Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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February 8, 2018

Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Binqing Wei; Janet Gunzner; Hui Yao; Tao Wang; Jing Wang; Zijin Xu; Jinhua Chen; John Wai; Jim Nonomiya; Siao Ping Tsai; Josefa Chuh; Katherine R. Kozak; Yichin Liu; Shang-Fan Yu; Jeffrey Lau; Guangmin Li; Gail L. Phillips; Douglas Leipold; Amrita Kamath; Dian Su; Keyang Xu; Eigenbrot; Stefan Steinbacher; Rachana Ohri; Helga Raab; Leanna Staben; Guiling Zhao; Flygare; Thomas H. Pillow; Vishal A. Verma; Luke Masterson; Philip W. Howard; Brian S. Safina

February 6, 2018

Grking the smoothened signal

Science Signaling, ISSN: 19379145 19450877

Hayley J. Sharpe; Frederic J. De Sauvage

February 6, 2018

Ocrelizumab: A New Therapeutic Paradigm for Multiple Sclerosis

Biochemistry, ISSN: 15204995 00062960

Peter Chin; Andrew A. Chan

February 6, 2018

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

eLife, ISSN: 2050084X

Daniel J. Fazakerley; Rima Chaudhuri; Pengyi Yang; Ghassan J. Maghzal; Kristen C. Thomas; James R. Krycer; Sean J. Humphrey; Benjamin L. Parker; Kelsey H. Fisher-Wellman; Christopher C. Meoli; Nolan J. Hoffman; Ciana Diskin; James G. Burchfield; Mark J. Cowley; Warren Kaplan; Zora Modrusan; Ganesh Kolumam; Yang; Daniel L. Chen; Samocha-Bonet; Greenfield; Kyle L. Hoehn; Roland Stocker; David E. James

February 1, 2018

Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: New evidence from real-world data

Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172

Sanjoy Ketan Paul; Olga Montvida; Jennie Best; Sara Gale; Attila Pethoe-Schramm; Khaled Sarsour

February 1, 2018

Curvature of designed armadillo repeat proteins allows modular peptide binding

Journal of Structural Biology, ISSN: 10958657 10478477

Simon Hansen; Patrick Ernst; Sebastian L.B. König; Christian Reichen; Christina Ewald; Daniel Nettels; Peer R. E. Mittl; Benjamin Schuler; Pluckthun

February 1, 2018

Response to omalizumab using patient enrichment criteria from trials of novel biologics in asthma

Allergy: European Journal of Allergy and Clinical Immunology, ISSN: 13989995 01054538

Thomas B. Casale; Bradley E. Chipps; Karin Rosén; Benjamin L. Trzaskoma; Tmirah Haselkorn; Theodore A. Omachi; Greenberg; Nicola A. Hanania

February 1, 2018

Does site-of-care for oncology infusion therapy influence treatment patterns, cost, and quality in the United States?

Journal of Medical Economics, ISSN: 1941837X 13696998

Sari Hopson; Adrianne Casebeer; Stephen Stemkowski; Dana Drzayich Antol; Zhuliang Tao; Andrew Howe; Jeffrey Patton; Art Small; Anthony Masaquel

February 1, 2018

Comparison of platform host cell protein ELISA to process-specific host cell protein ELISA

Biotechnology and Bioengineering, ISSN: 10970290 00063592

Feny Gunawan; Julie C. Nishihara; Peter S. Liu; Wendy N. Sandoval; Vanderlaan; Heidi Zhang; Denise C. Krawitz

February 1, 2018

The Use of a 2,2'-Azobis (2-Amidinopropane) Dihydrochloride Stress Model as an Indicator of Oxidation Susceptibility for Monoclonal Antibodies

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Michelle Z. Dion; Y. John Wang; Daniel Bregante; Wayman Chan; Nisana Andersen; Amy Hilderbrand; Danielle L. Leiske; Cleo M. Salisbury

February 1, 2018

Correction to: Population pharmacokinetics of trastuzumab emtansine in previously treated patients with HER2-positive advanced gastric cancer (AGC) (Cancer Chemotherapy and Pharmacology, (2017), 80, 6, (1147-1159), 10.1007/s00280-017-3443-1)

