Genentech: Publications

January 1, 2017

Compartment based population balance model development of a high shear wet granulation process via dry and wet binder addition

Chemical Engineering Research and Design, ISSN: 02638762

Anik Chaturbedi; Chandra Kanth Bandi; Dheeraj Reddy; Preetanshu Pandey; Ajit S. Narang; Dilbir Bindra; Li Tao; Junshu Zhao; Jinjiang Li; Munir A. Hussain; Rohit Ramachandran

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January 1, 2017

The second-generation maturation inhibitor GSK3532795 maintains potent activity toward HIV protease inhibitor-resistant clinical isolates

Journal of Acquired Immune Deficiency Syndromes, ISSN: 10779450 15254135

Neelanjana Ray; Tianbo Li; Zeyu Lin; Tricia Protack; Petronella Maria Van Ham; Carey Hwang; Mark Krystal; Monique Nijhuis; Max Lataillade; Ira Dicker

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January 1, 2017

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Jun Liang; Sharada Labadie; Birong Zhang; Daniel F. Ortwine; Snahel Patel; Maia Vinogradova; James R. Kiefer; Till Mauer; Victor S Gehling; Jean-Christophe Harmange; Richard T Cummings; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Yichin Liu; Amy Gustafson; Erica Vanderporten; Weifeng Mao; Bianca M. Liederer; Gauri Deshmukh; Le An; Yingqing Ran; Marie Classon; Patrick Trojer; Peter Dragovich; Lesley J. Murray

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January 1, 2017

The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target

Retina, ISSN: 15392864 0275004X

David S. Boyer; Ursula Schmidt-Erfurth; Menno Van Lookeren Campagne; Erin C. Henry; Christopher Brittain

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January 1, 2017

TREM2, Microglia, and Neurodegenerative Diseases

Trends in Molecular Medicine, ISSN: 14714914

Felix L. Yeh; David V. Hansen; Morgan Sheng

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January 1, 2017

A fully integrated, three-dimensional fluorescence to electron microscopy correlative workflow

Methods in Cell Biology, ISSN: 0091679X

Claudia S. López; Cedric Bouchet-Marquis; Christopher P. Arthur; Jessica L. Riesterer; Gregor Heiss; Guillaume Thibault; Lee Pullan; Sunjong Kwon; Joe W. Gray

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January 1, 2017

Expression of MET in circulating tumor cells correlates with expression in tumor tissue from advanced-stage lung cancer patients

Oncotarget, ISSN: 19492553

Marius Ilie; Edith Szafer-Glusman; Véronique Hofman; Elodie Long-Mira; Rebecca Suttmann; Darbonne; Catherine Butori; Salomé Lalvée; Julien Fayada; Eric Selva; Wei Yu; Charles-Hugo Marquette; David S. Shames; Elizabeth A. Punnoose; Paul Hofman

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January 1, 2017

Elements of cancer immunity and the cancer-immune set point

Nature, ISSN: 14764687 00280836

Daniel S. Chen; Ira Mellman

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January 1, 2017

Anti-CD22 and anti-CD79b antibody-drug conjugates preferentially target proliferating B cells

British Journal of Pharmacology, ISSN: 14765381 00071188

Franklin Fuh; Looney; Dongwei Li; Kirsten Achilles Poon; Randall Dere; Dimitry Danilenko; Jacqueline McBride; Chae Reed; Shan Chung; Bing Zheng; W Rodney Mathews; Andrew G. Polson; Saileta Prabhu; Marna Williams

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January 1, 2017

Ultrasensitive HIV-1 p24 assay detects single infected cells and differences in reservoir induction by latency reversal agents

Journal of Virology, ISSN: 10985514 0022538X

Caroline Pereira Bittencourt Passaes; Timothée Bruel; Jérémie Decalf; Annie David; Mathieu Angin; Valerie Monceaux; Michaela Muller-Trutwin; Nicolas Noel; Katia Bourdic; Olivier Lambotte; Matthew L. Albert; Darragh Duffy; Olivier Schwartz; Asier Sáez-Cirión; Christine Rouzioux; Brigitte Autran; Monsef Benkirane; Jeremie Guedj; Laurent Hocqueloux; Christine Katlama; Roger Legrand; Laurence Meyer; Hugo Mouquet; Michaela Müller-Trutwin; Anne- Marie Taburet; Carine Van Lint

