Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4351 - 4400 OF 16291 RESULTS

January 2, 2019

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

mAbs, ISSN: 19420870 19420862

Robert G. Brinson; John P. Marino; Frank Delaglio; Luke W. Arbogast; Ryan M. Evans; Anthony Kearsley; Geneviève Gingras; Houman Ghasriani; Yves Aubin; Gregory K. Pierens; Xinying Jia; Mehdi Mobli; Hamish G. Grant; David W. Keizer; Kristian Schweimer; Jonas Ståhle; Göran Widmalm; Edward R. Zartler; Chad W. Lawrence; Patrick N. Reardon; John R. Cort; Ping Xu; Feng Ni; Saeko Yanaka; Koichi Kato; Stuart R. Parnham; Desiree Tsao; Andreas Blomgren; Torgny Rundlöf; Nils Trieloff; Peter Schmieder; Ross; Ken Skidmore; Kang Chen; David Keire; Darón I. Freedberg; Thea Suter-Stahel; Gerhard Wider; Gregor Ilc; Janez Plavec; Scott A. Bradley; Donna M. Baldisseri; Mauricio Luis Sforça; Ana Carolina de Mattos Zeri; Julie Yu Wei; Christina M. Szabo; Carlos A. Amezcua; John B. Jordan; Mats Wikström

January 2, 2019

Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Chengfeng Ren; Aaron O. Bailey; Erica Vanderporten; Angela Oh; Wilson Phung; Melinda M. Mulvihill; Seth F. Harris; Yichin Liu; Guanghui Han; Wendy N. Sandoval

January 2, 2019

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer

Structure, ISSN: 18784186 09692126

Ping Wu; Chris J. Sneeringer; Keith Pitts; Eric S. Day; Bryan K. Chan; Binqing Wei; Isabelle Lehoux; Kyle Mortara; Hong Li; Jiansheng Wu; Yvonne Franke; John Moffat; Jane L. Grogan; Timothy P. Heffron; Weiru Wang

January 2, 2019

Borrowing From Historical Control Data in Cancer Drug Development: A Cautionary Tale and Practical Guidelines

Statistics in Biopharmaceutical Research, ISSN: 19466315

Connor Jo Lewis; Somnath Sarkar; Jiawen Zhu; Bradley P. Carlin

January 1, 2019

Genomic alterations associated with recurrence and TNBC subtype in high-risk early breast cancers

Molecular Cancer Research, ISSN: 15573125 15417786

Wilson; Akshata R. Udyavar; Ching-Wei Chang; Jill M. Spoerke; Junko Aimi; Heidi Savage; Anneleen Daemen; O'Shaughnessy; Richard Bourgon; Lackner

January 1, 2019

Micro-CT imaging and structural analysis of glomeruli in a model of adriamycin-induced nephropathy

American Journal of Physiology - Renal Physiology, ISSN: 15221466 03636127

Luke Xie; Georgios Koukos; Kai H. Barck; Oded Foreman; Wyne P. Lee; Robert Brendza; Jeffrey Eastham-Anderson; Brent Mckenzie; Andrew S. Peterson; Richard A. D. Carano

January 1, 2019

Continued access to investigational medicinal products for clinical trial participants-An industry approach

Cambridge Quarterly of Healthcare Ethics, ISSN: 14692147 09631801

Ariella Kelman; Anna Kang; Brian Crawford

January 1, 2019

The Escherichia coli -barrel assembly machinery is sensitized to perturbations under high membrane fluidity

Journal of Bacteriology, ISSN: 10985530 00219193

Kelly M. Storek; Rajesh Vij; Dawei Sun; Peter A. Smith; James T. Koerber; Steven T. Rutherford

January 1, 2019

Extracellular protein microarray technology for high throughput detection of low affinity receptor-ligand interactions

Journal of Visualized Experiments, ISSN: 1940087X

Bushra Husain; Sairupa Paduchuri; Sree R. Ramani; Nadia Martinez-Martin

January 1, 2019

Tumor-infiltrating lymphocytes in patients receiving trastuzumab/pertuzumab-based chemotherapy: A TRYPHAENA Substudy

