Scientists / Publications

Publications

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DISPLAYING 5151 - 5200 OF 15701 RESULTS

Neoadjuvant Systemic Therapy for Breast Cancer: Factors Influencing Surgeons’ Referrals
Annals of Surgical Oncology, ISSN: 15344681 10689265
Eleftherios P. Mamounas; Christine Poulos; Hans-Peter Goertz; Juan Marcos González; Amy Pugh; Vincent Antao
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Developing HSCs become Notch independent by the end of maturation in the AGM region
Blood, ISSN: 15280020 00064971
Céline Souilhol; Javier G. Lendinez; Stanislav Rybtsov; Fiona Murphy; Heather Wilson; David Hills; Antoniana Batsivari; Anahí Binagui-Casas; Alison C. McGarvey; H. Robson MacDonald; Kageyama; Christian W. Siebel; Suling Zhao; Alexander Medvinsky
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Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Mark Zak; Po-Wai Yuen; Xiongcai Liu; Snahel Patel; Deepak Sampath; Jason Oeh; Bianca M. Liederer; Weiru Wang; Thomas O'Brien; Yang Xiao; Nicholas J. Skelton; Rongbao Hua; Jasleen K. Sodhi; Yunli Wang; Lei Zhang; Guiling Zhao; Xiaozhang Zheng; Yen-Ching Ho; Kenneth W. Bair; Peter Dragovich
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Interfering with the chronic immune response rescues chronic degeneration after traumatic brain injury
Journal of Neuroscience, ISSN: 15292401 02706474
Ali Ertürk; Susanne Mentz; Erik E. Stout; Maj Hedehus; Sara L. Dominguez; Lisa Neumaier; Franziska Krammer; Gemma Llovera; Karpagam Srinivasan; David V. Hansen; Arthur Liesz; Kimberly Scearce-Levie; Morgan Sheng
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Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla)
Bioconjugate Chemistry, ISSN: 15204812 10431802
Yan Chen; Michael Kim; Laura Zheng; Galahad Deperalta; Fred Jacobson
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Preparation of 2-Azabicyclo[21.1]hexane Hydrochloride
Synlett, ISSN: 14372096 09365214
Haili Liao; Aimin Li; Xingsong Chen; Kun Liang; Yang Shen; Qingfeng Liang; Kewei Xu; Daniel G. Shore; Elisia Villemure; Michael Siu; Malcolm P. Huestis
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Synthesis of Fused Imidazole-Containing Ring Systems via Dual Oxidative Amination of C(sp3)-H Bonds
Journal of Organic Chemistry, ISSN: 15206904 00223263
Georgette M. Castanedo; Yanzhou Liu; James J. Crawford; Marie-Gabrielle Braun
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A phase i dose-escalation study evaluating the safety tolerability and pharmacokinetics of CUDC-427, a potent, oral, monovalent IAP antagonist, in patients with refractory solid tumors
Clinical Cancer Research, ISSN: 15573265 10780432
Anthony W. Tolcher; Bendell; Kyriakos P. Papadopoulos; Howard A. Burris; Amita Patnaik; Wayne J. Fairbrother; Harvey Wong; Nageshwar Budha; Darbonne; Franklin V. Peale Jr.; Michael Mamounas; Stephanie Royer-Joo; Ron Yu; Chia C. Portera; Jeffery R. Infante
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Generation and Protective Ability of Influenza Virus-Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge
Journal of Infectious Diseases, ISSN: 15376613 00221899
Sinthujan Jegaskanda; Catherine Luke; Heather D. Hickman; Mark Y. Sangster; Wendy F. Wieland-Alter; Jacqueline McBride; Jon W. Yewdell; Peter Wright; John Treanor; Carrie M. Rosenberger; Kanta Subbarao
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Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Sharada Labadie; Peter Dragovich; Richard T Cummings; Gauri Deshmukh; Amy Gustafson; Ning Han; Jean-Christophe Harmange; James R. Kiefer; Yue Li; Jun Liang; Bianca M. Liederer; Yichin Liu; Wanda Manieri; Weifeng Mao; Lesley J. Murray; Daniel F. Ortwine; Patrick Trojer; Erica Vanderporten; Maia Vinogradova; Li Wen
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Recent progress on nuclear receptor RORγ modulators
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Patrick Cyr; Sarah M. Bronner; James J. Crawford
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Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Olivier René; Benjamin P. Fauber; Adrian Barnard; Kerry Chapman; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Adam R. Johnson; Hank La; Maxine Norman; Gary Salmon; Susan Summerhill; Harvey Wong
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Validation of a treatment satisfaction questionnaire in non-hodgkin lymphoma: Assessing the change from intravenous to subcutaneous administration of rituximab
Patient Preference and Adherence, ISSN: 1177889X
Christina Theodore-Oklota; Louise Humphrey; Christof Wiesner; Gabriel Schnetzler; Stacie Hudgens; Alicyn K. Campbell