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January 1, 2017

A protective role for interleukin-1 signaling during mouse adenovirus type 1-induced encephalitis

Journal of Virology, ISSN: 10985514 0022538X

Luiza A. Castro-Jorge; Carla D. Pretto; Asa B. Smith; Oded Foreman; Kelly E. Carnahan; Katherine R. Spindler

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January 1, 2017

NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus

American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN: 15221547 01931857

Elise S. Demitrack; Gail B. Gifford; Theresa M. Keeley; Nobukatsu Horita; Andrea Todisco; Kim Turgeon; Christian W. Siebel; Linda C. Samuelson

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January 1, 2017

Differences in health care use and costs among patients with cancer receiving intravenous chemotherapy in physician offices versus in hospital outpatient settings

Journal of Oncology Practice, ISSN: 1935469X 15547477

Maxine D. Fisher; Rajeshwari Punekar; Yeun Mi Yim; Art Small; Joseph R. Singer; Jay Schukman; Barbara L. McAneny; Rakesh Luthra; Jennifer Malin

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January 1, 2017

A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains

Journal of Alzheimer's Disease, ISSN: 18758908 13872877

Patrick C. G. Haddick; Jessica L. Larson; Nisha Rathore; Tushar Bhangale; Qui Phung; Karpagam Srinivasan; David V. Hansen; Jennie R. Lill; Brian W. Kunkle; Jonathan L. Haines; Lindsay A. Farrer; John S.K. Kauwe; Gerard D. Schellenberg; Paul K. Crane; Alison M. Goate; Timothy W. Behrens; Ryan J. Watts; Robert R. Graham; Joshua S. Kaminker; Marcel P Van Der Brug

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January 1, 2017

Assessing sex differences in the risk of cardiovascular disease and mortality per increment in systolic blood pressure: A systematic review and meta-analysis of follow-up studies in the United States

PLoS ONE, ISSN: 19326203

Yu-Chung Wei; Nysia I. George; Ching-Wei Chang; Karen A. Hicks

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January 1, 2017

Bruton's tyrosine kinase small molecule inhibitors induce a distinct pancreatic toxicity in rats

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Rebecca Erickson; Leah Schutt; Jacqueline M. Tarrant; Michelle Mcdowell; Lichuan Liu; Adam R. Johnson; Sock-Cheng Lewin-Koh; Maj Hedehus; Ross; Richard A. D. Carano; Karin Staflin; Fiona Zhong; James J. Crawford; Shelly Zhong; Karin Reif; Arna Katewa; Harvey Wong; Wendy B. Young; Donna M. Dambach; Misner

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January 1, 2017

Mass cytometry panel optimization through the designed distribution of signal interference

Cytometry Part A, ISSN: 15524930 15524922

Chikara Takahashi; Amelia Au-Yeung; Franklin Fuh; Teresa Ramirez-Montagut; Christopher R. Bolen; W Rodney Mathews; William E. O'Gorman

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January 1, 2017

IL-22R ligands IL-20, IL-22, and IL-24 promote wound healing in diabetic db/db mice

PLoS ONE, ISSN: 19326203

Ganesh Kolumam; Xiumin Wu; Wyne P. Lee; Jason A. Hackney; Jose Zavala-Solorio; Vineela D. Gandham; Dimitry Danilenko; Puneet Arora; Xiaoting Wang; Wenjun Ouyang

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January 1, 2017

Preclinical efficacy of an antibody-drug conjugate targeting mesothelin correlates with quantitative89 Zr-ImmunoPET

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Anton G. T. Van Terwisscha Scheltinga; Annie Ogasawara; Glenn Pacheco; Alexander N. Vanderbilt; Jeff N. Tinianow; Nidhi Gupta; Dongwei Li; Ron Firestein; Jan Marik; Suzie J. Scales; Simon P. Williams

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January 1, 2017

Building proteomic tool boxes to monitor MHC class I and class II peptides

Proteomics, ISSN: 16159861 16159853

Frances-Rose Schumacher; Lélia Delamarre; Suchit Jhunjhunwala; Zora Modrusan; Qui Phung; Joshua E. Elias; Jennie R. Lill

