Genentech: Publications

October 6, 2010

Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon

Journal of Neuroscience, ISSN: 02706474 15292401

Abraham J. Langseth; Roeben N. Munji; Youngshik Choe; Trung Huynh; Christine D. Pozniak; Samuel J. Pleasure

October 4, 2010

Development and evaluation of a novel method for preclinical measurement of tissue vascular volume

Molecular Pharmaceutics, ISSN: 15438384 15438392

C. Andrew Boswell; Gregory Z. Ferl; Eduardo E. Mundo; Michelle G. Schweiger; Jan Marik; Mike Reich; Frank-Peter Theil; Fielder; Leslie A. Khawli

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October 1, 2010

Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis

Inflammatory Bowel Diseases, ISSN: 10780998 15364844

Colin L. Noble; Abbas Alexander; Charles W. Lees; Jennine Cornelius; Toy; Zora Modrusan; Hilary F. Clark; Ian D. Arnott; Ian D. Penman; Jack Satsangi; Laurie Diehl

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October 1, 2010

Diagnosis and differential diagnosis of multiple sclerosis

CONTINUUM Lifelong Learning in Neurology, ISSN: 10802371

Bruce A. C. Cree

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October 1, 2010

Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer

Clinical Cancer Research, ISSN: 10780432 15573265

Jagath R. Junutula; Kelly Flagella; Richard A. Graham; Kathryn Parsons; Edward Ha; Helga Raab; Sunil Bhakta; Trung Nguyen; Dugger; Guangmin Li; Elaine Mai; Gail L. Phillips; Hajime Hiraragi; Reina N. Fuji; Jay Tibbitts; Richard L. Vandlen; Spencer; Richard H. Scheller; Paul G. Polakis; Mark X. Sliwkowski

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October 1, 2010

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

Genes and Development, ISSN: 08909369 15495477

Saikat Mukhopadhyay; Xiaohui Wen; Ben Chih; Nelson; William Lane; Suzie J. Scales; Peter K Jackson

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October 1, 2010

Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Guozhi Tang; Denis J. Kertesz; Minmin Yang; Xianfeng Lin; Zhanguo Wang; Wentao Li; Zongxing Qiu; Junli Chen; Jianghua Mei; Li Chen; Taraneh Mirzadegan; Seth F. Harris; Armando G. Villaseñor; Jennifer Fretland; William L. Fitch; Julie Qi Hang; Gabrielle Heilek; Klumpp

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October 1, 2010

Safety and efficacy of erlotinib in first-relapse glioblastoma: A phase II open-label study

Neuro-Oncology, ISSN: 15228517 15235866

Alfred Yung; James Vredenburgh; Timothy Cloughesy; Phioanh L. Nghiemphu; Barbara Klencke; Mark R. Gilbert; David A. Reardon; Michael D. Prados

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October 1, 2010

Mri in multiple sclerosis

CONTINUUM Lifelong Learning in Neurology, ISSN: 10802371

Robert A. Bermel; Robert J. Fox

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October 1, 2010

Anatomical benefit from ranibizumab treatment of predominantly classic neovascular age-related macular degeneration in the 2-year ANCHOR study

Retina, ISSN: 0275004X

Srinivas Sadda; Glenn Stoller; David S. Boyer; Barbara A. Blodi; Howard Shapiro; Tsontcho Ianchulev

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October 1, 2010

APC/CCdc20 targets E2F1 for degradation in prometaphase

Cell Cycle, ISSN: 15514005 15384101

Melissa J. Peart; Masha V. Poyurovsky; Elizabeth M. Kass; Marshall Urist; Emmy W. Verschuren; Matthew K. Summers; Peter K Jackson; Carol Prives

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October 1, 2010

Dosing regimen and the frequency of macular hemorrhages in neovascular age-related macular degeneration treated with ranibizumab

