Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4051 - 4100 OF 15650 RESULTS

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation
Cell Reports, ISSN: 22111247
Ryan Raisner; Samir Kharbanda; Lingyan Jin; Edwin Jeng; Emily Chan; Mark Merchant; Matthias Peter; Russell Bainer; Tommy K. Cheung; David Arnott; E. Megan Flynn; F. Anthony Romero; Steven Magnuson; Karen Gascoigne
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Reply to J.J. Tao et al
Journal of Clinical Oncology, ISSN: 15277755 0732183X
John Hainsworth; Funda Meric-Bernstam; Charles Swanton; Herbert Hurwitz; David Spigel; Christopher J. Sweeney; Howard A. Burris; Ron Bose; Bongin Yoo; Alisha Stein; Beattie; Razelle Kurzrock
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Scaffold-Hopping Approach to Discover Potent, Selective, and Efficacious Inhibitors of NF-ΰB Inducing Kinase
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Georgette M. Castanedo; Jason D. Burch; Leonid M. Berezhkovskiy; Hans D. Brightbill; Suzanne Brown; Connie Chan; Po-Chang Chiang; James J. Crawford; Teresa Dong; Peter W. Fan; Jianwen A. Feng; Nico Ghilardi; Robert Godemann; Emily Gogol; Alice Grabbe; Alison J. Hole; Baihua Hu; Sarah G. Hymowitz; Moulay Hicham Alaoui Ismaili; Hoa Le; Patrick Lee; Wyne P. Lee; Xingyu Lin; Ning Liu; Paul A. McEwan; Brent Mckenzie; Hernani L. Silvestre; Eric Suto; Swathi Sujatha-Bhaskar; Guosheng Wu; Lawren C. Wu; Yamin Zhang; Zoe Zhong; Steven T. Staben
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The Effect of Low Ionic Strength on Diffusion and Viscosity of Monoclonal Antibodies
Molecular Pharmaceutics, ISSN: 15438392 15438384
Mariya Pindrus; Steven J. Shire; Sandeep Yadav; Devendra S. Kalonia
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Novel markers to track oxidative polysorbate degradation in pharmaceutical formulations
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Sanket Dahotre; Anthony Tomlinson; Baiwei Lin; Sandeep Yadav
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Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease
Nephrology Dialysis Transplantation, ISSN: 14602385 09310509
Irfana Soomro; Ying Sun; Zhai Li; Lonnette Diggs; Georgia Hatzivassiliou; Ajit G. Thomas; Rana Rais; Slusher; Stefan Somlo; Edward Y. Skolnik
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Comments on assays used to measure VEGF in the presence of anti-VEGF therapeutics
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Eric Wakshull; Robert L. Avery; Mauricio Maia
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Validation of a plasma-based comprehensive cancer genotyping assay utilizing orthogonal tissue- and plasma-based methodologies
Clinical Cancer Research, ISSN: 15573265 10780432
Justin I. Odegaard; John J. Vincent; Stefanie Mortimer; James V. Vowles; Bryan C. Ulrich; Kimberly C. Banks; Stephen R. Fairclough; Oliver A. Zill; Marcin Sikora; Reza Mokhtari; Diana Abdueva; Rebecca J. Nagy; Christine E. Lee; Lesli A. Kiedrowski; Cloud P. Paweletz; Helmy Eltoukhy; Richard Lanman; Darya I. Chudova; Talasaz
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Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Xiaoxu Wang; Menno Van Lookeren Campagne; Kenneth J. Katschke Jr.; Damodar Gullipalli; Takashi Miwa; Yoshiyasu Ueda; Yuan Wang; Matthew Palmer; Guolan Xing; Wen-Chao Song
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Sustained Response Following Discontinuation of Methotrexate in Patients With Rheumatoid Arthritis Treated With Subcutaneous Tocilizumab: Results From a Randomized, Controlled Trial
Arthritis and Rheumatology, ISSN: 23265205 23265191
Joel M. Kremer; William F. Rigby; Nora G. Singer; Christine Birchwood; Darcy Gill; William Reiss; Jinglan Pei; Margaret Michalska
