Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9101 - 9150 OF 15805 RESULTS

Meeting report on protein particles and immunogenicity of therapeutic proteins: Filling in the gaps in risk evaluation and mitigation
Biologicals, ISSN: 10451056 10958320
John F. Carpenter; Barry Cherney; Anthony Lubinecki; Stacey Ma; Ewa Marszal; Mire-Sluis; Thomas Nikolai; Jeanne Novak; Jack Ragheb; Jan Simak
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Development of a novel homogenous electrochemiluminescence assay for quantitation of ranibizumab in human serum
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
John Lowe; Mauricio Maia; Eric Wakshull; Patricia Siguenza; Patrick Liu; Saleem Lakhani; Jeriza Rusit; Rebecca Elliott; Quarmby
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Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Laurent Salphati; Leslie Lee; Jodie Pang; Emile G. Plise; Xiaolin Zhang
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Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Laurent Salphati; Harvey Wong; Marcia Belvin; Delia Bradford; Kyle A. Edgar; Wei Wei Prior; Deepak Sampath; Jeffery J. Wallin
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An improved manufacturing process for Xyntha/ReFacto AF
Haemophilia, ISSN: 13518216 13652516
Kelley; Jankowski; Booth
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Design space development for lyophilization using Doe and process modeling
BioPharm International, ISSN: 1542166X
Jagannathan Sundaram; Yun-Hua Max Shay; Chung C. Hsu; Samir Sane
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Assessing toxicities in a clinical trial: Bayesian inference for ordinal data nested within categories
Biometrics, ISSN: 0006341X 15410420
Leon-Novelo; Zhou; B. Nebiyou Bekele; Müller
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B-cell targeted therapies in human autoimmune diseases: An updated perspective
Immunological Reviews, ISSN: 01052896 1600065X
Michael J. Townsend; John G. Monroe; Andrew A. Chan
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Efficacy and safety of different doses and retreatment of rituximab: A randomised, placebo-controlled trial in patients who are biological naïve with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders (SERENE))
Annals of the Rheumatic Diseases, ISSN: 00034967 14682060
Paul Emery; Deodhar; William F. Rigby; John D. Isaacs; Bernard Combe; Artur J. Racewicz; Latinis; Abud-Mendoza; Leszek Szczepanski; Roschmann; Annie Chen; Gillian Armstrong; Douglass; Helen Tyrrell
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European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent
Genes and Immunity, ISSN: 14664879 14765470
Ilana B. Richman; Sharon A. Chung; Kimberly E. Taylor; Kosoy; Tian; Ward Ortmann; Joanne Nititham; Annette T. Lee; Rutman; Michelle Petri; Manzi; Timothy W. Behrens; Peter K. Gregersen; Michael F. Seldin; Lindsey A. Criswell
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Parallel stacking of caffeine with riboflavin in aqueous solutions: The potential mechanism for hydrotropic solubilization of riboflavin
International Journal of Pharmaceutics, ISSN: 03785173
Yong Cui
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X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Andreas Kuglstatter; Manjiri Ghate; Stan Tsing; Armando G. Villaseñor; David Shaw; Jim W. Barnett; Michelle F. Browner
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Comparative analysis of techniques to purify plasma membrane proteins
Journal of Biomolecular Techniques, ISSN: 15240215 19434731
Michael P. Weekes; Robin Antrobus; Jennie R. Lill; Lidia M. Duncan; Simon Hör; Paul J. Lehner
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Clinical and biological data integration for biomarker discovery
Drug Discovery Today, ISSN: 13596446
Marco Sorani; Ward Ortmann; Erik P. Bierwagen; Timothy W. Behrens
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Design and powering of cystic fibrosis clinical trials using rate of FEV1 decline as an efficacy endpoint
Journal of Cystic Fibrosis, ISSN: 15691993
Michael W. Konstan; Wagener; Ashley Yegin; Stefanie J. Millar; David J. Pasta; Donald R. VanDevanter
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Proteomic profiling of cancer-opportunities, challenges, and context
Journal of Pathology, ISSN: 00223417 10969896
David Arnott; Michael R. Emmert-Buck
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Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN: 10400605 15221504
Silvia Cardenas; Mario Scuri; Lennie Samsell; Barbara Ducatman; Pablo Bejarano; Alexander Auais; Melissa Doud; Kalai Mathee; Giovanni Piedimonte
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New insights into apoptosis signaling by Apo2L/TRAIL
Oncogene, ISSN: 09509232 14765594
François Gonzalvez; Avi Ashkenazi
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Structural basis for high-affinity HER2 receptor binding by an engineered protein
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Eigenbrot; Ultsch; Anatoly Dubnovitsky; Lars Abrahmsén; Torleif Härd