Retina, ISSN: 0275004X

Irene Barbazetto; Namrata Saroj; Howard Shapiro; Pamela Wong; K. Bailey Freund

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October 1, 2010

Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy

Nature Genetics, ISSN: 10614036 15461718

Edgar A. Otto; Toby W Hurd; Rannar Airik; Moumita Chaki; Weibin Zhou; Corinne Stoetzel; Suresh B Patil; Shawn Levy; Amiya K Ghosh; Carlos A Murga-Zamalloa; Jeroen Van Reeuwijk; Stef J F Letteboer; Liyun Sang; Rachel H. Giles; Qin Liu; Karlien L M Coene; Alejandro Estrada-Cuzcano; Rob W J Collin; Heather M McLaughlin; Susanne Held; Jennifer M Kasanuki; Gokul Ramaswami; Jinny Conte; Irma Lopez; Joseph Washburn; James MacDonald; Jinghua Hu; Yukiko Yamashita; Eamonn R Maher; Lisa M Guay-Woodford; Hartmut P H Neumann; Nicholas Obermüller; Robert K Koenekoop; Carsten Bergmann; Xiaoshu Bei; Richard A Lewis; Nicholas Katsanis; Vanda Lopes; David S Williams; Robert H Lyons; Chi V. Dang; Daniela A Brito; M'nica Bettencourt Dias; Xinmin Zhang; James D Cavalcoli; Gudrun Nürnberg; Peter Nürnberg; Eric A. Pierce; Peter K Jackson; Corinne Antignac; Sophie Saunier; Ronald Roepman; Helene Dollfus; Hemant Khanna; Friedhelm Hildebrandt

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October 1, 2010

Discovery of pyrrolopyrimidine inhibitors of Akt

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

James F. Blake; Nicholas C. Kallan; Dengming Xiao; Rui Xu; Josef R. Bencsik; Nicholas J. Skelton; Keith L. Spencer; Ian S. Mitchell; Richard D. Woessner; Susan L. Gloor; Tyler Risom; Stefan Gross; Matthew Martinson; Tony Morales; Guy Vigers; Barbara J. Brandhuber

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October 1, 2010

Use and evaluation of a CD-ROM-based decision aid for prostate cancer treatment decisions

Behavioral Medicine, ISSN: 08964289 19404026

Kathryn L. Taylor; Kimberly M. Davis; Tara Lamond; Randi M. Williams; Marc D. Schwartz; William Lawrence; Shibao Feng; Susan Brink; Amy Birney; John Lynch; James Regan; Anatoly Dritschilo

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October 1, 2010

Pharmacokinetic, pharmacodynamic and immunogenicity comparability assessment strategies for monoclonal antibodies

Trends in Biotechnology, ISSN: 01677799

Wendy Putnam; Saileta Prabhu; Zheng; Subramanyam; Yow-Ming C. Wang

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October 1, 2010

Pediatric multiple sclerosis

CONTINUUM Lifelong Learning in Neurology, ISSN: 10802371

Ellen M. Mowry; Waubant

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October 1, 2010

Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Steven T. Staben; Timothy P. Heffron; Daniel P. Sutherlin; Seema R. Bhat; Georgette M. Castanedo; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Lori S. Friedman; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Alan G. Olivero; Emile G. Plise; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Weismann; Ping Wu; Bing-Yan Zhu

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October 1, 2010

Bioequivalence studies for three formulations of a recombinant human growth hormone: Challenges and lessons learned

Growth Hormone and IGF Research, ISSN: 10966374 15322238

Dao; Joan R. Jacobs; Peter Kuebler; Bert Bakker; Barbara M. Lippe

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October 1, 2010

Bioavailability and population pharmacokinetics of voriconazole in lung transplant recipients

Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596

Kelong Han; Blair Capitano; Robert Bies; Potoski; Husain; Gilbert; Paterson; McCurry; Raman Venkataramanan

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October 1, 2010

Histologic Outcomes in Hepatitis C–Infected Patients with Varying Degrees of Virologic Response to Interferon-Based Treatments

Hepatology, ISSN: 02709139

Pockros; Hamzeh; Martin; Lentz; Zhou; Sugantha Govindarajan; Anna S. Lok

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October 1, 2010

Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages

European Journal of Immunology, ISSN: 00142980 15214141

Andrea J. McCoy; Yukiko Koizumi; Claudia Toma; Naomi Higa; Vishva M. Dixit; Shun'ichiro Taniguchi; Jurg Tschopp; Toshihiko Suzuki

