Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5101 - 5150 OF 16285 RESULTS

A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies
Biotechnology Progress, ISSN: 15206033 87567938
Zhilan Hu; Wei-Ting Hsu; Abigail F.J. Pynn; Domingos Ng; Donna Quicho; Yilma T. Adem; Zephie Kwong; Brad Mauger; John C. Joly; Snedecor; Mike Laird; Dana C. Andersen; Amy Shen
View on Scopus
Access to Cancer Specialist Care and Treatment in Patients With Advanced Stage Lung Cancer
Clinical Lung Cancer, ISSN: 19380690 15257304
Apar Kishor Ganti; Fred R. Hirsch; Murry W. Wynes; Arliene Ravelo; Suresh Ramalingam; Raluca Ionescu-Ittu; Irina Pivneva; Hossein Borghaei
View on Scopus
Tumor Microvessel Density as a Potential Predictive Marker for Bevacizumab Benefit: GOG-0218 Biomarker Analyses
Journal of the National Cancer Institute, ISSN: 14602105 00278874
Carlos Bais; Barbara Mueller; Mark F. Brady; Robert S. Mannel; Robert. A. Burger; Wei Wei; Koen M. Marien; Mark Kockx; Amreen Husain; Michael J. Birrer
View on Scopus
High throughput screening identifies novel, cell cycle-arresting small molecule enhancers of transient protein expression
Biotechnology Progress, ISSN: 15206033 87567938
Hermann-Josef Meyer; Rebecca Turincio; Shirley Ng; Juan Li; Blair Wilson; Pamela Chan; Mark Zak; Dorothea Reilly; Beresini; Athena W. Wong
View on Scopus
Advancements in Understanding Immunogenicity of Biotherapeutics in the Intraocular Space
AAPS Journal, ISSN: 15507416
Eric Wakshull; Quarmby; Hanns-Christian Mahler; Hongwen Rivers; Dhananjay Jere; Meg Ramos; Piotr Szczesny; Karoline Bechtold-Peters; Sharmila Masli; Swati Gupta
View on Scopus
Effect of Aggregation on the Hydrodynamic Properties of Bovine Serum Albumin
Pharmaceutical Research, ISSN: 1573904X 07248741
Mariya Pindrus; James L. Cole; Japneet Kaur; Steven J. Shire; Sandeep Yadav; Devendra S. Kalonia
View on Scopus
Approaches for Establishing Clinically Relevant Dissolution Specifications for Immediate Release Solid Oral Dosage Forms
AAPS Journal, ISSN: 15507416
Andre Hermans; Andreas M. Abend; Filippos Kesisoglou; Talia Flanagan; Michael J. Cohen; Dorys A. Diaz; Mao; Limin Zhang; Gregory K. Webster; Yiqing Lin; David Hahn; Carrie A. Coutant; Haiyan Grady
View on Scopus
Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound
Pharmaceutical Research, ISSN: 1573904X 07248741
Jialin Mao; Peter W. Fan; Susan C. Wong; Jianshuang Wang; Moulay Hicham Alaoui Ismaili; Brian J. Dean; Cornelis E. Hop; Matthew Wright; Yuan Chen
View on Scopus
Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Thomas M. Monticello; Thomas W. Jones; Donna M. Dambach; David M. Potter; Michael W. Bolt; Maggie Liu; Douglas A. Keller; Timothy K. Hart; Vivek J. Kadambi
View on Scopus
FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
Molecular Metabolism, ISSN: 22128778
Mark Chen; Joshua C. Chang; Jose Zavala-Solorio; Lance Kates; Minh Thai; Annie Ogasawara; Xiaobo Bai; Sean Flanagan; Victor Nunez; Khanhky Phamluong; James Ziai; Robert J. Newman; Søren Warming; Ganesh Kolumam; Junichiro Sonoda
View on Scopus
A phase IB dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with either paclitaxel and carboplatin (with or without bevacizumab) or pemetrexed and cisplatin (with or without bevacizumab) in patients with advanced non–small cell lung cancer
European Journal of Cancer, ISSN: 18790852 09598049
Jean-Charles Soria; Alex Adjei; Rastilav Bahleda; Benjamin Besse; Charles Ferte; David Planchard; Jing Zhou; Joseph A. Ware; Kari M. Morrissey; Geetha Shankar; Wei Lin; Jennifer L. Schutzman; Grace Dy; Harry J.M. Groen
View on Scopus
