langton; Michael O. Duff; Aaron E. Tenney; Chris Zaleski; Michael R. Brent; Roger A. Hoskins; Thomas C. Kaufman; Justen Andrews; Brenton R. Graveley; Norbert Perrimon; Susan E. Celniker; Thomas R. Gingeras; Peter Cherbas

February 1, 2011

Bleeding events in bevacizumab-treated cancer patients who received full-dose anticoagulation and remained on study

British Journal of Cancer, ISSN: 00070920 15321827

Natasha Leighl; Bennouna; Jing Yi; Moore; Julie Hambleton; Herbert Hurwitz

February 1, 2011

Budget impact of erlotinib for maintenance therapy in advanced non-small cell lung cancer

Journal of Medical Economics, ISSN: 13696998

Josh J. Carlson; Wong; David L. Veenstra; Carolina Reyes

February 1, 2011

Paper Covers Rock: In Search of the e-record Model

Law and Critique, ISSN: 09578536 15728617

Jacques Mourrain

February 1, 2011

From the authors

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Mark D. Eisner

February 1, 2011

Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab

Neurology, ISSN: 00283878 1526632X

Whitney B. Pope; Qi Xia; Virginia Paton; Asha Das; Julie Hambleton; Kim; Huo; Brown; Goldin; Timothy Cloughesy

February 1, 2011

Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms

Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642

Craig J. Goergen; Junya Azuma; Kyla N. Barr; Lars Magdefessel; Dara Y. Kallop; Alvin Gogineni; Amarjeet Grewall; Robby M. Weimer; Andrew J. Connolly; Ronald L. Dalman; Charles A. Taylor; Philip S. Tsao; Joan M. Greve

February 1, 2011

A new regulatory switch in a JAK protein kinase

Proteins: Structure, Function and Bioinformatics, ISSN: 08873585 10970134

Vickie Tsui; Paul Gibbons; Ultsch; Kyle Mortara; Christine Chang; Wade S. Blair; Rebecca Pulk; Mark S. Stanley; Melissa A. Starovasnik; David Williams; Maria Lamers; Phillip Leonard; Steven Magnuson; Jun Liang; Eigenbrot

February 1, 2011

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling

Developmental Dynamics, ISSN: 10588388 10970177

Sangho Yu; Dianna Crawford; Takatoshi Tsuchihashi; Timothy W. Behrens; Deepak Srivastava

February 1, 2011

Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells

Prostate, ISSN: 02704137 10970045

Manisha Tripathi; Alka A. Potdar; Hironobu Yamashita; Brandy Weidow; Peter T. Cummings; Daniel Kirchhofer; Vito Quaranta

February 1, 2011

TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro

PLoS ONE, ISSN: 19326203

Christina Menke; Tatiana Goncharov; Lubna Qamar; Christopher Korch; Heide L. Ford; Kian Behbakht; Andrew Thorburn

February 1, 2011

TRAPing a new gene for autoimmunity

Nature Genetics, ISSN: 10614036 15461718

Timothy W. Behrens; Robert R. Graham

January 30, 2011

Well differentiated follicular thyroid neoplasia: Impact of molecular and technological advances on detection, monitoring and treatment

Molecular and Cellular Endocrinology, ISSN: 03037207

Andrew G. Gianoukakis; Silvana M. Giannelli; Wael A. Salameh; Laron W. McPhaul

January 27, 2011

PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis

Oncogene, ISSN: 09509232 14765594

Bender; Opel; Naumann; Kappler; Lori S. Friedman; Von Schweinitz; Debatin; Fulda

January 26, 2011

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples

BMC Medical Genomics, ISSN: 17558794

Serban Nacu; Yuan; Zhengyan Kan; Deepali Bhatt; Rivers; Stinson; Brock A. Peters; Zora Modrusan; Kenneth Jung; Somasekar Seshagiri; Thomas D Wu

January 25, 2011

Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Zhenglei Pei; Bei Wang; Gang Chen; Motoshi Nagao; Masato Nakafuku; Kenneth Campbell

Join Our Team

The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.

Two Scientists Walk Into a Bar

Two Scientists Walk Into a Bar

Listen to our podcast, where researchers talk about their work answering the toughest questions in human biology.