Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10001 - 10050 OF 16881 RESULTS

A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Sarbjit S. Saini; Karin Rosén; Hsin-Ju Hsieh; Dennis A. Wong; Edward Conner; Allen P. Kaplan; Sheldon Spector; Marcus Maurer
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Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers
Cancer Cell, ISSN: 18783686 15356108
Wilson; Diana Y. Lee; Berry; David S. Shames; Jeffrey Settleman
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A new roadmap for biopharmaceutical drug product development: Integrating development, validation, and quality by design
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Sheryl Martin-Moe; Fred Lim; Wong; Alavattam Sreedhara; Jagannathan Sundaram; Samir Sane
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Analysis of 2,2'-Azobis (2-amidinopropane) dihydrochloride degradation and hydrolysis in aqueous solutions
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Jay Werber; Y. John Wang; Michael Milligan; Xiaohua Li; Junyan A. Ji
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Solubilities and transfer free energies of hydrophobic amino acids in polyol solutions: Importance of the hydrophobicity of polyols
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Shermeen A. Abbas; Vikas Sharma; Thomas W. Patapoff; Devendra S. Kalonia
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Phase 2 trial of linifanib (ABT-869) in patients with advanced non-small cell lung cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Eng-Huat Tan; Glenwood D. Goss; Ravi Salgia; Benjamin Besse; David R. Gandara; Nasser H. Hanna; James Chih-Hsin Yang; Raymond Thertulien; Michael Wertheim; Julien Mazieres; Thomas Hensing; Christa Lee; Neeraj Gupta; Rajendra Pradhan; Jiang Qian; Qin Qin; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Ross A. Soo
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Economic burden of impairment in children with severe or difficult-to-treat asthma
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Stanley J. Szefler; Robert S. Zeiger; Tmirah Haselkorn; David R. Mink; Tripthi V. Kamath; James E. Fish; Bradley E. Chipps
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Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4
mAbs, ISSN: 19420870 19420862
Daniela Bumbaca; Anne Wong; Elizabeth Drake; Arthur Reyes; Benjamin C. Lin; Jean-Philippe Stephan; Luc Desnoyers; Shen; Dennis
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Identification of amino acid residues responsible for the release of free drug from an antibody-drug conjugate utilizing lysine-succinimidyl ester chemistry
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Hung-Wei Chih; Benson Gikanga; Yi Yang; Boyan Zhang
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Mechanisms and molecules of neuronal wiring: A primer
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Alex L. Kolodkin; Marc Tessier-Lavigne
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Using molecular simulations to probe pharmaceutical materials
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui
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New imaging paradigms in drug development: The PET imaging approach
Drug Discovery Today: Technologies, ISSN: 17406749
Jan Marik; Sandra M. Sanabria-Bohorquez; Simon P. Williams; Nicholas Van Bruggen
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P21-activated kinase 1: PAK'ed with potential
Oncotarget, ISSN: 19492553
Christy C. Ong; Adrian M. Jubb; Wei Zhou; Matthias Peter; Adrian L. Harris; Marcia Belvin; Lori S. Friedman; Koeppen; Klaus P. Hoeflich
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On the accuracy of estimation of basic pharmacokinetic parameters by the traditional noncompartmental equations and the prediction of the steady-state volume of distribution in obese patients based upon data derived from normal subjects
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Perspective of clinical research in follicular NHL: Interaction between science and industry
Best Practice and Research: Clinical Haematology, ISSN: 15321924 15216926
Gregg D. Fine; Sandra J. Horning
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Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): A double-blind, placebo-controlled, phase 3 trial
The Lancet, ISSN: 1474547X 01406736
Roy S. Herbst; Rafat Ansari; Frederique Bustin; Patrick J. Flynn; Lowell Hart; Gregory A Otterson; Gordana Vlahovic; Chang-Heok Soh; Paula O'Connor; John Hainsworth
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Introduction to current and future protein therapeutics: A protein engineering perspective
Experimental Cell Research, ISSN: 10902422 00144827
Paul J. Carter
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Omalizumab in severe allergic asthma inadequately controlled with standard therapy: A randomized trial