Drug Target Interference in Immunogenicity Assays: Recommendations and Mitigation Strategies
AAPS Journal, ISSN: 15507416
Zhandong Don Zhong; Adrienne Clements-Egan; Boris Gorovits; Mauricio Maia; Giane Sumner; Valerie Theobald; Yuling Wu; Manoj Rajadhyaksha
View on Scopus
High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Yinghui Guan; Oleg Mayba; Thomas Sandmann; Shan Lu; Younjeong Choi; Darbonne; Vincent Leveque; Lisa Ryner; Eric W. Humke; Nga W.R. Tam; Sundari Sujathasarma; Anna Cheung; Richard Bourgon; Lackner; Wang
View on Scopus
Obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in previously untreated diffuse large b-cell lymphoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Umberto Vitolo; Marek Trneny; David Belada; John M. Burke; Angelo Michele Carella; Neil Chua; Pau Abrisqueta; Judit Demeter; Ian Flinn; Xiaonan Hong; Won Seog Kim; Antonio Pinto; Yuan-Kai Shi; Yoichi Tatsumi; Mikkel Z. Oestergaard; Michael Wenger; Guenter Fingerle-Rowson; Olivier Catalani; Tina Nielsen; Maurizio Martelli; Laurie H. Sehn
View on Scopus
Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates
British Journal of Pharmacology, ISSN: 14765381 00071188
Daniela Bumbaca; Janice Maloney; Kristin R. Wildsmith; Reina N. Fuji; William J. Meilandt; Hilda Solanoy; Yanmei Lu; Kun Peng; Blair Wilson; Pamela Chan; Kapil Gadkar; Andrew Kosky; Marisa Goo; Daugherty; Jessica A. Couch; Thomas Keene; Karen Hayes; Lisa Jungbauer Nikolas; Deanna Lane; Robert Switzer; Eric L. Adams; Ryan J. Watts; Kimberly Scearce-Levie; Saileta Prabhu; Lisa Shafer; Deepak R Thakker; Keith Hildebrand; Jasvinder K. Atwal
View on Scopus
Phase 2 randomized trial of the safety and efficacy of MHAA4549A, a broadly neutralizing monoclonal antibody, in a human influenza a virus challenge model
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jacqueline McBride; Jeremy Lim; Tracy Burgess; Rong Deng; Michael A. Derby; Mauricio Maia; Priscilla Horn; Omer Siddiqui; Daniel Sheinson; Haiyin Chen-Harris; Elizabeth Newton; Dimitri Fillos; Denise Nazzal; Carrie M. Rosenberger; Maikke B. Ohlson; Rob Lambkin-Williams; Hosnieh Fathi; Harris; Jorge A. Tavela
View on Scopus
Silencing of retrotransposons by SET DB1 inhibits the interferon response in acute myeloid leukemia
Journal of Cell Biology, ISSN: 15408140 00219525
Trinna L. Cuellar; Anna-Maria Herzner; Xiaotian Zhang; Yogesh Goyal; Colin K. Watanabe; Brad A. Friedman; Vasantharajan Janakiraman; Durinck; Stinson; David Arnott; Tommy K. Cheung; Subhra Chaudhuri; Zora Modrusan; Jonas Martin Doerr; Marie Classon; Benjamin Haley
View on Scopus
A blueprint to advance colorectal cancer immunotherapies
Cancer immunology research, ISSN: 23266074 23266066
Dung T. Le; Vanessa M. Hubbard-Lucey; Michael A. Morse; Christopher R. Heery; Andrea Dwyer; Thomas H. Marsilje; Arthur N. Brodsky; Emily Chan; Dustin A. Deming; Luis A. Diaz; Wolf H. Fridman; Richard M. Goldberg; Stanley R. Hamilton; Franck Housseau; Elizabeth M. Jaffee; S. Peter Kang; Smitha S. Krishnamurthi; Christopher H. Lieu; Wells A. Messersmith; Cynthia L. Sears; Neil H. Segal; Arvin Yang; Rebecca A. Moss; Edward Cha; Jill O'Donnell-Tormey; Roach; Anjelica Q. Davis; Keavy McAbee; Sharyn Worrall; Al B. Benson
View on Scopus
Higher order structure of proteins in biopharmaceutical development
Pharmacopeial Forum, ISSN: 15421945 03634655
Yves Aubin; Michael D. Brenowitz; Edward Chess; Thomas M. Laue; Jasper C. Lin; Donald MacLean; John P. Marino; Linda O. Narhi; William Weiss; Qin Zou
View on Scopus
A new lead to NLRP3 inhibition
Journal of Experimental Medicine, ISSN: 15409538 00221007
