Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9151 - 9200 OF 15805 RESULTS

Distal regions of the human IFNG locus direct cell type-specific expression
Journal of Immunology, ISSN: 00221767 15506606
Patrick L. Collins; Shaojing Chang; Melodie Henderson; Mohammed Soutto; Georgia M. Davis; Allyson G. McLoed; Michael J. Townsend; Laurie H. Glimcher; Douglas P. Mortlock; Aune
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High-yield expression of human vascular endothelial growth factor VEGF 165 in Escherichia coli and purification for therapeutic applications
Protein Expression and Purification, ISSN: 10465928
Shelly A. Pizarro; Jane Gunson; Field; Rachel Dinges; Stefanie Khoo; Milind Dalal; Michael Lee; Kimberly A. Kaleas; Kathryn Moiseff; Susan Garnick; Dorothea Reilly; Mike Laird; Charles H. Schmelzer
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Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Hanbiao Yang; Robert T. Hendricks; Nidhi Arora; Dov Nitzan; Calvin Yee; Matthew C. Lucas; Yanli Yang; Amy Fung; Sonal Rajyaguru; Seth F. Harris; Vincent J.P. Leveque; Julie Qi Hang; Sophie Le Pogam; Deborah Reuter; Gisele A. Tavares
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Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing
Clinical Therapeutics, ISSN: 01492918 1879114X
Kay Stubenrauch; Uwe Wessels; Herbert Birnboeck; Francisco Ramirez; Angelika Jahreis; Julia Schleypen
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Effect of trastuzumab on health-related quality of life in patients with HER2-positive metastatic breast cancer: Data from three clinical trials
Clinical Breast Cancer, ISSN: 15268209
Hope S. Rugo; Melissa Brammer; Fan Zhang; Deepa Lalla
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Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer
Biological Chemistry, ISSN: 14316730 14374315
Henry R. Maun; Daniel Kirchhofer; Lazarus
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Managing Successful Product Portfolio Creation and R&D Pipelines
Pharmaceutical and Biomedical Project Management in a Changing Global Environment,
Sue E. Steven
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Vertebrate Hedgehog signaling: Cilia rule
BMC Biology, ISSN: 17417007
Christopher W. Wilson; Didier Y. R. Stainier
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Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin
Journal of Neuroscience, ISSN: 02706474 15292401
Ozlem Bozdagi; Xiaobin Wang; Jessica S. Nikitczuk; Tonya R. Anderson; Erik B. Bloss; Glenn L. Radice; Qiang Zhou; Deanna L. Benson; George W. Huntley
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Preparation and separation of antimicrobial agents derived from capreomycin
Tetrahedron Letters, ISSN: 00404039
D. David Hennings; Daniel J. Watson; Joseph P. Lyssikatos; Andrew Allen
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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Lee Honigberg; Ashley Smith; Mint Sirisawad; Erik Verner; David Loury; Betty Chang; Shyr Li; Zhengying Pan; Douglas H. Thamm; Richard A. Miller; Joseph J. Buggy
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Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Faye Martin; Padmamalini Baskaran; Xiaolei Ma; Pete W. Dunten; Martina Schaefer; Johannes-Peter Stasch; Annie Beuve; Focco Van Den Akker
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Rituximab versus cyclophosphamide for ANCA-associated vasculitis
New England Journal of Medicine, ISSN: 15334406 00284793
John H. Stone; Merkel; Spiera; Seo; Langford; Hoffman; Cees Kallenberg; St.clair; Anthony Turkiewicz; Tchao; Lisa Webber; Linna Ding; Lourdes P. Sejismundo; Kathleen Mieras; David Weitzenkamp; Iklé; Vicki Seyfert-Margolis; Mark Mueller; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; Specks
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Predictive biomarkers of sensitivity to the phosphatidylinositol 3′ kinase inhibitor GDC-0941 in breast cancer preclinical models
Clinical Cancer Research, ISSN: 10780432 15573265
Carol O'Brien; Jeffery J. Wallin; Deepak Sampath; Debraj GuhaThakurta; Heidi Savage; Elizabeth A. Punnoose; Zhengyu Guan; Berry; Wei Wei Prior; Lukas Amler; Marcia Belvin; Lori S. Friedman; Lackner
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IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail
Journal of Immunology, ISSN: 00221767 15506606
Allen W. Ho; Fang Shen; Heather R. Conti; Nayan Patel; Erin E. Childs; Alanna C. Peterson; Nydiaris Herna´ndez-Santos; Jay K. Kolls; Lawrence P. Kane; Wenjun Ouyang; Sarah L. Gaffen
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Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance
Journal of Neuroscience, ISSN: 02706474 15292401
Alexander Jaworski; Hua Long; Marc Tessier-Lavigne
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Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
Nature, ISSN: 00280836 14764687
