Scientists / Publications

Publications

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DISPLAYING 4951 - 5000 OF 15805 RESULTS

Current Status of Companion and Complementary Diagnostics: Strategic Considerations for Development and Launch
Clinical and Translational Science, ISSN: 17528062 17528054
Heleen Scheerens; Malong; Bassett; Zachary Boyd; Vinita Gupta; Harris; Mesick; Simnett; Stevens; Houston N. Gilbert; Risser; Kalamegham; Jordan; Engel; Chen; Essioux; Williams
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Burden of illness of people with persistent symptoms of schizophrenia: A multinational cross-sectional study
International Journal of Social Psychiatry, ISSN: 17412854 00207640
Anna-Lena Nordstroem; Darren Talbot; Corrado Bernasconi; Carmen Galani Berardo; Justine Lalonde
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Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells
Biotechnology Progress, ISSN: 15206033 87567938
Cynthia Lam; Santell; Blair Wilson; Mandy Yim; Salina Louie; Danming Tang; David Shaw; Pamela Chan; Lazarus; Snedecor; Shahram Misaghi
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Innovative methods for the identification of predictive biomarker signatures in oncology: Application to bevacizumab
Contemporary Clinical Trials Communications, ISSN: 24518654
Paul Delmar; Cornelia Irl; Lu Tian
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Exposure–Response and Tumor Growth Inhibition Analyses of the Monovalent Anti-c-MET Antibody Onartuzumab (MetMAb) in the Second- and Third-Line Non-Small Cell Lung Cancer
AAPS Journal, ISSN: 15507416
Kelong Han; Pascal Chanu; Fredrik Jonsson; Helen Winter; Rene Bruno; Jin Y. Jin; Mark Stroh
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The financial burden and health care utilization patterns associated with amnestic mild cognitive impairment
Alzheimer's and Dementia, ISSN: 15525279 15525260
Thanh G.N. Ton; Thomas DeLeire; Suepattra G. May; Ningqi Hou; Mahlet G. Tebeka; Er Chen; Joshua Chodosh
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Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Halie M. Anderson; Robert F. Lemanske Jr.; Joseph R. Arron; Cécile T.J. Holweg; Victoria Rajamanickam; Ronald E. Gangnon; James E. Gern; Daniel J. Jackson
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FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Salina Louie; Benjamin Haley; Brett Marshall; Amy Heidersbach; Mandy Yim; Martina Brozynski; Danming Tang; Cynthia Lam; Bronislawa Petryniak; David Shaw; Jeongsup Shim; Aaron S. Miller; John Lowe; Snedecor; Shahram Misaghi
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Enabling drug discovery project decisions with integrated computational chemistry and informatics
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Vickie Tsui; Daniel F. Ortwine; Jeff Blaney
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Development of a Glucocorticoid Toxicity Index (GTI) using multicriteria decision analysis
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Miloslavsky; Ray P. Naden; Johannes W J Bijlsma; Paul A. Brogan; E. Sherwood Brown; Paul Brunetta; Frank Buttgereit; Hyon Choi; Jean-Francois DiCaire; Jeffrey M Gelfand; Liam G. Heaney; Liz Lightstone; Na Lu; Dedee F. Murrell; Michelle Petri; James T. Rosenbaum; Saag; Urowitz; Kevin L. Winthrop; John H. Stone
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Application of CRAFT in two-dimensional NMR data processing
Magnetic Resonance in Chemistry, ISSN: 1097458X 07491581
Krish Krishnamurthy; Andrea M. Sefler; David J. Russell
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Correspondence
Nature Methods, ISSN: 15487105 15487091
Elior Rahmani; Noah Zaitlen; Yael Baran; Celeste Eng; Donglei Hu; Joshua Galanter; Sam S. Oh; Esteban G. Burchard; Eleazar Eskin; James Zou; Eran Halperin
