Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9401 - 9450 OF 15657 RESULTS

October 1, 2009

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions

PLoS Genetics, ISSN: 15537390 15537404

Lisa F. Barcellos; Suzanne L. May; Ramsay; Hong L. Quach; Lane; Joanne Nititham; Janelle A. Noble; Kimberly E. Taylor; Diana L. Quach; Sharon A. Chung; Jennifer A. Kelly; Kathy L. Moser; Timothy W. Behrens; Michael F. Seldin; Glenys Thomson; John B. Harley; Patrick M. Gaffney; Lindsey A. Criswell

October 1, 2009

Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins

PLoS Biology, ISSN: 15449173 15457885

Raffi Tonikian; Xiaofeng Xin; Christopher P. Toret; David Gfeller; Christiane Landgraf; Simona Panni; Serena Paoluzi; Luisa Castagnoli; Bridget Currell; Somasekar Seshagiri; Haiyuan Yu; Barbara Winsor; Marc Vidal; Mark Gerstein; Gary D. Bader; Rudolf Volkmer; Gianni Cesareni; Drubin; Philip M. Kim; Sachdev S. Sidhu; Charles Boone

September 18, 2009

The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Hiroaki Uranishi; Andrei S. Zolotukhin; Susan Lindtner; Søren Warming; Gen-Mu Zhang; Jenifer Bear; Neal G. Copeland; Nancy A. Jenkins; George N. Pavlakis; Barbara K. Felber

September 18, 2009

Structural Ties between Cholesterol Transport and Morphogen Signaling

Cell, ISSN: 00928674

J.Fernando Bazan; Frederic J. De Sauvage

September 17, 2009

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

New England Journal of Medicine, ISSN: 15334406 00284793

Daniel D. Von Hoff; Patricia M. LoRusso; Charles M. Rudin; Josina C. Reddy; Robert Yauch; Raoul Tibes; Glen J. Weiss; Mitesh J. Borad; Christine L. Hann; Julie Brahmer; Howard M. Mackey; Bert L. Lum; Darbonne; James C. Marsters Jr.; Frederic J. De Sauvage; Low

September 17, 2009

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

New England Journal of Medicine, ISSN: 15334406 00284793

Charles M. Rudin; Christine L. Hann; John Laterra; Robert Yauch; Christopher Callahan; Ling Fu; Thomas Holcomb; Stinson; Stephen Gould; Barbara Coleman; Patricia M. LoRusso; Daniel D. Von Hoff; Frederic J. De Sauvage; Low

September 15, 2009

Local Guidance of Emerging Vessel Sprouts Requires Soluble Flt-1

Developmental Cell, ISSN: 15345807

John C. Chappell; Sarah M. Taylor; Napoleone Ferrara; Victoria L. Bautch

September 14, 2009

Genomic DNA microarray comparison of gene expression patterns in Paracoccidioides brasiliensis mycelia and yeasts in vitro

Microbiology, ISSN: 13500872

Jomar P. Monteiro; Karl V. Clemons; Laurence F. Mirels; John A. Coller Jr.; Thomas D Wu; Jata Shankar; Catalina R. Lopes; David A. Stevens

September 10, 2009

Estimating variance parameters from multivariate normal variables subject to limits of detection: MLE, REML, or Bayesian approaches?

Statistics in Medicine, ISSN: 02776715 10970258

Lei Nie; Haitao Chu; Shibao Feng

September 9, 2009

A modular platform for the rapid site-specific radiolabeling of proteins with 18F exemplified by quantitative positron emission tomography of human epidermal growth factor receptor 2

Journal of Medicinal Chemistry, ISSN: 00222623

Herman S. Gill; Jeff N. Tinianow; Annie Ogasawara; Judith E. Flores; Alexander N. Vanderbilt; Helga Raab; Justin M. Scheer; Richard L. Vandlen; Simon P. Williams; Jan Marik

September 8, 2009

Rapid evolution of functional complexity in a domain family

Science Signaling, ISSN: 19450877 19379145

Andreas Ernst; Stephen L. Sazinsky; Shirley Hui; Bridget Currell; Moyez Dharsee; Somasekar Seshagiri; Gary D. Bader; Sachdev S. Sidhu

