Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6101 - 6150 OF 15632 RESULTS

January 1, 2015

Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1)

Clinical Cancer Research, ISSN: 15573265 10780432

Hirdesh Uppal; Estelle Doudement; Kaushiki Mahapatra; Darbonne; Daniela Bumbaca; Shen; Xiaoyan Du; Ola M. Saad; Kristin Harden; Steve Olsen; Gail L. Phillips; Dylan P. Hartley; Mark X. Sliwkowski; Sandhya Girish; Donna M. Dambach; Vanitha Ramakrishnan

January 1, 2015

New stent leaves no polymer behind

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2015

Hamster phospholipase B-like 2 (PLBL2): A host-cell protein impurity in therapeutic monoclonal antibodies derived from chinese hamster ovary cells

BioProcess International, ISSN: 15426319

Vanderlaan; Wendy N. Sandoval; Peter S. Liu; Julie C. Nishihara; George Tsui; Margaret Lin; Feny Gunawan; Sara Parker; Robert Ming Wong; Justin Low; Xiangdan Wang; Yang; Karthik Veeravalli; McKay; X. Christopher Yu; O'Connell; Benjamin Tran; Rajesh Vij; Chris Fong; Kathleen Francissen; Judith Zhu-Shimoni; Quarmby; Denise C. Krawitz

January 1, 2015

Sequence variants and sequence variant analysis in biotherapeutic proteins

ACS Symposium Series, ISSN: 19475918 00976156

Oleg V. Borisov; Melissa Alvarez; James A. Carroll; Paul W. Brown

January 1, 2015

Predicting response to HER2 kinase inhibition

Oncotarget, ISSN: 19492553

Jeffrey Settleman

January 1, 2015

MEK inhibitors beyond monotherapy: Current and future development

Current Opinion in Pharmacology, ISSN: 14714973 14714892

Ian E. Templeton; Luna Musib

January 1, 2015

Dual B cell immunotherapy is superior to individual Anti-CD20 depletion or baff blockade in murine models of spontaneous or accelerated lupus

Arthritis and Rheumatology, ISSN: 23265205 23265191

Wei Yu Lin; Dhaya Seshasayee; Wyne P. Lee; Patrick Caplazi; Sami McVay; Eric Suto; Allen Nguyen; Zhonghua Lin; Yonglian Sun; Laura DeForge; Mercedesz Balazs; Flavius Martin; Ali A. Zarrin

January 1, 2015

Antibody isotype switching in vertebrates

Results and Problems in Cell Differentiation, ISSN: 18610412 00801844

Kate Senger; Jason A. Hackney; Jian Payandeh; Ali A. Zarrin

January 1, 2015

Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study

Liver International, ISSN: 14783231 14783223

Edward J. Gane; Pockros; Stefan Zeuzem; Marcellin; Anna Shikhman; Coen A. Bernaards; Julian Zhou; Ellen S. Yetzer; Rosa Ballester; Cindy Dwyer; Xiao Tong; Nájera; Anne Bertasso; Janet Hammond; Amy Kindrick; Peter N. Morcos; Patrick F. Smith; Saray Stancic; Nancy Shulman

January 1, 2015

Reply

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Aidan Long; Kenneth J. Rothman; Hubert Chen; Gillis Carrigan; Stanley J. Szefler

January 1, 2015

Functional and structural abnormalities in deferoxamine retinopathy: A review of the literature

BioMed Research International, ISSN: 23146141 23146133

Maura Di Nicola; Giulio Barteselli; Laura Dell'Arti; Roberto Ratiglia; Francesco Viola

January 1, 2015

CMC considerations when a drug development project is assigned breakthrough therapy status

Pharmaceutical Engineering, ISSN: 02738139

Earl S. Dye; John Groskoph; Kelley; George Millili; Moheb Nasr; Christopher J. Potter; Eric Thostesen; Hans Vermeersch

January 1, 2015

Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with 89Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts

Oncotarget, ISSN: 19492553

Eva J. ter Weele; Anton G.T. Terwisscha van Scheltinga; Jos G.W. Kosterink; Linda Pot; Silke R. Vedelaar; Laetitia E. Lamberts; Simon P. Williams; Marjolijn N. Lub-de Hooge; Elisabeth G. E. De Vries

