Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9001 - 9050 OF 15805 RESULTS

Selective activation of p53-mediated tumour suppression in high-grade tumours
Nature, ISSN: 00280836 14764687
Melissa Junttila; Anthony N. Karnezis; Daniel Garcia; Francesc Madriles; Roderik M. Kortlever; Fanya Rostker; Lamorna Brown Swigart; David M. Pham; Youngho Seo; Gerard I. Evan; Carla P. Martins
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Regulation of cytokine secretion in human CD127+ LTi-like innate lymphoid cells by toll-like receptor 2
Immunity, ISSN: 10747613
Natasha K Crellin; Sara Trifari; Charles D. Kaplan; Naoko Satoh-Takayama; James P. Di Santo; Hergen Spits
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Electrostatic docking of a supramolecular host-guest assembly to cytochrome c probed by bidirectional photoinduced electron transfer
Journal of the American Chemical Society, ISSN: 00027863 15205126
Katarzyna I. Jankowska; Cynthia Pagba; Eugene L. Piatnitski Chekler; Deshayes; Piotrowiak
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Rational design of inhibitors and activity-based probes targeting clostridium difficile virulence factor TcdB
Chemistry and Biology, ISSN: 10745521
Aaron W. Puri; Patrick J. Lupardus; Edgar Deu; Victoria E. Albrow; Garcia; Matthew Bogyo; Aimee Shen
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Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling
Molecular Cell, ISSN: 10972765
Ivan Bosanac; Ingrid E. Wertz; Borlan Pan; Christine Yu; Saritha Kusam; Cynthia Lam; Lilian Phu; Qui Phung; Brigitte Maurer; David Arnott; Donald S. Kirkpatrick; Vishva M. Dixit; Sarah G. Hymowitz
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Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia
Journal of Experimental Medicine, ISSN: 00221007 15409538
Letetia Jones; Guangwei Wei; Sabina Sevcikova; Vernon T. Phan; Sachi Jain; Angell Shieh; Jasmine C. Y. Wong; Min Li; Joshua Dubansky; Mei Lin Maunakea; Rachel Ochoa; George Zhu; Thelma R. Tennant; Kevin Shannon; Scott W. Lowe; Michelle M. Le Beau; Scott C. Kogan
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Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia
Journal of Experimental Medicine, ISSN: 00221007 15409538
Letetia Jones; Guangwei Wei; Sabina Sevcikova; Vernon T. Phan; Sachi Jain; Angell Shieh; Jasmine C. Y. Wong; Min Li; Joshua Dubansky; Mei Lin Maunakea; Rachel Ochoa; George Zhu; Thelma R. Tennant; Kevin Shannon; Scott W. Lowe; Michelle M. Le Beau; Scott Kogan
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Effect of FCGR2A and FCGR3A variants on CLL outcome
Blood, ISSN: 15280020 00064971
David Dornan; Olivia Spleiss; Ru-Fang Yeh; Guillemette Duchateau-Nguyen; Annika Dufour; Jianguo Zhi; Tadeusz Robak; Sergey I. Moiseev; Anna Dmoszynska; Philippe Solal-Celigny; Krzysztof Warzocha; Javier Loscertales; John Catalano; Boris V. Afanasiev; Loree Larratt; Viktor A. Rossiev; Isabelle Bence-Bruckler; Christian H. Geisler; Marco Montillo; Michael Wenger; Martin Weisser
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Reply to Talloen et al.: Independent filtering is a generic approach that needs domain specif c adaptation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Richard Bourgon; Robert Gentleman; Wolfgang Huber
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Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Feng Su; Kathy R. Kozak; Satoshi Imaizumi; Feng Gao; Malaika W. Amneus; Victor Grijalva; Carey Ng; Alan Wagner; Greg Hough; Gina Farias-Eisner; Anantharamaiah; Brian J. Van Lenten; Mohamad Navab; Alan M. Fogelman; Srinivasa T. Reddy; Robin Farias-Eisner
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Metabolism and toxicity of menthofuran in rat liver slices and in rats
Chemical Research in Toxicology, ISSN: 0893228X 15205010
S. Cyrus Khojasteh; Shimako Oishi; Sidney D. Nelson
