Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9551 - 9600 OF 15657 RESULTS

How can we improve the translational landscape for a faster cure of type 1 diabetes?
Journal of Clinical Investigation, ISSN: 00219738 15588238
Matthias von Herrath; Andrew Chan
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Increasing IgG concentration modulates the conformational heterogeneity and bonding network that influence solution properties
Journal of Physical Chemistry B, ISSN: 15206106
Tim J. Kamerzell; Sonoko Kanai; Jun Liu; Steven J. Shire; Y. John Wang
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Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
Oncogene, ISSN: 09509232 14765594
Kwek; Roy; Zhou; Climent; Martinez-Climent; Jane Fridlyand; Albertson
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Crystal structure of full-length KcsA in its closed conformation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Serdar Uysal; Valeria Vásquez; Valentina Tereshko; Kaori Esaki; Frederic A. Fellouse; Sachdev S. Sidhu; Shohei Koide; Eduardo Perozo; Anthony A. Kossiakoff
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High-throughput, high-accuracy array-based resequencing
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jianbiao Zheng; Martin Moorhead; Li Weng; Farooq Siddiqui; Victoria E. H. Carlton; James S. Ireland; Liana Lee; Joseph Peterson; Jennifer Wilkins; Sean Lin; Zhengyan Kan; Somasekar Seshagiri; Ronald W. Davis; Malek Faham
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G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Farbod Shojaei; Xiumin Wu; Xueping Qu; Marcin Kowanetz; Lanlan Yu; Martha Tan; Meng; Napoleone Ferrara
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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
Immunity, ISSN: 10747613
Paul G. Thomas; Pradyot Dash; Jerry R. Aldridge Jr.; Ali H. Ellebedy; Cory Reynolds; Amy J. Funk; William J. Martin; Lamkanfi; Richard Webby; Kelli L. Boyd; Peter C. Doherty; Thirumala-Devi Kanneganti
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Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Kenneth J. Katschke Jr.; Scott Stawicki; Micah Steffek; Jianping Yin; Hongkang Xi; Lizette Sturgeon; Hass; Kelly M. Loyet; Laura DeForge; Yan Wu; Menno Van Lookeren Campagne; Wiesmann
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Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: Reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism
Toxicological Sciences, ISSN: 10966080 10960929
Lloyd Lecureux; Matthew Z. Dieter; David M. Nelson; Linda Watson; Harvey Wong; Brian Gemzik; Curtis D. Klaassen; Lois D. Lehman-McKeeman
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Efficient error determination in sequential clinical trial design
Journal of Computational and Graphical Statistics, ISSN: 10618600
Jiaqiao Hu; Zheng Su
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Small molecule clearance in ultrafiltration/diafiltration in relation to protein interactions: Study of citrate binding to a fab
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Chithkala Harinarayan; Ken Skidmore; Kao; Andrew Zydney; Robert Van Reis
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Comment on "Reassessment of the role of mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching"
Journal of Immunology, ISSN: 00221767 15506606
Hideharu Sekine; Ricardo C. Ferreira; Qiang Pan-Hammarström; Lennart Hammarström; Gary S. Gilkeson; Timothy W. Behrens
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The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf
Development (Cambridge), ISSN: 09501991 14779129
Idit Eshkar-Oren; Sergey V. Viukov; Sharbel Salameh; Sharon Krief; Chun-Do Oh; Haruhiko Akiyama; Hans-Peter Gerber; Napoleone Ferrara; Elazar Zelzer
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Characterization and regulation of Bv8 in human blood cells
Clinical Cancer Research, ISSN: 10780432
Cuiling Zhong; Xueping Qu; Martha Tan; Meng; Napoleone Ferrara
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VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Fan Zhang; Zhongshu Tang; Xu Hou; Johan Lennartsson; Yang Li; Alexander W. Koch; Pierre Scotney; Chunsik Lee; Pachiappan Arjunan; Lijin Dong; Anil Kumar; Tuomas T. Rissanen; Bin Wang; Nobuo Nagai; Pierre Fons; Robert Fariss; Yongqing Zhang; Eric Wawrousek; Ginger Tansey; James Raber; Guo-Hua Fong; Hao Ding; David A. Greenberg; Kevin G. Becker; Jean-Marc Herbert; Andrew Nash; Seppo Yla-Herttuala; Yihai Cao; Ryan J. Watts; Xuri Lia
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Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nature Chemical Biology, ISSN: 15524469 15524450
Yingnan Zhang; Brent A. Appleton; Wiesmann; Ted Lau; Michael Costa; Rami N. Hannoush; Sachdev S. Sidhu
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Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAF V600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression
Cancer Research, ISSN: 00085472 15387445
Klaus P. Hoeflich; Sylvia Herter; Janet Y. Tien; Leo Wong; Berry; Jocelyn Chan; Carol O'Brien; Zora Modrusan; Somasekar Seshagiri; Lackner; Howard M. Stern; Edna F. Choo; Lesley J. Murray; Lori S. Friedman; Marcia Belvin
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Follow: The Raptiva (efalizumab) Pregnancy Registry
Journal of the American Academy of Dermatology, ISSN: 01909622
David Margolis; Elizabeth Andrews; Winifred Werther
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A Novel, Q-PCR based approach to measuring endogenous retroviral clearance by capture protein a chromatography
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Min Zhang; Scott Lute; Lenore A Norling; Connie Hong; Aurelia Safta; Deborah O'Connor; Lisa J. Bernstein; Hua Wang; Gregory S. Blank; Kurt Brorson; Qi Chen
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Autophagy, an Achilles′ heel AKTing against cancer?