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January 1, 2017

A first-in-human phase I study of the ATP-competitive AKT inhibitor Ipatasertib demonstrates Robust and safe targeting of AKT in patients with solid tumors

Cancer Discovery, ISSN: 21598290 21598274

Saura; Desamparados Roda; Susana Roselló; Oliveira; Teresa Macarulla; José Alejandro Pérez-Fidalgo; Rafael Morales-Barrera; Juan Manuel Sanchis-García; Luna Musib; Nageshwar Budha; Jin Zhu; Michelle Nannini; Wai Y. Chan; Sandra M. Sanabria-Bohorquez; Raymond D. Meng; Kui Lin; Yibing Yan; Premal Patel; Baselga; Tabernero; Andrés Cervantes

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January 1, 2017

Efficacy and Safety Results From a Phase II, Placebo-Controlled Study of Onartuzumab Plus First-Line Platinum-Doublet Chemotherapy for Advanced Squamous Cell Non–Small-Cell Lung Cancer

Clinical Lung Cancer, ISSN: 19380690 15257304

Fred R. Hirsch; Ramaswamy Govindan; Zanete Zvirbule; Fadi S. Braiteh; Achim Rittmeyer; Cristóbal Belda-Iniesta; Dolores Isla; Thomas Cosgriff; Michelle Boyer; Masamichi Ueda; See Phan; David R. Gandara

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January 1, 2017

Genotype-phenotype correlations in pathology caused by collagen type IV alpha 1 and 2 mutations

Matrix Biology, ISSN: 15691802 0945053X

Marion Jeanne; Douglas B. Gould

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January 1, 2017

Quantitative proteomics reveals fundamental regulatory differences in oncogenic hras and isocitrate dehydrogenase (IDH1) driven astrocytoma

Molecular and Cellular Proteomics, ISSN: 15359484 15359476

Sophia Doll; Anatoly Urisman; Juan A. Oses-Prieto; David Arnott; Alma Burlingame

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January 1, 2017

Tumour-infiltrating lymphocytes in advanced HER2-positive breast cancer treated with pertuzumab or placebo in addition to trastuzumab and docetaxel: a retrospective analysis of the CLEOPATRA study

The Lancet Oncology, ISSN: 14745488 14702045

Stephen J Luen; Roberto Salgado; Stephen B. Fox; Peter Savas; Jennifer Eng-Wong; Emma Clark; Astrid Kiermaier; Sandra M. Swain; Baselga; Stefan Michiels; Sherene Loi

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January 1, 2017

Efficacy and Safety of Onartuzumab in Combination With First-Line Bevacizumab- or Pemetrexed-Based Chemotherapy Regimens in Advanced Non-Squamous Non–Small-Cell Lung Cancer

Clinical Lung Cancer, ISSN: 19380690 15257304

Heather A. Wakelee; Zanete Zvirbule; Filippo De Braud; C. Daniel Kingsley; Tarek Mekhail; Thomas Lowe; Wolfgang Schütte; Hervé Lena; William Lawler; Fadi S. Braiteh; Thomas Cosgriff; Diego Kaen; Michelle Boyer; Jessie Hsu; See Phan; Silvia Novello

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January 1, 2017

Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis

The Lancet Respiratory Medicine, ISSN: 22132619 22132600

Steven D Nathan; Carlo Albera; Williamson Bradford; Ulrich Costabel; Ian Glaspole; Marilyn K Glassberg; David Kardatzke; Monica Daigl; Klaus-Uwe Kirchgaessler; Lisa H Lancaster; David J Lederer; Carlos A Pereira; Jeffrey J. Swigris; Dominique Valeyre; Paul W. Noble

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January 1, 2017

Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma

Gastroenterology, ISSN: 15280012 00165085

Yiwei Wang; Dan Huang; Kai-Yuan Chen; Min Cui; Weihuan Wang; Xiaoran Huang; Amad Awadellah; Qing Li; Ann Friedman; William Xin; Luca Di Martino; Fabio Cominelli; Alex Miron; Ricky Chan; James G. Fox; Yan Xu; Xiling Shen; Mathew F. Kalady; Sanford D. Markowitz; Ivan Maillard; John Lowe; Wei Xin; Lan Zhou

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January 1, 2017

Bevacizumab plus paclitaxel versus placebo plus paclitaxel as first-line therapy for HER2-negative metastatic breast cancer (MERiDiAN): A double-blind placebo-controlled randomised phase III trial with prospective biomarker evaluation

