Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6151 - 6200 OF 15632 RESULTS

January 1, 2015

The BioMart community portal: An innovative alternative to large, centralized data repositories

Nucleic Acids Research, ISSN: 13624962 03051048

Damian Smedley; Syed Haider; Durinck; Luca Pandini; Paolo Provero; James Allen; Olivier Arnaiz; Mohammad H.amza Awedh; Richard Baldock; Giulia Barbiera; Philippe Bardou; Tim Beck; Andrew Blake; Merideth Bonierbale; Anthony J. Brookes; Gabriele Bucci; Iwan Buetti; Sarah Burge; Cédric Cabau; Joseph W. Carlson; Claude Chelala; Charalambos Chrysostomou; Davide Cittaro; Olivier Collin; Raul Cordova; Rosalind J. Cutts; Erik Dassi; Alex Di Genova; Anis Djari; Anthony Esposito; Heather Estrella; Eduardo Eyras; Julio Fernandez-Banet; Simon Forbes; Robert C. Free; Takatomo Fujisawa; Emanuela Gadaleta; Jose M. Garcia-Manteiga; David Goodstein; Kristian Gray; José Afonso Guerra-Assunção; Bernard Haggarty; Dong-Jin Han; Byung Woo Han; Todd Harris; Jayson Harshbarger; Robert K. Hastings; Richard D. Hayes; Claire Hoede; Shen Hu; Zhi-Liang Hu; Lucie Hutchins; Zhengyan Kan; Hideya Kawaji; Aminah Keliet; Arnaud Kerhornou; Sunghoon Kim; Rhoda Kinsella; Christophe Klopp; Lei Kong; Daniel Lawson; Dejan Lazarevic; Ji-Hyun Lee; Thomas Letellier; Chuan-Yun Li; Pietro Lio; Chu-Jun Liu; Jie Luo; Alejandro Maass; Jerome Mariette; Thomas Maurel; Stefania Merella; Azza Mostafa Mohamed; Francois Moreews; Ibounyamine Nabihoudine; Nelson Ndegwa; Céline Noirot; Cristian Perez-Llamas; Michael Primig; Alessandro Quattrone; Hadi Quesneville; Davide Rambaldi; James Reecy; Michela Riba; Steven Rosanoff; Amna Ali Saddiq; Elisa Salas; Olivier Sallou; Rebecca Shepherd; Reinhard Simon; Linda Sperling; William Spooner; Daniel M. Staines; Delphine Steinbach; Kevin Stone; Elia Stupka; Jon W. Teague; Abu Z. Dayem Ullah; Jun Wang; Doreen Ware; Marie Wong-Erasmus; Ken Youens-Clark; Amonida Zadissa; Shi-Jian Zhang; Arek Kasprzyk

January 1, 2015

Molecular assessment of monoclonal antibody-based therapeutics enabling lead selection for clinical development

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Vikas Sharma; Robert F. Kelley

January 1, 2015

Pharmacokinetics/pharmacodynamics and disposition of antibody-drug conjugates

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Siddharth Sukumaran; Kedan Lin

January 1, 2015

Application of QbD principles to late-stage formulation development for biological liquid products

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Alavattam Sreedhara; Wong; Yvonne Lentz; Karin Schoenhammer; Christoph Stark

January 1, 2015

Application of quality by design principles to the drug product technology transfer process

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Fred Lim; Jagannathan Sundaram; Alavattam Sreedhara

January 1, 2015

Drug substance frozen storage and thawing

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Philippe Lam; Fred Lim; Samir Sane

January 1, 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yi Zhang; Xiaohui Wei; Gaurav Bajaj; Jeffrey S. Barrett; Bernd Meibohm; Amita Joshi; Manish Gupta

January 1, 2015

Oxidative degradation of polysorbate surfactants studied by liquid chromatography-mass spectrometry

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Oleg V. Borisov; Junyan A. Ji; Y. John Wang

January 1, 2015

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

Journal of Chromatography A, ISSN: 18733778 00219673

Lulu Dai; Larry Wigman; Kelly Zhang

January 1, 2015

Effect of individual fc methionine oxidation on FcRn binding: Met252 oxidation impairs fcrn binding more profoundly than Met428 oxidation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Xuan Gao; Junyan A. Ji; Karthik Veeravalli; Y. John Wang; Taylor Zhang; William Mcgreevy; Kai Zheng; Robert F. Kelley; Mike Laird; Jun Liu; Cromwell