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Correcting for cell-type heterogeneity in DNA methylation: A comprehensive evaluation
Nature Methods, ISSN: 15487105 15487091
Elior Rahmani; Noah Zaitlen; Yael Baran; Celeste Eng; Donglei Hu; Joshua Galanter; Sam S. Oh; Esteban G. Burchard; Eleazar Eskin; James Zou; Eran Halperin
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KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer
Cell, ISSN: 10974172 00928674
Michael R. Burgess; Eugene Hwang; Rana Mroue; Craig M. Bielski; Anica M. Wandler; Benjamin J. Huang; Ari J. Firestone; Amy Young; Jennifer A. Lacap; Lisa Crocker; Saurabh Asthana; Elizabeth M. Davis; Jin Xu; Keiko Akagi; Michelle M. Le Beau; Qing Li; Benjamin Haley; David Stokoe; Deepak Sampath; Barry S. Taylor; Marie Evangelista; Kevin Shannon
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Improving Stepwise Assembly of a Bispecific F(ab′)2 from Two Different Fab′ Molecules
Industrial and Engineering Chemistry Research, ISSN: 15205045 08885885
Ambrose Jon Williams; Robert Ovadia; Glen Giese
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Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
Nature Communications, ISSN: 20411723
Janet Lau; Jeanne Cheung; Armando Navarro; Steve Lianoglou; Benjamin Haley; Klara Totpal; Laura A. Strickland; Koeppen; Patrick Caplazi; Jacqueline McBride; Chiu; Rebecca Hong; Jane L. Grogan; Vincent Javinal; Robert Yauch; Bryan Irving; Marcia Belvin; Ira Mellman; Kim; Maike Schmidt
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Green Chemistry Articles of Interest to the Pharmaceutical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Marian C. Bryan; Louis Diorazio; Zhongbo Fei; Kenneth Fraunhoffer; John Hayler; Matthew Hickey; Shaun Hughes; Luke Humphreys; Paul Richardson; Markus Schober; Alan Steven; Timothy White; Stijn Wuyts; Jingjun Yin
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Trace Analysis of Potentially Mutagenic Boronic Acids and Esters in Drug Substance by ICP-MS
Organic Process Research and Development, ISSN: 1520586X 10836160
Ila Patel; Venkatramani; Andreas Stumpf; Larry Wigman; Peter M. Yehl
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Brafv600 mutations in solid tumors, other than metastatic melanoma and papillary thyroid cancer, or multiple myeloma: A screening study
OncoTargets and Therapy, ISSN: 11786930
Cohn; Bann-Mo Day; Sarang Abhyankar; Edward McKenna; Todd Riehl; Igor Puzanov
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Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells
mAbs, ISSN: 19420870 19420862
Michael Dillon; Yiyuan Yin; Jianhui Zhou; Luke McCarty; Diego Ellerman; Dionysos S. Slaga; Teemu T. Junttila; Guanghui Han; Wendy N. Sandoval; Meric A. Ovacik; Kedan Lin; Zhilan Hu; Amy Shen; Jacob E. Corn; Christoph Spiess; Paul J. Carter
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Impact of SPR biosensor assay configuration on antibody: Neonatal Fc receptor binding data
mAbs, ISSN: 19420870 19420862
Xiangdan Wang; McKay; Liliana T. Yee; George Dutina; Hass; Ihsan Nijem; David E. Allison; Kyra J. Cowan; Kevin Lin; Quarmby; Yang
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GeneAttribution: Trait agnostic identification of candidate genes associated with noncoding variation
Bioinformatics, ISSN: 14602059 13674803
Arthur Wuster; Diana Chang; Timothy W. Behrens; Tushar Bhangale
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Domain-specific free thiol variant characterization of an IgG1 by reversed-phase high-performance liquid chromatography mass spectrometry
Analytical Biochemistry, ISSN: 10960309 00032697
Ying Cheng; Matthew T. Chen; Lisa C. Patterson; X. Christopher Yu; Taylor Zhang; Braydon Burgess; Yonghong Chen