Ira Surolia; Stephan P. Pirnie; Vasant Chellappa; Kendra N. Taylor; Annaiah Cariappa; Jesse Moya; Haoyuan Liu; Daphne W. Bell; David R. Driscoll; Sven Diederichs; Khaleda Haider; Ilka Netravali; Sheila Le; Roberto Elia; Ethan Dow; Annette T. Lee; Jan Freudenberg; Philip L. De Jager; Yves Chretien; Ajit Varki; Marcy E. MacDonald; Tammy Gillis; Timothy W. Behrens; Donald Bloch; Deborah Collier; Joshua Korzenik; Daniel K. Podolsky; David A. Hafler; Mandakolathur Murali; Bruce Sands; John H. Stone; Peter K. Gregersen; Shiv Pillai
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Response
Science, ISSN: 10959203 00368075
Levinson
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Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Janet Jackman; Yongmei Chen; Arthur Huang; Moffat; Justin M. Scheer; Leong; Wyne P. Lee; Juan Zhang; Navneet Sharma; Yanmei Lu; Suhasini Iyer; Robert L. Shields; Nancy Y. Chiang; Michele Bauer; Diana Jakubiak; Merone Roose-Girma; Richard L. Vandlen; Yansura; Yan Wu; Lawren C. Wu
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Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II
Nature Immunology, ISSN: 15292908 15292916
Hyota Takamatsu; Noriko Takegahara; Yukinobu Nakagawa; Michio Tomura; Masahiko Taniguchi; Roland H. Friedel; Helen Rayburn; Marc Tessier-Lavigne; Yutaka Yoshida; Tatsusada Okuno; Masayuki Mizui; Sujin Kang; Satoshi Nojima; Tohru Tsujimura; Yuji Nakatsuji; Ichiro Katayama; Toshihiko Toyofuku; Hitoshi Kikutani; Atsushi Kumanogoh
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Pre-sterilized, single use filling systems for liquid bio-pharmaceuticals
American Pharmaceutical Review, ISSN: 10998012
Lindsay Leveen
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The adaptor protein Sh2d3c is critical for marginal zone B cell development and function
Journal of Immunology, ISSN: 00221767 15506606
Amin Al-Shami; Carrie Wilkins; Jeannette Crisostomo; Dhaya Seshasayee; Flavius Martin; Nianhua Xu; Adisak Suwanichkul; Stephen J. Anderson; Tamás Oravecz
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Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens
Journal of Immunology, ISSN: 15506606 00221767
Sheela Ramanathan; Stephanie Dubois; Julien Gagnon; Chantal Leblanc; Sanjeev Mariathasan; Gerardo Ferbeyre; Robert Rottapel; Pamela S. Ohashi; Subburaj Ilangumaran
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Increasing parvovirus filter throughput of monoclonal antibodies using ion exchange membrane adsorptive pre-filtration
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Arick Brown; Charity Bechtel; Jerome Bill; Hui F. Liu; Jun Liu; Daniel J. McDonald; Satyan Pai; Asha Radhamohan; Ryan Renslow; Brooke Thayer; Stefan T. Yohe; Chris Dowd
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Increased targeting of donor switch region and IgE in Sγ1-deficient B cells
Journal of Immunology, ISSN: 00221767 15506606
Shahram Misaghi; Christopher Garris; Yonglian Sun; Allen Nguyen; Juan Zhang; Andrew Sebrell; Kate Senger; Donghong Yan; Maria N. Lorenzo; Sherry Heldens; Wyne P. Lee; Min Xu; Jiansheng Wu; Laura DeForge; Tao Sai; Vishva M. Dixit; Ali A. Zarrin
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SEC assay for polyvinylsulfonic impurities in 2-(N-morpholino) ethanesulfonic acid using a charged aerosol detector
Chromatographia, ISSN: 00095893 16121112
Taylor Zhang; Daniel Hewitt; Kao
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Quantitative modeling of viable cell density, cell size, intracellular conductivity, and membrane capacitance in batch and fed-batch CHO processes using dielectric spectroscopy
Biotechnology Progress, ISSN: 87567938 15206033
Cary F. Opel; Jincai Li; Ashraf Amanullah
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Process transfer to contract manufacturing organizations: A case study on process development support past regulatory approval
Pharmaceutical Engineering, ISSN: 02738139
Amy Webb; David H. Reifsnyder; Bender
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PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
Journal of Clinical Investigation, ISSN: 00219738 15588238
Scott N. Mueller; Vijay K. Vanguri; Sang-Jun Ha; Erin E. West; Mary E. Keir; Jonathan N. Glickman; Arlene H. Sharpe; Rafi Ahmed
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Modulation of inflammasome activity for the treatment of auto-inflammatory disorders
Journal of Clinical Immunology, ISSN: 02719142 15732592
Naik; Vishva M. Dixit
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Inline ultrafiltration
Biotechnology Progress, ISSN: 87567938 15206033
Christopher A. Teske; Lebreton
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Use of disposable reactors to generate inoculum cultures for E. coli production fermentations
Biotechnology Progress, ISSN: 87567938 15206033
Ekta Mahajan; Timothy Matthews; Ryan Hamilton; Mike Laird
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Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells
Journal of Clinical Investigation, ISSN: 00219738 15588238
