Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9001 - 9050 OF 15657 RESULTS

A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress
Cancer Research, ISSN: 00085472 15387445
David Peterson; James Lee; Xingye Lei; William F. Forrest; David P. Davis; Peter K Jackson; Lisa D. Belmont
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The Type 1 Diabetes PhysioLab® Platform: A validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse
Clinical and Experimental Immunology, ISSN: 00099104 13652249
Shoda; Kreuwel; Kapil Gadkar; Zheng; Whiting; Mark Atkinson; Jeffrey A. Bluestone; Mathis; Young; Ramanujan
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The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes
Journal of Virology, ISSN: 0022538X 10985514
Sanjay Chandriani; Yiyang Xu; Don Ganem
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Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression
Neuron, ISSN: 08966273
Ken-ichiro Kuwako; Kyoko Kakumoto; Takao Imai; Mana Igarashi; Takao Hamakubo; Shin-ichi Sakakibara; Marc Tessier-Lavigne; Hirotaka James Okano; Hideyuki Okano
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A plate-based assay to measure cellular ERK substrate phosphorylation: Utility for drug discovery of the MAPK-signaling cascade
Assay and Drug Development Technologies, ISSN: 1540658X
Sreemathy Ramaswamy; Ivana Yen; Steve Sideris; Shiva Malek; Christopher E. Heise
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Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Athena W. Wong; Tomasz K. Baginski; Dorothea Reilly
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Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy
Clinical Cancer Research, ISSN: 10780432 15573265
Anil Bagri; Berry; Bert Gunter; Mallika Singh; Ian Kasman; Lisa A. Damico; Hong Xiang; Maike Schmidt; Fuh; Beth A Hollister; Oliver Rosen; Greg D. Plowman
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Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia
Nature Immunology, ISSN: 15292908 15292916
Daniel J. Hodson; Michelle L. Janas; Alison Galloway; Sarah E. Bell; Simon Andrews; Cheuk M. Li; Richard Pannell; Christian W. Siebel; H. Robson MacDonald; Kim De Keersmaecker; Adolfo A. Ferrando; Gerald Grutz; Martin Turner
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Avoiding infusion therapy prime benefit of new MS drug: The search for an acceptable oral MS drug may be over if fingolimod (Gilenia) survives an FDA review this fall
Managed Care, ISSN: 10623388
Thomas Morrow
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Vive la science! Vive le hérisson!
EMBO Reports, ISSN: 1469221X 14693178
Jeremy Reiter; Frederic J. De Sauvage
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Vertebrate Hedgehog signaling: Cilia rule
BMC Biology, ISSN: 17417007
Christopher W. Wilson; Didier Y. R. Stainier
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Managing Successful Product Portfolio Creation and R&D Pipelines
Pharmaceutical and Biomedical Project Management in a Changing Global Environment,
Sue E. Steven
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Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin
Journal of Neuroscience, ISSN: 02706474 15292401
Ozlem Bozdagi; Xiaobin Wang; Jessica S. Nikitczuk; Tonya R. Anderson; Erik B. Bloss; Glenn L. Radice; Qiang Zhou; Deanna L. Benson; George W. Huntley
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Preparation and separation of antimicrobial agents derived from capreomycin
Tetrahedron Letters, ISSN: 00404039
D. David Hennings; Daniel J. Watson; Joseph P. Lyssikatos; Andrew Allen
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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Lee Honigberg; Ashley Smith; Mint Sirisawad; Erik Verner; David Loury; Betty Chang; Shyr Li; Zhengying Pan; Douglas H. Thamm; Richard A. Miller; Joseph J. Buggy
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Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Faye Martin; Padmamalini Baskaran; Xiaolei Ma; Pete W. Dunten; Martina Schaefer; Johannes-Peter Stasch; Annie Beuve; Focco Van Den Akker
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IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail
Journal of Immunology, ISSN: 00221767 15506606
Allen W. Ho; Fang Shen; Heather R. Conti; Nayan Patel; Erin E. Childs; Alanna C. Peterson; Nydiaris Herna´ndez-Santos; Jay K. Kolls; Lawrence P. Kane; Wenjun Ouyang; Sarah L. Gaffen
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Predictive biomarkers of sensitivity to the phosphatidylinositol 3′ kinase inhibitor GDC-0941 in breast cancer preclinical models
Clinical Cancer Research, ISSN: 10780432 15573265
Carol O'Brien; Jeffery J. Wallin; Deepak Sampath; Debraj GuhaThakurta; Heidi Savage; Elizabeth A. Punnoose; Zhengyu Guan; Berry; Wei Wei Prior; Lukas Amler; Marcia Belvin; Lori S. Friedman; Lackner