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Shang-Chiung Chen; Kagedal; Yuying Gao; Wang; Marie-Laurence Harle-Yge; Sandhya Girish; Jin Y. Jin; Chunze Li

February 1, 2018

A short field guide to fibroblast function in immunity

Seminars in Immunology, ISSN: 10963618 10445323

Matthew B. Buechler; Shannon J. Turley

February 1, 2018

Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Jinze Li; Eric Morinello; Thomas Larsen; Denzil Frost; Ivor Caro; Stephen Gould; Lisa Wong; Angela Hendricks; Noel Dybdal; Donna M. Dambach; Melissa Schutten

February 1, 2018

Leveraging Humanized Animal Models to Understand Human Drug Disposition: Opportunities, Challenges, and Future Directions

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Edna F. Choo; Laurent Salphati

February 1, 2018

Pharmacokinetics and exposure-response analysis of RG7667, a combination of two anticytomegalovirus monoclonal antibodies, in a phase 2a randomized trial to prevent cytomegalovirus infection in high-risk kidney transplant recipients

Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804

Rong Deng; Yehong Wang; Mauricio Maia; Tracy Burgess; Jacqueline McBride; X. Charlene Liao; Jorge A. Tavel; William D. Hanley

February 1, 2018

Dual Effect of Histidine on Polysorbate 20 Stability: Mechanistic Studies

Pharmaceutical Research, ISSN: 1573904X 07248741

Lin Zhang; Sandeep Yadav; John Wang; Olivier Mozziconacci; Christian Schöneich

February 1, 2018

Transporter expression in noncancerous and cancerous liver tissue from donors with hepatocellular carcinoma and chronic hepatitis C infection quantified by LC-MS/MS proteomics

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Sarah Billington; Adrian S. Ray; Laurent Salphati; Guangqing Xiao; Xiaoyan Chu; W. Griffith Humphreys; Mingxiang Liao; Caroline A. Lee; Anita Mathias; Cornelis E. Hop; Christopher Rowbottom; Raymond Evers; Yurong Lai; Edward J. Kelly; Bhagwat Prasad; Jashvant D. Unadkat

February 1, 2018

Effect of Microenvironmental pH Modulation on the Dissolution Rate and Oral Absorption of the Salt of a Weak Acid – Case Study of GDC-0810

Pharmaceutical Research, ISSN: 1573904X 07248741

Hao Helen Hou; Wei Jia; Lichuan Liu; Sravanthi Cheeti; Jane Li; Ewa Nauka; Karthik Nagapudi

February 1, 2018

SUV420H2 is an epigenetic regulator of epithelial/ mesenchymal states in pancreatic cancer

Journal of Cell Biology, ISSN: 15408140 00219525

Manuel Viotti; Catherine Wilson; Mark L. McCleland; Koeppen; Benjamin Haley; Suchit Jhunjhunwala; Christiaan N. Klijn; Zora Modrusan; David Arnott; Marie Classon; Jean-Philippe Stephan; Ira Mellman

February 1, 2018

Microglia in Alzheimer's disease

Journal of Cell Biology, ISSN: 15408140 00219525

David V. Hansen; Jesse E. Hanson; Morgan Sheng

February 1, 2018

Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: Results from the open-label period of a phase II randomised controlled trial (faSScinate)

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Dinesh Khanna; Christopher P. Denton; Celia J.F. Lin; Jacob M. Van Laar; Tracy M. Frech; Marina E. Anderson; Murray Baron; Lorinda Chung; Gerhard Fierlbeck; Santhanam Lakshminarayanan; Yannick Allanore; Janet E. Pope; Gabriela Riemekasten; Virginia D. Steen; Ulf Müller-Ladner; Helen Spotswood; Laura Burke; Jeffrey N. Siegel; Angelika Jahreis; Daniel E. Furst

February 1, 2018

Racial and Ethnic Composition of Cancer Clinical Drug Trials: How Diverse Are We?