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Double TIP-ping
Science, ISSN: 00368075 10959203
Harinder Singh; Ignacio A. Demarco
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Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature
PLoS ONE, ISSN: 19326203
Andrew Scott; Michael B. Powner; Pranita Gandhi; Claire Clarkin; David H. Gutmann; Randall S. Johnson; Napoleone Ferrara; Marcus Fruttiger
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Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Henry R. Maun; Xiaohui Wen; Andreas Lingel; Frederic J. De Sauvage; Lazarus; Suzie J. Scales; Sarah G. Hymowitz
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Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCδ
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Yaowu He; Andreas Wortmann; Les J. Burke; Janet C. Reid; Mark N. Adams; Ibtissam Abdul-Jabbar; James P. Quigley; Richard Leduc; Daniel Kirchhofer; John D. Hooper
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Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Edoardo Fiorillo; Valeria Orrú; Stephanie M. Stanford; Yingge Liu; Mogjiborahman Salek; Novella Rapini; Aaron D. Schenone; Patrizia Saccucci; Lucia G. Delogu; Federica Angelini; Maria Luisa Manca Bitti; Christian Schmedt; Andrew A. Chan; Oreste Acuto; Nunzio Bottini
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Cloning, expression and functional characterization of cytochrome P450 3A37 from Turkey liver with high aflatoxin B1 epoxidation activity
Chemical Research in Toxicology, ISSN: 0893228X 15205010
Sumit Rawal; Shirley S. M. Yip; Roger A. Coulombe Jr.
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Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer
Cancer Research, ISSN: 15387445 00085472
Ciara Metcalfe; Ashraf E. K. Ibrahim; Michael Graeb; Marc De La Roche; Thomas Schwarz-Romond; Marc Fiedler; Douglas J. Winton; Anthony Corfield; Mariann Bienz
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β-catenin balances immunity
Science, ISSN: 00368075 10959203
Ira Mellman; Björn E. Clausen
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Imbalanced pattern completion vs. separation in cognitive disease: Network simulations of synaptic pathologies predict a personalized therapeutics strategy
BMC Neuroscience, ISSN: 14712202
Jesse E. Hanson; Daniel V. Madison
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Diverse somatic mutation patterns and pathway alterations in human cancers
Nature, ISSN: 00280836 14764687
Zhengyan Kan; Bijay S. Jaiswal; Stinson; Vasantharajan Janakiraman; Deepali Bhatt; Howard M. Stern; Peng Yue; Matthias Peter; Richard Bourgon; Jianbiao Zheng; Martin Moorhead; Subhra Chaudhuri; Lynn P. Tomsho; Brock A. Peters; Kanan Pujara; Shaun Cordes; David P. Davis; Victoria E. H. Carlton; Yuan; Li Li; Weiru Wang; Eigenbrot; Joshua S. Kaminker; Eberhard; Waring; Stephan C. Schuster; Zora Modrusan; Zemin Zhang; David Stokoe; Frederic J. De Sauvage; Malek Faham; Somasekar Seshagiri
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Preface
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Feroz Jameel; Susan Hershenson
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Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Feroz Jameel; Susan Hershenson
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High-Concentration Antibody Formulations
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Steven J. Shire; Jun Liu; Wolfgang Friess; Susanne Jörg; Hanns-Christian Mahler
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Experimental Detection and Characterization of Protein Aggregates
Aggregation of Therapeutic Proteins,
Vikas Sharma; Devendra S. Kalonia
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Reversible Self-Association of Pharmaceutical Proteins: Characterization and Case Studies
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Vikas Sharma; Harminder Bajaj; Devendra S. Kalonia
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The Structure of Biological Therapeutics
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Sheryl Martin-Moe; Tim Osslund; Y. John Wang; Tahir Mahmood; Rohini Deshpande; Susan Hershenson
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Considerations for Successful Lyophilization Process Scale-Up, Technology Transfer, and Routine Production
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Samir Sane; Chung C. Hsu
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Construction, MD simulation, and hydrodynamic validation of an all-atom model of a monoclonal IgG antibody
Biophysical Journal, ISSN: 15420086 00063495
J. Paul Brandt; Thomas W. Patapoff; Sergio R. Aragon
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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
Journal of Experimental Medicine, ISSN: 15409538 00221007
Petr Broz; Kim Newton; Lamkanfi; Sanjeev Mariathasan; Vishva M. Dixit; Denise M. Monack
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Vive la science! Vive le hérisson!