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Rituximab versus cyclophosphamide for ANCA-associated vasculitis
New England Journal of Medicine, ISSN: 15334406 00284793
John H. Stone; Merkel; Spiera; Seo; Langford; Hoffman; Cees Kallenberg; St.clair; Anthony Turkiewicz; Tchao; Lisa Webber; Linna Ding; Lourdes P. Sejismundo; Kathleen Mieras; David Weitzenkamp; Iklé; Vicki Seyfert-Margolis; Mark Mueller; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; Specks
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Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance
Journal of Neuroscience, ISSN: 02706474 15292401
Alexander Jaworski; Hua Long; Marc Tessier-Lavigne
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Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
Nature, ISSN: 00280836 14764687
Ira Surolia; Stephan P. Pirnie; Vasant Chellappa; Kendra N. Taylor; Annaiah Cariappa; Jesse Moya; Haoyuan Liu; Daphne W. Bell; David R. Driscoll; Sven Diederichs; Khaleda Haider; Ilka Netravali; Sheila Le; Roberto Elia; Ethan Dow; Annette T. Lee; Jan Freudenberg; Philip L. De Jager; Yves Chretien; Ajit Varki; Marcy E. MacDonald; Tammy Gillis; Timothy W. Behrens; Donald Bloch; Deborah Collier; Joshua Korzenik; Daniel K. Podolsky; David A. Hafler; Mandakolathur Murali; Bruce Sands; John H. Stone; Peter K. Gregersen; Shiv Pillai
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Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Janet Jackman; Yongmei Chen; Arthur Huang; Moffat; Justin M. Scheer; Leong; Wyne P. Lee; Juan Zhang; Navneet Sharma; Yanmei Lu; Suhasini Iyer; Robert L. Shields; Nancy Y. Chiang; Michele Bauer; Diana Jakubiak; Merone Roose-Girma; Richard L. Vandlen; Yansura; Yan Wu; Lawren C. Wu
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Response
Science, ISSN: 10959203 00368075
Levinson
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Prosthetic hand provides nearly normal function: It might seem to be straight out of science fiction, but there's solid science and engineering behind it
Managed Care, ISSN: 10623388
Thomas Morrow
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Unique challenges and opportunities for enabling and supporting preclinical and translational areas of biologic development in India - A perspective
American Pharmaceutical Outsourcing, ISSN: 15296318
Ashwin Datt; Sara Kenkare-Mitra
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US cost burden of ischemic stroke: A systematic literature review
American Journal of Managed Care, ISSN: 10880224
Bart M. Demaerschalk; Ha-Mill Hwang; Grace Leung
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Lymphotoxin-αβ heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis
Cytokine, ISSN: 10434666
Judy Young; Xin Yu; Kristen Wolslegel; Allen Nguyen; Catherine Kung; Eugene Y. Chiang; Ganesh Kolumam; Nathan Wei; Wai Lee T. Wong; Laura DeForge; Michael J. Townsend; Jane L. Grogan
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Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapy
Arthritis and Rheumatism, ISSN: 00043591 15290131
Jing Cui; Saedis Saevarsdottir; Brian Thomson; Leonid Padyukov; Annette H. M. Van Der Helm-van Mil; Joanne Nititham; Laura B. Hughes; Niek De Vries; Soumya Raychaudhuri; Lars Alfredsson; Johan Askling; Wedren; Bo Ding; Candace Guiducci; Gert Jan Wolbink; J. Bart A. Crusius; Irene E. Van Der Horst-Bruinsma; Marieke Herenius; Michael E. Weinblatt; Nancy A. Shadick; Jane Worthington; Franak Batliwalla; Marlena Kern; Ann W. Morgan; Anthony G. Wilson; John D. Isaacs; Kimme Hyrich; Michael F. Seldin; Larry W. Moreland; Timothy W. Behrens; Allaart; Lindsey A. Criswell; Tom W. J. Huizinga; Paul P. Tak; S. Louis Bridges Jr.; Toes; Anne Barton; Lars Klareskog; Peter K. Gregersen; Elizabeth W. Karlson; Robert M. Plenge
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Response
Chest, ISSN: 19313543 00123692
Sarika Ogale; Todd A. Lee; Sean D. Sullivan
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Zinc Finger Nucleases as tools to understand and treat human diseases
BMC Medicine, ISSN: 17417015
David P. Davis; David Stokoe
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Reply to S.N. Wolff
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Suman Bhattacharya; Gwendolyn Fyfe; Robert Gray; Daniel J. Sargent
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Year-to-year changes in lung function in individuals with cystic fibrosis
Journal of Cystic Fibrosis, ISSN: 15691993
Liou; Eric Elkin; David J. Pasta; Joan R. Jacobs; Michael W. Konstan; Morgan; Wagener
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Targeting the tumour vasculature: Insights from physiological angiogenesis
Nature Reviews Cancer, ISSN: 1474175X 14741768
Alicia S Chung; John Lee; Napoleone Ferrara
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Characterization of a monoclonal antibody cell culture production process using a quality by design approach