January 1, 2015

The VEGF receptor family

Receptor Tyrosine Kinases: Family and Subfamilies,

Guanglei Zhuang; Napoleone Ferrara

January 1, 2015

Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control

Journal of Neuroscience, ISSN: 15292401 02706474

Shih-Ching Lo; Yuanyuan Wang; Martin Weber; Jessica L. Larson; Kimberly Scearce-Levie; Morgan Sheng

January 1, 2015

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

Thorax, ISSN: 14683296 00406376

Daryle J. DePianto; Sanjay Chandriani; Abbas Alexander; Guiquan Jia; Elsa N. N'Diaye; Patrick Caplazi; Steven E. Kauder; Sabyasachi Biswas; Satyajit K. Karnik; Connie Ha; Zora Modrusan; Michael A. Matthay; Kukreja; Harold R. Collard; Jackson G. Egen; Paul J. Wolters; Joseph R. Arron

January 1, 2015

Neoadjuvant breast cancer treatment as a sensitive setting for trastuzumab biosimilar development and extrapolation

Future Oncology, ISSN: 17448301 14796694

Christian Jackisch; Frank A. Scappaticci; Dominik Heinzmann; Fabio Bisordi; Thomas Schreitmüller; Gunter Von Minckwitz; Javier Cortés

January 1, 2015

Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?

Scientific World Journal, ISSN: 1537744X 23566140

Savita V. Dandapani; Ying Zhang; Richard Jennelle; Yvonne G. Lin

January 1, 2015

Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked toll-like receptor 8

Frontiers in Immunology, ISSN: 16643224

Gabrielle McDonald; Nicholas Cabal; Augustin Vannier; Benjamin Umiker; Raymund H. Yin; Arturo V. Orjalo; Hans E. Johansson; Jin-Hwan Han; Thereza Imanishi-Kari

January 1, 2015

Toward an era of utilizing methionine overproducing hosts for recombinant protein production in Escherichia coli

Bioengineered, ISSN: 21655987 21655979

Karthik Veeravalli; Mike Laird

January 1, 2015

Separation science in drug development, part 1: High-throughput purification

LC-GC Europe, ISSN: 14716577

Mengling Wong; Brent Murphy; Joseph H. Pease; Michael W. Dong

January 1, 2015

Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma

Oncotarget, ISSN: 19492553

Lindi Chen; Raphaël F. Rousseau; Steven A. Middleton; Gwen L. Nichols; David R. Newell; John Lunec; Deborah A. Tweddle

January 1, 2015

Derivation of phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 1: Modeling optimal treatment duration and sustained virologic response rates

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Xiaodong Wang; Matthew Hruska; Phyllis Chan; Alaa Ahmad; Jeremy Freeman; Maria Arantxa Horga; Jan Hillson; Vikram Kansra; Juan-Carlos Lopez-Talavera

January 1, 2015

Erlotinib therapy after initial platinum doublet therapy in patients with EGFR wild type non-small cell lung cancer: Results of a combined patient-level analysis of the NCIC CTG BR.21 and SATURN trials

Translational Lung Cancer Research, ISSN: 22264477 22186751

Raymond U. Osarogiagbon; Federico Cappuzzo; Tudor Ciuleanu; Larry Leon; Barbara Klughammer

January 1, 2015

89Zr-Bevacizumab PET visualizes heterogeneous tracer accumulation in tumor lesions of renal cell carcinoma patients and differential effects of antiangiogenic treatment

Journal of Nuclear Medicine, ISSN: 01615505

Sjoukje F. Oosting; Adrienne H. Brouwers; Suzanne C. Van Es; Wouter B. Nagengast; Thijs H. Oude Munnink; Marjolijn N. Lub-de Hooge; Harry Hollema; Johan R. De Jong; Igle J. De Jong; Sanne De Haas; Stefan J. Scherer; Wim J. Sluiter; Rudi A. Dierckx; Alfons H.H. Bongaerts; Jourik A. Gietema; Elisabeth G. E. De Vries

January 1, 2015

Nanomedicine based on nucleic acids: Pharmacokinetic and pharmacodynamic perspectives

Current Pharmaceutical Biotechnology, ISSN: 18734316 13892010

Chenguang Zhou; Zhaogang Yang; Lesheng Teng

January 1, 2015

Biophysical techniques for characterizing the higher order structure and interactions of monoclonal antibodies