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Biomarker analysis of the NeoSphere study: Pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treatment of HER2-positive breast cancer
Breast Cancer Research, ISSN: 1465542X 14655411
Giampaolo Bianchini; Astrid Kiermaier; Giulia V. Bianchi; Im; Tadeusz Pienkowski; Mei-Ching Liu; Ling-Ming Tseng; Mitch Dowsett; Lila Zabaglo; Sarah Kirk; Szado; Jennifer Eng-Wong; Lukas Amler; Pinuccia Valagussa; Luca Gianni
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Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma
Allergy, Asthma and Clinical Immunology, ISSN: 17101492 17101484
Cripps; Cécile T.J. Holweg; Matthews; Maillot; James Fingleton; Mark Weatherall; Richard Beasley; Irene Braithwaite; Caswell-Smith; Beasley; Tony Mallon; Judith Riley; Janine Pilcher; Mathew Williams; Philippa Shirtcliffe; Thomas Charles; Holliday; Maureen Stretch; Alison Pritchard; Denise Fabian; Hosking; Meghana Handigol; Cecile Holweg; John Matthews
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Characterization of protein-excipient microheterogeneity in biopharmaceutical solid-state formulations by confocal fluorescence microscopy
Molecular Pharmaceutics, ISSN: 15438392 15438384
Stijn H.S. Koshari; Jean L. Ross; Purnendu K. Nayak; Isidro E. Zarraga; Karthikan Rajagopal; Norman J. Wagner; Abraham M. Lenhoff
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An anti-CD3/anti-CLL-1 bispecific antibody for the treatment of acute myeloid leukemia
Blood, ISSN: 15280020 00064971
Leong; Siddharth Sukumaran; Maria Hristopoulos; Klara Totpal; Shannon Stainton; Elizabeth Lu; Alfred Wong; Lucinda Tam; Robert J. Newman; Brian R. Vuillemenot; Diego Ellerman; Chen Gu; Mary Mathieu; Dennis; Allen Nguyen; Bing Zheng; Crystal Zhang; Genee Y. Lee; Yu-Waye Chu; Prell; Kedan Lin; Steven T. Laing; Andrew G. Polson
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Mantle cell lymphoma initial therapy with abbreviated R-CHOP followed by 90Y-ibritumomab tiuxetan: 10-year follow-up of the phase 2 ECOG-ACRIN study E1499
Leukemia, ISSN: 14765551 08876924
Smith; Fangxin Hong; Hailun Li; Leo I. Gordon; Randy D. Gascoyne; Elisabeth M. Paietta; Ranjana H. Advani; Andres Forero; Sandra J. Horning; Wojciech Jurczak
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Accurately measuring and modeling Th2 and Th17 endotypes in severe asthma
Annals of Translational Medicine, ISSN: 23055847 23055839
Kevin M. Hart; David F. Choy; Peter Bradding; Thomas A. Wynn; Joseph R. Arron
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MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats
Toxicologic Pathology, ISSN: 15331601 01926233
Dolores Diaz; Rama Pai; Cain; Nghi La; Donna M. Dambach; Jacob Schwartz; Jacqueline M. Tarrant
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What is the value of conducting a trial of r-tPA for the treatment of mild stroke patients?
International Journal of Stroke, ISSN: 17474949 17474930
Gregory F. Guzauskas; Er Chen; Deepa Lalla; Elaine B. Yu; Darren Tayama; David L. Veenstra
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Mantle cell lymphoma initial therapy with abbreviated R-CHOP followed by 90Y-ibritumomab tiuxetan: 10-year follow-up of the phase 2 ECOG-ACRIN study E1499
Leukemia, ISSN: 14765551 08876924
Smith; Fangxin Hong; Hailun Li; Leo I. Gordon; Randy D. Gascoyne; Elisabeth M. Paietta; Ranjana H. Advani; Andres Forero; Sandra J. Horning; Brad Kahl
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Five-year Efficacy and safety of tocilizumab monotherapy in patients with rheumatoid arthritis who were methotrexate-And biologic-naive or free of methotrexate for 6 months: The ambition study
Journal of Rheumatology, ISSN: 14992752 0315162X
Graeme Jones; Thomas Wallace; Matthew J. McIntosh; Laura Brockwell; Juan Gomez-Reino; Anthony Sebba