Annals of Internal Medicine, ISSN: 15393704 00034819
Nicola A. Hanania; Oral Alpan; Daniel L. Hamilos; John Condemi; Reyes-Rivera; Jin Zhu; Karin Rosén; Mark D. Eisner; Dennis A. Wong; William W. Busse
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Fatty acid and water-soluble polymer-based controlled release drug delivery system
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Divyakant Desai; Sanjeev Kothari; Wei Chen; Jennifer Wang; Ming Huang; Laxmikant Sharma
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BOLD MRI Applied to a Murine Model of Peripheral Artery Disease
Methods in Molecular Biology, ISSN: 19406029 10643745
Joan M. Greve
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The BOLD Effect
Methods in Molecular Biology, ISSN: 19406029 10643745
Joan M. Greve
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Ganciclovir pharmacokinetic parameters do not change when extending valganciclovir cytomegalovirus prophylaxis from 100 to 200 days
Transplantation, ISSN: 00411337
Horst Welker; Mahdi Farhan; Atul Humar; Carla Washington
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UNCovering the Molecular Machinery of Dependence Receptor Signaling
Molecular Cell, ISSN: 10972765 10974164
Anil Bagri; Avi Ashkenazi
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IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
Journal of Experimental Medicine, ISSN: 00221007 15409538
Marcel Batten; Nandhini Ramamoorthi; Noelyn Kljavin; Cindy S. Ma; Jennifer Cox; Hart S. Dengler; Dimitry Danilenko; Patrick Caplazi; Melanie Wong; David A. Fulcher; Matthew C. Cook; Cecile King; Stuart G. Tangye; Frederic J. De Sauvage; Nico Ghilardi
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Clinical experience with hedgehog pathway inhibitors
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Low; Frederic J. De Sauvage
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Allosteric peptide activators of pro-hepatocyte growth factor stimulate Met signaling
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Kyle E. Landgraf; Santell; Karen L Billeci; Quan; Judy Young; Henry R. Maun; Daniel Kirchhofer; Lazarus
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Effects of charge on antibody tissue distribution and pharmacokinetics
Bioconjugate Chemistry, ISSN: 15204812 10431802
C. Andrew Boswell; Devin B. Tesar; Kiran Mukhyala; Frank-Peter Theil; Fielder; Leslie A. Khawli
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Estimating recurrences prevented from using trastuzumab in HER-2/neu-positive adjuvant breast cancer in the United States
Cancer, ISSN: 0008543X 10970142
Mark Danese; Deepa Lalla; Melissa Brammer; Quan Doan; Kevin Knopf
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Actin-bundling protein L-plastin regulates T cell activation
Journal of Immunology, ISSN: 00221767 15506606
Wang Chen; Sharon Celeste Morley; David Donermeyer; Ivan Peng; Wyne P. Lee; Jason Devoss; Dimitry Danilenko; Zhonghua Lin; Juan Zhang; Zhou Jie; Paul M. Allen; Eric J. Brown
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C-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
EMBO Journal, ISSN: 02614189 14602075
Jasmin N. Dynek; Tatiana Goncharov; Erin C. Dueber; Anna V. Fedorova; Anita Izrael-Tomasevic; Lilian Phu; Elizabeth Helgason; Wayne J. Fairbrother; Deshayes; Donald S. Kirkpatrick; Domagoj Vucic
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Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christine D. Pozniak; Abraham J. Langseth; Gerrit J. P. Dijkgraaf; Youngshik Choe; Zena Werb; Samuel J. Pleasure
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Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Marcin Kowanetz; Xiumin Wu; John Lee; Martha Tan; Thijs Hagenbeek; Xueping Qu; Lanlan Yu; Ross; Nina Korsisaari; Tim C. Cao; Hani Bou-Reslan; Dara Y. Kallop; Robby M. Weimer; Mary J. C. Ludlam; Joshua S. Kaminker; Zora Modrusan; Nicholas Van Bruggen; Franklin V. Peale Jr.; Richard A. D. Carano; Meng; Napoleone Ferrara
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Allosteric activation mechanism of the mycobacterium tuberculosis receptor Ser/Thr protein Kinase, PknB
Structure, ISSN: 09692126
T. Noelle Lombana; Nathaniel Echols; Matthew C. Good; Nathan D. Thomsen; Ho-Leung Ng; Andrew E. Greenstein; Arnold M. Falick; David S. King; Tom Alber
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A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphoma
British Journal of Cancer, ISSN: 00070920 15321827
Younes; Julie Vose; Zelenetz; Smith; Howard A. Burris; Stephen Ansell; Klein; Wendy Halpern; Miceli; Kumm; Fox; Myron S. Czuczman
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Association of host pharmacodynamic effects with virologic response to pegylated interferon alfa-2a/ribavirin in chronic hepatitis C
