Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9251 - 9300 OF 15805 RESULTS

May 1, 2010

Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm

Molecular Immunology, ISSN: 01615890

Adi Drori; Shahram Misaghi; Joseph Haimovich; Martin Messerle; Boaz Tirosh

April 29, 2010

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

Nature, ISSN: 00280836 14764687

Sergio E. Baranzini; Joann Mudge; Jennifer C. Van Velkinburgh; Pouya Khankhanian; Irina Khrebtukova; Neil A. Miller; Lu Zhang; Andrew D. Farmer; Callum J. Bell; Ryan W. Kim; Gregory D. May; Jimmy E. Woodward; Stacy J. Caillier; Joseph P. McElroy; Refujia Gomez; Marcelo J. Pando; Leonda E. Clendenen; Elena E. Ganusova; Faye D. Schilkey; Thiruvarangan Ramaraj; Omar A. Khan; Jim J. Huntley; Shujun Luo; Pui-Yan Kwok; Thomas D Wu; Gary P. Schroth; Jorge R. Oksenberg; Stephen L. Hauser; Stephen F. Kingsmore

April 20, 2010

Reply to W. Wick et al

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Henry S. Friedman; Michael D. Prados; Patrick Y. Wen; Tom Mikkelsen; David Schiff; Lauren E. Abrey; Alfred Yung; Nina Paleologos; Martin K. Nicholas; Randy Jensen; James Vredenburgh; Jane E. Huang; Maoxia Zheng; Timothy Cloughesy

April 16, 2010

Ladder polyether synthesis via epoxide-opening cascades directed by a disappearing trimethylsilyl group

Journal of Organic Chemistry, ISSN: 00223263 15206904

Timothy P. Heffron; Graham L. Simpson; Estibaliz Merino; Timothy F. Jamison

April 15, 2010

IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis

Journal of Immunology, ISSN: 00221767 15506606

Yan Hu; Naruhisa Ota; Ivan Peng; Refino; Dimitry Danilenko; Patrick Caplazi; Wenjun Ouyang

April 15, 2010

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Timothy P. Heffron; Megan Berry; Georgette M. Castanedo; Christine Chang; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Janet Gunzner; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Alan G. Olivero; Jodie Pang; David Peterson; Laurent Salphati; Deepak Sampath; Steve Sideris; Daniel P. Sutherlin; Vickie Tsui; Nan Chi Wan; Shumei Wang; Susan C. Wong; Bing-Yan Zhu

April 15, 2010

A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life

Cancer Research, ISSN: 00085472 15387445

Yik Andy Yeung; Xiumin Wu; Arthur Reyes; Jean-Michel Vernes; Samantha Lien; John Lowe; Mauricio Maia; William F. Forrest; Meng; Lisa A. Damico; Napoleone Ferrara; Henry B. Lowman

April 15, 2010

Therapeutic antibody targeting of individual Notch receptors

Nature, ISSN: 00280836 14764687

Yan Wu; Carol Cain-Hom; Lisa Choy; Thijs Hagenbeek; Gladys P. De Leon; Yongmei Chen; David Finkle; Rayna Venook; Xiumin Wu; John B.B. Ridgway; Dorreyah Schahin-Reed; Graham J. Dow; Amy Shelton; Scott Stawicki; Ryan J. Watts; Jeff Zhang; Robert Choy; Peter Howard; Lisa Kadyk; Minhong Yan; Jiping Zha; Christopher Callahan; Sarah G. Hymowitz; Christian W. Siebel

April 14, 2010

Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons

Journal of Neuroscience, ISSN: 02706474 15292401

Yanling Wang; Catherine A. Dye; Vikaas Sohal; Jason E. Long; Rosanne C. Estrada; Tomas Roztocil; Thomas Lufkin; Karl Deisseroth; Scott C. Baraban; John L. R. Rubenstein

April 13, 2010

Differential effects of divalent manganese and magnesium on the kinase activity of Leucine-Rich Repeat Kinase 2 (LRRK2)