Molecular Biotechnology, ISSN: 10736085
Brian Horvath; Melissa Mun; Mike Laird
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The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment
Clinical Cancer Research, ISSN: 10780432 15573265
Ivor Caro; Low
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Cost analysis review of stroke centers, telestroke, and rt-PA
American Journal of Managed Care, ISSN: 10880224
Bart M. Demaerschalk; Ha-Mill Hwang; Grace Leung
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New neurons clear the path of astrocytic processes for their rapid migration in the adult brain
Neuron, ISSN: 08966273
Naoko Kaneko; Oscar Marín; Masato Koike; Yuki Hirota; Yasuo Uchiyama; Jane Y. Wu; Qiang Lu; Marc Tessier-Lavigne; Arturo Alvarez-Buylla; Hideyuki Okano; John L. R. Rubenstein; Kazunobu Sawamoto
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Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells
Journal of Clinical Investigation, ISSN: 00219738 15588238
Sheng Cao; Usman Yaqoob; Amitava Das; Uday Shergill; Kumaravelu Jagavelu; Robert C. Huebert; Chittaranjan Routray; Soha Abdelmoneim; Meher Vasdev; Edward Leof; Michael R. Charlton; Ryan J. Watts; Debabrata Mukhopadhyay; Vijay H. Shah
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Use of disposable reactors to generate inoculum cultures for E. coli production fermentations
Biotechnology Progress, ISSN: 87567938 15206033
Ekta Mahajan; Timothy Matthews; Ryan Hamilton; Mike Laird
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Inline ultrafiltration
Biotechnology Progress, ISSN: 87567938 15206033
Christopher A. Teske; Lebreton
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Modulation of inflammasome activity for the treatment of auto-inflammatory disorders
Journal of Clinical Immunology, ISSN: 02719142 15732592
Naik; Vishva M. Dixit
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PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
Journal of Clinical Investigation, ISSN: 00219738 15588238
Scott N. Mueller; Vijay K. Vanguri; Sang-Jun Ha; Erin E. West; Mary E. Keir; Jonathan N. Glickman; Arlene H. Sharpe; Rafi Ahmed
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Process transfer to contract manufacturing organizations: A case study on process development support past regulatory approval
Pharmaceutical Engineering, ISSN: 02738139
Amy Webb; David H. Reifsnyder; Bender
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Quantitative modeling of viable cell density, cell size, intracellular conductivity, and membrane capacitance in batch and fed-batch CHO processes using dielectric spectroscopy
Biotechnology Progress, ISSN: 87567938 15206033
Cary F. Opel; Jincai Li; Ashraf Amanullah
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Pre-sterilized, single use filling systems for liquid bio-pharmaceuticals
American Pharmaceutical Review, ISSN: 10998012
Lindsay Leveen
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Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II
Nature Immunology, ISSN: 15292908 15292916
Hyota Takamatsu; Noriko Takegahara; Yukinobu Nakagawa; Michio Tomura; Masahiko Taniguchi; Roland H. Friedel; Helen Rayburn; Marc Tessier-Lavigne; Yutaka Yoshida; Tatsusada Okuno; Masayuki Mizui; Sujin Kang; Satoshi Nojima; Tohru Tsujimura; Yuji Nakatsuji; Ichiro Katayama; Toshihiko Toyofuku; Hitoshi Kikutani; Atsushi Kumanogoh
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The adaptor protein Sh2d3c is critical for marginal zone B cell development and function
Journal of Immunology, ISSN: 00221767 15506606
Amin Al-Shami; Carrie Wilkins; Jeannette Crisostomo; Dhaya Seshasayee; Flavius Martin; Nianhua Xu; Adisak Suwanichkul; Stephen J. Anderson; Tamás Oravecz
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SEC assay for polyvinylsulfonic impurities in 2-(N-morpholino) ethanesulfonic acid using a charged aerosol detector
Chromatographia, ISSN: 00095893 16121112
Taylor Zhang; Daniel Hewitt; Kao
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Increased targeting of donor switch region and IgE in Sγ1-deficient B cells
Journal of Immunology, ISSN: 00221767 15506606
Shahram Misaghi; Christopher Garris; Yonglian Sun; Allen Nguyen; Juan Zhang; Andrew Sebrell; Kate Senger; Donghong Yan; Maria N. Lorenzo; Sherry Heldens; Wyne P. Lee; Min Xu; Jiansheng Wu; Laura DeForge; Tao Sai; Vishva M. Dixit; Ali A. Zarrin
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Increasing parvovirus filter throughput of monoclonal antibodies using ion exchange membrane adsorptive pre-filtration
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Arick Brown; Charity Bechtel; Jerome Bill; Hui F. Liu; Jun Liu; Daniel J. McDonald; Satyan Pai; Asha Radhamohan; Ryan Renslow; Brooke Thayer; Stefan T. Yohe; Chris Dowd
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