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Updated Efficacy Analysis Including Secondary Population Results for OAK: A Randomized Phase III Study of Atezolizumab versus Docetaxel in Patients with Previously Treated Advanced Non–Small Cell Lung Cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Louis Fehrenbacher; Joachim Von Pawel; Keunchil Park; Achim Rittmeyer; David R. Gandara; Santiago Ponce Aix; Ji-Youn Han; Shirish M. Gadgeel; Toyoaki Hida; Diego L Cortinovis; Manuel Cobo; Dariusz M Kowalski; Filippo De Marinis; Mayank Gandhi; Bradford Danner; Christina Matheny; Marcin Kowanetz; Pei He; Federico Felizzi; Hina Patel; Alan Sandler; Ballinger; Fabrice Barlesi
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Effect of pirfenidone on gastric emptying in a rat model
Pulmonary Pharmacology and Therapeutics, ISSN: 15229629 10945539
Lin Pan; Thomas R. Gelzleichter; Yuan Chen; Cindy Burg; Susan L. Limb; Linda Nguyen
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Prognostic and predictive biomarkers for patients with idiopathic pulmonary fibrosis treated with pirfenidone: post-hoc assessment of the CAPACITY and ASCEND trials
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Margaret Neighbors; Christopher R. Cabanski; Thirumalai R. Ramalingam; X Rebecca Sheng; Tew; Chunyan Gu; Guiquan Jia; Kun Peng; Jill M. Ray; Brett Ley; Paul J. Wolters; Harold R. Collard; Joseph R. Arron
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Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
Cell Death and Differentiation, ISSN: 14765403 13509047
Mable Lam; David Lawrence; Avi Ashkenazi; Peter Walter
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Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Digoxin in Patients With BRAFV600 Mutation–Positive Metastatic Malignancy
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Weijiang Zhang; Christine McIntyre; Melissa Kuhn; Harper Forbes; Kim; Jeeyun Lee; Lev Demidov; Dawn Colburn
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Corrigendum to ‘Effects of RG7652, a Monoclonal Antibody Against PCSK9, on Low-Density Lipoprotein Cholesterol (LDL-C), LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or with Established Coronary Heart Disease (From the Phase 2 EQUATOR Study)’ (The American Journal of Cardiology (2017) 119(10) (1576–1583), (S0002914917302060) (10.1016/j.amjcard.2017.02.020))
American Journal of Cardiology, ISSN: 18791913 00029149
Amos Baruch; Mosesova; John Davis; Nageshwar Budha; Alexandr Vilimovskij; Robert S. Kahn; Kun Peng; Kyra J. Cowan; Laura Pascasio Harris; Thomas R. Gelzleichter; Josh Lehrer; John C. Davis; Whittemore G. Tingley
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Alteplase for the treatment of acute ischemic stroke in patients with low National Institutes of Health Stroke Scale and not clearly disabling deficits (Potential of rtPA for Ischemic Strokes with Mild Symptoms PRISMS): Rationale and design
International Journal of Stroke, ISSN: 17474949 17474930
Sharon D. Yeatts; Joseph P. Broderick; Anjan Chatterjee; Edward C Jauch; Steven R. Levine; Jose G Romano; Jeffrey L. Saver; Achala Vagal; Barbara Purdon; Jenny Devenport; Pooja Khatri
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Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Amy Dressen; Abbas Alexander; Christopher R. Cabanski; Janina Reeder; Thirumalai R. Ramalingam; Margaret Neighbors; Tushar Bhangale; Matthew J. Brauer; Julie Hunkapiller; Jens Reeder; Kiran Mukhyala; Karen T. Cuenco; Jennifer A. Tom; Amy Cowgill; Jan Vogel; William F. Forrest; Harold R. Collard; Paul J. Wolters; Jonathan A Kropski; Lisa H Lancaster; Timothy S. Blackwell; Joseph R. Arron; Brian L. Yaspan
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Characterization and survival of patients with metastatic basal cell carcinoma in the Department of Veterans Affairs: a retrospective electronic health record review
Archives of Dermatological Research, ISSN: 1432069X 03403696