September 8, 2009

Science signaling podcast: 8 September 2009

Science Signaling, ISSN: 19450877 19379145

Sachdev S. Sidhu; Annalisa M. VanHook

September 1, 2009

Single-use technology and the carbon and water footprints of biopharm manufacturing

American Pharmaceutical Review, ISSN: 10998012

Lindsay Leveen

September 1, 2009

Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

British Journal of Pharmacology, ISSN: 00071188 14765381

Florio; Christine Loh; Huang; Iwamaye; Kitto; Fowler; Treiberg; Hayflick; Walker; Fairbanks; Lai

September 1, 2009

A Phase IIIb Study to Evaluate the Safety of Ranibizumab in Subjects with Neovascular Age-related Macular Degeneration

Ophthalmology, ISSN: 01616420

David S. Boyer; Jeffrey S. Heier; David M. Brown; Steve Francom; Tsontcho Ianchulev; Roman G. Rubio

September 1, 2009

The prioritization of cancer antigens: A National Cancer Institute pilot project for the acceleration of translational research

Clinical Cancer Research, ISSN: 10780432

Martin A. Cheever; James P. Allison; Andrea Stern Ferris; Olivera J. Finn; Benjamin M. Hastings; Toby T. Hecht; Ira Mellman; Sheila A. Prindiville; Jaye L. Viner; Louis M. Weiner; Lynn M. Matrisian

September 1, 2009

Laplace's approximation for relative risk frailty models

Lifetime Data Analysis, ISSN: 13807870

Shibao Feng; Lei Nie; Robert A. Wolfe

September 1, 2009

Response to Charlton et al.

Birth Defects Research Part A - Clinical and Molecular Teratology, ISSN: 15420752 15420760

Angela E. Scheuerle; Vani X. Vannappagari; Mary K. Miller

September 1, 2009

Development of a high throughput protein a well-plate purification method for monoclonal antibodies

Biotechnology Progress, ISSN: 87567938

Jennifer Hopp; Ross Pritchett; Maria R. Darlucio; Junfen Ma; Judy H. Chou

September 1, 2009

Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

British Journal of Pharmacology, ISSN: 00071188 14765381

Florio; Loh; Huang; Iwamaye; Kitto; Fowler; Treiberg; Hayflick; Walker; Fairbanks; Lai

September 1, 2009

Stimulant medication use and response to growth hormone therapy: An NCGS database analysis

Hormone Research, ISSN: 03010163

J. Paul Frindik; Alba Morales; John Fowlkes; Stephen F. Kemp; Kathryn Thrailkill; Barbara M. Lippe; Ken Dana

September 1, 2009

T-helper type 2-driven inflammation defines major subphenotypes of asthma

American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970

Prescott G. Woodruff; Barmak Modrek; David F. Choy; Guiquan Jia; Abbas Alexander; Almut Ellwanger; Joseph R. Arron; Laura L. Koth; John V. Fahy

September 1, 2009

SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition

Cell Cycle, ISSN: 15514005 15384101

Lin Fang; Akiko Seki; Guowei Fang

September 1, 2009

Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: The BRiTE observational cohort study

Oncologist, ISSN: 10837159 1549490X

Kozloff; Marianne Ulcickas Yood; Jordan Berlin; Patrick J. Flynn; Fairooz F. Kabbinavar; David M. Purdie; Ashby; Wei Dong; Mary M. Sugrue; Grothey

September 1, 2009

Design, synthesis and discovery of 1-(2-(6-chloro-3-methylsulfonyl)- naphthyl)-1H-pyrazole-5-carboxylamides as highly potent factor Xa inhibitors

Chemical and Pharmaceutical Bulletin, ISSN: 00092363 13475223

Zhaozhong J. Jia; Robert M. Scarborough; Penglie Zhang; Sherin Halfon; Ann Elizabeth Arfsten; Uma Sinha; Bing-Yan Zhu