Journal of the National Cancer Institute, ISSN: 14602105 00278874

Michail Ignatiadis; Gert G.G.M. Van Den Eynden; Salgado Roberto; Marco Fornili; Yacine Bareche; Christine Desmedt; Rothé; Maetens; David Venet; Esther Holgado; Virginia McNally; Astrid Kiermaier; Heidi Savage; Wilson; Javier Cortés; Andreas Schneeweiss; Karen Willard-Gallo; Elia Biganzoli; Christos Sotiriou

January 1, 2019

Investigating the Value of Urine Volume, Creatinine, and Cystatin C for Urinary Biomarkers Normalization for Drug Development Studies

International Journal of Toxicology, ISSN: 1092874X 10915818

Adedeji; Tony Pourmohamad; Yafei Chen; Jennifer Burkey; Catherine J. Betts; Susan J. Bickerton; Manisha Sonee; James E. McDuffie

January 1, 2019

Split-cakes, still delicious

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Philippe Lam; Thomas W. Patapoff

January 1, 2019

Quantifying the vial capping process: Residual seal force and container closure integrity

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Robert Ovadia; Alexander Streubel; Yenny Webb-Vargas; Lea Ulland; Joerg Luemkemann; Kamila Rauch; Juergen Eder; Philippe Lam; Vassia Tegoulia; Maa

January 1, 2019

Timely, consistent, transparent assessment of market access evidence: Implementing tools based on the HTA Core Model® in a pharmaceutical company

International Journal of Technology Assessment in Health Care, ISSN: 14716348 02664623

Pierre Ducournau; Cornelia Irl; Iain Tatt; Mary McCarvil; Marlene Gyldmark

January 1, 2019

Current trends in biotherapeutic higher order structure characterization by irreversible covalent footprinting mass spectrometry

Protein and Peptide Letters, ISSN: 18755305 09298665

Natalie K. Garcia; Galahad Deperalta; Aaron T. Wecksler

January 1, 2019

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Xiaojing Wang; Wesley P. Blackaby; Vivienne Allen; Grace Chan; Jae H. Chang; Po-Chang Chiang; Coura Diène; Jason H. Drummond; Steven Do; Eric Fan; Eric Harstad; Alastair J. Hodges; Huiyong Hu; Wei Jia; William Kofie; Aleksandr Kolesnikov; Joseph P. Lyssikatos; Justin Ly; Mizio Matteucci; John Moffat; Veerendra Munugalavadla; Jeremy Murray; David Nash; Cameron Noland; Geoffrey Del Rosario; Leanne Ross; Craig Rouse; Andrew Sharpe; Dionysos S. Slaga; Minghua Sun; Vickie Tsui; Heidi J. A. Wallweber; Shang-Fan Yu; Allen Ebens

January 1, 2019

Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to induce type 2 inflammation from human lymphocytes

Journal of Immunology, ISSN: 15506606 00221767

Vladimir Ramirez-Carrozzi; Naruhisa Ota; Arivazhagan Sambandam; Kit Wong; Jason A. Hackney; Nadia Martinez-Martin; Wenjun Ouyang; Rajita Pappu

January 1, 2019

Making the move towards modernized greener separations: Introduction of the analytical method greenness score (AMGS) calculator

Green Chemistry, ISSN: 14639270 14639262

Michael B. Hicks; William P. Farrell; Christine Aurigemma; Laurent Lehmann; Lauren Weisel; Kelly Nadeau; Heewon Lee; Carol Moraff; Mengling Wong; Yun Huang; Paul Ferguson

January 1, 2019

Rheumatoid arthritis-interstitial lung disease in the United States: Prevalence, incidence, and healthcare costs and mortality

Journal of Rheumatology, ISSN: 14992752 0315162X

Karina Raimundo; Joshua J. Solomon; Amy L. Olson; Amanda M. Kong; Ashley L. Cole; Aryeh Fischer; Jeffrey J. Swigris

