Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10101 - 10150 OF 16481 RESULTS

Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors
Clinical Cancer Research, ISSN: 10780432
William P. Tew; Michael S. Gordon; John Murren; Jakob Dupont; Sandra Pezzulli; Carol Aghajanian; Paul Sabbatini; David Mendelson; Lawrence Schwartz; Scott Gettinger; Amanda Psyrri; Jesse M. Cedarbaum; David R. Spriggs
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Immunization responses in rheumatoid arthritis patients treated with rituximab: Results from a controlled clinical trial
Arthritis and Rheumatism, ISSN: 00043591 15290131
Bingham; R. John Looney; Deodhar; Neal Halsey; Maria Greenwald; Christine Codding; Benjamin L. Trzaskoma; Flavius Martin; Sunil Agarwal; Ariella Kelman
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A two-stage algorithm for designing phase I cancer clinical trials for two new molecular entities
Contemporary Clinical Trials, ISSN: 15517144
Zheng Su
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B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity
Annals of Neurology, ISSN: 15318249 03645134
Martin Weber; Thomas Prod'homme; Juan C. Patarroyo; Nicolas Molnarfi; Tara Karnezis; Klaus Lehmann-Horn; Dimitry Danilenko; Jeffrey Eastham-Anderson; Anthony J. Slavin; Christopher Linington; Claude C.A. Bernard; Flavius Martin; Scott S. Zamvil
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The conserved bardet-biedl syndrome proteins assemble a coat that traffics membrane proteins to Cilia
Cell, ISSN: 00928674
Hua Jin; Susan Roehl White; Toshinobu Shida; Stefan Schulz; Mike Aguiar; Steven P. Gygi; J.Fernando Bazan; Maxence V. Nachury
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Pharmaceutical medical information contact centers: Results of three benchmarking surveys
Drug Information Journal, ISSN: 00928615
Pete Guillot; Stacey M. Fung
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Cancer: MiRNA addiction - Depending on life's little things
Current Biology, ISSN: 09609822
David Dornan; Jeffrey Settleman
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A generic headspace GC method for residual solvents in pharmaceuticals: Benefits, rationale, and adaptations for new chemical entities
LCGC North America, ISSN: 15275949
Lulu Dai; Amanda C. Quiroga; Kelly Zhang; Heather B. Runes; Derrick T. Yazzie; Kavita Mistry; Nik P. Chetwyn; Michael W. Dong
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An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Satish K. Singh; Nataliya Afonina; Michel Awwad; Karoline Bechtold-Peters; Jeffrey T. Blue; Danny Chou; Cromwell; Hans-Juergen Krause; Hanns-Christian Mahler; Brian K. Meyer; Linda O. Narhi; Doug P. Nesta; Thomas Spitznagel
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Single-use technology and its carbon and water footprints, part 2: "Bioreactors - To be or not to be: That is the question"
American Pharmaceutical Review, ISSN: 10998012
Lindsay Leveen
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Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model
British Journal of Dermatology, ISSN: 13652133 00070963
Wang; Fujita; Prado; Tousson; Hsu; Arndt J Schottelius; Kelly; Yang; Wu; Chen; Xu; Elmets; Mountz; Edwards Iii
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Pharmaceutical Medical Information Contact Centers: Results of Three Benchmarking Surveys
Therapeutic Innovation and Regulatory Science, ISSN: 21684790
Pete Guillot; Stacey M. Fung
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Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data.