January 1, 2015

Antibody engineering & therapeutics 2015: The antibody society’s annual meeting december 7–10, 2015, San Diego, CA

mAbs, ISSN: 19420870 19420862

Paul W. H. I. Parren; Dennis R. Burton; Andrew Bradbury; James S. Huston; Paul J. Carter; Trudi Veldman; Kerry A. Chester; James W. Larrick; Mark R. Alfenito; Jamie K. Scott; Louis M. Weiner; Gregory P. Adams; Janice M. Reichert

January 1, 2015

Ocular angiogenesis: Vascular endothelial growth factor and other factors

Developments in Ophthalmology, ISSN: 16622790 02503751

Roman G. Rubio; Anthony P. Adamis

January 1, 2015

100% Container closure integrity testing of lyophilized drug products by the oxygen head space analysis methodology

Pharmazeutische Industrie, ISSN: 0031711X

Tobias Posset; Misael Schleger; Fred Lim; Mumenthaler; Sebastian Schneider; Thomas Kaiser

January 1, 2015

Prediction of Drug Distribution in Subcutaneous Xenografts of Human Tumor Cell Lines and Healthy Tissues in Mouse: Application of the Tissue Composition-Based Model to Antineoplastic Drugs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Yunghsiang Chen; Xiao Ding; Stephen Gould; Cornelis E. Hop; Kirsten Messick; Jason Oeh; Bianca M. Liederer

January 1, 2015

Derivation of phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 2: Exposure-response analyses for efficacy and safety variables

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Matthew Hruska; Xiaodong Wang; Phyllis Chan; Alaa Ahmad; Jeremy Freeman; Maria Arantxa Horga; Jan Hillson; Vikram Kansra; Juan-Carlos Lopez-Talavera

January 1, 2015

Dusp5 negatively regulates IL-33-mediated eosinophil survival and function

EMBO Journal, ISSN: 14602075 02614189

Derek A. Holmes; Jung-Hua Yeh; Donghong Yan; Min Xu; Andrew A. Chan

January 1, 2015

Randomized study of danoprevir/ritonavir-based therapy for HCV genotype 1 patients with prior partial or null responses to peginterferon/ribavirin

Journal of Hepatology, ISSN: 16000641 01688278

Jordan J. Feld; Ira M. Jacobson; Donald Jensen; Graham R. Foster; Stanislas Pol; Edward Tam; Maciej Jablkowski; Hanna Berak; John M. Vierling; Eric Yoshida; Héctor R. Perez-Gomez; Astrid Scalori; Gregory J. Hooper; Jorge A. Tavel; Mercidita T. Navarro; Saba Shahdad; Rohit Kulkarni; Sophie Le Pogam; Nájera; Simon Eng; Chin Yin Lim; Nancy Shulman; Ellen S. Yetzer

January 1, 2015

Tocilizumab in rheumatoid arthritis: A case study of safety evaluations of a large postmarketing data set from multiple data sources

Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172

Jeffrey R. Curtis; Susana Perez-Gutthann; Samy Suissa; Pavel Napalkov; Natasha Singh; Liz Thompson; Benjamin Porter-Brown

January 1, 2015

Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma

Genes and Cancer, ISSN: 19476027 19476019

Chen; James Lee; Noelyn Kljavin; Benjamin Haley; Anneleen Daemen; Leisa Johnson; Yuxin Liang

January 1, 2015

Analytical technologies for genotoxic impurities in pharmaceutical compounds

LCGC North America, ISSN: 15275949

Archana Kumar; Kelly Zhang; Larry Wigman

January 1, 2015

Separation science in drug development, part I: High-throughput purification

LCGC North America, ISSN: 15275949

Joseph H. Pease; Brent Murphy; Mengling Wong; Michael W. Dong

January 1, 2015

Separation science in drug development, part II: High-throughput characterization