Vanessa W. Stevens; David D. Stenehjem; Olga V. Patterson; Kamauu; Yeun Mi Yim; Rob Morlock; Scott L. Duvall
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Phase I study of the anti-α5β1 monoclonal antibody MINT1526A with or without bevacizumab in patients with advanced solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Colin D. Weekes; Lee Rosen; Anna Capasso; Kit Man Wong; Weilan Ye; Maria Anderson; Bruce Mccall; Jill Fredrickson; Eric Wakshull; Stephen M. Eppler; Quyen Shon-Nguyen; Rupal Desai; Mahrukh Huseni; Priti Hegde; Tony Pourmohamad; Ina Rhee; Alberto Bessudo
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Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Navpreet Kaur; Ajit S. Narang; Arvind Kumar Bansal
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Adsorption of polysorbate 20 and proteins on hydrophobic polystyrene surfaces studied by neutron reflectometry
Colloids and Surfaces B: Biointerfaces, ISSN: 18734367 09277765
Zhenhuan Zhang; Sara Orski; Ann Marie Woys; Guangcui Yuan; Isidro E. Zarraga; Norman J. Wagner; Yun Liu
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Considerations for the Use of Polysorbates in Biopharmaceuticals
Pharmaceutical Research, ISSN: 1573904X 07248741
Michael T. Jones; Hanns-Christian Mahler; Sandeep Yadav; Dilbir Bindra; Vincent Corvari; R. Matthew Fesinmeyer; Kapil Gupta; Alexander M. Harmon; Kenneth D. Hinds; Atanas Koulov; Wei Liu; Kevin Maloney; John Wang; Ping Y. Yeh; Satish K. Singh
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In vitro assessment of chemotherapy-induced neuronal toxicity
Toxicology in Vitro, ISSN: 18793177 08872333
Chelsea Snyder; Lanlan Yu; Tin Ngo; Daniel Sheinson; Yuda Zhu; Min Tseng; Misner; Karin Staflin
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LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis
Science, ISSN: 10959203 00368075
Poffenberger; Metcalfe-Roach; Aguilar; Chen; Hsu; Wong; Johnson; Flynn; Samborska; Ma; Gravel; Tonelli; Devorkin; Kim; Hall; Izreig; Loginicheva; Beauchemin; Siegel; Maxim N. Artyomov; Julian J. Lum; Zogopoulos; Blagih; Jones
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Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines
Genome Medicine, ISSN: 1756994X
Petar Scepanovic; Cécile Alanio; Christian Hammer; Flavia Hodel; Jacob Bergstedt; Etienne Patin; Christian W. Thorball; Nimisha Chaturvedi; Bruno Charbit; Laurent Abel; Lluis Quintana-Murci; Darragh Duffy; Matthew L. Albert; Jacques Fellay; Andres Alcover; Hugues Aschard; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Odile Gelpi; Ivo Gomperts-Boneca; Milena Hasan; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Frédéric Tangy; Marie-Noëlle Ungeheuer; Kalla Astrom; Serge Hercberg; Mathilde Touvier; Olivier Lantz; Vassili Soumelis; Stanislas Pol; Antonio Rausell; Eric Tartour; Antoine Toubert
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Serum periostin levels following small bone fractures, long bone fractures and joint replacements: An observational study
Allergy, Asthma and Clinical Immunology, ISSN: 17101492 17101484
Rachel Varughese; Ruth Semprini; Claire Munro; James Fingleton; Cécile T.J. Holweg; Mark Weatherall; Beasley; Irene Braithwaite
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Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation
eLife, ISSN: 2050084X
Ryan Ferrao; Heidi J. A. Wallweber; Patrick J. Lupardus
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Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity
Journal of the American Chemical Society, ISSN: 15205126 00027863
Seung Wook Kim; Thomas Wurm; Gilmar A. Brito; Woo-Ok Jung; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische
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FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody-Drug Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Byoung-Chul Lee; Cecile Chalouni; Sophia Doll; Nalle; Martine Darwish; Siao Ping Tsai; Katherine R. Kozak; Geoffrey Del Rosario; Shang-Fan Yu; Hans Erickson; Richard L. Vandlen
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A model of overall survival predicts treatment outcomes with atezolizumab versus chemotherapy in non–small cell lung cancer based on early tumor kinetics
Clinical Cancer Research, ISSN: 15573265 10780432
Laurent Claret; Jin Y. Jin; Charles Ferte; Helen Winter; Sandhya Girish; Mark Stroh; Pei He; Ballinger; Alan Sandler; Amita Joshi; Achim Rittmeyer; David R. Gandara; Jean-Charles Soria; Rene Bruno
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Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing
JCI insight, ISSN: 23793708
Omar H. Maarouf; Mayuko Uehara; Vivek Kasinath; Zhabiz Solhjou; Naima Banouni; Baharak Bahmani; Liwei Jiang; Osman A. Yilmam; Indira Guleria; Scott B. Lovitch; Jane L. Grogan; Paolo Fiorina; Peter T. Sage; Jonathan S. Bromberg; Martina M. McGrath; Reza Abdi
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Palladium-Catalyzed Site-Selective Amidation of Dichloroazines
Organic Letters, ISSN: 15237052 15237060
Ian S. Young; Anna-Lena Glass; Theresa Cravillion; Chong Han; Haiming Zhang; Francis Gosselin
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OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Nature, ISSN: 14764687 00280836
Klaus D. Heger; Katherine E. Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Donald S. Kirkpatrick; Domagoj Vucic; Wyne P. Lee; Merone Roose-Girma; Robert J. Newman; Søren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva M. Dixit
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Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche
Nature, ISSN: 14764687 00280836
Ysbrand M. Nusse; Adam K. Savage; Pauline Marangoni; Axel K. M. Rosendahl-Huber; Tyler A. Landman; Frederic J. De Sauvage; Richard M. Locksley; Ophir D. Klein
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Interplay of DDP4 and IP-10 as a potential mechanism for cell recruitment to tuberculosis lesions
Frontiers in Microbiology, ISSN: 1664302X
Thomas Blauenfeldt; Linda Petrone; Franca del Nonno; Andrea Baiocchini; Laura Falasca; Teresa Chiacchio; Vincent Bondet; Valentina Vanini; Fabrizio Palmieri; Gianni Galluccio; Armanda Casrouge; Jesper Eugen-Olsen; Matthew L. Albert; Delia Goletti; Darragh Duffy; Morten Ruhwald
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Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC
mAbs, ISSN: 19420870 19420862
Isabel Figueroa; Douglas Leipold; Leong; Bing Zheng; Montserrat Triguero-Carrasco; Aimee Fourie-O'Donohue; Katherine R. Kozak; Keyang Xu; Melissa Schutten; Hong Wang; Andrew G. Polson; Amrita Kamath
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Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice
Frontiers in Immunology, ISSN: 16643224
Daxin Chen; Ke Li; El-Li Tham; Lin-Lin Wei; Ning Ma; Philippa C. Dodd; Yi Luo; Daniel Kirchhofer; John H. McVey; Anthony Dorling
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The Systemic Safety of Ranibizumab in Patients 85 Years and Older with Neovascular Age-Related Macular Degeneration
Kidney International Reports, ISSN: 24686530
Pravin U. Dugel; Natasha Singh; Steve Francom; Ronald A. Cantrell; Susanna M. Grzeschik; Anne E. Fung
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Vapor phase hydrogen peroxide decontamination or sanitization of an isolator for aseptic filling of monoclonal antibody drug product—hydrogen peroxide uptake and impact on protein quality
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Aaron Hubbard; Thomas Roedl; Ada Hui; Stephanie Knueppel; Kirk Eppler; Siegfried Lehnert; Maa