Biochemistry, ISSN: 00062960 15204995

Brian Lovitt; Erica Vanderporten; Zejuan Sheng; Haitao Zhu; Jake Drummond; Yichin Liu

April 13, 2010

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

Cancer Cell, ISSN: 15356108

Ruihuan Chen; Merry C. Nishimura; Stephanie M. Bumbaca; Samir Kharbanda; William F. Forrest; Ian Kasman; Joan M. Greve; Robert Soriano; Laurie L. Gilmour; Rivers; Zora Modrusan; Serban Nacu; Steve Guerrero; Kyle A. Edgar; Jeffery J. Wallin; Katrin Lamszus; Manfred Westphal; Susanne Heim; C. David James; Scott R. VandenBerg; Joseph F. Costello; Scott Moorefield; Cynthia J. Cowdrey; Michael D. Prados; Phillips

April 9, 2010

Cancer therapy reform

Science, ISSN: 00368075 10959203

Levinson

April 8, 2010

Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies

Biotechnology and Bioengineering, ISSN: 10970290 00063592

Laetitia Malphettes; Yevgeniy Freyvert; Chang; Pei-Qi Liu; Edmond Chan; Jeffrey C. Miller; Zhe Zhou; Nguyen; Christina Tsai; Andrew Snowden; Trevor N. Collingwood; Philip D. Gregory; Gregory J. Cost

April 1, 2010

An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G

Current Opinion in Structural Biology, ISSN: 0959440X

Devin B. Tesar; Pamela J. Bjorkman

April 1, 2010

The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility

Journal of Immunology, ISSN: 00221767 15506606

Sharon Celeste Morley; Chen Wang; Wan-Lin Lo; Chan-Wang J. Lio; Bernd H. Zinselmeyer; Mark J. Miller; Eric J. Brown; Paul M. Allen

April 1, 2010

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

Nature Cell Biology, ISSN: 14657392

Yaron Pereg; Bob Y. Liu; Karen M. O'Rourke; Meredith Sagolla; Anwesha Dey; László Kömüves; French; Vishva M. Dixit

April 1, 2010

Characteristics of rhVEGF release from topical hydrogel formulations

Pharmaceutical Research, ISSN: 07248741 1573904X

Junyan A. Ji; Jun Liu; Steven J. Shire; Tim J. Kamerzell; Sung Hong; Karen L Billeci; Ye Shen; Y. John Wang

April 1, 2010

A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice

Developmental Biology, ISSN: 1095564X 00121606

Setsu Endoh-Yamagami; Kameel M. Karkar; Scott R. May; Inma Cobos; Myo T. Thwin; Jason E. Long; Amir M. Ashique; Konstantinos Zarbalis; John L. R. Rubenstein; Andrew S. Peterson

April 1, 2010

Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother

April 1, 2010

Novel method for genotyping hepatitis B virus on the basis of taqMan real-time PCR

Journal of Clinical Microbiology, ISSN: 00951137

Sebastian Malmström; Ida Enquist; Magnus Lindh

April 1, 2010

Cytosol as battleground: Ubiquitin as a weapon for both host and pathogen

Trends in Cell Biology, ISSN: 09628924

Cathleen A. Collins; Eric J. Brown

April 1, 2010

Estimating duration in partnership studies: Issues, methods and examples

Sexually Transmitted Infections, ISSN: 13684973 14723263

Bart Burington; James P. Hughes; William L. H. Whittington; Brad Stoner; Geoff Garnett; Sevgi O. Aral; King K. Holmes

April 1, 2010

Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET

Nuclear Medicine and Biology, ISSN: 09698051

Jeff N. Tinianow; Herman S. Gill; Annie Ogasawara; Judith E. Flores; Alexander N. Vanderbilt; Luis; Richard L. Vandlen; Martine Darwish; Jagath R. Junutula; Simon P. Williams; Jan Marik

April 1, 2010

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

Annals of Neurology, ISSN: 03645134 15318249

Amit Bar-Or; Lama Fawaz; Boli Fan; Peter J. Darlington; Aja Rieger; Christine Ghorayeb; Peter A Calabresi; Waubant; Stephen L. Hauser; Jiameng Zhang; Craig H. Smith