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Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette M. Castanedo; Shumei Wang; Kirk D. Robarge; Elizabeth M. Blackwood; Burdick; Christine Chang; Gerrit J. P. Dijkgraaf; Stephen Gould; Janet Gunzner; Oivin Guichert; Jason S Halladay; S. Cyrus Khojasteh; Leslie Lee; James C. Marsters Jr.; Lesley J. Murray; David Peterson; Emile G. Plise; Laurent Salphati; Frederic J. De Sauvage; Susan C. Wong; Daniel P. Sutherlin
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Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor
Development (Cambridge), ISSN: 09501991 14779129
Kerstin Seidel; Christina Ahn; David Lyons; Alexander Nee; Kevin Ting; Isaac Brownell; Tim C. Cao; Richard A. D. Carano; Tom Curran; Markus Schober; Elaine Fuchs; Alexandra Joyner; Gail R. Martin; Frederic J. De Sauvage; Ophir D. Klein
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Identification and functional analysis of endothelial tip cell-enriched genes
Blood, ISSN: 15280020 00064971
Raquel del Toro; Claudia Prahst; Thomas Mathivet; Geraldine Siegfried; Joshua S. Kaminker; Bruno Larrivee; Christiane Bréant; Antonio Duarte; Nobuyuki Takakura; Akiyoshi Fukamizu; Josef Penninger; Anne Eichmann
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Dendritic sodium channels regulate network integration in globus pallidus neurons: A modeling study
Journal of Neuroscience, ISSN: 02706474 15292401
Jeremy R. Edgerton; Jesse E. Hanson; Cengiz Günay; Dieter Jaeger
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Mild and general one-pot reduction and cyclization of aromatic and heteroaromatic 2-nitroamines to bicyclic 2 H -imidazoles
Synlett, ISSN: 09365214 14372096
Emily J. Hanan; Bryan K. Chan; Anthony A. Estrada; Daniel G. Shore; Joseph P. Lyssikatos
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MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function
Journal of Neuroscience, ISSN: 02706474 15292401
Natasha K. Hussain; Honor Hsin; Richard Huganir; Morgan Sheng
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Foreword
Separation Science and Technology, ISSN: 01496395 15205754
James M. Van Alstine; Philip M. Lester
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New bone kit uses platelet growth factor
Managed Care, ISSN: 10623388
Thomas Morrow
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Mechanism of antibody reduction in cell culture production processes
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Kao; Daniel Hewitt; Melody Trexler-Schmidt; Mike Laird
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MR angiogenesis imaging with Robo4- vs. αVβ 3-targeted nanoparticles in a B16/F10 mouse melanoma model
FASEB Journal, ISSN: 08926638 15306860
Kent S. Boles; Anne H. Schmieder; Alexander W. Koch; Richard A. D. Carano; Yan Wu; Shelton D. Caruthers; Raymond K. Tong; Scott Stawicki; Grace Hu; Michael J. Scott; Huiying Zhang; Benton A. Reynolds; Samuel A. Wickline; Gregory M. Lanza
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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats
mAbs, ISSN: 19420862
Leslie A. Khawli; Sirj Goswami; Ryan Hutchinson; Zephania Kwong Glover; Yang; Xiangdan Wang; Zhenling Yao; Alavattam Sreedhara; Tony Cano; Devin B. Tesar; Ihsan Nijem; David E. Allison; Wong; Kao; Quan; Amita Joshi; Reed J. Harris; Paul Motchnik
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Care of asthma patients in relation to guidelines
Allergy and Asthma Proceedings, ISSN: 10885412 15396304
Michael S. Broder; Eunice Chang; Sandhya Sapra
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Crystallization of trehalose in frozen solutions and its phase behavior during drying
Pharmaceutical Research, ISSN: 07248741 1573904X
Prakash Sundaramurthi; Thomas W. Patapoff; Raj Suryanarayanan
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Practical approaches to dose selection for first-in-human clinical trials with novel biopharmaceuticals
Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295
Jay Tibbitts; Joy A. Cavagnaro; Christine A. Haller; Marafino Jr.; Paul A. Andrews; John T. Sullivan
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Assessing the success probability of a Phase III clinical trial based on Phase II data
Contemporary Clinical Trials, ISSN: 15517144
Zheng Su
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A model for harmonizing flow cytometry in clinical trials
Nature Immunology, ISSN: 15292908 15292916
Holden T. Maecker; J Philip McCoy; Michael Amos; John Elliott; Adolfas Gaigalas; Lili Wang; Richard Aranda; Jacques Banchereau; Chris Boshoff; Jonathan Braun; Yael Korin; Elaine Reed; Judy H. Cho; David A. Hafler; Mark M. Davis; C Garrison Fathman; William Robinson; Thomas Denny; Kent Weinhold; Bela Desai; Betty Diamond; Peter K. Gregersen; Paola Dimeglio; Frank Nestle; Mark Peakman; Federica Villnova; John Ferbas; Elizabeth Field; Aaron Kantor; Thomas Kawabata; Wendy Komocsar; Michael Lotze; Gerald Nepom; Hans D. Ochs; Raegan O'Lone; Deborah J. Phippard; Scott E. Plevy; Stephen S. Rich; Mario Roederer; Dan Rotrosen; Jung-Hua Yeh
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High-throughput multi-product liquid chromatography for the characterization of monoclonal antibodies
BioPharm International, ISSN: 1542166X
Jennifer C. Rea; G. Tony Moreno; Yun Lou; Rahul Parikh; Dell Farnan
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Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans
Experimental and Toxicologic Pathology, ISSN: 09402993
Mark Fielden; Mary Hassani; Hirdesh Uppal; Patricia Day-Lollini; Donald Button; Renee S. Martin; Rosario Garrido; Xingrong Liu; Kolaja
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Unleashing cell death: The Fas-FADD complex
Nature Structural and Molecular Biology, ISSN: 15459993 15459985
Sarah G. Hymowitz; Vishva M. Dixit
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Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies
PLoS ONE, ISSN: 19326203
Yan Gong; Eric Bourhis; Cecilia Chiu; Scott Stawicki; Venita I. DeAlmeida; Bob Y. Liu; Khanhky Phamluong; Tim C. Cao; Richard A. D. Carano; James A. Ernst; Mark J. Solloway; Bonnee Rubinfeld; Rami N. Hannoush; Yan Wu; Paul G. Polakis; Michael Costa
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Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor
Xenobiotica, ISSN: 00498254 13665928
Edna F. Choo; Marcia Belvin; Jocelyn Chan; Klaus P. Hoeflich; Christine Orr; Kirk D. Robarge; Xiaoye Yang; Mark Zak; Jason Boggs
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Leachables from saline-containing IV bags can alter therapeutic protein properties
Pharmaceutical Research, ISSN: 07248741 1573904X
Judy H. Chang; Nina Xiao; Min Zhu; Jennifer Zhang; Ed Hoff; Russell; Viswanatham Katta; Steven J. Shire
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Systematic approaches to develop chemically defined cell culture feed media
BioPharm International, ISSN: 1542166X
Efren Pacis; Natarajan Vijayasankaran; Jincai Li; Martin Gawlitzek; Ashraf Amanullah; Feng Li
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A novel homogeneous Biotin-digoxigenin based assay for the detection of human anti-therapeutic antibodies in autoimmune serum
Journal of Immunological Methods, ISSN: 00221759
Zhihua Julia Qiu; Yong Ying; Michael Fox; Kun Peng; Sock-Cheng Lewin-Koh; Daniel A. Coleman; Jeremy Good; John Lowe; Amena Rahman; Yang; Jenny Jiang; Quarmby; An Song
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Evaluation of heterophilic antibody blocking agents in reducing false positive interference in immunoassays for IL-17AA, IL-17FF, and IL-17AF
Journal of Immunological Methods, ISSN: 00221759
Laura DeForge; Kelly M. Loyet; Donnie Delarosa; Jason Chinn; Fojan Zamanian; Anan Chuntharapai; James Lee; Hass; Nathan Wei; Michael J. Townsend; Jianyong Wang; Wai Lee T. Wong