Lamkanfi; Vishva M. Dixit
View on Scopus
Combining "bottom-up" and "top-down" approaches to assess the impact of food and gastric pH on pictilisib (GDC-0941) pharmacokinetics
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Tong Lu; Grazyna Fraczkiewicz; Laurent Salphati; Nageshwar Budha; Gena Dalziel; Gillian S. Smelick; Kari M. Morrissey; John Davis; Jin Y. Jin; Joseph A. Ware
View on Scopus
Effect of docetaxel duration on clinical outcomes: Exploratory analysis of CLEOPATRA, a phase III randomized controlled trial
Annals of Oncology, ISSN: 15698041 09237534
David W. Miles; Im; Fung; Bongin Yoo; Adam Knott; Sarah Heeson; Beattie; Sandra M. Swain
View on Scopus
An exploratory, open-label, randomized, multicenter study to investigate the pharmacodynamics of a glycoengineered antibody (imgatuzumab) and cetuximab in patients with operable head and neck squamous cell carcinoma
Annals of Oncology, ISSN: 15698041 09237534
Stéphane Temam; Spicer; Farzaneh; Jean-Charles Soria; Oppenheim; McGurk; Antoine Hollebecque; Sarini; Hussain; Soehrman Brossard; Manenti; Stefan Evers; Paul Delmar; Di Scala; Christoph Mancao; Feuerhake; Luc Andries; Ott; Passioukov; Delord
View on Scopus
Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19F–MRI and Multispectral Analysis
Neoplasia (United States), ISSN: 14765586 15228002
Yunzhou Shi; Jason Oeh; Anna Hitz; Maj Hedehus; Jeffrey Eastham-Anderson; Franklin V. Peale Jr.; Patricia Hamilton; Thomas O'Brien; Deepak Sampath; Richard A. D. Carano
View on Scopus
Concordance between plasma-based and tissue-based next-generation sequencing in LOTUS
The Lancet Oncology, ISSN: 14745488 14702045
Sung-Bae Kim; Rebecca Dent; Matthew Wongchenko; Stina M. Singel; Baselga
View on Scopus
High-resolution two-dimensional liquid chromatography analysis of key linker drug intermediate used in antibody drug conjugates
Journal of Chromatography A, ISSN: 18733778 00219673
Venkatramani; Shu Rong Huang; Mohammad Al-Sayah; Ila Patel; Larry Wigman
View on Scopus
USP7 small-molecule inhibitors interfere with ubiquitin binding
Nature, ISSN: 14764687 00280836
Kategaya; Paola Di Lello; Lionel Rouge; Richard Pastor; Clark; Jason H. Drummond; Tracy L. Kleinheinz; Eva Lin; John-Paul Upton; Sumit Prakash; Johanna Heideker; Mark L. McCleland; Maria Stella Ritorto; Dario R. Alessi; Matthias Trost; Travis W. Bainbridge; Michael Kwok; Taylur P. Ma; Zachary Stiffler; Bradley Brasher; Yinyan Tang; Priyadarshini Jaishankar; Brian R. Hearn; Adam R. Renslo; Michelle R. Arkin; Frederick Cohen; Kebing Yu; Franklin V. Peale Jr.; Florian Gnad; Matthew T. Chang; Christiaan N. Klijn; Elizabeth M. Blackwood; Scott E. Martin; William F. Forrest; James A. Ernst; Chudi O. Ndubaku; Xiaojing Wang; Beresini; Vickie Tsui; Carsten Schwerdtfeger; Robert A. Blake; Jeremy Murray; Till Maurer; Ingrid E. Wertz
View on Scopus
Grid-Based Surface Generalized Born Model for Calculation of Electrostatic Binding Free Energies
Journal of Chemical Information and Modeling, ISSN: 15205142 15499596
Negin Forouzesh; Saeed Izadi; Alexey V. Onufriev
View on Scopus
Grid-Based Surface Generalized Born Model for Calculation of Electrostatic Binding Free Energies
Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596
Negin Forouzesh; Saeed Izadi; Alexey V. Onufriev
View on Scopus
Green Chemistry Articles of Interest to the Pharmaceutical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Marian C. Bryan; Andrew Cosbie; Louis Diorazio; Zhongbo Fei; Kenneth Fraunhoffer; John Hayler; Matthew Hickey; Shaun Hughes; Mark McLaws; Paul Richardson; Gheorghe-Doru Roiban; Markus Schober; Alan Steven; Timothy White; Jingjun Yin