September 1, 2009

Converting cancer mutations into therapeutic opportunities

EMBO Molecular Medicine, ISSN: 17574676 17574684

Thomas O'Brien; David Stokoe

September 1, 2009

Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers

Molecular Cancer Research, ISSN: 15417786

Eva Lin; Li Li; Yinghui Guan; Robert Soriano; Rivers; Sankar Mohan; Ajay Pandita; Zhijun Tang; Zora Modrusan

August 31, 2009

Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity

Journal of Immunological Methods, ISSN: 00221759

Emily Bond; William C. Adams; Anna Smed-Sörensen; Kerrie J. Sandgren; Leif Perbeck; Anette Hofmann; Jan Andersson; Karin Loré

August 24, 2009

Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2

PLoS ONE, ISSN: 19326203

Wendy R. Gordon; Didem Vardar-Ulu; Sarah L'Heureux; Todd Ashworth; Michael J. Malecki; Cheryll Sanchez-Irizarry; Debbie G. McArthur; Gavin Histen; Jennifer L. Mitchell; Jon C. Aster; Stephen C. Blacklow

August 20, 2009

A highly annotated whole-genome sequence of a Korean individual

Nature, ISSN: 00280836 14764687

Jong-Il Kim; Young Seok Ju; Hansoo Park; Sheehyun Kim; Seonwook Lee; Jae-Hyuk Yi; Joann Mudge; Neil A. Miller; Dongwan Hong; Callum J. Bell; Hye-Sun Kim; In-Soon Chung; Woo-Chung Lee; Ji-Sun Lee; Seung-Hyun Seo; Ji-Young Yun; Hyun Nyun Woo; Heewook Lee; Dongwhan Suh; Seungbok Lee; Hyun-Jin Kim; Maryam Yavartanoo; Minhye Kwak; Ying Zheng; Mi Kyeong Lee; Hyunjun Park; Jeong Yeon Kim; Omer Gokcumen; Ryan E. Mills; Alexander Wait Zaranek; Joseph Thakuria; Xiaodi Wu; Ryan W. Kim; Jim J. Huntley; Shujun Luo; Gary P. Schroth; Thomas D Wu; Hyeran Kim; Kap-Seok Yang; Woong-Yang Park; Hyungtae Kim; George M. Church; Charles Lee; Stephen F. Kingsmore; Jeong-Sun Seo

August 18, 2009

Validation of tangential flow filtration in biopharmaceutical applications task force

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440

Chris Antoniou; Neil Bingham; Glen Bolton; Chris Bussineau; Michael Dosmar; Chithkala Harinarayan; Robert W. Juffras; James Klein; Peter Levy; Richard V. Levy; Mike Mulcare; Jon Petrone; Jon Romero; Ganesh Vedantham; Robert Velcheck

August 15, 2009

BCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells

International Journal of Cancer, ISSN: 00207136 10970215

Saritha Kusam; Veerendra Munugalavadla; Deepali Sawant; Alexander Dent

August 15, 2009

Identification of cell culture conditions to control N-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Martin Gawlitzek; Michael Estacio; Tobias Fürch; Robert Kiss

August 15, 2009

Investigation of sample preparation artifacts formed during the enzymatic release of N-linked glycans prior to analysis by capillary electrophoresis

Analytical Chemistry, ISSN: 00032700

Yong Liu; Oscar Salas-Solano; Lynn Gennaro

August 12, 2009

A multi-tiered analytical approach for the analysis and quantitation of high-molecular-weight aggregates in a recombinant therapeutic glycoprotein

AAPS Journal, ISSN: 15507416

Heather Hughes; Charles Morgan; Elizabeth Brunyak; Kristen Barranco; Emily Cohen; Tim Edmunds; Karen Lee

August 11, 2009

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

Current Biology, ISSN: 09609822

Setsu Endoh-Yamagami; Marie Evangelista; Deanna G. Wilson; Xiaohui Wen; Jan-Willem Theunissen; Khanhky Phamluong; Matti Davis; Suzie J. Scales; Mark J. Solloway; Frederic J. De Sauvage; Andrew S. Peterson