BMC Cancer, ISSN: 14712407
Erich P. Huang; Jane Fridlyand; Nicholas Lewin-Koh; Peng Yue; Xiaoyan Shi; David Dornan; Bart Burington
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Targeting inhibitor of apoptosis (IAP) proteins in cancer
Apoptosis: Modern Insights into Disease from Molecules to Man,
Eugene Varfolomeev; Domagoj Vucic
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Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture
PLoS Computational Biology, ISSN: 15537358 1553734X
Ju Han; Hang Chang; Orsi Giricz; Genee Y. Lee; Frederick L. Baehner; Joe W. Gray; Mina J. Bissell; Paraic A. Kenny; Bahram Parvin
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Foreword
Separation Science and Technology, ISSN: 15205754 01496395
James M. van Alstine; Philip M. Lester
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Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia
Journal of Immunology, ISSN: 15506606 00221767
Lamkanfi; Anasuya Sarkar; Vande Walle; Alberto C. Vitari; Amal O. Amer; Mark D. Wewers; Kevin J. Tracey; Thirumala-Devi Kanneganti; Vishva M. Dixit
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Robust preparation of novel imidazo[5,1-b][1,3,4]oxadiazoles
Organic and Biomolecular Chemistry, ISSN: 14770520
Tuan P. Tran; Nandini C. Patel; Brian Samas; Jacob B. Schwarz
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Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
Journal of Experimental Medicine, ISSN: 00221007 15409538
Melba Muñoz; Markus Heimesaat; Kerstin Danker; Daniela Struck; Uwe Lohmann; Rita Plickert; Stefan Bereswill; André Fischer; Ildikò Rita Dunay; Kerstin Wolk; Christoph Loddenkemper; Hans-Willi Krell; Claude Libert; Leif R. Lund; Oliver Frey; Christoph Hölscher; Yoichiro Iwakura; Nico Ghilardi; Wenjun Ouyang; Thomas Kamradt; Robert Sabat; Oliver Liesenfeld
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Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Bing Li; Hongkang Xi; Laurie Diehl; Wyne P. Lee; Lizette Sturgeon; Jason Chinn; Laura DeForge; Robert F. Kelley; Wiesmann; Menno Van Lookeren Campagne; Sachdev S. Sidhu
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Interlaced size exclusion liquid chromatography of monoclonal antibodies
Journal of Chromatography A, ISSN: 00219673
Dell Farnan; G. Tony Moreno; Stults; Andreas Becker; Guillaume Tremintin; Mark van Gils
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Cutting edge: Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
Journal of Immunology, ISSN: 00221767 15506606
Kim; Katharina Lahl; Shohei Hori; Christoph Loddenkemper; Ashutosh Chaudhry; Paul DeRoos; Alexander Y. Rudensky; Tim Sparwasser
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IL-23 is required for protection against systemic infection with Listeria monocytogenes
Journal of Immunology, ISSN: 00221767 15506606
Karen D. Meeks; Amy N. Sieve; Jay K. Kolls; Nico Ghilardi; Rance E. Berg
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X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eugene Varfolomeev; Bruno Alicke; J. Michael Elliott; Zobel; Kristina West; Harvey Wong; Justin M. Scheer; Avi Ashkenazi; Stephen Gould; Wayne J. Fairbrother; Domagoj Vucic
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Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody
Structure, ISSN: 09692126
Rajkumar Ganesan; Eigenbrot; Yan Wu; Wei-Ching Liang; Steven Shia; Michael T. Lipari; Daniel Kirchhofer
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Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation
Cancer Cell, ISSN: 15356108
Bijay S. Jaiswal; Vasantharajan Janakiraman; Noelyn Kljavin; Subhra Chaudhuri; Howard M. Stern; Weiru Wang; Zhengyan Kan; Hashem A. Dbouk; Brock A. Peters; Waring; Trisha Dela Vega; Denise M. Kenski; Krista K. Bowman; Maria N. Lorenzo; Hong Li; Jiansheng Wu; Zora Modrusan; Stinson; Mike Eby; Peng Yue; Joshua S. Kaminker; Frederic J. De Sauvage; Jonathan M. Backer; Somasekar Seshagiri
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Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy
Breast Cancer Research, ISSN: 14655411 1465542X
Nancy Dumont; Yongping Crawford; Mahvash Sigaroudinia; Shefali S. Nagrani; Matthew B. Wilson; Gertrude C. Buehring; Gulisa Turashvili; Samuel A. Aparicio; Mona L. Gauthier; Colleen A. Fordyce; Kimberly M. McDermott; Thea D. Tlsty
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Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2
Molecular Pharmaceutics, ISSN: 15438384 15438392
Henriette E. Meyer Zu Schwabedissen; Joseph A. Ware; Rommel G. Tirona; Richard B. Kim
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Transport-metabolism interplay
Molecular Pharmaceutics, ISSN: 15438384 15438392
Laurent Salphati
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Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Martin L. Sos; Stefanie Fischer; Roland Ullrich; Martin Peifer; Johannes M. Heuckmann; Mirjam Koker; Stefanie Heynck; Isabel Stückrath; Jonathan Weiss; Florian Fischer; Kathrin Michel; Aviva Goel; Lucia Regales; Katerina Politi; Samanthi Perera; Matthäus Getlik; Lukas C. Heukamp; Sascha Ansén; Thomas Zander; Rameen Beroukhim; Hamid Kashkar; Kevan Shokat; William R. Sellers; Daniel Rauh; Christine Orr; Klaus P. Hoeflich; Lori S. Friedman; Kwok-Kin Wong; William Pao; Roman K. Thomas
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Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells
Carcinogenesis, ISSN: 01433334 14602180
Cho S. Aung; Weilan Ye; Greg D. Plowman; Amelia A. Peters; Gregory R. Monteith; Sarah J. Roberts-Thomson
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Identification of codon-specific serine to asparagine mistranslation in recombinant monoclonal antibodies by high-resolution mass spectrometry
Analytical Chemistry, ISSN: 00032700
X. Christopher Yu; Oleg V. Borisov; Melissa Alvarez; David A. Michels; Yajun Jennifer Wang; Victor Ling
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The effects of paroxetine on the pharmacokinetics of paliperidone extended-release tablets
Pharmacopsychiatry, ISSN: 01763679 14390795
Berwaerts; Cleton; Herben; I. Van De Vliet; Chang; P. Van Hoek; Eerdekens
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Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies
Trends in Pharmacological Sciences, ISSN: 01656147
Yongping Crawford; Napoleone Ferrara
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Unison: An integrated platform for computational biology discovery
Pacific Symposium on Biocomputing 2009, PSB 2009,
Reece K. Hart; Kiran Mukhyala
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Bi-directional SIFT predicts a subset of activating mutations
PLoS ONE, ISSN: 19326203
William Lee; Yan Zhang; Kiran Mukhyala; Lazarus; Zemin Zhang
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Formulation and manufacturability of biologics
Current Opinion in Biotechnology, ISSN: 09581669
Steven J. Shire
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VEGF-A: A critical regulator of blood vessel growth
European Cytokine Network, ISSN: 11485493
Napoleone Ferrara
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Protease expression colocalizes to regions of abdominal aortic expansion and stiffening in a murine aneurysm model
Proceedings of the ASME Summer Bioengineering Conference, SBC2008,
Craig J. Goergen; Dara Y. Kallop; Charles A. Taylor; Robby M. Weimer; Joan M. Greve
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Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear Viscosity of monoclonal antibodies under shear
Pharmaceutical Development and Technology, ISSN: 10837450 10979867
Thomas W. Patapoff; Osigwe Esue
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Safety of biological therapies following rituximab treatment in rheumatoid arthritis patients
Annals of the Rheumatic Diseases, ISSN: 00034967 14682060
Mark C. Genovese; Ferdinand Breedveld; Paul Emery; Stanley B. Cohen; Edward Keystone; Matteson; Baptiste; Akiko Chai; Laura Burke; William Reiss; Marianne Sweetser; Tim Shaw
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Recovery from hind limb ischemia is less effective in type 2 than in type 1 diabetic mice: Roles of endothelial nitric oxide synthase and endothelial progenitor cells
Journal of Vascular Surgery, ISSN: 07415214
Jinglian Yan; Guodong Tie; Brian Park; Yagai Yang; Philip T. Nowicki; Louis M. Messina
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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Haiyan Wu; Chandra Shekar; Rory J. Flinn; Mirvat El-Sibai; Bijay S. Jaiswal; K. Ilker Sen; Vasantharajan Janakiraman; Somasekar Seshagiri; Gary J. Gerfen; Mark E. Girvin; Jonathan M. Backer
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Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro
Molecular Biology of the Cell, ISSN: 10591524
Gyu-Un Bae; Youn-Joo Yang; Guoying Jiang; Mingi Hong; Hye-Jin Lee; Marc Tessier-Lavigne; Jong-Sun Kang; Robert S. Krauss
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Generation of an OMgp allelic series in mice
Genesis, ISSN: 1526954X 1526968X
Jae K. Lee; Lauren C Case; Andrea F. Chan; Yuhong Zhu; Marc Tessier-Lavigne; Binhai Zheng
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Foreword
Recent Advances in Angiogenesis and Antiangiogenesis,
Napoleone Ferrara
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Macrophage metalloelastase: Stretching therapeutic opportunities
Journal of Molecular Cell Biology, ISSN: 16742788 17594685
Jeannie Q. He; Menno Van Lookeren Campagne
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The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation
Nature Structural and Molecular Biology, ISSN: 15459993 15459985
Stephen Tam; Christoph Spiess; William Auyeung; Lukasz Joachimiak; Bryan Chen; Michelle A. Poirier; Judith Frydman
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SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
Molecular Cancer Therapeutics, ISSN: 15357163
Sean G. Buchanan; Jorg Hendle; Patrick S. Lee; Christopher R. Smith; Pierre-Yves Bounaud; Katti A. Jessen; Crystal M. Tang; Nanni H. Huser; Jeremy D. Felce; Karen J. Froning; Marshall C. Peterman; Brandon E. Aubol; Steve F. Gessert; J. Michael Sauder; Kenneth D. Schwinn; Marijane Russell; Isabelle A. Rooney; Jason Adams; Barbara C. Leon; Tuan H. Do; Jeff Blaney; Paul A. Sprengeler; Devon A. Thompson; Lydia Smyth; Laura A. Pelletier; Shane Atwell; Kevin Holme; Stephen R. Wasserman; Spencer Emtage; Stephen K. Burley; Siegfried H. Reich
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Correlation between aortic motion and vessel bulging in a murine aneurysm model using small animal magnetic resonance imaging
Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009,
Craig J. Goergen; Gilwoo Choi; Maj Hedehus; Charles A. Taylor; Philip S. Tsao; Joan M. Greve
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