January 1, 2019

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1

Science, ISSN: 10959203 00368075

Meng He; Mira S. Chaurushiya; Webster; Sarah K. Kummerfeld; Rohit Reja; Subhra Chaudhuri; Ying-Jiun Chen; Zora Modrusan; Benjamin Haley; Dugger; Jeffrey Eastham-Anderson; Shari Lau; Anwesha Dey; Roger Caothien; Merone Roose-Girma; Kim Newton; Vishva M. Dixit

January 1, 2019

MAVERICC, a randomized, biomarker-stratified, phase II study of mFOLFOX6-Bevacizumab versus FOLFIRI-bevacizumab as first-line chemotherapy in metastatic colorectal cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Aparna R. Parikh; Fa-Chyi Lee; Linda Yau; Han Koh; James Knost; Edith Mitchell; Ivan Bosanac; Nicholas Choong; Frank A. Scappaticci; Christoph Mancao; Heinz-Josef Lenz

January 1, 2019

Exposure-effect relationships in established rat adjuvant-induced and collagen-induced arthritis: A translational pharmacokinetic-pharmacodynamic analysis

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Harvey Wong; Lichuan Liu; Wenjun Ouyang; Yuzhong Deng; Matthew Wright; Cornelis E. Hop

January 1, 2019

Mutational analysis of patients with colorectal cancer in CALGB/SWOG 80405 identifies new roles of microsatellite instability and tumor mutational burden for patient outcome

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Federico Innocenti; Fang-Shu Ou; Xueping Qu; Tyler J. Zemla; Donna Niedzwiecki; Rachel Tam; Shilpi Mahajan; Richard M. Goldberg; Monica M. Bertagnolli; Charles D. Blanke; Hanna Sanoff; James Atkins; Blase Polite; Alan P. Venook; Heinz-Josef Lenz; Omar Kabbarah

January 1, 2019

Visualization of mass cytometry signal background to enable optimal core panel customization and signal threshold gating

Methods in Molecular Biology, ISSN: 10643745

Amelia Au-Yeung; Chikara Takahashi; W Rodney Mathews; William E. O'Gorman

January 1, 2019

Cellular mechanisms of etrolizumab treatment in inflammatory bowel disease

Frontiers in Pharmacology, ISSN: 16639812

Charlotte Lichnog; Sha Klabunde; Emily Becker; Franklin Fuh; Philipp Tripal; Raja Atreya; Entcho Klenske; Erickson; Chiu; Chae Reed; Shan Chung; Clemens Neufert; Imke Atreya; Jacqueline McBride; Markus F. Neurath; Sebastian Zundler

January 1, 2019

Probing interaction of lipid-modified wnt protein and its receptors by ELISA

Methods in Molecular Biology, ISSN: 19406029 10643745

Aaron H Nile; Rami N. Hannoush

January 1, 2019

Unequal absorption of radiolabeled and nonradiolabeled drug from the oral dose leads to incorrect estimates of drug absorption and circulating metabolites in a mass balance study

Drug Metabolism Letters, ISSN: 18723128

Ryan Takahashi; Jae H. Chang; Jodie Pang; Xiaorong Liang; Shuguang Ma

January 1, 2019

Correction: First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL (Oncotarget(2018) 9 (13023 -13035) DOI: 10.18632/oncotarget.24310)

Oncotarget, ISSN: 19492553

John C. Byrd; Stephen Smith; Nina D. Wagner-Johnston; Jeff P. Sharman; Chen; Ranjana H. Advani; Bradley Augustson; Paula Marlton; Renee Commerford; Kwame Okrah; Lichuan Liu; Elaine R. Murray; Elicia M. Penuel; Ashley F. Ward; Ian W. Flinn

January 1, 2019

Durable remissions with obinutuzumab-based chemoimmunotherapy: Long-term follow-up of the phase 1b GALTON trial in CLL