Oncologist, ISSN: 1549490X 10837159

Leslie Dickmann; Jennifer L. Schutzman

February 1, 2018

Polarized trafficking: the palmitoylation cycle distributes cytoplasmic proteins to distinct neuronal compartments

Current Opinion in Cell Biology, ISSN: 18790410 09550674

Elena Tortosa; Casper C Hoogenraad

February 1, 2018

Engineered cysteine antibodies: An improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability

Protein Engineering, Design and Selection, ISSN: 17410134 17410126

Sussman; Westendorf; Meyer; Leiske; Anderson; Okeley; Stephen C. Alley; Lyon; Sanderson; Paul J. Carter; Benjamin

February 1, 2018

IFN-stimulated gene expression, type 2 inflammation, and endoplasmic reticulum stress in asthma

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Nirav R. Bhakta; Stephanie Christenson; Srilaxmi Nerella; Owen D. Solberg; Christine Nguyen; David F. Choy; Kyle L. Jung; Suresh Garudadri; Luke R. Bonser; Joshua L. Pollack; Lorna T. Zlock; David J. Erle; Charles Langelier; Joseph L. Derisi; Joseph R. Arron; John V. Fahy; Prescott G. Woodruff

February 1, 2018

Peak purity in liquid chromatography, part 1: Basic concepts, commercial software, and limitations

LC-GC Europe, ISSN: 14716577

Sarah C. Rutan; Venkatramani; Dwight R. Stoll

February 1, 2018

Clinicopathologic Correlation of Anti–Vascular Endothelial Growth Factor–Treated Type 3 Neovascularization in Age-Related Macular Degeneration

Ophthalmology, ISSN: 15494713 01616420

Miaoling Li; Rosa Dolz-Marco; Jeffrey D. Messinger; Lan Wang; Richard M. Feist; Christopher A. Girkin; Sarra Gattoussi; Daniela Ferrara; Christine A. Curcio; K. Bailey Freund

January 31, 2018

Amphiphilic π-Allyliridium C,O-Benzoates Enable Regio- and Enantioselective Amination of Branched Allylic Acetates Bearing Linear Alkyl Groups

Journal of the American Chemical Society, ISSN: 15205126 00027863

Arismel Tena Meza; Thomas Wurm; Lewis Smith; Seung Wook Kim; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische

January 30, 2018

DEM based computational model to predict moisture induced cohesion in pharmaceutical powders

International Journal of Pharmaceutics, ISSN: 18733476 03785173

Raj Mukherjee; Chen Mao; Sayantan Chattoraj; Bodhisattwa Chaudhuri

January 30, 2018

Trace level determination of chloroacetyl chloride and degradation products by derivatization gas chromatography

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Marie-France Morissette; Larry Wigman; Jerry Tso

January 30, 2018

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors

Breast Cancer Research, ISSN: 1465542X 14655411

Anneleen Daemen; Gerard Manning

January 26, 2018

Process Design for Bispecific Antibodies

Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes,

Ambrose Jon Williams; Glen Giese; Andreas Schaubmar; Thomas von Hirschheydt

January 26, 2018

Post-Licensure Purification Process Improvements for Therapeutic Antibodies: Current and Future States

Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes,

Kelley; Annika Kleinjans; Philip M. Lester

January 23, 2018

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Tania Chernov-Rogan; Tianbo Li; Gang Lu; Henry Verschoof; Kuldip Khakh; Steven W Jones; Beresini; Chang Liu; Daniel F. Ortwine; Steven J. McKerrall; David Hackos; Daniel P. Sutherlin; Charles J. Cohen; Jun Chen

January 20, 2018

Reply to M. Mo et al

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Manish A. Shah; Luis A. Herráez-Baranda; Amit Garg; Tabernero

January 19, 2018

Molecular characterization of human anti-hinge antibodies derived from single-cell cloning of normal human B cells

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Tao Huang; Mary Mathieu; Sophia Lee; Xinhua Wang; Yee Seir Kee; Jack Bevers; Claudio Ciferri; Alberto Estavez; Manda Wong; Nancy Y. Chiang; Nakamura; Randall J. Brezski

January 16, 2018

Monoclonal Antibody Interfaces: Dilatation Mechanics and Bubble Coalescence

Langmuir, ISSN: 15205827 07437463

Aadithya Kannan; Ian C. Shieh; Danielle L. Leiske; Gerald G. Fuller

January 16, 2018

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models

Cell Reports, ISSN: 22111247

Brad A. Friedman; Karpagam Srinivasan; Gai Ayalon; William J. Meilandt; Han Lin; Melanie A. Huntley; Yi Cao; Seung-Hye Lee; Patrick C. G. Haddick; Hai Ngu; Zora Modrusan; Jessica L. Larson; Joshua S. Kaminker; Marcel P Van Der Brug; David V. Hansen