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Fast and Efficient non-reduced Lys-C digest using pressure cycling technology for antibody disulfide mapping by LC–MS
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Ying Cheng; Yonghong Chen; X. Christopher Yu
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Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression
Oncogene, ISSN: 14765594 09509232
Franciosa; Diluvio; Del Gaudio; Giuli; Palermo; Grazioli; Campese; Talora; Bellavia; D'Amati; Besharat; Nicoletti; Christian W. Siebel; Lisa Choy; Rustighi; G Del Sal; Screpanti; Checquolo
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Rapid, semi-automated protein terminal characterization using ISDetect
Nature Biotechnology, ISSN: 15461696 10870156
Corey Bakalarski; Yutian Gan; Ingrid E. Wertz; Jennie R. Lill; Wendy N. Sandoval
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High cell-surface density of HER2 deforms cell membranes
Nature Communications, ISSN: 20411723
Inhee Chung; Mike Reichelt; Lily Shao; Robert W. Akita; Koeppen; Linda Rangell; Gabriele Schaefer; Ira Mellman; Mark X. Sliwkowski
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Ocular therapeutics: Drug delivery and pharmacology
Molecular Pharmaceutics, ISSN: 15438392 15438384
Leslie Dickmann
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Contribution of antibody hydrodynamic size to vitreal clearance revealed through rabbit studies using a species-matched fab
Molecular Pharmaceutics, ISSN: 15438392 15438384
Whitney Shatz; Hass; Mary Mathieu; Hok Seon Kim; Kimberly D. Leach; Michelle Zhou; Yongping Crawford; Amy Shen; Kathryn Wang; Debby P. Chang; Mauricio Maia; Susan R. Crowell; Leslie Dickmann; Justin M. Scheer; Robert F. Kelley
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Characterization of the pH and temperature in the rabbit, pig, and monkey eye: Key parameters for the development of long-acting delivery ocular strategies
Molecular Pharmaceutics, ISSN: 15438392 15438384
Florence Lorget; Audrey Parenteau; Michel Carrier; Daniel Lambert; Ana Gueorguieva; Chris Schuetz; Vlad Bantseev; Evan A Thackaberry
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Mixed-mode chromatography in pharmaceutical and biopharmaceutical applications
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Kelly Zhang; Xiaodong Liu
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Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant
Nature Communications, ISSN: 20411723
Jill M. Spoerke; Steven Gendreau; Kimberly Walter; Jiaheng Qiu; Wilson; Heidi Savage; Junko Aimi; Mika K. Derynck; Meng Chen; Iris Chan; Lukas Amler; Garret M. Hampton; Stephen Johnston; Ian E. Krop; Schmid; Lackner
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Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses
Cell Reports, ISSN: 22111247
Alejandra Urrutia; Darragh Duffy; Vincent Rouilly; Céline Posseme; Raouf Djebali; Gabriel Illanes; Valentina Libri; Benoit Albaud; David Gentien; Barbara Piasecka; Milena Hasan; Magnus Fontes; Laurent Abel; Andres Alcover; Kalla Astrom; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Jacques Fellay; Antonio Freitas; Odile Gelpi; Ivo Gomperts-Boneca; Serge Hercberg; Olivier Lantz; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Stanislas Pol; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Vassili Soumelis; Frédéric Tangy; Eric Tartour; Antoine Toubert; Marie-Noëlle Ungeheuer; Lluis Quintana-Murci; Matthew L. Albert
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First-Line Treatment with Bevacizumab and Platinum Doublet Combination in Non-Squamous Non-Small Cell Lung Cancer: A Retrospective Cohort Study in US Oncology Community Practices
Drugs - Real World Outcomes, ISSN: 21989788 21991154
Orsolya Lunacsek; Arliene Ravelo; Anna D. Coutinho; Sebastien J. Hazard; Mark R. Green; Joanne Willey; Michael Eaddy; Hans-Peter Goertz
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Application of 19F quantitative NMR to pharmaceutical analysis
Concepts in Magnetic Resonance Part A: Bridging Education and Research, ISSN: 15525023 15466086
Allison O. Mattes; David J. Russell; Evgeny Tishchenko; Yanzhou Liu; Robert H. Cichewicz; Sarah J. Robinson
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Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses
Cell Reports, ISSN: 22111247
Alejandra Urrutia; Darragh Duffy; Vincent Rouilly; Céline Posseme; Raouf Djebali; Gabriel Illanes; Valentina Libri; Benoit Albaud; David Gentien; Barbara Piasecka; Milena Hasan; Magnus Fontes; Matthew L. Albert; Laurent Abel; Andres Alcover; Kalla Astrom; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Jacques Fellay; Antonio Freitas; Odile Gelpi; Ivo Gomperts-Boneca; Serge Hercberg; Olivier Lantz; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Stanislas Pol; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Vassili Soumelis; Frédéric Tangy; Eric Tartour; Antoine Toubert; Marie-Noëlle Ungeheuer; Lluis Quintana-Murci; Matthew L. Albert