April 1, 2010

Spatial control of EGF receptor activation by reversible dimerization on living cells

Nature, ISSN: 00280836 14764687

Inhee Chung; Robert W. Akita; Richard L. Vandlen; Derek Toomre; Schlessinger; Ira Mellman

April 1, 2010

Cross-species comparison of the metabolism and excretion of zoniporide: Contribution of aldehyde oxidase to interspecies differences

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Deepak Dalvie; Chenghong Zhang; Weichao Chen; Teresa Smolarek; R. Scott Obach; Cho-Ming Loi

April 1, 2010

Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin e for the treatment of melanoma and breast cancer

Current Opinion in Molecular Therapeutics, ISSN: 14648431

Louie Naumovski; Jagath R. Junutula

April 1, 2010

A phase III, randomized, double-blind, placebo-controlled study of tenecteplase for improvement of hemodialysis catheter function: TROPICS 3

Clinical Journal of the American Society of Nephrology, ISSN: 15559041 1555905X

James Tumlin; Jesse Goldman; David M. Spiegel; David Roer; K. Adu Ntoso; Martha Blaney; Joan R. Jacobs; Barbara S. Gillespie; Susan M. Begelman

April 1, 2010

Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

Molecular and Cellular Biology, ISSN: 02707306

Xiaohui Wen; Cary K. Lai; Marie Evangelista; Hongo; Frederic J. De Sauvage; Suzie J. Scales

April 1, 2010

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-α antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Rong Deng; Kelly M. Loyet; Samantha Lien; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Henry B. Lowman; Fielder; Saileta Prabhu

April 1, 2010

Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions

Nature Methods, ISSN: 15487091 15491676

Anita A. Koshy; Ashley Fouts; Melissa B. Lodoen; Ozan Alkan; Helen M. Blau; John C. Boothroyd

March 30, 2010

Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Jin I. Lee; Damien M. O'Halloran; Jeffrey Eastham-Anderson; Bi-Tzen Juang; Julia A. Kaye; O. Scott Hamilton; Bluma Lesch; Andrei Goga; Noelle D. L'Etoile

March 26, 2010

Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Desiree H. Fong; Christopher T. Lemke; Jiyoung Hwang; Bing Xiong; Albert M. Berghuis

March 19, 2010

Reconstitution of a Frizzled8·Wnt3a·LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eric Bourhis; Christine Tam; Yvonne Franke; J.Fernando Bazan; James A. Ernst; Jiyoung Hwang; Michael Costa; Andrea G Cochran; Rami N. Hannoush

March 18, 2010

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Nature, ISSN: 00280836 14764687

Georgia Hatzivassiliou; Kyung Song; Ivana Yen; Barbara J. Brandhuber; Daniel J Anderson; Ryan Alvarado; Mary J. C. Ludlam; David Stokoe; Susan L. Gloor; Guy Vigers; Tony Morales; Ignacio Aliagas; Bonnie Liu; Steve Sideris; Klaus P. Hoeflich; Bijay S. Jaiswal; Somasekar Seshagiri; Koeppen; Marcia Belvin; Lori S. Friedman; Shiva Malek

March 16, 2010

The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in netrin-mediated axon attraction and branching

Developmental Cell, ISSN: 18781551 15345807

Joe C. Hao; Carolyn E. Adler; Leslie Mebane; Frank B. Gertler; Cornelia I. Bargmann; Marc Tessier-Lavigne

March 16, 2010

Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the abl-related gene (Arg) tyrosine kinase and N-WASp

Biochemistry, ISSN: 00062960 15204995

Matthew M. Miller; Stefanie Lapetina; Stacey M. MacGrath; Mindan K. Sfakianos; Thomas D. Pollard; Anthony J. Koleske

March 15, 2010

Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors

Cancer, ISSN: 0008543X 10970142

Faye M. Johnson; Shruti Agrawal; Howard A. Burris; Lee Rosen; Navneet Dhillon; David Hong; Anne Blackwood-Chirchir; Feng R. Luo; Oumar Sy; Sanjeev Kaul; Alberto A. Chiappori