ACS Symposium Series, ISSN: 19475918 00976156

Yatin Gokarn; Sanjeev Agarwal; Kelly Arthur; Alexander Bepperling; Eric S. Day; Dana I. Filoti; Daniel G. Greene; David Hayes; Rachel Kroe-Barrett; Thomas M. Laue; Jasper C. Lin; Brian McGarry; Vladimir Razinkov; Sanjaya Singh; Rosalynn Taing; Sathyadevi Venkataramani; William Weiss; Danlin Yang; Isidro E. Zarraga

January 1, 2015

Design and pharmacokinetic characterization of novel antibody formats for ocular therapeutics

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Kapil Gadkar; Cinthia V Pastuskovas; Jennifer Le Couter; J. Michael Elliott; Jianhuan Zhang; Chingwei V. Lee; Sarah Sanowar; Fuh; Hok Seon Kim; T. Noelle Lombana; Christoph Spiess; Makia Nakamura; Hass; Whitney Shatz; Meng; Justin M. Scheer

January 1, 2015

Adventitious Agent Testing of Biologicals: Changing to a New Frontier of Technology, Cell-Based to Nucleic Acid-Based Detection

ACS Symposium Series, ISSN: 19475918 00976156

Ivar Kljavin; Kevin McCarthy; Dieter Schmalzing

January 1, 2015

Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: A retrospective, exploratory analysis in EMILIA

Annals of Oncology, ISSN: 15698041 09237534

Ian E. Krop; Lin; Kimberly Blackwell; Ellie Guardino; Huober; Michael W. Lu; David W. Miles; Meghna Samant; Manfred Welslau; Diéras

January 1, 2015

Sorbitol crystallization-induced aggregation in frozen mAb formulations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Deirdre Murphy Piedmonte; Alison Hair; Priti Baker; Lejla Brych; Karthik Nagapudi; Hong Lin; Wenjin Cao; Susan Hershenson; Gayathri Ratnaswamy

January 1, 2015

Gas-wall partitioning of oxygenated organic compounds: Measurements, structure-activity relationships, and correlation with gas chromatographic retention factor

Aerosol Science and Technology, ISSN: 15217388 02786826

Geoffrey K. Yeh; Paul J. Ziemann

January 1, 2015

Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on h 1 antihistamines: A randomized, placebo-controlled study

Journal of Investigative Dermatology, ISSN: 15231747 0022202X

Sarbjit S. Saini; Carsten Bindslev-Jensen; Marcus Maurer; Jean-Jacques Grob; Emel Bülbül Baskan; Mary S. Bradley; Janice Canvin; Abdelkader Rahmaoui; Panayiotis Georgiou; Oral Alpan; Sheldon Spector; Karin Rosén

January 1, 2015

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

Cell Death and Disease, ISSN: 20414889

Joel D. Leverson; Haichao Zhang; Jun Chen; Stephen K. Tahir; Darren C. Phillips; John Xue; Paul M. Nimmer; Sha Jin; Morey L. Smith; Yu Xiao; Peter J. Kovar; Tanaka; Bruncko; Sheppard; Le Wang; Sarah Gierke; Kategaya; Daniel J Anderson; Wong; Jeffrey Eastham-Anderson; Ludlam; Deepak Sampath; Wayne J. Fairbrother; Ingrid E. Wertz; Saul H. Rosenberg; Chris Tse; Steven W. Elmore; Andrew J. Souers

January 1, 2015

Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Melissa Junttila; Vidusha Devasthali; Jason H. Cheng; Joseph Castillo; Ciara Metcalfe; Anne C. Clermont; Doug Den Otter; Emily Chan; Hani Bou-Reslan; Tim C. Cao; William F. Forrest; Michelle Nannini; French; Richard A. D. Carano; Mark Merchant; Klaus P. Hoeflich; Mallika Singh

January 1, 2015

Clinical outcomes and medication adherence in acute coronary syndrome patients with and without type 2 diabetes mellitus: A longitudinal analysis 2006-2011

Journal of Managed Care Pharmacy, ISSN: 10834087

Mark J. Cziraky; Vanessa S. Reddy; Rakesh Luthra; Yaping Xu; Kenneth Wilhelm; Thomas P. Power; Maxine D. Fisher