Blood, ISSN: 15280020 00064971

Jennifer R. Brown; Susan O'Brien; C. Daniel Kingsley; Herbert Eradat; John M. Pagel; Jamie Hirata; Tammy McIver; Rodica Morariu-Zamfir; Thomas J. Kipps

January 1, 2019

Palladium-catalyzed enantioselective decarboxylative allylic alkylation of fully substituted: N -acyl indole-derived enol carbonates

Chemical Science, ISSN: 20416539 20416520

Eric J. Alexy; Tyler J. Fulton; Haiming Zhang; Brian M. Stoltz

January 1, 2019

Structural and Functional Variation in Outer Membrane Polysaccharide Export (OPX) Proteins from the Two Major Capsule Assembly Pathways Present in Escherichia coli

Journal of Bacteriology, ISSN: 10985530 00219193

Caitlin Sande; Catrien Bouwman; Elisabeth Kell; Nicholas N. Nickerson; Sharookh B. Kapadia; Chris Whitfield

January 1, 2019

Bioanalytical challenges in development of ultrasensitive Home Brew assays: A case study using IL-13

Bioanalysis, ISSN: 17576199 17576180

Gizette Sperinde; Martha Hokom; Kun Peng; Saloumeh Kadkhodayan Fischer

January 1, 2019

Effects of PI3K inhibition on afucosylated antibody-driven FcgRIIIa events and phospho-S6 activity in NK cells

Journal of Immunology, ISSN: 15506606 00221767

Valentina Romeo; Sarah Gierke; Kyle A. Edgar; Scot D. Liu

January 1, 2019

Quantitative Comparison of Conventional and t-SNE-guided Gating Analyses

Frontiers in Immunology, ISSN: 16643224

Shadi Toghi Eshghi; Amelia Au-Yeung; Chikara Takahashi; Christopher R. Bolen; Maclean N. Nyachienga; Sean P. Lear; Cherie Green; William Mathews; William E. O'Gorman

January 1, 2019

Time-to-Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine-Citrulline-Monomethylauristatin E Antibody–Drug Conjugates

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Kagedal; Divya Samineni; Gillespie; Dan Lu; Bernard M. Fine; Sandhya Girish; Chunze Li; Jin Y. Jin

January 1, 2019

High-throughput protein analysis using negative stain electron microscopy and 2D classification

Methods in Molecular Biology, ISSN: 19406029 10643745

Christopher P. Arthur; Claudio Ciferri

January 1, 2019

A flexible and scalable high-throughput platform for recombinant membrane protein production

Methods in Molecular Biology, ISSN: 19406029 10643745

Hui Xu; Thomas Clairfeuille; Christine C. Jao; Hoangdung Ho; Zachary K. Sweeney; Jian Payandeh; Christopher M. Koth

January 1, 2019

Semiautomated small-scale purification method for high-throughput expression analysis of recombinant proteins

Methods in Molecular Biology, ISSN: 19406029 10643745

Edward Kraft; Yvonne Franke; Katharine Heeringa; Stephanie K. Shriver; Inna Zilberleyb; Christine Kugel; Trisha Dela Vega; Athena W. Wong; Bobby Brillantes; Claudio Ciferri; George Dutina; Grace Lee; Isabelle Lehoux; Zhong Rong Li; Lee Lior-Hoffmann; Jiyoung Hwang; Chris Lonergan; Lynn Martin; Kyle Mortara; Lananh Nguyen; Jian Payandeh; Andrew Perez; Jun Sampang; Lovejit Singh; Kurt A. Schroeder; Christine Tam; Shu Ti; Ye Naing Win; Krista K. Bowman

January 1, 2019

A clinically applicable gene-expression classifier reveals intrinsic and extrinsic contributions to consensus molecular subtypes in primary and metastatic colon cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Robert Piskol; Huw; Ismail Sergin; Christiaan Kljin; Zora Modrusan; Doris Kim; Noelyn Kljavin; Rachel Tam; Rajesh Patel; Jeremy B. Burton; Elicia M. Penuel; Xueping Qu; Koeppen; Teiko Sumiyoshi; Frederic J. De Sauvage; Lackner; Felipe de Sousa e Melo; Omar Kabbarah

