Genentech: Publications

January 1, 2019

Disposable bioreactors

Comprehensive Biotechnology,

Oosterhuis; Terry Hudson; Alberto D’Avino; Zijlstra; Ashraf Amanullah

January 1, 2019

Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study

Nature Methods, ISSN: 15491676 15491277

Michael Wainberg; Anubha Mahajan; Anshul Kundaje; Mark I. McCarthy; Erik Ingelsson; Nasa Sinnott-Armstrong; Manuel Rivas

View on Scopus

January 1, 2019

Cisplatin Ineligibility for Patients with Metastatic Urothelial Carcinoma: A Survey of Clinical Practice Perspectives among US Oncologists

Bladder Cancer, ISSN: 23523735 23523727

Matthew D. Galsky; Esprit Ma; Bijal Shah-Manek; Rosalina Mills; Long Ha; Craig Krebsbach; Eric Blouin; Darren Tayama; Sarika Ogale

View on Scopus

January 1, 2019

Healthcare costs of potential glucocorticoid-associated adverse events in patients with giant cell arteritis

ClinicoEconomics and Outcomes Research, ISSN: 11786981

Jennie Best; Amanda M. Kong; David Smith; Ibrahim Abbass; Margaret Michalska

View on Scopus

January 1, 2019

Phase i Study of DSTP3086S, an antibody-drug conjugate targeting six-transmembrane epithelial antigen of prostate 1, in metastatic castration-resistant prostate cancer

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Daniel C. Danila; Russell Z. Szmulewitz; Ulka Vaishampayan; Celestia S. Higano; Ari Baron; Houston N. Gilbert; Flavia Brunstein; Marija Milojic-Blair; Wang; Omar Kabbarah; Michael Mamounas; Bernard M. Fine; Daniel Maslyar; Alexander Ungewickell; Scher

View on Scopus

January 1, 2019

Immunoaffinity LC-MS/MS to quantify a PEGylated anti-Factor D Fab biotherapeutic in cynomolgus monkey serum

Bioanalysis, ISSN: 17576199 17576180

Luna Liu; Yanqiu Liu; Lu Dai; Cinzia Stella; Morse Faria; Junlong Shao; Jamie L Hicks; Diego F. Cortes; William R. Mylott; Eric Wakshull; Surinder Kaur; Keyang Xu

View on Scopus

January 1, 2019

2019 White Paper on Recent Issues in Bioanalysis: FDA BMV Guidance, ICH M10 BMV Guideline and Regulatory Inputs (Part 2-Recommendations on 2018 FDA BMV Guidance, 2019 ICH M10 BMV Draft Guideline and Regulatory Agencies' Input on Bioanalysis, Biomarkers and Immunogenicity)

Bioanalysis, ISSN: 17576199 17576180

Brian Booth; Lauren Stevenson; Renuka Pillutla; Michael H. Buonarati; Chris Beaver; Daniela Fraier; Fabio Garofolo; Sam Haidar; Rafiqul Islam; Christopher James; John Kadavil; Olga Kavetska; Li; Christina Satterwhite; Natasha Savoie; Sriram Subramaniam; Nilufer Tampal; Theingi Thway; Eric Woolf; Olivier Le Blaye; Matthew Andisik; Chad Briscoe; Stephanie Cape; Arindam Dasgupta; Saloumeh Kadkhodayan Fischer; Roger Hayes; John Kamerud; Gustavo Mendes Lima Santos; Corey Nehls; Catherine Soo; Stephen Vinter; Emma Whale; Keyang Xu; Seongeun Julia Cho; Anna Edmison; Sean Kassim; Thais Correa Rocha; Jan Welink; Shashi Amur; Abbas Bandukwala; Elana Cherry; Shirley Hopper; Akiko Ishii-Watabe; Susan Kirshner; Kevin Maher; Joao Pedras-Vasconcelos; Yoshiro Saito; Therese Solstad Saunders; Venke Skibeli; Verthelyi; Yow-Ming C. Wang; Haoheng Yan

View on Scopus

January 1, 2019

2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3-Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62)