January 16, 2018

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Barbara Piasecka; Darragh Duffy; Alejandra Urrutia; Hélène Quach; Etienne Patin; Céline Posseme; Jacob Bergstedt; Bruno Charbit; Vincent Rouilly; Cameron R. MacPherson; Milena Hasan; Benoit Albaud; David Gentien; Jacques Fellay; Matthew L. Albert; Lluis Quintana-Murci

January 12, 2018

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Nature Communications, ISSN: 20411723

Hans D. Brightbill; Eric Suto; Nicole Blaquiere; Nandhini Ramamoorthi; Swathi Sujatha-Bhaskar; Emily Gogol; Georgette M. Castanedo; Benjamin T. Jackson; Youngsu C. Kwon; Susan Haller; Justin Lesch; Karin Bents; Christine Everett; Pawan Bir Kohli; Sandra Linge; Laura Christian; Kathy Barrett; Allan Jaochico; Leonid M. Berezhkovskiy; Peter W. Fan; Zora Modrusan; Kelli Veliz; Michael J. Townsend; Jason Devoss; Adam R. Johnson; Robert Godemann; Wyne P. Lee; Cary D. Austin; Brent Mckenzie; Jason A. Hackney; James J. Crawford; Steven T. Staben; Moulay Hicham Alaoui-Ismaili; Lawren C. Wu; Nico Ghilardi

January 2, 2018

Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation

Structure, ISSN: 18784186 09692126

Ayşegül Özen; Lionel Rouge; Charlene Bashore; Brian R. Hearn; Nicholas J. Skelton; Erin C. Dueber

January 2, 2018

Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations

Molecular Pharmaceutics, ISSN: 15438392 15438384

Balakrishnan S. Moorthy; Isidro E. Zarraga; Lokesh Kumar; Benjamin T. Walters; Pierre Goldbach; Elizabeth M. Topp; Andrea Allmendinger

January 2, 2018

Safety testing of monoclonal antibodies in non-human primates: Case studies highlighting their impact on human risk assessment

mAbs, ISSN: 19420870 19420862

Frank R. Brennan; Joy A. Cavagnaro; Kathleen McKeever; Patricia C. Ryan; Melissa Schutten; John Vahle; Gerhard F. Weinbauer; Estelle Marrer-Berger; Lauren E. Black

January 1, 2018

An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3Kδ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Po-Chang Chiang; Jodie Pang; Jia Liu; Laurent Salphati

January 1, 2018

Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System

Biotechnology Journal, ISSN: 18607314 18606768

Danming Tang; Cynthia Lam; Salina Louie; Kam Hon Hoi; David Shaw; Mandy Yim; Snedecor; Shahram Misaghi

January 1, 2018

Asthma Exacerbations and Triggers in Children in TENOR: Impact on Quality of Life

Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198

Bradley E. Chipps; Tmirah Haselkorn; Karin Rosén; David R. Mink; Benjamin L. Trzaskoma; Allan T. Luskin

January 1, 2018

IgG Fc engineering to modulate antibody effector functions

Protein and Cell, ISSN: 16748018 1674800X

Xinhua Wang; Mary Mathieu; Randall J. Brezski

January 1, 2018

An impedance-based cell contraction assay using human primary smooth muscle cells and fibroblasts

Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719

Daniel D. Bravo; Tania Chernov-Rogan; Jun Chen; Jianyong Wang

January 1, 2018

Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Kwong Wah Lai; F. Anthony Romero; Vickie Tsui; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Kevin Chen; Zhongguo Chen; Edna F. Choo; Terry Crawford; Patrick Cyr; Susan Kaufman; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jeremy Murray; Weichao Shen; John Wai; Fei Wang; Caicai Zhu; Xiaoyu Zhu; Steven Magnuson

January 1, 2018

Computational support of medicinal chemistry in industrial settings

Methods in Molecular Biology, ISSN: 10643745

Daniel F. Ortwine

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