European Journal of Cancer, ISSN: 18790852 09598049

David W. Miles; David Cameron; Igor Bondarenko; Lyudmila Manzyuk; Juan Carlos Alcedo; Roberto Ivan Lopez; Seock-Ah Im; Jean-Luc Canon; Yaroslav Shparyk; Denise A. Yardley; Norikazu Masuda; Jungsil Ro; Neelima Denduluri; Stanislas Hubeaux; Quah; Carlos Bais; O'Shaughnessy

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January 1, 2017

Quantitative Systems Pharmacology: A Case for Disease Models

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Musante; Ramanujan; Brian J. Schmidt; Ghobrial; Lu; Heatherington

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January 1, 2017

TIGIT: A Key Inhibitor of the Cancer Immunity Cycle

Trends in Immunology, ISSN: 14714981 14714906

Nicholas A. Manieri; Eugene Y. Chiang; Jane L. Grogan

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January 1, 2017

Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products

Pharmaceutical Research, ISSN: 1573904X 07248741

Jessica Bane; Olivier Mozziconacci; Li Yi; Y. John Wang; Alavattam Sreedhara; Christian Schöneich

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January 1, 2017

Specific Immune Response to Phospholipase B-Like 2 Protein, a Host Cell Impurity in Lebrikizumab Clinical Material

AAPS Journal, ISSN: 15507416

Saloumeh Kadkhodayan Fischer; Melissa Cheu; Kun Peng; John Lowe; James Araujo; Elaine R. Murray; Mcclintock; Matthews; Patricia Siguenza; An Song

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January 1, 2017

Degradation Mechanisms of Polysorbate 20 Differentiated by 18O-labeling and Mass Spectrometry

Pharmaceutical Research, ISSN: 1573904X 07248741

Lin Zhang; Sandeep Yadav; Barthélemy Demeule; Y. John Wang; Olivier Mozziconacci; Christian Schöneich

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January 1, 2017

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics

AAPS Journal, ISSN: 15507416

Siddharth Sukumaran; Crystal Zhang; Douglas Leipold; Ola M. Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Wang; Marija Milojic-Blair; Montserrat Carrasco-Triguero; Bonnee Rubinfeld; Fielder; Kedan Lin; Ramanujan

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January 1, 2017

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

Cell Death and Differentiation, ISSN: 14765403 13509047

Maria Cristina De Almagro; Tatiana Goncharov; Anita Izrael-Tomasevic; Stefanie Duttler; Matthias Kist; Eugene Varfolomeev; Xiumin Wu; Wyne P. Lee; Jeremy Murray; Webster; Kebing Yu; Donald S. Kirkpatrick; Kim Newton; Domagoj Vucic

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January 1, 2017

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs

Xenobiotica, ISSN: 13665928 00498254

Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Cornelis E. Hop; S. Cyrus Khojasteh; Edna F. Choo

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December 28, 2016

Utilization of In Vitro Neurotoxicity Models in Pre-Clinical Toxicity Assessment

Stem Cells in Toxicology and Medicine,

Karin Staflin; Misner; Donna M. Dambach

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December 22, 2016

IL-13 is a therapeutic target in radiation lung injury

Scientific Reports, ISSN: 20452322

Su I. Chung; Jason A. Horton; Thirumalai R. Ramalingam; Ayla O. White; Eun Joo Chung; Kathryn E. Hudak; Bradley T. Scroggins; Joseph R. Arron; Thomas A. Wynn; Deborah E. Citrin

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December 20, 2016

Characterization of chain pairing variants of bispecific IgG Expressed in a single host cell by high-resolution native and denaturing mass spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Luis Schachner; Guanghui Han; Michael Dillon; Jianhui Zhou; Luke McCarty; Diego Ellerman; Yiyuan Yin; Christoph Spiess; Jennie R. Lill; Paul J. Carter; Wendy N. Sandoval

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December 20, 2016

Structure of crenezumab complex with aβ shows loss of β-hairpin

Scientific Reports, ISSN: 20452322

Ultsch; Bing Li; Till Maurer; Mary Mathieu; Oskar Adolfsson; Andreas Muhs; Andrea Pfeifer; Maria Pihlgren; Travis W. Bainbridge; Mike Reichelt; James A. Ernst; Eigenbrot; Fuh; Jasvinder K. Atwal; Ryan J. Watts; Weiru Wang