Bioanalysis, ISSN: 17576199 17576180

Steven Piccoli; Devangi Mehta; Alessandra Vitaliti; John Allinson; Shashi Amur; Steven Eck; Cherie Green; Michael Hedrick; Shirley Hopper; Allena Ji; Alison Joyce; Virginia Litwin; Kevin Maher; Joel Mathews; Kun Peng; Afshin Safavi; Yow-Ming C. Wang; Yan Zhang; Lakshmi Amaravadi; Nisha Palackal; Sai Thankamony; Chris Beaver; Eris Bame; Thomas Emrich; Grimaldi; Jonathan Haulenbeek; Vellalore Kakkanaiah; David Lanham; Andrew Mayer; Paul C Trampont; Laurent Vermet; Naveen Dakappagari; Catherine Aversa Fleener; Fabio Garofolo; Cynthia Rogers; Shabnam Tangri; Yuanxin Xu; Meina Liang; Manoj Rajadhyaksha; Susan Richards; Becky Schweighardt; Shobha Purushothama; Daniel Baltrukonis; Jochen Brumm; Elana Cherry; Jason Delcarpini; Carol Gleason; Susan Kirshner; Robert J Kubiak; Luying Pan; Michael A. Partridge; Joao Pedras-Vasconcelos; Qiang Qu; Venke Skibeli; Therese Solstad Saunders; Roland F Staack; Kay Stubenrauch; Albert Torri; Verthelyi; Haoheng Yan; Boris Gorovits; Rachel Palmer; Milton; Brian Long; Bart Corsaro; Vahid Farrokhi; Michele Fiscella; Neil Henderson; Vibha Jawa; Jim McNally; Rocio Murphy; Hanspeter Waldner; Tong-Yuan Yang

View on Scopus

January 1, 2019

2019 white paper on recent issues in bioanalysis: Chromatographic assays (part 1 - Innovation in small molecules and oligonucleotides & mass spectrometric method development strategies for large molecule bioanalysis)

Bioanalysis, ISSN: 17576199 17576180

Christine Fandozzi; Christopher Evans; Amanda Wilson; Dian Su; Melanie Anderson; Valerie Clausen; Lieve Dillen; Fabio Garofolo; Chris Holliman; Elliott Nickbarg; Timothy Olah; Ragu Ramanathan; Hui Zhang; Surinder Kaur; Renuka Pillutla; Hongbin Yu; Kevin Bateman; Lorella Di Donato; Shawna Hengel; Wenying Jian; Barry Jones; John Kellie; Anita Lee; Joe Palandra; Natasha Savoie; Petia Shipkova; Susan Spitz; Matthew Szapacs; Jian Wang; Katherine Wright; Jianing Zeng

View on Scopus

January 1, 2019

Microglia in Brain Development, Homeostasis, and Neurodegeneration

Annual Review of Genetics, ISSN: 15452948 00664197

Christopher J. Bohlen; Brad A. Friedman; Borislav Dejanovic; Morgan Sheng

View on Scopus

January 1, 2019

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer

Oncotarget, ISSN: 19492553

C. Andrew Boswell; Daniela Bumbaca Yadav; Eduardo E. Mundo; Shang-Fan Yu; Jennifer A. Lacap; Aimee Fourie-O’Donohue; Katherine R. Kozak; Gregory Z. Ferl; Crystal Zhang; Jason Ho; Sheila Ulufatu; Leslie A. Khawli; Kedan Lin

View on Scopus

January 1, 2019

Streamlined Characterization of an Antibody-Drug Conjugate by Two-Dimensional and Four-Dimensional Liquid Chromatography/Mass Spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Alexandre Goyon; Michael Kim; Lu Dai; Christopher Cornell; Fred Jacobson; Davy Guillarme; Cinzia Stella

View on Scopus

January 1, 2019

Immunogenicity of antibody-drug conjugates: Observations across 8 molecules in 11 clinical trials

Bioanalysis, ISSN: 17576199 17576180

Montserrat Carrasco-Triguero; Randall Dere; Marija Milojic-Blair; Ola M. Saad; Denise Nazzal; Kyu Hong; Surinder Kaur

View on Scopus

January 1, 2019

Evaluation of in-study cut points to enable appropriate interpretation of clinical immunogenicity results

Bioanalysis, ISSN: 17576199 17576180

Jochen Brumm; Kun Peng

View on Scopus

January 1, 2019

Cis -Selective synthesis of 1,3-disubstituted tetrahydro-β-carbolines from N -sulfonyl N, S -acetals

Organic and Biomolecular Chemistry, ISSN: 14770520

Shao-Xiong Luo; Yanzhou Liu; Michael J. Lambrecht; Daniel F. Ortwine; Antonio G. DiPasquale; Jun Liang; Xiaojing Wang; Jason R. Zbieg; Jun Li

View on Scopus

January 1, 2019

Imaging patients with metastatic castration-resistant prostate cancer using 89Zr-DFO-MSTP2109A anti-STEAP1 antibody