March 15, 2010

Using precipitation by polyamines as an alternative to chromatographic separation in antibody purification processes

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232

Junfen Ma; Hai Hoang; Thomas Myint; Thanmaya Peram; Fahrner; Judy H. Chou

March 15, 2010

Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232

Xiao Ding; Bilin Chou; Richard A. Graham; Sravanthi Cheeti; Percey; Matassa; Reuschel; Meng; Liu; Voelker; Bert L. Lum; Patrick J. Rudewicz; Cornelis E. Hop

March 15, 2010

A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles

Molecular Biology of the Cell, ISSN: 10591524

Jorge Z. Torres; Kenneth H. Ban; Peter K Jackson

March 12, 2010

Restriction of receptor movement alters cellular response: Physical force sensing by EphA2

Science, ISSN: 00368075 10959203

Khalid Salaita; Pradeep Nair; Rebecca S. Petit; Richard M. Neve; Debopriya Das; Joe W. Gray; Jay T. Groves

March 11, 2010

CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus

Blood, ISSN: 15280020 00064971

Daniel A. Zlotoff; Arivazhagan Sambandam; Theodore D. Logan; J. Jeremiah Bell; Benjamin A. Schwarz; Avinash Bhandoola

March 9, 2010

Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor

Biochemistry, ISSN: 00062960 15204995

Christopher M. Koth; Norzehan Abdul-Manan; Christopher A. Lepre; Peter J. Connolly; Sanghee Yoo; Arun K. Mohanty; Judith A. Lippke; Jacque Zwahlen; Joyce T. Coll; John D. Doran; Miguel Garcia-Guzman; Jonathan M. Moore

March 5, 2010

Phospho-regulation of DDA3 function in mitosis

Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104

Chang-Young Jang; Judith A. Coppinger; John R. Yates; Guowei Fang

March 2, 2010

Mature dendritic cells use endocytic receptors to capture and present antigens

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Craig D. Platt; Jessica K. Ma; Cecile Chalouni; Melanie Ebersold; Hani Bou-Reslan; Richard A. D. Carano; Ira Mellman; Lélia Delamarre

March 1, 2010

Practical applications of quality risk management

BioProcess International, ISSN: 15426319

Mire-Sluis; Emma Ramnarine; Joseph Siemiatkoski; Dan Weese; Patrick Swann; Richard O'Keeffe; Joe Kutza; Julia Edwards; Lorna McLeod

March 1, 2010

Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation

DMM Disease Models and Mechanisms, ISSN: 17548403 17548411

Nathalie Ortega; Ke Wang; Napoleone Ferrara; Zena Werb; Thiennu H. Vu

March 1, 2010

Membrane transporters in drug development

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Kathleen M. Giacomini; Huang; Donald J. Tweedie; Leslie Z. Benet; Kim L.R. Brouwer; Xiaoyan Chu; Amber Dahlin; Raymond Evers; Volker Fischer; Kathleen M. Hillgren; Keith Hoffmaster; Toshihisa Ishikawa; Dietrich Keppler; Richard B. Kim; Caroline A. Lee; Mikko Niemi; Polli; Yuichi Sugiyama; Peter W. Swaan; Joseph A. Ware; Stephen H. Wright; Sook Wah Yee; Zamek-Gliszczynski; Lei Zhang

March 1, 2010

Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available Pan-PI3-kinase and dual Pan-PI3-kinase/mTOR inhibitors for the treatment of cancer

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Daniel P. Sutherlin; Deepak Sampath; Megan Berry; Georgette M. Castanedo; Zhigang Chang; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Lori S. Friedman; Richard Goldsmith; Timothy P. Heffron; Leslie Lee; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Wei Wei Prior; Laurent Salphati; Steve Sideris; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Wiesmann; Susan C. Wong; Bing-Yan Zhu

Join Our Team

The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.

Two Scientists Walk Into a Bar

Two Scientists Walk Into a Bar

Listen to our podcast, where researchers talk about their work answering the toughest questions in human biology.