View on Scopus
Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Breanna S. Vollmar; Binqing Wei; Rachana Ohri; Jianhui Zhou; Jintang He; Shang-Fan Yu; Douglas Leipold; Ely Cosino; Sharon Fong Yee; Aimee Fourie-O'Donohue; Guangmin Li; Gail L. Phillips; Katherine R. Kozak; Amrita Kamath; Keyang Xu; Genee Y. Lee; Greg A. Lazar; Hans Erickson
View on Scopus
Host-derived fatty acids activate type VII secretion in Staphylococcus aureus
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Michael S. Lopez; Irene S. Tan; Donghong Yan; Jing Kang; Mark McCreary; Zora Modrusan; Cary D. Austin; Min Xu; Eric J. Brown
View on Scopus
Therapeutic targeting of the CBP/p300 bromodomain blocks the growth of castration-resistant prostate cancer
Cancer Research, ISSN: 15387445 00085472
Lingyan Jin; Jesse Garcia; Emily Chan; Cecile C. de la Cruz; Ehud Segal; Mark Merchant; Samir Kharbanda; Ryan Raisner; Matthias Peter; Zora Modrusan; Justin Ly; Edna F. Choo; Susan Kaufman; Beresini; F. Anthony Romero; Steven Magnuson; Karen Gascoigne
View on Scopus
Bringing lung function prediction equations to diverse populations
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Joshua Galanter
View on Scopus
VariantTools: An extensible framework for developing and testing variant callers
Bioinformatics, ISSN: 14602059 13674803
Michael Lawrence; Robert Gentleman
View on Scopus
Trial of tocilizumab in giant-cell arteritis
New England Journal of Medicine, ISSN: 15334406 00284793
John H. Stone; Micki Klearman; Neil Collinson
View on Scopus
Stabilizing a Tubulysin Antibody-Drug Conjugate to Enable Activity Against Multidrug-Resistant Tumors
ACS Medicinal Chemistry Letters, ISSN: 19485875
Leanna Staben; Shang-Fan Yu; Jinhua Chen; Gang Yan; Zijin Xu; Geoffrey Del Rosario; Jeffrey Lau; Luna Liu; Jun Guo; Bing Zheng; Josefa Dela Cruz-Chuh; Byoung-Chul Lee; Rachana Ohri; Wenwen Cai; Hongxiang Zhou; Katherine R. Kozak; Keyang Xu; Gail L. Phillips; Jiawei Lu; John Wai; Andrew G. Polson; Thomas H. Pillow
View on Scopus
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Snahel Patel; William J. Meilandt; Rebecca Erickson; Jinhua Chen; Gauri Deshmukh; Anthony A. Estrada; Reina N. Fuji; Paul Gibbons; Amy Gustafson; Seth F. Harris; Jose Imperio; Wendy Liu; Xingrong Liu; Yichin Liu; Joseph P. Lyssikatos; Changyou Ma; Jianping Yin; Joe Lewcock; Michael Siu
View on Scopus
Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Cell Host and Microbe, ISSN: 19346069 19313128
Lewis J. Entwistle; Victoria S. Pelly; Stephanie M. Coomes; Yashaswini Kannan; Jimena Perez-Lloret; Stephanie Czieso; Mariana Silva dos Santos; James I. MacRae; Lucy Collinson; Abdul Sesay; Nikolay Nikolov; Amina Metidji; Helena Helmby; David Y. Hui; Mark S. Wilson
View on Scopus
Mutation load and an effector T-cell gene signature may distinguish immunologically distinct and clinically relevant lymphoma subsets
Blood advances, ISSN: 24739537 24739529
Christopher R. Bolen; Mccord; Sarah Huet; Garrett M Frampton; Richard Bourgon; Fabrice Jardin; Peggy Dartigues; Elizabeth A. Punnoose; Edith Szafer-Glusman; Luc Xerri; Pierre Sujobert; Gilles Salles; Jeffrey M. Venstrom
View on Scopus
Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Yingnan Zhang; Ultsch; Nicholas J. Skelton; Burdick; Beresini; Wei Li; Monica Kong-Beltran; Andrew S. Peterson; John Quinn; Cecilia Chiu; Yan Wu; Steven Shia; Paul Moran; Paola Di Lello; Eigenbrot; Daniel Kirchhofer
View on Scopus
Cost-effectiveness analysis of ocrelizumab versus subcutaneous interferon beta-1a for the treatment of relapsing multiple sclerosis