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October 1, 2010

Antibody purification: Drivers of change

Pharmaceutical Formulation and Quality, ISSN: 15312135 19363435

Narahari Pujar; Duncan Low; O'Leary

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October 1, 2010

Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing

Molecular BioSystems, ISSN: 1742206X 17422051

Andreas Ernst; David Gfeller; Zhengyan Kan; Somasekar Seshagiri; Philip M. Kim; Gary D. Bader; Sachdev S. Sidhu

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October 1, 2010

Peginterferon α-2a plus ribavirin in latino and non-latino whites with HCV genotype 1: Histologic outcomes and tolerability from the LATINO study

American Journal of Gastroenterology, ISSN: 00029270 15720241

Luis Balart; Mauricio Lisker-Melman; Hamzeh; Ambrose Kwok; Lentz; Maribel Rodriguez-Torres

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September 29, 2010

Connecting vascular and nervous system development: Angiogenesis and the blood-brain barrier

Annual Review of Neuroscience, ISSN: 0147006X 15454126

Stephen Tam; Ryan J. Watts

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September 28, 2010

Toxicogenomics and cancer risk assessment: A framework for key event analysis and dose-response assessment for nongenotoxic carcinogens

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Joel P. Bercu; Robert A. Jolly; Kelly Flagella; Thomas K. Baker; Pedro Romero; James L. Stevens

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September 24, 2010

Display of peptides on the surface of tobacco mosaic virus particles

Current Topics in Microbiology and Immunology, ISSN: 0070217X

Smith; Fitzmaurice; Turpen; Palmer

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September 23, 2010

Vegf regulates embryonic erythroid development through Gata1 modulation

Blood, ISSN: 15280020 00064971

Benjamin Drogat; Joanna Kalucka; Laura Gutiérrez; Hamida Hammad; Steven Goossens; Morvarid Farhang Ghahremani; Sonia Bartunkova; Katharina Haigh; Kim Deswarte; Omar Nyabi; Michael Naessens; Napoleone Ferrara; Ursula Klingmüller; Bart N. Lambrecht; Andras Nagy; Sjaak Philipsen; Jody Haigh

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September 23, 2010

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

Oncogene, ISSN: 09509232 14765594

Ye; Li; Scott Stawicki; Suzana Couto; Jeffrey Eastham-Anderson; Dara Y. Kallop; Robby M. Weimer; Yan Wu; Lin Pei

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September 17, 2010

Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: A case-control association study

Arthritis Research and Therapy, ISSN: 14786354 14786362

Aya Kawasaki; Satoshi Ito; Hiroshi Furukawa; Taichi Hayashi; Daisuke Goto; Isao Matsumoto; Makio Kusaoi; Jun Ohashi; Robert R. Graham; Kunio Matsuta; Timothy W. Behrens; Shigeto Tohma; Yoshinari Takasaki; Hiroshi Hashimoto; Takayuki Sumida; Naoyuki Tsuchiya

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September 16, 2010

Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments

Blood, ISSN: 15280020 00064971

Markus Moll; Sofia K. Andersson; Anna Smed-Sörensen; Johan K. Sandberg

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September 15, 2010

A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity

Journal of Immunology, ISSN: 00221767 15506606

Kate H. Gartlan; Gabrielle T Belz; Jacqueline M. Tarrant; Gabriela Minigo; Maria Katsara; Kuo-Ching Sheng; Mariam Sofi; Annemiek B. Van Spriel; Vasso Apostolopoulos; Magdalena Plebanski; Lorraine Robb; Mark D. Wright

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September 15, 2010

Physicochemical stability of the antibody - Drug conjugate trastuzumab-DM1: Changes due to modification and conjugation processes

Bioconjugate Chemistry, ISSN: 15204812 10431802

Aditya A. Wakankar; Maria B. Feeney; Javier Rivera; Yan Chen; Michael Kim; Vikas Sharma; Y. John Wang