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Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
Cell Reports, ISSN: 22111247
Leonard D. Goldstein; James Lee; Florian Gnad; Christiaan N. Klijn; Annalisa Schaub; Jens Reeder; Anneleen Daemen; Corey Bakalarski; Thomas Holcomb; David S. Shames; Ryan J. Hartmaier; Juliann Chmielecki; Somasekar Seshagiri; Robert Gentleman; David Stokoe
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Translational pharmacokinetic/pharmacodynamic analysis in cancer pharmacology: a tool to maximize the value of antitumor efficacy from tumor bearing mice
Drug Discovery Today: Technologies, ISSN: 17406749
Harvey Wong; Stephen Gould
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Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies
Drug Discovery Today: Technologies, ISSN: 17406749
Amrita Kamath
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Quantitative systems pharmacology: a promising approach for translational pharmacology
Drug Discovery Today: Technologies, ISSN: 17406749
Kapil Gadkar; Kirouac; Neil Parrott; Ramanujan
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Pharmacogenomics in the age of personalized medicine
Drug Discovery Today: Technologies, ISSN: 17406749
Leslie Dickmann; Joseph A. Ware
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Introduction to the theme ‘technology – translational pharmacology’
Drug Discovery Today: Technologies, ISSN: 17406749
Saileta Prabhu
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Foreword: Quality by Design for monoclonal antibodies: Description of an integrated system
Biologicals, ISSN: 10958320 10451056
Kelley
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Introduction to the application of QbD principles for the development of monoclonal antibodies
Biologicals, ISSN: 10958320 10451056
Christof Finkler; Lynne Krummen
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Establishing a control system using QbD principles
Biologicals, ISSN: 10958320 10451056
Kepert; Cromwell; Niklas Engler; Christof Finkler; Gerald Gellermann; Lynn Gennaro; Reed J. Harris; Raquel Iverson; Kelley; Lynne Krummen; Nathan McKnight; Paul Motchnik; Volker Schnaible; Ron Taticek
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Determination of critical quality attributes for monoclonal antibodies using quality by design principles
Biologicals, ISSN: 10958320 10451056
Nadja Alt; Taylor Zhang; Paul Motchnik; Ron Taticek; Quarmby; Tilman Schlothauer; Hermann Beck; Thomas Emrich; Reed J. Harris
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Vemurafenib in patients with BRAFV600E-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial
The Lancet Oncology, ISSN: 14745488 14702045
Marcia S Brose; Maria E Cabanillas; Ezra E W Cohen; Lori Wirth; Todd Riehl; Huibin Yue; Steven I Sherman; Eric J Sherman
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Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial
The Lancet Oncology, ISSN: 14745488 14702045
Paolo A. Ascierto; McArthur; Brigitte Dréno; Victoria Atkinson; Gabriella Liszkay; Anna Maria Di Giacomo; Mario Mandala; Lev Demidov; Daniil Stroyakovskiy; Luc Thomas; Luis De La Cruz-Merino; Caroline Dutriaux; Claus Garbe; Yibing Yan; Matthew Wongchenko; Ilsung Chang; Jessie Hsu; Daniel Koralek; Isabelle Rooney; Antoni Ribas; James Larkin
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A putative bacterial ABC transporter circumvents the essentiality of signal peptidase
mBio, ISSN: 21507511 21612129
J. Hiroshi Morisaki; Peter A. Smith; Shailesh V. Date; Kimberly K. Kajihara; Chau Linda Truong; Zora Modrusan; Donghong Yan; Jing Kang; Min Xu; Ishita M. Shah; Robert Mintzer; Eric M. Kofoed; Tommy K. Cheung; David Arnott; Michael F. T. Koehler; Christopher E. Heise; Eric J. Brown; Man-Wah Tan; Wouter L. W. Hazenbos
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Erratum: Corrigendum to “Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry” (Journal of Chromatography B (2016) 1020 (111–119) (S157002321630188X) (10.1016/j.jchromb.2016.03.039))
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Xiaorong Liang; Michael Van Parys; Xiao Ding; Ning Zeng; Luke Bi; Dorshorst; McKnight; Dennis Milanowski; Jialin Mao; Yuan Chen; Joseph A. Ware; Brian J. Dean; Cornelis E. Hop; Yuzhong Deng
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Should Therapeutic Drug Monitoring for Monoclonal Antibodies Remain the Exception or Become the Norm?