Journal of Nuclear Medicine, ISSN: 2159662X 01615505

Jorge A. Carrasquillo; Bernard M. Fine; Neeta Pandit-Taskar; Steven M. Larson; Stephen E. Fleming; Josef J. Fox; Sarah M. Cheal; Joseph A. O’Donoghue; Shutian Ruan; Govind Ragupathi; Serge K. Lyashchenko; John L. Humm; Scher; Mithat Gonen; Simon P. Williams; Daniel C. Danila; Michael J. Morris

View on Scopus

January 1, 2019

A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155

Molecular and Cellular Proteomics, ISSN: 15359484 15359476

Bushra Husain; Sree R. Ramani; Eugene Y. Chiang; Isabelle Lehoux; Sairupa Paduchuri; Tia A. Arena; Patel; Blair Wilson; Pamela Chan; Yvonne Franke; Athena W. Wong; Jennie R. Lill; Shannon J. Turley; Lino C. Gonzalez Jr.; Jane L. Grogan; Nadia Martinez-Martin

View on Scopus

January 1, 2019

Comparative effectiveness of first-line nab-paclitaxel versus paclitaxel monotherapy in triple-negative breast cancer

Journal of Comparative Effectiveness Research, ISSN: 20426313 20426305

Patricia Luhn; Chui; Angela Hsieh; Jingbo Yi; Almut Mecke; Preeti S. Bajaj; Waseem Hasnain; Adeline Falgas; Thanh G.N. Ton; Allison W. Kurian

View on Scopus

January 1, 2019

From Discovery to Market Readiness: The Research and Development of the β-Sparing Phosphatidylinositol 3-Kinase Inhibitor Taselisib

ACS Symposium Series, ISSN: 19475918 00976156

Remy Angelaud; Steven T. Staben; Timothy P. Heffron; Andreas M. Schuster; Frederic St-Jean

View on Scopus

January 1, 2019

Discovery and Development of the First Antibody-Antibiotic Conjugate Linker-Drug

ACS Symposium Series, ISSN: 19475918 00976156

Stefan G. Koenig; Thomas H. Pillow

View on Scopus

January 1, 2019

The Discovery of the Nav1.7 Inhibitor GDC-0276 and Development of an Efficient Large-Scale Synthesis

ACS Symposium Series, ISSN: 19475918 00976156

Andreas Stumpf; Daniel P. Sutherlin; Christoph Dehnhardt; Remy Angelaud

View on Scopus

January 1, 2019

Discovery and Development of Non-Covalent, Reversible Bruton's Tyrosine Kinase Inhibitor Fenebrutinib (GDC-0853)

ACS Symposium Series, ISSN: 19475918 00976156

James J. Crawford; Haiming Zhang

View on Scopus

January 1, 2019

Discovery of two highly divergent negative-sense RNA viruses associated with the parasitic nematode, Capillaria hepatica, in wild Mus musculus from New York City

Journal of General Virology, ISSN: 14652099 00221317

Simon H. Williams; Xiaoyu Che; Alexandra Oleynik; Joel A. Garcia; Dorothy Muller; Tanja S. Zabka; Cadhla Firth; Robert M. Corrigan; Thomas Briese; Komal Jain; W. Ian Lipkin

View on Scopus

January 1, 2019

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

Journal of Experimental Medicine, ISSN: 15409538 00221007

Quang T. Le; Jonathan J. Lyons; Andrea N. Naranjo; Ana Olivera; Lazarus; Dean D. Metcalfe; Joshua D. Milner; Lawrence B. Schwartz

View on Scopus

January 1, 2019

Investigating the impact of albumin on the liver uptake of pitavastatin and warfarin in nagase analbuminemic rats

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Jae H. Chang; Yi-Chen Chen; Jonathan Cheong; Robert S. Jones; Jodie Pang

View on Scopus

January 1, 2019

Physician characteristics associated with treatment initiation patterns in idiopathic pulmonary fibrosis

Chronic Respiratory Disease, ISSN: 14799731 14799723

Peter P. LaCamera; Susan L. Limb; Tmirah Haselkorn; Elizabeth A. Morgenthien; John L. Stauffer; Mark L. Wencel

View on Scopus

January 1, 2019

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

PLoS Biology, ISSN: 15457885 15449173

Vande Walle; Irma B. Stowe; Pavel Šácha; Bettina L. Lee; Dieter Demon; Amelie Fossoul; Filip Van Hauwermeiren; Pedro H.V. Saavedra; Petr Šimon; Vladimír Šubrt; Libor Kostka; Craig E. Stivala; Victoria Pham; Steven T. Staben; Sayumi Yamazoe; Jan Konvalinka; Nobuhiko Kayagaki; Lamkanfi