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September 15, 2010

Interactions between Hedgehog proteins and their binding partners come into view

Genes and Development, ISSN: 15495477 08909369

Philip A. Beachy; Sarah G. Hymowitz; Lazarus; Daniel J. Leahy; Christian Siebold

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September 10, 2010

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II

PLoS ONE, ISSN: 19326203

Rachael E. Hawtin; David E. Stockett; Jo Ann W. Byl; Robert S. McDowell; Nguyen Tan; Michelle R. Arkin; Andrew Conroy; Wenjin Yang; Neil Osheroff; Judy Fox

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September 10, 2010

Simultaneous determination of positive and negative pharmaceutical counterions using mixed-mode chromatography coupled with charged aerosol detector

Journal of Chromatography A, ISSN: 00219673

Kelly Zhang; Lulu Dai; Nik P. Chetwyn

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September 8, 2010

Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer

Science Translational Medicine, ISSN: 19466234 19466242

Jeffery J. Wallin; Zhengyu Guan; Wei Wei Prior; Kyle A. Edgar; Robert Kassees; Deepak Sampath; Marcia Belvin; Lori S. Friedman

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September 1, 2010

Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs

American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN: 10400605 15221504

Silvia Cardenas; Mario Scuri; Lennie Samsell; Barbara Ducatman; Pablo Bejarano; Alexander Auais; Melissa Doud; Kalai Mathee; Giovanni Piedimonte

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September 1, 2010

Proteomic profiling of cancer-opportunities, challenges, and context

Journal of Pathology, ISSN: 00223417 10969896

David Arnott; Michael R. Emmert-Buck

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September 1, 2010

Design and powering of cystic fibrosis clinical trials using rate of FEV1 decline as an efficacy endpoint

Journal of Cystic Fibrosis, ISSN: 15691993

Michael W. Konstan; Wagener; Ashley Yegin; Stefanie J. Millar; David J. Pasta; Donald R. VanDevanter

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September 1, 2010

Clinical and biological data integration for biomarker discovery

Drug Discovery Today, ISSN: 13596446

Marco Sorani; Ward Ortmann; Erik P. Bierwagen; Timothy W. Behrens

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September 1, 2010

Comparative analysis of techniques to purify plasma membrane proteins

Journal of Biomolecular Techniques, ISSN: 15240215 19434731

Michael P. Weekes; Robin Antrobus; Jennie R. Lill; Lidia M. Duncan; Simon Hör; Paul J. Lehner

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September 1, 2010

X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Andreas Kuglstatter; Manjiri Ghate; Stan Tsing; Armando G. Villaseñor; David Shaw; Jim W. Barnett; Michelle F. Browner

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September 1, 2010

Parallel stacking of caffeine with riboflavin in aqueous solutions: The potential mechanism for hydrotropic solubilization of riboflavin

International Journal of Pharmaceutics, ISSN: 03785173

Yong Cui

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September 1, 2010

European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent

Genes and Immunity, ISSN: 14664879 14765470

Ilana B. Richman; Sharon A. Chung; Kimberly E. Taylor; Kosoy; Tian; Ward Ortmann; Joanne Nititham; Annette T. Lee; Rutman; Michelle Petri; Manzi; Timothy W. Behrens; Peter K. Gregersen; Michael F. Seldin; Lindsey A. Criswell

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September 1, 2010

Efficacy and safety of different doses and retreatment of rituximab: A randomised, placebo-controlled trial in patients who are biological naïve with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders (SERENE))

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Paul Emery; Deodhar; William F. Rigby; John D. Isaacs; Bernard Combe; Artur J. Racewicz; Latinis; Abud-Mendoza; Leszek Szczepanski; Roschmann; Annie Chen; Gillian Armstrong; Douglass; Helen Tyrrell

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September 1, 2010

B-cell targeted therapies in human autoimmune diseases: An updated perspective

Immunological Reviews, ISSN: 01052896 1600065X

Michael J. Townsend; John G. Monroe; Andrew A. Chan

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September 1, 2010

Assessing toxicities in a clinical trial: Bayesian inference for ordinal data nested within categories

Biometrics, ISSN: 0006341X 15410420

Leon-Novelo; Zhou; B. Nebiyou Bekele; Müller

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September 1, 2010