January 1, 2015

HSP105 recruits protein phosphatase 2A To dephosphorylate ß-catenin

Molecular and Cellular Biology, ISSN: 10985549 02707306

Nancy Yu; Michael Kakunda; Victoria Pham; Jennie R. Lill; Pan Du; Matthew Wongchenko; Yibing Yan; Ron Firestein; Xiaodong Huang

January 1, 2015

Retinal ganglion cells thinning in eyes with nonproliferative idiopathic macular telangiectasia type 2A

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Abhilash Goud; Ganesh Babu Jonnadulla

January 1, 2015

Neurodegeneration in type 2 diabetes: Evidence from spectral-domain optical coherence tomography

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Apoorva Sharma; Abhilash Goud; Hari Kumar Peguda; Harsha L. Rao; Viquar Unnisa Begum; Giulio Barteselli

January 1, 2015

Strain engineering to prevent norleucine incorporation during recombinant protein production in Escherichia coli

Biotechnology Progress, ISSN: 15206033 87567938

Karthik Veeravalli; Mike Laird; Mark Fedesco; Yu Zhang; X. Christopher Yu

January 1, 2015

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Deepti R. Nagarkar; Vladimir Ramirez-Carrozzi; David F. Choy; Kevin Lee; Robert Soriano; Guiquan Jia; Abbas Alexander; Zora Modrusan; Rajita Pappu; Joseph R. Arron

January 1, 2015

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Yuan Chen; Divya Samineni; Sophie Mukadam; Harvey Wong; Shen; Dan Lu; Sandhya Girish; Cornelis E. Hop; Jin Y. Jin; Chunze Li

January 1, 2015

Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer

European Journal of Cancer, ISSN: 18790852 09598049

Gilles Vassal; Raphaël F. Rousseau; Patricia Blanc; Lucas Moreno; Gerlind Bode; Stefan Schwoch; Martin Schrappe; Jeffrey Skolnik; Bergmann; Mary Brigid Bradley-Garelik; Vaskar Saha; Andy Pearson; Heinz Zwierzina

January 1, 2015

Clinical and economic burden of commercially insured patients with acromegaly in the United States: A retrospective analysis

Journal of Managed Care Pharmacy, ISSN: 10834087

Hilary Placzek; Yaping Xu; Yunming Mu; Susan M. Begelman; Maxine D. Fisher

January 1, 2015

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Haematologica, ISSN: 15928721 03906078

Erica Sparkenbaugh; Pichika Chantrathammachart; Shaobin Wang; Will Jonas; Daniel Kirchhofer; David Gailani; Andras Gruber; Raj Kasthuri; Nigel S. Key; Nigel Mackman; Rafal Pawlinski

January 1, 2015

Performance bounds for particle filters using the optimal proposal

Monthly Weather Review, ISSN: 15200493 00270644

Chris Snyder; Thomas Bengtsson; Mathias Morzfeld

January 1, 2015

Using lysine-reactive fluorescent dye for surface characterization of a mAb

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Ming Lei; Kao; Christian Schöneich

January 1, 2015

Onartuzumab with or without bevacizumab in combination with weekly paclitaxel does not prolong QTc or adversely affect other ECG parameters in patients with locally recurrent or metastatic triple-negative breast cancer

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Marie T. Borin; Meng Chen; Mocci; Igor Rubets; Jason Chittenden; Wassim Aldairy; Mark Stroh

January 1, 2015

Semiconductor-based sequencing of formalin-fixed, paraffin-embedded colorectal cancer samples

Oncologist, ISSN: 1549490X 10837159

Shidong Jia; Liangxuan Zhang; Gary J. Latham

January 1, 2015

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Sharada Labadie; Peter Dragovich; Jinhua Chen; Benjamin P. Fauber; Jason Boggs; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Qunh Ho; Kwong Wah Lai; Shuguang Ma; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou

January 1, 2015

Cell-specific aptamer characterization

Aptamers Selected by Cell-SELEX for Theranostics,

Tao Chen; Cuichen Wu; Weihong Tan

January 1, 2015

Clinical impact of chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care system

Journal of Managed Care Pharmacy, ISSN: 10834087

Nazia Rashid; Han A. Koh; Hilda C. Baca; Zhaoliang Li; Susan Malecha; Oyewale Abidoye; Anthony Masaquel

January 1, 2015

New HPLC systems and products introduced at Pittcon 2015: A brief review

LC-GC Europe, ISSN: 14716577

Michael W. Dong

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