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Mark Stroh; Bert L. Lum
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Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma
European Respiratory Journal, ISSN: 13993003 09031936
Emma Doran; David F. Choy; Aarti Shikotra; Claire A. Butler; Declan M. O'Rourke; James A. Johnston; Adrien Kissenpfennig; Peter Bradding; Joseph R. Arron; Liam G. Heaney
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Safety and efficacy of vismodegib in patients with basal cell carcinoma nevus syndrome: Pooled analysis of two trials
Orphanet Journal of Rare Diseases, ISSN: 17501172
Anne Lynn S. Chang; Sarah T. Arron; Michael R. Migden; James A. Solomon; Simon Yoo; Bann-Mo Day; Edward McKenna; Aleksandar Sekulic
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Minipiloting Tools for Pharmaceutical Development
AAPS PharmSciTech, ISSN: 19398042 18725120
Julia ZH Gao; Ajit S. Narang; Sailesh A. Varia
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Brief Report: Whole-Exome Sequencing for Identification of Potential Causal Variants for Diffuse Cutaneous Systemic Sclerosis
Arthritis and Rheumatology, ISSN: 23265205 23265191
Angel C. Y. Mak; Paul L. F. Tang; Clare Cleveland; Melanie H. Smith; Kari Connolly; Tamiko R. Katsumoto; Paul J. Wolters; Pui-Yan Kwok; Lindsey A. Criswell
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Two phase 1, randomized, double-blind, placebo-controlled, single- ascending-dose studies to investigate the safety, tolerability, and pharmacokinetics of an anti-influenza a virus monoclonal antibody, MHAA4549A, in healthy volunteers
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jeremy Lim; Rong Deng; Michael A. Derby; Richard Larouche; Priscilla Horn; Malia Anderson; Mauricio Maia; Stephanie Carrier; Isabelle Pelletier; Tracy Burgess; Priya Kulkarni; Elizabeth Newton; Jorge A. Tavel
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Survey of Health Care Practitioners’ Preferences for Medical Information: Collective Insights for Impacting Patient Care
Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790
Stacey M. Fung; Dannis Y. Chang; Roshni Patel-Romero; Matt Suchodolski
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Occurrence and outcome of de novo metastatic breast cancer by subtype in a large, diverse population
Cancer Causes and Control, ISSN: 15737225 09575243
Li Tao; Laura Chu; Lisa I. Wang; Lisa Moy; Melissa Brammer; Chunyan Song; Marjorie Green; Allison W. Kurian; Scarlett Lin Gomez; Christina A. Clarke
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Chemical structure and concentration of intratumor catabolites determine efficacy of antibody drug conjugates
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Donglu Zhang; Shang-Fan Yu; Yong Ma; Keyang Xu; Peter Dragovich; Thomas H. Pillow; Luna Liu; Geoffrey Del Rosario; Jintang He; Zhonghua Pei; Jack D. Sadowsky; Hans Erickson; Cornelis E. Hop; S. Cyrus Khojasteh
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Integration of QbD risk assessment tools and overall risk management
Biologicals, ISSN: 10958320 10451056
Kelley; Cromwell; Joe Jerkins
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