Autophagy, ISSN: 15548635 15548627
Michael Degtyarev; Ann De Mazière; Judith Klumperman; Kui Lin
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Genetic alterations and oncogenic pathways associated with breast cancer subtypes
Molecular Cancer Research, ISSN: 15417786
Hu; Howard M. Stern; Lin Ge; Carol O'Brien; Lauren Haydu; Cynthia D. Honchell; Matthias Peter; Brock A. Peters; Thomas D Wu; Lukas Amler; John Chant; David Stokoe; Lackner; Guy Cavet
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Association of C-terminal ubiquitin hydrolase BRCAl-associated protein 1 with cell cycle regulator host cell factor 1
Molecular and Cellular Biology, ISSN: 02707306
Shahram Misaghi; Søren Ottosen; Anita Izrael-Tomasevic; David Arnott; Lamkanfi; James Lee; Jinfeng Liu; Karen M. O'Rourke; Vishva M. Dixit; Angus C. Wilson
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Interleukin-22-producing innate immune cells: New players in mucosal immunity and tissue repair?
Nature Reviews Immunology, ISSN: 14741733
Eric Vivier; Hergen Spits; Tom Cupedo
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Pharmacodynamics of 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]- 3-(pyridine-4-yl)-1H-pyrazol-1-yl}ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: Understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Harvey Wong; Marcia Belvin; Sylvia Herter; Klaus P. Hoeflich; Lesley J. Murray; Leo Wong; Edna F. Choo
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Inhibitory properties of trapping agents: Glutathione, potassium cyanide, and methoxylamine, against major human cytochrome p450 isoforms
Drug Metabolism Letters, ISSN: 18723128
Chenghong Zhang; Susan C. Wong; Erlie Marie Delarosa; Jane R. Kenny; Jason S. Hallday; Cornelis E. Hop; S. Cyrus Khojasteh
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A census of human transcription factors: Function, expression and evolution
Nature Reviews Genetics, ISSN: 14710056 14710064
Juan M. Vaquerizas; Sarah K. Kummerfeld; Sarah A. Teichmann; Nicholas M. Luscombe
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PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
Journal of Immunology, ISSN: 00221767 15506606
Julie Zikherman; Michelle Hermiston; David Steiner; Kiminori Hasegawa; Andrew A. Chan; Arthur Weiss
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Tissue factor-dependent coagulation contributes to α- naphthylisothiocyanate-induced cholestatic liver injury in mice
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN: 01931857 15221547
James P. Luyendyk; Glenn H. Cantor; Daniel Kirchhofer; Nigel Mackman; Bryan L. Copple; Ruipeng Wang
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Genetic alterations and oncogenic pathways associated with breast cancer subtypes
Molecular Cancer Research, ISSN: 15417786
Xiaolan Hu; Howard M. Stern; Lin Ge; Carol O'Brien; Lauren Haydu; Cynthia D. Honchell; Matthias Peter; Brock A. Peters; Thomas D Wu; Lukas Amler; John Chant; David Stokoe; Lackner; Guy Cavet
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The art of making an exit
Science, ISSN: 00368075 10959203
Fredric Carlsson; Eric J. Brown
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Death receptor signal transducers: Nodes of coordination in immune signaling networks
Nature Immunology, ISSN: 15292908 15292916
Nicholas S. Wilson; Vishva M. Dixit; Avi Ashkenazi
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Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
Journal of Medicinal Chemistry, ISSN: 00222623
Frederick Cohen; Bruno Alicke; Linda O. Elliott; Flygare; Tatiana Goncharov; Stephen F. Keteltas; Matthew C Franklin; Stacy Frankovitz; Jean-Philippe Stephan; Vickie Tsui; Domagoj Vucic; Harvey Wong; Wayne J. Fairbrother
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Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, ISSN: 00368075 10959203
Jenny Bostrom; Shang-Fan Yu; David Kan; Brent A. Appleton; Chingwei V. Lee; Karen L Billeci; Wenyan Man; Franklin V. Peale Jr.; Ross; Wiesmann; Fuh
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Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab
Journal of Clinical Oncology, ISSN: 0732183X
Alan Sandler; Joan H. Schiller; Robert Gray; Isaiah Dimery; Julie Brahmer; Meghna Samant; Lisa I. Wang; David H. Johnson