August 5, 2009

High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors

BMC Medical Genomics, ISSN: 17558794

Matthias Peter; Lawrence S. Hon; Joshua S. Kaminker; John Chant; Zemin Zhang

August 5, 2009

Microarray analysis of RNA extracted from formalin-fixed, paraffin-embedded and matched fresh-frozen ovarian adenocarcinomas

BMC Medical Genomics, ISSN: 17558794

Grazyna Fedorowicz; Steve Guerrero; Thomas D Wu; Zora Modrusan

August 1, 2009

FAM29A, a target of Plk1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes

Journal of Cell Science, ISSN: 00219533

Hui Zhu; Kayleen Fang; Guowei Fang

August 1, 2009

Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

Molecular Cancer Therapeutics, ISSN: 15357163

Jiping Zha; Carol O'Brien; Heidi Savage; Huw; Fiona Zhong; Berry; Gail L. Phillips; Luis; Guy Cavet; Hu; Lukas Amler; Lackner

August 1, 2009

Oncogenic activating mutations are associated with local copy gain

Molecular Cancer Research, ISSN: 15417786

Barmak Modrek; Lin Ge; Ajay Pandita; Eva Lin; Sankar Mohan; Peng Yue; Steve Guerrero; William M. Lin; Thinh Q. Pham; Zora Modrusan; Somasekar Seshagiri; Howard M. Stern; Waring; Levi A. Garraway; John Chant; David Stokoe; Guy Cavet

August 1, 2009

A phase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma

Cancer Investigation, ISSN: 07357907 15324192

Agop Y. Bedikian; Nicholas E. Papadopoulos; Kevin B. Kim; Wen-Jen Hwu; Jade Homsi; Michelle R. Glass; Suzanne Cain; Patrick J. Rudewicz; Laurent Vernillet; Patrick Hwu

August 1, 2009

European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus

Arthritis and Rheumatism, ISSN: 00043591 15290131

Sharon A. Chung; Tian; Kimberly E. Taylor; Annette T. Lee; Ward Ortmann; Geoffrey Hom; Robert R. Graham; Joanne Nititham; Jennifer A. Kelly; Jean Morrisey; Hui Wu; Hong Yin; Marta E. Alarcón-Riquelme; Betty P. Tsao; John B. Harley; Patrick M. Gaffney; Kathy L. Moser; Manzi; Michelle Petri; Peter K. Gregersen; Carl D. Langefeld; Timothy W. Behrens; Michael F. Seldin; Lindsey A. Criswell

August 1, 2009

Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling

FEBS Journal, ISSN: 1742464X 17424658

Niko Föger; Silvia Bulfone-Paus; Andrew A. Chan; Kyeong-Hee Lee

August 1, 2009

Paracrine hedgehog signaling in cancer

Cancer Research, ISSN: 00085472 15387445

Jan-Willem Theunissen; Frederic J. De Sauvage

August 1, 2009

Churg-Strauss syndrome in patients treated with omalizumab

Chest, ISSN: 19313543 00123692

Michael E. Wechsler; Dennis A. Wong; Mary K. Miller; Lisa Lawrence-Miyasaki

August 1, 2009

Antibody binding to a tethered vesicle assembly using QCM-D

Analytical Chemistry, ISSN: 00032700

Ankit Patel; Kay K. Kanazawa; Curtis W. Frank

August 1, 2009

Health benefit costs and absenteeism due to insomnia from the employer's perspective: A retrospective, case-control, database study

Journal of Clinical Psychiatry, ISSN: 01606689

Nathan L. Kleinman; Richard A. Brook; Justin Doan; Arthur K. Melkonian; Robert W. Baran

August 1, 2009

Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

Molecular Cancer Therapeutics, ISSN: 15357163

Jiping Zha; Carol O'Brien; Heidi Savage; Huw; Fiona Zhong; Berry; Gail L. Phillips; Luis; Guy Cavet; Xiaolan Hu; Lukas Amler; Lackner

July 31, 2009

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Ching Ching Leow; Bu-Er Wang; Ross; Sara M. Chan; Jiping Zha; Richard A. D. Carano; Gretchen D. Frantz; Michael M. Shen; Frederic J. De Sauvage; Gao

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