Sheng Cao; Usman Yaqoob; Amitava Das; Uday Shergill; Kumaravelu Jagavelu; Robert C. Huebert; Chittaranjan Routray; Soha Abdelmoneim; Meher Vasdev; Edward Leof; Michael R. Charlton; Ryan J. Watts; Debabrata Mukhopadhyay; Vijay H. Shah
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New neurons clear the path of astrocytic processes for their rapid migration in the adult brain
Neuron, ISSN: 08966273
Naoko Kaneko; Oscar Marín; Masato Koike; Yuki Hirota; Yasuo Uchiyama; Jane Y. Wu; Qiang Lu; Marc Tessier-Lavigne; Arturo Alvarez-Buylla; Hideyuki Okano; John L. R. Rubenstein; Kazunobu Sawamoto
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Cost analysis review of stroke centers, telestroke, and rt-PA
American Journal of Managed Care, ISSN: 10880224
Bart M. Demaerschalk; Ha-Mill Hwang; Grace Leung
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The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment
Clinical Cancer Research, ISSN: 10780432 15573265
Ivor Caro; Low
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Characterization of a monoclonal antibody cell culture production process using a quality by design approach
Molecular Biotechnology, ISSN: 10736085
Brian Horvath; Melissa Mun; Mike Laird
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Targeting the tumour vasculature: Insights from physiological angiogenesis
Nature Reviews Cancer, ISSN: 1474175X 14741768
Alicia S Chung; John Lee; Napoleone Ferrara
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Year-to-year changes in lung function in individuals with cystic fibrosis
Journal of Cystic Fibrosis, ISSN: 15691993
Liou; Eric Elkin; David J. Pasta; Joan R. Jacobs; Michael W. Konstan; Morgan; Wagener
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Reply to S.N. Wolff
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Suman Bhattacharya; Gwendolyn Fyfe; Robert Gray; Daniel J. Sargent
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Zinc Finger Nucleases as tools to understand and treat human diseases
BMC Medicine, ISSN: 17417015
David P. Davis; David Stokoe
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Response
Chest, ISSN: 19313543 00123692
Sarika Ogale; Todd A. Lee; Sean D. Sullivan
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Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapy
Arthritis and Rheumatism, ISSN: 00043591 15290131
Jing Cui; Saedis Saevarsdottir; Brian Thomson; Leonid Padyukov; Annette H. M. Van Der Helm-van Mil; Joanne Nititham; Laura B. Hughes; Niek De Vries; Soumya Raychaudhuri; Lars Alfredsson; Johan Askling; Wedren; Bo Ding; Candace Guiducci; Gert Jan Wolbink; J. Bart A. Crusius; Irene E. Van Der Horst-Bruinsma; Marieke Herenius; Michael E. Weinblatt; Nancy A. Shadick; Jane Worthington; Franak Batliwalla; Marlena Kern; Ann W. Morgan; Anthony G. Wilson; John D. Isaacs; Kimme Hyrich; Michael F. Seldin; Larry W. Moreland; Timothy W. Behrens; Allaart; Lindsey A. Criswell; Tom W. J. Huizinga; Paul P. Tak; S. Louis Bridges Jr.; Toes; Anne Barton; Lars Klareskog; Peter K. Gregersen; Elizabeth W. Karlson; Robert M. Plenge
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Lymphotoxin-αβ heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis
Cytokine, ISSN: 10434666
Judy Young; Xin Yu; Kristen Wolslegel; Allen Nguyen; Catherine Kung; Eugene Y. Chiang; Ganesh Kolumam; Nathan Wei; Wai Lee T. Wong; Laura DeForge; Michael J. Townsend; Jane L. Grogan
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US cost burden of ischemic stroke: A systematic literature review
American Journal of Managed Care, ISSN: 10880224
Bart M. Demaerschalk; Ha-Mill Hwang; Grace Leung
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Unique challenges and opportunities for enabling and supporting preclinical and translational areas of biologic development in India - A perspective
American Pharmaceutical Outsourcing, ISSN: 15296318
Ashwin Datt; Sara Kenkare-Mitra
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Prosthetic hand provides nearly normal function: It might seem to be straight out of science fiction, but there's solid science and engineering behind it
Managed Care, ISSN: 10623388
Thomas Morrow
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Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol- 4,5-bisphosphate distribution is required for MAPK signaling
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Lindsay S. Garrenton; Christopher J. Stefan; Michael A. McMurray; Scott D. Emr; Jeremy Thorner
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Vectors and parameters that enhance the efficacy of RNAi-mediated gene disruption in transgenic Drosophila
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Benjamin Haley; Bryon Foys; Michael Levine
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The functional capacity of the natural amino acids for molecular recognition
Molecular BioSystems, ISSN: 1742206X 17422051
Sara Birtalan; Robert D. Fisher; Sachdev S. Sidhu
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