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Designing vaccines based on biology of human dendritic cell subsets
Immunity, ISSN: 10747613
A. Karolina Palucka; Jacques Banchereau; Ira Mellman
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Diffusion and sedimentation interaction parameters for measuring the second virial coefficient and their utility as predictors of protein aggregation
Biophysical Journal, ISSN: 15420086 00063495
Atul Saluja; R. Matthew Fesinmeyer; Sabine Hogan; David N. Brems; Yatin Gokarn
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Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes
Developmental Cell, ISSN: 15345807
Diego Correa; Eric Hesse; Dutmanee Seriwatanachai; Riku Kiviranta; Hiroaki Saito; Kei Yamana; Lynn Neff; Azeddine Atfi; Lucie Coillard; Despina Sitara; Yukiko Maeda; Søren Warming; Nancy A. Jenkins; Neal G. Copeland; William C. Horne; Beate Lanske; Roland Baron
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Genome-wide inference of regulatory networks in Streptomyces coelicolor
BMC Genomics, ISSN: 14712164
Marlene Castro-Melchor; Salim Charaniya; George Karypis; Eriko Takano; Hu
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Analysis of multi-arm tumor growth trials in xenograft animals using phase change adaptive piecewise quadratic models
Statistics in Medicine, ISSN: 02776715 10970258
Kingshuk Roy Choudhury; Ian Kasman; Greg D. Plowman
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Monocyte-derived dendritic cells exhibit increased levels of lysosomal proteolysis as compared to other human dendritic cell populations
PLoS ONE, ISSN: 19326203
Nathanael Mccurley; Ira Mellman
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Intermolecular interactions of IgG1 monoclonal antibodies at high concentrations characterized by light scattering
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Thomas M. Scherer; Jun Liu; Steven J. Shire; Allen P. Minton
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Incidence of progressive multifocal leukoencephalopathy in patients without HIV
Neurology, ISSN: 1526632X 00283878
Amend; Turnbull; Foskett; Pavel Napalkov; Kurth; Seeger
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Chromatography-Advances and Applications in Pharmaceutical Analysis in the Corporate Sector
Chromatography: A Science of Discovery,
Pat Noland; Terry N. Hopper; Michael W. Dong; Yong Guo; Todd D. Maloney; Raymond N. Xu
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ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
Oncogene, ISSN: 09509232 14765594
Sheryl R. Krig; Miller; Frietze; Beckett; Richard M. Neve; Farnham; Paul Yaswen; Colleen A. Sweeney
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Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon
Journal of Neuroscience, ISSN: 02706474 15292401
Abraham J. Langseth; Roeben N. Munji; Youngshik Choe; Trung Huynh; Christine D. Pozniak; Samuel J. Pleasure
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Development and evaluation of a novel method for preclinical measurement of tissue vascular volume
Molecular Pharmaceutics, ISSN: 15438384 15438392
C. Andrew Boswell; Gregory Z. Ferl; Eduardo E. Mundo; Michelle G. Schweiger; Jan Marik; Mike Reich; Frank-Peter Theil; Fielder; Leslie A. Khawli
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Histologic Outcomes in Hepatitis C–Infected Patients with Varying Degrees of Virologic Response to Interferon-Based Treatments
Hepatology, ISSN: 02709139
Pockros; Hamzeh; Martin; Lentz; Zhou; Sugantha Govindarajan; Anna S. Lok
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Peginterferon α-2a plus ribavirin in latino and non-latino whites with HCV genotype 1: Histologic outcomes and tolerability from the LATINO study
American Journal of Gastroenterology, ISSN: 00029270 15720241
Luis Balart; Mauricio Lisker-Melman; Hamzeh; Ambrose Kwok; Lentz; Maribel Rodriguez-Torres
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