LCGC North America, ISSN: 15275949

Baiwei Lin; Joseph H. Pease; Michael W. Dong

January 1, 2015

Iridium(III)-catalyzed benzylic amine directed C-H sulfonamidation of arenes with sulfonyl azides

ChemCatChem, ISSN: 18673899 18673880

Heng Chen; Malcolm P. Huestis

January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun J. Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J. Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N. Kinch; Nick V Grishin; Matthias Peter; Bernard Chow; Julian S. Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

January 1, 2015

Manufacturing of High-Concentration Monoclonal Antibody Formulations via Spray Drying-the Road to Manufacturing Scale

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Benson Gikanga; Robert Turok; Ada Hui; Mayumi Bowen; Oliver B. Stauch; Maa

January 1, 2015

Cognitive deficits, changes in synaptic function, and brain pathology in a mouse model of normal aging

eNeuro, ISSN: 23732822

Martin Weber; Tiffany Wu; Jesse E. Hanson; Nazia M. Alam; Hilda Solanoy; Hai Ngu; Benjamin E. Lauffer; Han H. Lin; Sara L. Dominguez; Jens Reeder; Jennifer A. Tom; Pascal Steiner; Oded Foreman; Glen T. Prusky; Kimberly Scearce-Levie

January 1, 2015

Comparison of Healthcare Costs Between Rheumatoid Arthritis Patients Treated with Infused Biologics After Switching from Another Biologic

Drugs - Real World Outcomes, ISSN: 21989788 21991154

Stephen S. Johnston; Donna McMorrow; Amanda M. Farr; Paul Juneau; Sarika Ogale

January 1, 2015

Exploring protein-protein interactions using peptide libraries displayed on phage

Phage Display in Biotechnology and Drug Discovery, Second Edition,

Deshayes; Jacob E. Corn

January 1, 2015

Antibody humanization and affinity maturation using phage display

Phage Display in Biotechnology and Drug Discovery, Second Edition,

Jonathan S. Marvin; Henry B. Lowman

January 1, 2015

Viral clearance of traditional unit operations: virus-retentive filtration

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Qi Chen; Dayue Chen

January 1, 2015

Orchestrating high-throughput genomic analysis with Bioconductor

Nature Methods, ISSN: 15487105 15487091

Wolfgang Huber; Vincent J. Carey; Robert Gentleman; Simon Anders; Marc Carlson; Benilton S. Carvalho; Hector Corrada Bravo; Sean Davis; Laurent Gatto; Thomas Girke; Raphael Gottardo; Florian Hahne; Kasper D. Hansen; Rafael A. Irizarry; Michael Lawrence; Michael I. Love; James MacDonald; Valerie Obenchain; Andrzej K. Oles̈; Hervé Pagès; Alejandro Reyes; Paul Shannon; Gordon K. Smyth; Dan Tenenbaum; Levi Waldron; Martin Morgan

January 1, 2015

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

Immunity, ISSN: 10974180 10747613

Natalia B. Pikor; Jillian L. Astarita; Leslie Summers-Deluca; Georgina Galicia; Joy Qu; Lesley A. Ward; Susan Armstrong; Claudia X. Dominguez; Deepali Malhotra; Brendan Heiden; Robert Kay; Valera Castanov; Hanane Touil; Louis Boon; Paul O'Connor; Amit Bar-Or; Alexandre Prat; Valeria Ramaglia; Samuel Ludwin; Shannon J. Turley; Jennifer L. Gommerman

January 1, 2015

Expanded change protocols: Benefits, cost considerations, and regulatory views

BioProcess International, ISSN: 15426319

Nadine Ritter; Julia Edwards; Stefanie Pluschkell; Suzanne Stella; Rebekah Logan; Chana Fuchs; Wassim Nashabeh; Rohin Mahtre

January 1, 2015

United States comparative costs and absenteeism of diabetic ophthalmic conditions

Postgraduate Medicine, ISSN: 19419260 00325481

Richard A. Brook; Nathan L. Kleinman; Sunil Patel; Jim E. Smeeding; Ian A. Beren; Adam Turpcu

January 1, 2015

Enhancing efficiency of trace metals analysis using a validated generic ICP-OES method