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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Hua Tian; Christopher Callahan; Kelly J. DuPree; Darbonne; Christina Ahn; Suzie J. Scales; Frederic J. De Sauvage
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Neuropilins in tumor biology
Clinical Cancer Research, ISSN: 10780432
Anil Bagri; Marc Tessier-Lavigne; Ryan J. Watts
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Chitin is a size-dependent regulator of macrophage TNF and IL-10 production
Journal of Immunology, ISSN: 00221767 15506606
Carla A. Da Silva; Cecile Chalouni; Adam Williams; Dominik Hartl; Chun G. Lee; Jack A. Elias
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Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: Target and linker-drug selection
Cancer Research, ISSN: 00085472 15387445
Andrew G. Polson; Jill Calemine-Fenaux; Pamela Chan; Wesley S. Chang; Erin Christensen; Suzanna Clark; Frederic J. De Sauvage; Dan L. Eaton; Kristi Elkins; J. Michael Elliott; Gretchen D. Frantz; Reina N. Fuji; Gray; Kristin Harden; Gladys S. Ingle; Noelyn Kljavin; Koeppen; Nelson; Saileta Prabhu; Helga Raab; Ross; Jean-Philippe Stephan; Suzie J. Scales; Spencer; Richard L. Vandlen; Bernd Wranik; Shang-Fan Yu; Bing Zheng; Allen Ebens
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Yas3p, an opi1 family transcription factor, regulates Cytochrome P450 expression in response to n-alkanes inYarrowia lipolytica
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Kiyoshi Hirakawa; Satoshi Kobayashi; Takuro Inoue; Setsu Endoh-Yamagami; Ryouichi Fukuda; Akinori Ohta
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Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5, 7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5, 6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
Journal of Medicinal Chemistry, ISSN: 00222623
Hui Li; John Tatlock; Angelica Linton; Javier Gonzalez; Tanya Jewell; Leena Patel; Sarah Ludlum; Matthew Drowns; Sadayappan V. Rahavendran; Heather Skor; Robert Hunter; Stephanie Shi; Koleen J. Herlihy; Hans Parge; Michael Hickey; Xiu Yu; Fannie Chau; Jim Nonomiya; Lewis
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Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms
Oncogene, ISSN: 09509232 14765594
Hollmén; Jorma Määttä; Bald; Mark X. Sliwkowski; Elenius
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The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase in study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Jing Yi; William L. Ince; Novotny; Oliver Rosen
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The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase in study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Jing Yi; William Ince; Novotny; Oliver Rosen
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Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
J. Michael Elliott; Lionel Rouge; Wiesmann; Justin M. Scheer
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dsRNA with 5′ overhangs contributes to endogenous and antiviral RNA silencing pathways in plants
EMBO Journal, ISSN: 02614189 14602075
Ryuya Fukunaga; Jennifer A. Doudna
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Two-state selection of conformation-specific antibodies
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Junjun Gao; Sachdev S. Sidhu; James A. Wells
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Selective antibody precipitation using polyelectrolytes: A novel approach to the purification of monoclonal antibodies
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Paul McDonald; Corazon Victa; Jayme N. Carter-Franklin; Fahrner
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A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Christina J. Lee; Gargi Seth; Joni Tsukuda; Robert W. Hamilton
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New methods allowing the detection of protein aggregates: A case study on trastuzumab
mAbs, ISSN: 19420862
Barthélemy Demeule; Caroline Palais; Gia Machaidze; Robert Gurny; Tudor Arvinte
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Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children
Pediatrics, ISSN: 00314005 10984275
Gabriele Renzetti; Gaetano Silvestre; Claudio D'Amario; Egidio Bottini; Fulvia Gloria-Bottini; Nunzio Bottini; Alexander Auais; Miriam K. Perez; Giovanni Piedimonte
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