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December 16, 2016

Transition-Metal-Free Synthesis of Tertiary Aminocyclopropanes

Organic Letters, ISSN: 15237052 15237060

Patrick Cyr; Alexandre Côté-Raiche; Sarah M. Bronner

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December 16, 2016

Rhodium(III)-Catalyzed C-H Functionalization of 1-(2H)-Phthalazinones at C8

Journal of Organic Chemistry, ISSN: 15206904 00223263

Malcolm P. Huestis

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December 15, 2016

Impact of blood-brain barrier integrity on tumor growth and therapy response in brain metastases

Clinical Cancer Research, ISSN: 15573265 10780432

Matthias Osswald; Jonas Blaes; Yunxiang Liao; Gergely Solecki; Miriam Gömmel; Anna S. Berghoff; Laurent Salphati; Jeffery J. Wallin; Phillips; Wick; Frank Winkler

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December 15, 2016

Phase Ib study of duligotuzumab (MEHD7945A) plus cisplatin/5-fluorouracil or carboplatin/paclitaxel for first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck

Cancer, ISSN: 10970142 0008543X

Antonio Jimeno; Jean-Pascal Machiels; Lori Wirth; Pol Specenier; Tanguy Y. Seiwert; Feby Mardjuadi; Xiaodong Wang; Amy V. Kapp; Stephanie Royer-Joo; Elicia M. Penuel; Bruce Mccall; Andrea Pirzkall; Paul M. Clement

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December 15, 2016

Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter

Oncogene, ISSN: 14765594 09509232

Xueping Qu; Thomas Sandmann; Frierson; Ling Fu; Eloisa Fuentes; Kimberly Walter; Kwame Okrah; Rumpel; Moskaluk; Shan Lu; Wang; Richard Bourgon; Elicia M. Penuel; Andrea Pirzkall; Lukas Amler; Lackner; Tabernero; Garret M. Hampton; Omar Kabbarah

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December 14, 2016

The molecular landscape of high-risk early breast cancer: Comprehensive biomarker analysis of a phase III adjuvant population

npj Breast Cancer, ISSN: 23744677

Wilson; Yu; Xuyang Lu; Jill M. Spoerke; Yuanyuan Xiao; Carol O’brien; Heidi Savage; Huw; Wei Zou; Koeppen; William F. Forrest; Jane Fridlyand; Ling Fu; Rachel Tam; Erica Schleifman; Teiko Sumiyoshi; Luciana L. Molinero; Garret M. Hampton; O'Shaughnessy; Lackner

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December 13, 2016

Communicating laboratory test results for rheumatoid factor: What do patients and physicians want?

Patient Preference and Adherence, ISSN: 1177889X

Ariella Kelman; Caroline O. Robinson; Elisenda Cochin; Nina J. Ahluwalia; Julia Braverman; Emil Chiauzzi; Kristina Simacek

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December 9, 2016

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models

Molecular Neurodegeneration, ISSN: 17501326

Mitchell S. Wold; Junghyun Lim; Véronik Lachance; Zhiqiang Deng; Zhenyu Yue

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December 8, 2016

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Terry Crawford; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Alexander M. Taylor; Gladys De Leon Boenig; Cameron Noland; Jeremy Murray; Justin Ly; Edna F. Choo; Thomas Hunsaker; Emily Chan; Mark Merchant; Samir Kharbanda; Karen Gascoigne; Susan Kaufman; Beresini; Jiangpeng Liao; Wenfeng Liu; Kevin Chen; Zhongguo Chen; Andrew R. Conery; Alexandre Côté; Hariharan Jayaram; Ying Jiang; James R. Kiefer; Tracy L. Kleinheinz; Yingjie Li; Jonathan M. Maher; Eneida Pardo; Florence Poy; Kerry L. Spillane; Fei Wang; Jian Wang; Xiaocang Wei; Zhaowu Xu; Zhongya Xu; Ivana Yen; Laura E. Zawadzke; Xiaoyu Zhu; Steve Bellon; Richard T Cummings; Andrea G Cochran; Brian K Albrecht; Steven Magnuson

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