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Phase 2 randomized, double-blind, placebo-controlled trial of RG7667, a combination monoclonal antibody, for prevention of cytomegalovirus infection in high-risk kidney transplant recipients
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Julie H. Ishida; Anita Patel; Aneesh K. Mehta; Philippe Gatault; Jacqueline McBride; Tracy Burgess; Michael A. Derby; David R. Snydman; Brinda Emu; Becket Feierbach; Ashley Fouts; Mauricio Maia; Rong Deng; Carrie M. Rosenberger; Lynn Gennaro; Natalee S. Striano; X. Charlene Liao; Jorge A. Tavel
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Antibody–Antibiotic Conjugates: A Novel Therapeutic Platform against Bacterial Infections
Trends in Molecular Medicine, ISSN: 1471499X 14714914
Sanjeev Mariathasan; Man-Wah Tan
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Pharmacokinetic and exposure–response analyses of pertuzumab in combination with trastuzumab and docetaxel during neoadjuvant treatment of HER2+ early breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Angelica Quartino; Hanbin Li; Jin Y. Jin; D. Russell Wada; Benyunes; Virginia McNally; Lucia Viganò; Ihsan Nijem; Bert L. Lum; Amit Garg
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A Random Forest Approach for Counting Silicone Oil Droplets and Protein Particles in Antibody Formulations Using Flow Microscopy
Pharmaceutical Research, ISSN: 1573904X 07248741
Miguel Saggu; Ankit Patel; Theodoro Koulis
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Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Vladimir Ramirez-Carrozzi; Arivazhagan Sambandam; Meijuan Zhou; Donghong Yan; Jing Kang; Xiumin Wu; Eric Suto; Miriam Baca; Cary D. Austin; Min Xu; Wyne P. Lee; Rajita Pappu
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Health-related quality of life and symptoms in patients with rituximab-refractory indolent non-Hodgkin lymphoma treated in the phase III GADOLIN study with obinutuzumab plus bendamustine versus bendamustine alone
Annals of Hematology, ISSN: 14320584 09395555
Bruce D. Cheson; Peter C. Trask; John G. Gribben; Natalie Dimier; Eva Kimby; Pieternella J. Lugtenburg; Catherine Thieblemont; Elisabeth Wassner-Fritsch; Aino Launonen; Laurie H. Sehn
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FDG-PET is prognostic and predictive for progression-free survival in relapsed follicular lymphoma: exploratory analysis of the GAUSS study
Leukemia and Lymphoma, ISSN: 10292403 10428194
Lale Kostakoglu; Andre Goy; Giovanni Martinelli; Dolores Caballero; Michael Crump; Gianluca Gaidano; Tara Baetz; Rena Buckstein; Gregg D. Fine; Guenter Fingerle-Rowson; Claude Berge; Deniz Sahin; Oliver W. Press; Laurie H. Sehn
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Clinical translation of ferumoxytol-based vessel size imaging (VSI): Feasibility in a phase I oncology clinical trial population
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Jill Fredrickson; Natalie J. Serkova; Shelby K. Wyatt; Richard A. D. Carano; Andrea Pirzkall; Ina Rhee; Lee Rosen; Alberto Bessudo; Colin D. Weekes; De Crespigny
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THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
Nature Communications, ISSN: 20411723
Florencia Cayrol; Pannee Praditsuktavorn; Tharu M. Fernando; Nicholas Kwiatkowski; Rossella Marullo; M. Nieves Calvo-Vidal; Jude Phillip; Benet Pera; Shao-Ning Yang; Kaipol Takpradit; Lidia Roman; Marcello Gaudiano; Ramona Crescenzo; Jia Ruan; Giorgio Inghirami; Tinghu Zhang; Graciela Cremaschi; Nathanael S. Gray; Leandro Cerchietti
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Development of a multi-matrix LC–MS/MS method for urea quantitation and its application in human respiratory disease studies