Journal of Medical Economics, ISSN: 1941837X 13696998
Hongbo Yang; Emilie Duchesneau; Rebekah Foster; Annie Guérin; Esprit Ma; Nina Parikh Thomas
View on Scopus
Tissue-aware RNA-Seq processing and normalization for heterogeneous and sparse data
BMC Bioinformatics, ISSN: 14712105
Joseph N. Paulson; Cho-Yi Chen; Camila M. Lopes-Ramos; Marieke L. Kuijjer; John Platig; Abhijeet R. Sonawane; Maud Fagny; Kimberly Glass; John Quackenbush
View on Scopus
Biorelevant Dissolution Models for a Weak Base to Facilitate Formulation Development and Overcome Reduced Bioavailability Caused by Hypochlordyria or Achlorhydria
Molecular Pharmaceutics, ISSN: 15438392 15438384
Dawen Kou; Sudharsan Dwaraknath; Yannick Fischer; Daniel Nguyen; Myeonghui Kim; Hiuwing Yiu; Preeti Patel; Tania Ng; Chen Mao; Matthew Durk; Leslie Chinn; Helen Winter; Larry Wigman; Peter M. Yehl
View on Scopus
Systemic pharmacokinetics and pharmacodynamics of intravitreal aflibercept, bevacizumab, and ranibizumab
Retina, ISSN: 15392864 0275004X
Robert L. Avery; Alessandro A. Castellarin; Nathan C. Steinle; Dilsher S. Dhoot; Dante Joseph Pieramici; Robert See; Stephen Couvillion; MA'An A. Nasir; Melvin D. Rabena; Mauricio Maia; Sherri A. Van Everen; Kha Le; William D. Hanley
View on Scopus
Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective
Drug Discovery Today, ISSN: 18785832 13596446
Harvey Wong; Tonika Bohnert; Valeriu Damian-Iordache; Christopher Gibson; Cheng-Pang Hsu; Anu Shilpa Krishnatry; Bianca M. Liederer; Jing Lin; Qiang Lu; Jerome T Mettetal; Daniel R Mudra; Marjoleen JMA Nijsen; Patricia Schroeder; Edgar Schuck; Satyendra Suryawanshi; Patrick Trapa; Alice Tsai; Haiqing Wang; Fan Wu
View on Scopus
Omalizumab substantially improves dermatology-related quality of life in patients with chronic spontaneous urticaria
Journal of the European Academy of Dermatology and Venereology, ISSN: 14683083 09269959
Finlay; Allen P. Kaplan; Beck; Evgeniya Antonova; Maria-Magdalena Balp; James L. Zazzali; Sam Khalil; Marcus Maurer
View on Scopus
Risk of cutaneous squamous cell carcinoma after treatment of basal cell carcinoma with vismodegib
Journal of the American Academy of Dermatology, ISSN: 10976787 01909622
Tina Bhutani; Michael Abrouk; Camelia S. Sima; Natalia Sadetsky; Jeannie Hou; Ivor Caro; Mary-Margaret Chren; Sarah T. Arron
View on Scopus
Notch signaling in development, tissue homeostasis, and disease
Physiological Reviews, ISSN: 15221210 00319333
Christian W. Siebel; Urban Lendahl
View on Scopus
Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
The Lancet Oncology, ISSN: 14745488 14702045
Sung-Bae Kim; Daniel Maslyar; Rebecca Dent; Seock-Ah Im; Sibel Blau; Antoinette R Tan; Oliveira; Saura; Matthew Wongchenko; Amy V Kapp; Wai Y. Chan; Stina M. Singel; Baselga; Sung-Bae Kim; Keun Seok Lee; Seock-Ah Im; Marc Espié; Hwei-Chung Wang; Sibel Blau; Antoinette Tan; Joo-Hyuk Sohn; De Laurentiis; Laura Garcia Estevez; Chiun-Sheng Huang; Romieu; Michel Velez; Rafael Villanueva; Pier Franco Conte; Shaker R. Dakhil; Marc Debled; Antonio González-Martín; Sara A. Hurvitz; Jee Hyun Kim; Christelle Levy; Mafalda Oliveira; Pedro Sanchez-Rovira; Jae Hong Seo; Vicente Valero; Gregory Vidal; Andrea Wong; Mary Ann K Allison; Robert A. Figlin; David Chan; Shin-Cheh Chen; Yen-Hsun Chen; Melody A. Cobleigh; Filippo De Braud; Luc Dirix; Vincent Hansen; Anne Hardy Bessard; Nicholas Iannotti; Isakoff; William Lawler; Alvaro Montaño; Mohamad Salkini; Leonard Seigel
View on Scopus
© 2026 Genentech, Inc. All rights reserved. This site is intended for US residents only.