Hepatology, ISSN: 02709139 15273350
Raymond T. Chung; Fred F. Poordad; Tarek Hassanein; Zhou; Lentz; Avinash Prabhakar; Adrian M. Di Bisceglie
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BioIDMapper: A cross-referencing and managing platform for biological IDs in R
Proceedings - 2010 3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010,
Xiaoyong Sun; Michael Lawrence; Zhaoquan Liu; Zhongxu Sun
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Characterization of particles in protein solutions: Reaching the limits of current technologies
AAPS Journal, ISSN: 15507416
Barthélemy Demeule; Steven Messick; Steven J. Shire; Jun Liu
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SABRE-B: An evaluation of paclitaxel and bevacizumab with or without sunitinib as first-line treatment of metastatic breast cancer
Annals of Oncology, ISSN: 09237534 15698041
Mayer; Dhakil; Taral Patel; Sundaram; Fabian; Kozloff; Qamar; Volterra; Hema Parmar; Meghna Samant; Burstein
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Statistical analysis of variation in the human plasma proteome
Journal of Biomedicine and Biotechnology, ISSN: 11107243 11107251
Todd H. Corzett; Imola K. Fodor; Megan W. Choi; Vicki L. Walsworth; Kenneth W. Turteltaub; Sandra L McCutchen-Maloney; Brett A Chromy
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Proapoptotic DR4 and DR5 signaling in cancer cells: Toward clinical translation
Current Opinion in Cell Biology, ISSN: 09550674
Annie Yang; Nicholas S. Wilson; Avi Ashkenazi
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Corticosteroid use in patients with glioblastoma at first or second relapse treated with bevacizumab in the BRAIN study
Oncologist, ISSN: 10837159 1549490X
James Vredenburgh; Timothy Cloughesy; Meghna Samant; Michael D. Prados; Patrick Y. Wen; Tom Mikkelsen; David Schiff; Lauren E. Abrey; Alfred Yung; Nina Paleologos; Martin K. Nicholas; Randy Jensen; Asha Das; Henry S. Friedman
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Effect of immune complex formation on the distribution of a novel antibody to the ovarian tumor antigen CA125
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Cinthia V Pastuskovas; William Mallet; Suzanna Clark; Margaret Kenrick; Nicholas Majidy; Michelle G. Schweiger; Marjie Van Hoy; Siao Ping Tsai; Bennett; Shen; Ross; Fielder; Leslie A. Khawli; Jay Tibbitts
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Challenges in treatment development for lupus: Is it the targets or the trials?
International Journal of Advances in Rheumatology, ISSN: 1478856X
Merrill; Paul Brunetta
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Quantification of abdominal aortic aneurysm disease progression using small animal magnetic resonance imaging
ASME 2010 Summer Bioengineering Conference, SBC 2010,
Kyla N. Barr; Craig J. Goergen; Maj Hedehus; Junya Azuma; Charles A. Taylor; Philip S. Tsao; Joan M. Greve
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Wireless monitoring delivers fast payback
Control (Chicago, Ill), ISSN: 10495541
Chris Stubbs
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Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation
Infection and Immunity, ISSN: 00199567 10985522
Lakshmi Ramachandra; Yan Qu; Ying Wang; Colleen J. Lewis; Brian A. Cobb; Kiyoshi Takatsu; W. Henry Boom; George R. Dubyak; Clifford V. Harding
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Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Josef R. Bencsik; Dengming Xiao; James F. Blake; Nicholas C. Kallan; Ian S. Mitchell; Keith L. Spencer; Rui Xu; Susan L. Gloor; Matthew Martinson; Tyler Risom; Richard D. Woessner; Faith Dizon; Wen-I. Wu; Guy Vigers; Barbara J. Brandhuber; Nicholas J. Skelton; Wei Wei Prior; Lesley J. Murray
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Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross
PLoS ONE, ISSN: 19326203
Jonathan M.J. Derry; Hua Zhong; Cliona Molony; Doug MacNeil; Debraj GuhaThakurta; Bin Zhang; John Mudgett; Kersten Small; Lahcen El Fertak; Alain Guimond; Mohammed Selloum; Wenqing Zhao; Marie France Champy; Laurent Monassier; Thomas F. Vogt; Doris Cully; Andrew Kasarskis; Eric E. Schadt
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Mechanisms of cell death and disease: Advances in therapeutic intervention and drug discovery-ESH's eighth international conference
IDrugs, ISSN: 13697056
Domagoj Vucic
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Assessment of Hydroxypropyl Methylcellulose, Propylene Glycol, Polysorbate 80, and Hydroxypropyl-β-Cyclodextrin for use in developmental and reproductive toxicology studies
Birth Defects Research Part B - Developmental and Reproductive Toxicology, ISSN: 15429733 15429741
Brian P. Enright; Barry S. McIntyre; Evan A Thackaberry; Kimberley A. Treinen; Stephan J. Kopytek
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