American Pharmaceutical Review, ISSN: 10998012

Ila Patel; Venkatramani; Colin D. Medley; Kavita Mistry; Larry Wigman; Nik P. Chetwyn

January 1, 2015

Creating a specialist protein resource network: A meeting report for the protein bioinformatics and community resources retreat

Database, ISSN: 17580463

Patricia C. Babbitt; Pantelis G. Bagos; Amos Bairoch; Alex Bateman; Arnaud Chatonnet; Mark J. Chen; David J. Craik; Robert D. Finn; David Gloriam; Daniel H. Haft; Bernard Henrissat; Gemma L. Holliday; Vignir Isberg; Quentin Kaas; David Landsman; Nicolas Lenfant; Gerard Manning; Nozomi Nagano; Narayanaswamy Srinivasan; Claire O'Donovan; Kim D. Pruitt; Ramanathan Sowdhamini; Neil D. Rawlings; Milton H. Saier Jr.; Joanna L. Sharman; Michael Spedding; Konstantinos D. Tsirigos; Ake Vastermark; Gerrit Vriend

January 1, 2015

The authors explore and define common industry approaches and practices when applying GMPs in early development

Pharmaceutical Technology, ISSN: 21507376 15432521

Q. Chan Li; Jackson D. Pellett; Michael Szulc; Mark D. Trone; Kirby Wong-Moon

January 1, 2015

A biopharmaceutical industry perspective on single-use sensors for biological process applications

BioPharm International, ISSN: 19391862 1542166X

Bradley H. Diehl; Mark A. Lapack; Tony Y. Wang; Robert E. Kottmeier; Stacey M. Kaneshiro; Michael C. Brandenstein; Yongchun Zhang; Yuk Chun Chiu; Seongkyu Yoon; Victor Saucedo

January 1, 2015

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: Addressing methodologic issues of plasma membrane isolation and expression-activity relationship

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Vineet Kumar; Bhagwat Prasad; Gabriela Patilea; Anshul Gupta; Laurent Salphati; Raymond Evers; Cornelis E. Hop; Jashvant D. Unadkat

January 1, 2015

Development and implementation of a double-blind corticosteroid-tapering regimen for a clinical trial

International Journal of Rheumatology, ISSN: 16879279 16879260

Neil Collinson; Katie Tuckwell; Frank Habeck; Monique Chapman; Micki Klearman; John H. Stone

January 1, 2015

First million-dollar syringe could be a sight for sore eyes

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2015

Predictors of early discontinuation of pegylated interferon for reasons other than lack of efficacy in United States veterans with chronic hepatitis c

Gastroenterology Nursing, ISSN: 15389766 1042895X

Joanne Lafleur; Hoop; Korner; Scott L. Duvall; Timothy Morgan; Prashant K. Pandya; Jian Han; Kristin Knippenberg; Richard E. Nelson

January 1, 2015

Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants

Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642

Dwight R. Stoll; Eric S. Talus; David C. Harmes; Kelly Zhang

January 1, 2015

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

Oncotarget, ISSN: 19492553

Nitu Bansal; Prasun J. Mishra; Mark Stein; Robert S. DiPaola; Joseph R. Bertino

January 1, 2015

Anemia Predicts Sustained Virological Response in Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C Treated with Peginterferon Alfa-2a and Ribavirin

Current Hepatitis Reports, ISSN: 15410706 15403416

Reau; Korner; Jian Han; Donald Jensen

January 1, 2015

Safety, virology and pharmacokinetics of oseltamivir in infants with laboratory-confirmed influenza: A Phase I/II, prospective, open-label, multicentre clinical trial

Antiviral Therapy, ISSN: 20402058 13596535

Barbara A. Rath; Jerzy Brzostek; Sara Guillén; Vis Niranjan; Colombe Chappey; Craig R. Rayner; Barry Clinch

January 1, 2015

Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425

Translational and Clinical Pharmacology, ISSN: 22890882

Young G. Shin; Henri Meijering; Fred H. van Heuveln; Jaap Wieling; Jason S Halladay; Srikumar Sahasranaman; Cornelis E. Hop

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