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Usability of the Ranibizumab 0.5 mg prefilled syringe: Human factors studies to evaluate critical task completion by healthcare professionals
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Andrew N. Antoszyk; Carl Baker; Jorge Calzada; Howard Cummings; Joanna; Carlos Quezada-Ruiz; Zdenka Haskova
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Implementation of plate imaging for demonstration of monoclonality in biologics manufacturing development
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Kyle Zingaro; David Shaw; Jerry Carson; Anke Mayer-Bartschmid; Christian Bender; Christina Alves; Duncan McVey; Nan-Xin Qian; Qingxiang Wei; Mike Laird; Yuan Zhu; Robyn Emmins; John A. Follit; Alison Porter; Andrew J. Racher; Sarah Milne; Ivan Carubelli; Zhimei; Ankita Khatri; Marilyne Failly; Hervé Broly; Frank Lee; Matthew Reeser; Jared Spidel; Karin Anderson; Christine Demaria; Jennifer Di-Carlo; John Gill; Amie Lundquist; Sampath R. Kumar; Tony Gill
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Determination of the acceptable ambient light exposure during drug product manufacturing for long-term stability of monoclonal antibodies
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Lin M. Luis; Yuzhe Hu; Camellia Zamiri; Alavattam Sreedhara
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Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage
Journal of the International AIDS Society, ISSN: 17582652
Mickaël J Ploquin; Armanda Casrouge; Yoann Madec; Nicolas Noel; Beatrice Jacquelin; Nicolas Huot; Darragh Duffy; Simon P Jochems; Luca Micci; Camille Lécuroux; Faroudy Boufassa; Thijs Booiman; Thalia Garcia-Tellez; Mathilde Ghislain; Roger Le Grand; Olivier Lambotte; Neeltje Kootstra; Laurence Meyer; Cecile Goujard; Mirko Paiardini; Matthew L. Albert; Michaela Muller-Trutwin
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New opportunities with quantification of protein therapeutics by LC-MS
Bioanalysis, ISSN: 17576199 17576180
Hendrik Neubert; Keyang Xu
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Mechanisms of acquired resistance to trastuzumab emtansine in breast cancer cells
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Guangmin Li; Jun Guo; Shen; Daniela Bumbaca; Mark X. Sliwkowski; Lisa Crocker; Jennifer A. Lacap; Gail L. Phillips
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Association of p27 and cyclin D1 expression and benefit from adjuvant trastuzumab treatment in HER2-positive early breast cancer: A TransHERA study
Clinical Cancer Research, ISSN: 15573265 10780432
Martin Filipits; Urania Dafni; Michael Gnant; Polydoropoulou; Margaret Hills; Astrid Kiermaier; Evandro De Azambuja; Denis Larsimont; Federico Rojo; Giuseppe Viale; Masakazu Toi; Nadia Harbeck; Kathleen I. Prichard; Richard D. Gelber; Phuong Dinh; Zardavas; Brian R. Leyland-Jones; Martine Piccart; Mitch Dowsett
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Cryo-EM in drug discovery: Achievements, limitations and prospects
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Jean-Paul Renaud; Ashwin Chari; Claudio Ciferri; Wen-Ti Liu; Hervé-William Rémigy; Holger Stark; Wiesmann
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Experience with host cell protein impurities in biopharmaceuticals
Biotechnology Progress, ISSN: 15206033 87567938
Vanderlaan; Judith Zhu-Shimoni; Sansan Lin; Feny Gunawan; Thomas Waerner; Kevin E. Van Cott
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Immune Characteristics of Chinese Diffuse Large B-Cell Lymphoma Patients: Implications for Cancer Immunotherapies
EBioMedicine, ISSN: 23523964
Peng-peng Xu; Chun Sun; Xu Cao; Xia Zhao; Hang-jun Dai; Shan Lu; Jian-jun Guo; Shi-jing Fu; Yu-xia Liu; Su-chun Li; Meng Chen; Mccord; Jeffrey M. Venstrom; Edith Szafer-Glusman; Elizabeth A. Punnoose; Astrid Kiermaier; Gang Cheng; Wei-li Zhao
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