January 1, 2019

Early notch signals induce a pathogenic molecular signature during priming of alloantigen-specific conventional CD4+ T cells in graft-versus-host disease

Journal of Immunology, ISSN: 15506606 00221767

Jooho Chung; Vedran Radojcic; Eric Perkey; Timothy J. Parnell; Yashar Niknafs; Xi Jin; Ann Friedman; Nathalie Labrecque; Bruce R. Blazar; Todd V. Brennan; Christian W. Siebel; Ivan Maillard

January 1, 2019

Carfilzomib is not an appropriate payload of antibody-drug conjugates due to rapid inactivation by lysosomal enzymes

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Yong Ma; Josefa Dela Cruz-Chuh; S. Cyrus Khojasteh; Peter Dragovich; Thomas H. Pillow; Donglu Zhang

January 1, 2019

CHAPTER 11: Duocarmycin-PBD Dimers as Antibody-Drug Conjugate (ADC) Payloads

RSC Drug Discovery Series, ISSN: 20413211 20413203

Thomas H. Pillow; Moana Tercel

January 1, 2019

A potent and effective suicidal listeria vaccine platform

Infection and Immunity, ISSN: 10985522 00199567

William G. Hanson; Erin L. Benanti; Edward E. Lemmens; Weiqun Liu; Justin Skoble; Meredith L. Leong; Chris S. Rae; Marcella Fassò; Dirk Brockstedt; Chen Chen; Daniel A. Portnoy; Thomas W. Dubensky; Peter Lauer

January 1, 2019

Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Advances in Therapy, ISSN: 18658652 0741238X

Marilyn K Glassberg; Steven D Nathan; Chin-Yu Lin; Elizabeth A. Morgenthien; John L. Stauffer; Willis Chou; Paul W. Noble

January 1, 2019

Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging

JCI insight, ISSN: 23793708

Denise P. Muñoz; Steven M. Yannone; Anneleen Daemen; Yu Sun; Funda Vakar-Lopez; Misako Kawahara; Adam M. Freund; Francis Rodier; Jennifer D. Wu; Pierre-Yves Desprez; David H. Raulet; Peter S. Nelson; Laura J. van't Veer; Judith Campisi; Jean-Philippe Coppé

January 1, 2019

The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs

Life Science Alliance, ISSN: 25751077

Mattias Rydenfelt; Matthew Wongchenko; Bertram Klinger; Yibing Yan; Nils Blüthgen

January 1, 2019

GDC-0810 pharmacokinetics and transporter-mediated drug interaction evaluation with an endogenous biomarker in the first-in-human, dose escalation study

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Kit Wun Kathy Cheung; Yoshida; Sravanthi Cheeti; Buyun Chen; Roland Morley; Iris Chan; Srikumar Sahasranaman; Lichuan Liu

January 1, 2019

Pharmacokinetics of pertuzumab administered concurrently with trastuzumab in Chinese patients with HER2-positive early breast cancer

Anti-Cancer Drugs, ISSN: 14735741 09594973

Yang Luo; Wei Li; Zefei Jiang; Qingyuan Zhang; Liwei Wang; Yixiang Mao; Vivianne C G Tjan-Heijnen; Seock-Ah Im; Robin McConnell; Sara Bejarano; Fumagalli; José Bines; Wang; Amit Garg; Whitney P. Kirschbrown; Binghe Xu

January 1, 2019

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

eLife, ISSN: 2050084X

Anna Shemorry; Jonathan M. Harnoss; Ofer Guttman; Scot A. Marsters; László Kömüves; David Lawrence; Avi Ashkenazi

January 1, 2019

Absence of pharmacokinetic interactions between the Bruton’s tyrosine kinase inhibitor fenebrutinib and methotrexate

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Nicholas Steven Jones; Helen Winter; Tamiko R. Katsumoto; Marilyn Florero; Elaine R. Murray; Helen Walker; Nand Singh; Leslie Chinn

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