View on Scopus

January 1, 2019

Perspectives from the innovation and quality consortium induction working group on factors impacting clinical drug-drug interactions resulting from induction: Focus on cytochrome 3a substrates

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Diane Ramsden; Conrad Fung; Niresh Hariparsad; Jane R. Kenny; Michael A. Mohutsky; Neil Parrott; Sarah M. Robertson; Donald J. Tweedie

View on Scopus

January 1, 2019

Drug concentration asymmetry in tissues and plasma for small molecule-related therapeutic modalities

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Donglu Zhang; Cornelis E. Hop; Gabriela Patilea-Vrana; Gautham Gampa; Herana Kamal Seneviratne; Jashvant D. Unadkat; Jane R. Kenny; Karthik Nagapudi; Li Di; Lian Zhou; Mark Zak; Matthew Wright; Namandjé N. Bumpus; Richard Zang; Xingrong Liu; Yurong Lai; Cyrus Khojasteh

View on Scopus

January 1, 2019

Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody-drug conjugates

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Donglu Zhang; Aimee Fourie-O'Donohue; Peter Dragovich; Thomas H. Pillow; Jack D. Sadowsky; Katherine R. Kozak; Robert T. Cass; Liling Liu; Yuzhong Deng; Yichin Liu; Cornelis E. Hop; Cyrus Khojasteh

View on Scopus

January 1, 2019

Exposure-efficacy analysis of antibody-drug conjugates delivering an excessive level of payload to tissues

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Donglu Zhang; Peter Dragovich; Shang-Fan Yu; Yong Ma; Thomas H. Pillow; Jack D. Sadowsky; Dian Su; Wei Wang; Andrew G. Polson; Cyrus Khojasteh; Cornelis E. Hop

View on Scopus

January 1, 2019

Absence of pharmacokinetic interactions between the Bruton’s tyrosine kinase inhibitor fenebrutinib and methotrexate

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Nicholas Steven Jones; Helen Winter; Tamiko R. Katsumoto; Marilyn Florero; Elaine R. Murray; Helen Walker; Nand Singh; Leslie Chinn

View on Scopus

January 1, 2019

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

eLife, ISSN: 2050084X

Anna Shemorry; Jonathan M. Harnoss; Ofer Guttman; Scot A. Marsters; László Kömüves; David Lawrence; Avi Ashkenazi

View on Scopus

January 1, 2019

Pharmacokinetics of pertuzumab administered concurrently with trastuzumab in Chinese patients with HER2-positive early breast cancer

Anti-Cancer Drugs, ISSN: 14735741 09594973

Yang Luo; Wei Li; Zefei Jiang; Qingyuan Zhang; Liwei Wang; Yixiang Mao; Vivianne C G Tjan-Heijnen; Seock-Ah Im; Robin McConnell; Sara Bejarano; Fumagalli; José Bines; Wang; Amit Garg; Whitney P. Kirschbrown; Binghe Xu

View on Scopus

January 1, 2019

GDC-0810 pharmacokinetics and transporter-mediated drug interaction evaluation with an endogenous biomarker in the first-in-human, dose escalation study

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Kit Wun Kathy Cheung; Yoshida; Sravanthi Cheeti; Buyun Chen; Roland Morley; Iris Chan; Srikumar Sahasranaman; Lichuan Liu

View on Scopus

January 1, 2019

The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs

Life Science Alliance, ISSN: 25751077

Mattias Rydenfelt; Matthew Wongchenko; Bertram Klinger; Yibing Yan; Nils Blüthgen

View on Scopus

January 1, 2019

Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging

JCI insight, ISSN: 23793708

Denise P. Muñoz; Steven M. Yannone; Anneleen Daemen; Yu Sun; Funda Vakar-Lopez; Misako Kawahara; Adam M. Freund; Francis Rodier; Jennifer D. Wu; Pierre-Yves Desprez; David H. Raulet; Peter S. Nelson; Laura J. van't Veer; Judith Campisi; Jean-Philippe Coppé

View on Scopus

January 1, 2019

Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Advances in Therapy, ISSN: 18658652 0741238X

Marilyn K Glassberg; Steven D Nathan; Chin-Yu Lin; Elizabeth A. Morgenthien; John L. Stauffer; Willis Chou; Paul W. Noble

View on Scopus

January 1, 2019

A potent and effective suicidal listeria vaccine platform

Infection and Immunity, ISSN: 10985522 00199567

William G. Hanson; Erin L. Benanti; Edward E. Lemmens; Weiqun Liu; Justin Skoble; Meredith L. Leong; Chris S. Rae; Marcella Fassò; Dirk Brockstedt; Chen Chen; Daniel A. Portnoy; Thomas W. Dubensky; Peter Lauer