EMBO Reports, ISSN: 1469221X 14693178
Jeremy Reiter; Frederic J. De Sauvage
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Avoiding infusion therapy prime benefit of new MS drug: The search for an acceptable oral MS drug may be over if fingolimod (Gilenia) survives an FDA review this fall
Managed Care, ISSN: 10623388
Thomas Morrow
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Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia
Nature Immunology, ISSN: 15292908 15292916
Daniel J. Hodson; Michelle L. Janas; Alison Galloway; Sarah E. Bell; Simon Andrews; Cheuk M. Li; Richard Pannell; Christian W. Siebel; H. Robson MacDonald; Kim De Keersmaecker; Adolfo A. Ferrando; Gerald Grutz; Martin Turner
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Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy
Clinical Cancer Research, ISSN: 10780432 15573265
Anil Bagri; Berry; Bert Gunter; Mallika Singh; Ian Kasman; Lisa A. Damico; Hong Xiang; Maike Schmidt; Fuh; Beth A Hollister; Oliver Rosen; Greg D. Plowman
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Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Athena W. Wong; Tomasz K. Baginski; Dorothea Reilly
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A plate-based assay to measure cellular ERK substrate phosphorylation: Utility for drug discovery of the MAPK-signaling cascade
Assay and Drug Development Technologies, ISSN: 1540658X
Sreemathy Ramaswamy; Ivana Yen; Steve Sideris; Shiva Malek; Christopher E. Heise
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Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression
Neuron, ISSN: 08966273
Ken-ichiro Kuwako; Kyoko Kakumoto; Takao Imai; Mana Igarashi; Takao Hamakubo; Shin-ichi Sakakibara; Marc Tessier-Lavigne; Hirotaka James Okano; Hideyuki Okano
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The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes
Journal of Virology, ISSN: 0022538X 10985514
Sanjay Chandriani; Yiyang Xu; Don Ganem
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The Type 1 Diabetes PhysioLab® Platform: A validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse
Clinical and Experimental Immunology, ISSN: 00099104 13652249
Shoda; Kreuwel; Kapil Gadkar; Zheng; Whiting; Mark Atkinson; Jeffrey A. Bluestone; Mathis; Young; Ramanujan
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A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress
Cancer Research, ISSN: 00085472 15387445
David Peterson; James Lee; Xingye Lei; William F. Forrest; David P. Davis; Peter K Jackson; Lisa D. Belmont
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K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody
Molecular Cell, ISSN: 10972765
Marissa L. Matsumoto; Katherine E. Wickliffe; Ken Dong; Christine Yu; Ivan Bosanac; Daisy J. Bustos; Lilian Phu; Donald S. Kirkpatrick; Sarah G. Hymowitz; Michael Rape; Robert F. Kelley; Vishva M. Dixit
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Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas
Modern Pathology, ISSN: 08933952 15300285
Xingxing Zang; Peggy S. Sullivan; Robert A. Soslow; Rebecca Waitz; Victor E. Reuter; Andrew Wilton; Howard T. Thaler; Manonmani Arul; Susan F. Slovin; Joyce Wei; David R. Spriggs; Jakob Dupont; James P. Allison
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