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Jianshuang Wang; Yang Gao; Dorshorst; Fang Cai; Meire C. Bremer; Dennis Milanowski; Tracy Staton; Stephanie Cape; Brian J. Dean; Xiao Ding
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Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Georgette M. Castanedo; Nicole Blaquiere; Beresini; Brandon Bravo; Hans D. Brightbill; Jacob Z. Chen; Haifeng Cui; Eigenbrot; Christine Everett; Jianwen A. Feng; Robert Godemann; Emily Gogol; Sarah G. Hymowitz; Adam R. Johnson; Nobuhiko Kayagaki; Pawan Bir Kohli; Kathleen Knüppel; Joachim Kraemer; Susanne Kruger; Pui Loke; Paul A. McEwan; Christian A.G.N. Montalbetti; David Allen Roberts; Myron Smith; Stefan Steinbacher; Swathi Sujatha-Bhaskar; Ryan Takahashi; Xiaolu Wang; Lawren C. Wu; Yamin Zhang; Steven T. Staben
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Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Georgette M. Castanedo; Nicole Blaquiere; Beresini; Brandon Bravo; Hans D. Brightbill; Jacob Z. Chen; Haifeng Cui; Eigenbrot; Christine Everett; Jianwen A. Feng; Robert Godemann; Emily Gogol; Sarah G. Hymowitz; Adam R. Johnson; Nobuhiko Kayagaki; Pawan Bir Kohli; Kathleen Knüppel; Joachim Kraemer; Susan Krüger; Pui Loke; Paul A. McEwan; Christian A.G.N. Montalbetti; David Allen Roberts; Myron Smith; Stefan Steinbacher; Swathi Sujatha-Bhaskar; Ryan Takahashi; Xiaolu Wang; Lawren C. Wu; Yamin Zhang; Steven T. Staben
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Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Patrick Koenig; Chingwei V. Lee; Benjamin T. Walters; Vasantharajan Janakiraman; Stinson; Thomas W. Patapoff; Fuh
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Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial
The Lancet, ISSN: 1474547X 01406736
Achim Rittmeyer; Fabrice Barlesi; Waterkamp; Keunchil Park; Fortunato Ciardiello; Joachim Von Pawel; Shirish M. Gadgeel; Toyoaki Hida; Dariusz M Kowalski; Manuel Cobo Dols; Diego L Cortinovis; Joseph W. Leach; Jonathan Polikoff; Carlos H. Barrios; Fairooz F. Kabbinavar; Osvaldo Arén Frontera; Filippo De Marinis; Hande Turna; Jong-Seok Lee; Ballinger; Marcin Kowanetz; Pei He; Daniel S. Chen; Alan Sandler; David R. Gandara
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Randomized, double-blind, placebo-controlled, multicenter phase II study of onartuzumab plus bevacizumab versus placebo plus bevacizumab in patients with recurrent glioblastoma: Efficacy, safety, and hepatocyte growth factor and O6-methylguanine-DNA methyltransferase biomarker analyses
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Timothy Cloughesy; Gaetano Finocchiaro; Cristóbal Belda-Iniesta; Lawrence Recht; Alba A. Brandes; Estela Pineda; Tom Mikkelsen; Olivier L. Chinot; Carmen Balana; David R. Macdonald; Manfred Westphal; Kirsten Hopkins; Michael Weller; Carlos Bais; Thomas Sandmann; Jean-Marie Bruey; Koeppen; Bo Liu; Wendy Verret; See Phan; David S. Shames
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Ocrelizumab versus interferon beta-1a in relapsing multiple sclerosis
New England Journal of Medicine, ISSN: 15334406 00284793
Stephen L. Hauser; Amit Bar-Or; Comi; Giovannoni; Hartung; Hemmer; Lublin; Montalban; Rammohan; Selmaj; Traboulsee; Wolinsky; Douglas L. Arnold; Gaëlle Klingelschmitt; Masterman; Fontoura; Belachew; Peter Chin; Mairon; Hideki Garren; Ludwig Kappos
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Ocrelizumab versus placebo in primary progressive multiple sclerosis
New England Journal of Medicine, ISSN: 15334406 00284793
Montalban; Stephen L. Hauser; Ludwig Kappos; Douglas L. Arnold; Amit Bar-Or; Comi; De Seze; Giovannoni; Hartung; Hemmer; Lublin; Rammohan; Selmaj; Traboulsee; Sauter; Masterman; Fontoura; Belachew; Hideki Garren; Mairon; Peter Chin; Wolinsky
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