View on Scopus

January 1, 2019

CHAPTER 11: Duocarmycin-PBD Dimers as Antibody-Drug Conjugate (ADC) Payloads

RSC Drug Discovery Series, ISSN: 20413211 20413203

Thomas H. Pillow; Moana Tercel

View on Scopus

January 1, 2019

Carfilzomib is not an appropriate payload of antibody-drug conjugates due to rapid inactivation by lysosomal enzymes

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Yong Ma; Josefa Dela Cruz-Chuh; S. Cyrus Khojasteh; Peter Dragovich; Thomas H. Pillow; Donglu Zhang

View on Scopus

January 1, 2019

Early notch signals induce a pathogenic molecular signature during priming of alloantigen-specific conventional CD4+ T cells in graft-versus-host disease

Journal of Immunology, ISSN: 15506606 00221767

Jooho Chung; Vedran Radojcic; Eric Perkey; Timothy J. Parnell; Yashar Niknafs; Xi Jin; Ann Friedman; Nathalie Labrecque; Bruce R. Blazar; Todd V. Brennan; Christian W. Siebel; Ivan Maillard

View on Scopus

January 1, 2019

A clinically applicable gene-expression classifier reveals intrinsic and extrinsic contributions to consensus molecular subtypes in primary and metastatic colon cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Robert Piskol; Huw; Ismail Sergin; Christiaan Kljin; Zora Modrusan; Doris Kim; Noelyn Kljavin; Rachel Tam; Rajesh Patel; Jeremy B. Burton; Elicia M. Penuel; Xueping Qu; Koeppen; Teiko Sumiyoshi; Frederic J. De Sauvage; Lackner; Felipe de Sousa e Melo; Omar Kabbarah

View on Scopus

January 1, 2019

Semiautomated small-scale purification method for high-throughput expression analysis of recombinant proteins

Methods in Molecular Biology, ISSN: 19406029 10643745

Edward Kraft; Yvonne Franke; Katharine Heeringa; Stephanie K. Shriver; Inna Zilberleyb; Christine Kugel; Trisha Dela Vega; Athena W. Wong; Bobby Brillantes; Claudio Ciferri; George Dutina; Grace Lee; Isabelle Lehoux; Zhong Rong Li; Lee Lior-Hoffmann; Jiyoung Hwang; Chris Lonergan; Lynn Martin; Kyle Mortara; Lananh Nguyen; Jian Payandeh; Andrew Perez; Jun Sampang; Lovejit Singh; Kurt A. Schroeder; Christine Tam; Shu Ti; Ye Naing Win; Krista K. Bowman

View on Scopus

January 1, 2019

A flexible and scalable high-throughput platform for recombinant membrane protein production

Methods in Molecular Biology, ISSN: 19406029 10643745

Hui Xu; Thomas Clairfeuille; Christine C. Jao; Hoangdung Ho; Zachary K. Sweeney; Jian Payandeh; Christopher M. Koth

View on Scopus

January 1, 2019

High-throughput protein analysis using negative stain electron microscopy and 2D classification

Methods in Molecular Biology, ISSN: 19406029 10643745

Christopher P. Arthur; Claudio Ciferri

View on Scopus

January 1, 2019

Time-to-Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine-Citrulline-Monomethylauristatin E Antibody–Drug Conjugates

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Kagedal; Divya Samineni; Gillespie; Dan Lu; Bernard M. Fine; Sandhya Girish; Chunze Li; Jin Y. Jin

View on Scopus

January 1, 2019

Quantitative Comparison of Conventional and t-SNE-guided Gating Analyses

Frontiers in Immunology, ISSN: 16643224

Shadi Toghi Eshghi; Amelia Au-Yeung; Chikara Takahashi; Christopher R. Bolen; Maclean N. Nyachienga; Sean P. Lear; Cherie Green; William Mathews; William E. O'Gorman

View on Scopus

January 1, 2019

Effects of PI3K inhibition on afucosylated antibody-driven FcgRIIIa events and phospho-S6 activity in NK cells

Journal of Immunology, ISSN: 15506606 00221767

Valentina Romeo; Sarah Gierke; Kyle A. Edgar; Scot D. Liu

View on Scopus

January 1, 2019

Bioanalytical challenges in development of ultrasensitive Home Brew assays: A case study using IL-13

Bioanalysis, ISSN: 17576199 17576180

Gizette Sperinde; Martha Hokom; Kun Peng; Saloumeh Kadkhodayan Fischer

View on Scopus